Clinical trials: Respiratory Aspiration
Ventilator Associated Pneumonia, Morality
Endotracheal Tube Cuff Pressure Measurement
The effect of endotracheal cuff pressure measurement technique for preventing ventilatory associated pneumonia.
- Conditions
- Ventilator Associated Pneumonia, Morality, Trauma, Brain, Endotracheal Aspiration
- Trial name
- NCT04397952
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Bagcilar Training and Research Hospital
Hypertension
RCT of Effects of Device-guided Breathing on Ambulatory BP
Our aim is to conduct a randomized controlled trial (RCT) to test the efficacy of a guided breathing intervention on ambulatory blood pressure (ABP), both systolic and diastolic BP.
- Trial name
- RESPeRate (NCT01184755)
- Testing
- Relaxation, RESPeRate
- Where
- 2 sites in United States
- Volunteers
- 253 people
- Sponsor
- Rutgers, The State University of New Jersey
Asthma
Comparison of Methacholine Bronchial Provocation With Wright and Devilbiss646 Nebulizers
The purpose of this study is to compare the diagnostic validity (sensitivity and specificity) and evaluate the safety of 2-min Tidal Breathing methacholine bronchial provocation tests with the Wright and Devilbiss646 nebulizers…
- Trial name
- NCT02502825
- Testing
- methacholine, Wright Nebulizer, Devilbiss646 Nebulizer
- Where
- China
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Guangzhou Institute of Respiratory Disease
Asthma
Efficacy of Ciclesonide Inhaled Once Daily Versus Fluticasone Propionate Inhaled Twice Daily in Children With Asthma (4 to 15 y) (BY9010/M1-205)
The aim of the study is to compare the efficacy of ciclesonide versus fluticasone propionate on lung function, symptoms, and use of rescue medication in children with persistent asthma.
- Trial name
- NCT00163410
- Testing
- Ciclesonide
- Where
- 16 sites in India
- Volunteers
- 500 people
- Sponsor
- AstraZeneca
Pulmonary Arterial Hypertension
Efficacy and Safety of Seralutinib in Adult Subjects With PAH (PROSERA)
The primary objective of the study is to determine the effect of seralutinib on improving exercise capacity in subjects with WHO Group 1 PAH who are FC II or III.
- Trial name
- NCT05934526
- Testing
- Seralutinib, Generic Dry Powder Inhaler
- Where
- 166 sites in United States, Argentina and 29 more
- Volunteers
- 390 people
- Sponsor
- GB002, Inc.
Diabetes Mellitus, Type 1
INHALE-3: Afrezza® Combined With Insulin Degludec Versus Usual Care in Adults With Type 1 Diabetes
INHALE-3 is a Phase 4, randomized controlled trial (RCT) that will randomly assign participants ≥18 years of age with type 1 diabetes (T1D) using multiple daily injections (MDI), an automated insulin delivery (AID) system, or a…
- Trial name
- NCT05904743
- Testing
- Afrezza, insulin degludec, Rapid-acting Insulin Analog
- Where
- 19 sites in United States
- Volunteers
- 141 people
- Sponsor
- Mannkind Corporation
Ventilation, End-Tidal Carbon Dioxide
End-tidal Carbon Dioxide Monitoring in Low Tidal Volume Ventilation
In cases where there is no ventilation-perfusion problem, the end-tidal carbon dioxide (ETCO2) value is closely associated with partial arterial carbon dioxide pressure (PaCO2); therefore, the PaCO2 value can be estimated using…
- Trial name
- ETCO2 (NCT04281589)
- Testing
- if the ventilation parameter caused desaturation or hypercapnia we will change the parameter
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Occupational Exposure
Prehospital Inhaled Methoxyflurane Non-Clinical Occupational Exposure Study
Methoxyflurane is an anesthetic gas and at low doses has shown to help with pain. Methoxyflurane was approved in Canada in 2018. Low-dose methoxyflurane is self-administered by patients via a handheld inhaler.
- Trial name
- NCT05766397
- Testing
- Methoxyflurane
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
ARDS
Electrical Impedance Tomography-Derived Dorsal Recruitment-to-Inflation Ratio Identifies PEEP Responsiveness and Risk Phenotypes in ARDS
In the treatment of critically ill patients, mechanical ventilation is a key link, and appropriate mechanical ventilation strategies can open the alveoli and improve oxygenation, while inappropriate mechanical ventilation can…
- Trial name
- NCT06823804
- Testing
- Electrical Impedance tomography Monitoring
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Ruijin Hospital
Multiple Sclerosis
Intermittent Low Oxygen Breathing: A First Study Testing Different Disease Stages in People Living With MS
This study will look at the safety, tolerability and feasibility of a non-invasive treatment called Acute Intermittent Hypoxia (AIH) in people with Multiple Sclerosis (MS) at different stages of the disease course.
- Trial name
- LOxyMS (NCT07631143)
- Testing
- Acute Intermittent Hypoxia
- Volunteers
- 9 people
- Sponsor
- University of Saskatchewan
Breathing-Related Sleep Disorder, Sleep Disorder (Disorder)
Wearable Technology in the Detection and Evaluation of Sleep-Related Breathing Disorders
This project is an observational study that aims to evaluate the accuracy of wearable devices in detecting potential sleep-related breathing disorders (SRBD) in individuals visiting the Sleep-Related Breathing Disorders and Home…
- Trial name
- ReSTech (NCT06606691)
- Testing
- Xiaomi Mi Smart Band 8
- Where
- 2 sites in Spain
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Universidade da Coruña
Nitrous Oxide, Dentistry
Demand-Driven Method for Gas Delivery in a Dental Setting
This study compares two methods of gas delivery in a dental setting: 1) demand-driven (DD) and 2) free-flow (FF). Nitrous oxide and oxygen sedation (NOS) is a common form of minimal sedation for adult and paediatric patients…
- Conditions
- Nitrous Oxide, Dentistry, Drug Delivery System, Comfort
- Trial name
- NCT04305990
- Testing
- Demand-driven delivery method, Free-flow delivery method
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Pulmonary Arterial Hypertension
A Study of AV-101 (Dry Powder Inhaled Imatinib) in Patients With Pulmonary Arterial Hypertension (PAH)
IMPAHCT: Inhaled iMatinib Pulmonary Arterial Hypertension Clinical Trial is a Phase 2b/Phase 3 study to evaluate the safety and efficacy of AV-101 (dry powder inhaled imatinib) in patients with Pulmonary Arterial Hypertension…
- Trial name
- IMPAHCT (NCT05036135)
- Testing
- AV-101
- Where
- 128 sites in United States, Argentina and 24 more
- Volunteers
- 202 people
- Sponsor
- Aerovate Therapeutics
Asthma
A Study to Evaluate the Effect of AZD8154 Administered Via Nebulizer Once Daily in Subjects With Mild Allergic Asthma Challenged With an Inhaled Allergen
This is a Phase IIa, double blind, randomized, parallel group, placebo controlled multi centre study to evaluate the effect of AZD8154 (administered via nebulizer daily [QD]) on allergen-induced inflammation in subjects with mild…
- Trial name
- NCT04187508
- Testing
- AZD8154 nebulizer suspension, 20 mg/mL
- Where
- 5 sites in Canada
- Sponsor
- AstraZeneca
Type 2 Diabetes Mellitus (T2DM)
Ayurveda Diet & Lifestyle Protocol for Type 2 Diabetes: A Feasibility Study
This study looked at whether a 12-week Maharishi Ayurveda diet and lifestyle program was practical and acceptable for adults with Type 2 Diabetes.
- Trial name
- AYU-LIFE-T2D (NCT07400276)
- Testing
- Maharishi Ayurveda Lifestyle Program
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Maharishi International University
Critical Illness, Respiratory Insufficiency
Combined Predictive Value of RSBI and CALLY Index in Predicting Weaning Success in ICU Patients
The primary objective of this prospective observational study is to evaluate the effectiveness of combining the Rapid Shallow Breathing Index (RSBI) and CRP-Albumin-Lymphocyte (CALLY) index to predict weaning success in adult…
- Conditions
- Critical Illness, Respiratory Insufficiency, Ventilator Weaning, Weaning Failure of Mechanical Ventilation
- Trial name
- NCT07571317
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people
- Sponsor
- Istanbul University - Cerrahpasa
Cancer
Remote Mindfulness Breathing Training for Patients Undergoing Chemotherapy
This randomized controlled trial will evaluate the effects of a mobile-delivered remote mindfulness breathing training program on symptom distress, fatigue, anxiety, and depression in adults with cancer who are receiving…
- Trial name
- NCT07806760
- Testing
- Mobile Remote Mindfulness Breathing Training, Brief Mindfulness Breathing Instruction
- Where
- 2 sites in Taiwan
- Volunteers
- 80 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Awareness, Anesthesia, Recall Phenomenon
Awareness in Old Aged Patients During Laryngoscopy and Intubation Using Isolated Forearm Technique
Awareness during general anesthesia - that has an incidence between 0.1% and 0.9% of cases and may be more in elderly - remains a concern for anesthesiologists.
- Conditions
- Awareness, Anesthesia, Recall Phenomenon, Inhalation; Gas
- Trial name
- NCT05019560
- Testing
- Sevoflurane, TIVA
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Asthma
High-intensity Inspiratory Muscle Training in Patients With Asthma
The aim of this study is to examine the effects of high-intensity and low-intensity inspiratory muscle training added to the standard pulmonary rehabilitation exercise program including aerobic and peripheral muscle strengthening…
- Trial name
- NCT06516848
- Testing
- High Intensity Inspiratory Muscle Training Group (H-IMT), Low Intensity Inspiratory Muscle Training Group (L-IMT)
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Istanbul Medipol University Hospital
Coronary Artery Disease
The Predictive Value of the Heart Rate Response to Breathing Maneuvers for Inducible Myocardial Perfusion Deficits
Breathing maneuvers, i.e. hyperventilation followed by breath-holding, have been shown to change coronary dynamics; hyperventilating narrows the coronary arteries, puts "stress" on the heart, and increases the heart rate, whereas…
- Trial name
- SCREEN-MORE (NCT05516615)
- Testing
- 4 minute breathing maneuver
- Where
- Canada
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre