Clinical trials: Respiratory Aspiration
Respiratory Distress Syndrome, Adult
Pilot Study of Positive-End Expiratory Pressure in Acute Respiratory Distress Syndrome
Randomized controlled pilot trial in 70 patients with Acute Respiratory Distress Syndrome (ARDS) ventilated with low tidal volumes and limitation on airway pressure at 35 centimeters of water (cmH2O), to compare two different…
- Trial name
- PEEP-HUPA (NCT01119872)
- Testing
- Positive End-expiratory Pressure (PEEP)
- Where
- Spain
- Volunteers
- 70 people
- Sponsor
- Hospital Universitario Principe de Asturias
Respiration, Artificial
Feasibility of Ventilation Detection Via Standard Defibrillator Pads in Mechanically Ventilated Pediatric Patients
This study is a prospective, observational case series of a convenience sample of mechanically ventilated pediatric patients in the Pediatric ICU, Progressive Care Unit and Operating Room at the Children's Hospital of…
- Trial name
- Vent Detection (NCT00628875)
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Children's Hospital of Philadelphia
Atelectasis, Ventilation, Mechanical
Impact of Nebulized Dornase Alpha on Mechanically Ventilated Patients
The investigators hypothesized that dornase alpha, administered twice a day (BID) by in-line nebulizer, would improve oxygenation, compliance, and time to extubation in adult patients receiving mechanical ventilation.
- Trial name
- NCT01095276
- Testing
- Pulmozyme (nebulized dornase alpha), Saline
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
Critical Illness, Length of Stay
Advantages and Disadvantages of Long Term Sedation in Intensive Care Unit Patients
The purpose of the study is to determine whether sedation of the critical ill patient prolongs the time receiving mechanical ventilation.
- Conditions
- Critical Illness, Length of Stay, Respiration, Artificial, Intensive Care Units
- Trial name
- NCT00466492
- Testing
- Sedation or no sedation during mechanical ventilation
- Where
- Denmark
- Volunteers
- 140 people
- Sponsor
- Odense University Hospital
Healthy Volunteers
AZD8683 Single Ascending Dose Study
The aim of the study is to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of AZD8683 following single ascending dose administrations in healthy male subjects.
- Trial name
- NCT00979849
- Testing
- AZD8683
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Morbid Obesity
Oxygenation and Pulmonary Function in Morbidly Obese Patients Undergoing Bariatric Surgery
This is a randomized controlled study in which morbidly obese patients undergoing bariatric surgery will be recruited in the preoperative clinic.
- Trial name
- NCT01002599
- Testing
- Boussignac TM CPAP, Venturi Face Mask
- Where
- Canada
- Volunteers
- 54 people
- Sponsor
- University Health Network, Toronto
Periodic Breathing
Developing a New, Dynamic, Therapeutic Pacemaker Algorithm for Stabilising Periodic Breathing in Chronic Heart Failure.
To evaluate whether cardiac output manipulation via a cardiac pacemaker can stabilise ventilation.
- Trial name
- NCT01044407
- Testing
- Pacemaker manipulation
- Where
- United Kingdom
- Volunteers
- 14 people
- Sponsor
- Imperial College London
Respiration
Comparison of Pressure-, Flow- and Neurally Adjusted Ventilatory Assistance (NAVA)-Triggering in Pediatric and Neonatal Ventilatory Care
The purpose of this study is to study whether neurally adjusted ventilatory assist (NAVA) provides advantages over current methods in detecting patients own breathing efforts in pediatric and neonatal ventilatory care.
- Trial name
- NCT00893087
- Testing
- Triggering mode of the ventilator, Triggering method of the ventilator
- Where
- Finland
- Volunteers
- 18 people
- Sponsor
- University of Oulu
Aging, Respiration, Artificial
ABC Trial: Awakening and Breathing Controlled
The purpose of this study is to determine the impact of a new RN/RRT (Registered Nurse/Registered Respiratory Therapist) directed 2-step protocol to wean patients off of a ventilator.
- Trial name
- NCT00097630
- Testing
- SAT: Spontaneous Awakening Trial, SBT: Spontaneous Breathing Trial
- Where
- 4 sites in United States
- Volunteers
- 334 people
- Sponsor
- National Institute on Aging (NIA)
Healthy Volunteers
Lung Deposition Via Different Inhalation Devices
The purpose of this study is to assess the deposition of budesonide to the lung after inhalation with 5 different devices and to relate the findings to in vitro properties of inhaled budesonide.
- Trial name
- NCT00975754
- Testing
- Pulmicort pMDI HFA, Budesonide pMDI HFA, Pulmicort Repulses
- Where
- Sweden
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Mouth Breathing
Posture and Pulmonary Function of Mouth-breathing Children
The purpose of this study is to characterize the posture and respiratory function of mouth-breathing children.
- Trial name
- NCT01019525
- Where
- Brazil
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio de Janeiro
Respiratory Failure
Extubation With or Without Spontaneous Breathing Trial
Spontaneous breathing trial (SBT) has long been thought to be a essential process before extubation. In this study,the investigator hypothesized that SBT could be not essential during weaning from ventilator and investigated…
- Trial name
- SBT (NCT01020773)
- Testing
- spontaneous breathing trial
- Volunteers
- 67 people
- Sponsor
- Beijing Shijitan Hospital, Capital Medical University
Healthy
AZD9164 Single Ascending Dose Study in Healthy Male Subjects
The aims of the study are to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of AZD9164 following single ascending dose administrations to healthy male subjects.
- Trial name
- NCT00847249
- Testing
- AZD9164
- Where
- Sweden
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Sedation, Respiration, Artificial
Dexmedetomidine for Postoperative Sedation in Patients Undergoing Repair of Thoracoabdominal Aortic Aneurysms
The primary objective of this study is to test the hypothesis that time on the ventilator and ICU length of stay will be shorter in TAA patients given postoperative sedation with dexmedetomidine compared to those given standard…
- Conditions
- Sedation, Respiration, Artificial, Length of Stay
- Trial name
- NCT00409344
- Testing
- Dexmedetomidine, Normal Saline
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Respiratory Distress Syndrome
Effect of Different Ventilatory Strategies on Cardiac Function in Patients With Acute Respiratory Failure
Mechanical ventilation with low tidal volume (about 6 ml.kg-1) reduces mortality in ALI/ARDS patients respect to high tidal volume ventilation (about 12 ml.kg-1).
- Trial name
- VITALI (NCT00713713)
- Testing
- Mechanical ventilation with low and high tidal volume
- Where
- Italy
- Volunteers
- 16 people
- Sponsor
- Fondazione Poliambulanza Istituto Ospedaliero
Respiration, Artificial, Respiratory Insufficiency
Tracheobronchial Secretion Removal
Patients undergoing intubation and mechanical ventilation require removal of secretion by means of trachoebronchial suctioning. Timing of the procedure is mainly based on clinical parameters.
- Trial name
- NCT00932776
- Testing
- TBA care device, Control
- Where
- Italy
- Sponsor
- University of Milano Bicocca
Ventilation, Mechanical
Clinical Evaluation of AutoFlow Mode During Mechanical Ventilation
The purpose of this study is to evaluate the long term use of AutoFlow mode during mechanical ventilation in ICU patients
- Trial name
- AFON (NCT00927745)
- Testing
- AutoFlow mode on Evita 4 Dräger ventilators, Evita 4 Dräger ventilators
- Where
- France
- Volunteers
- 42 people
- Sponsor
- Centre Hospitalier Victor Dupouy
Respiration, Artificial, Ventilator Weaning
Pressure Support Reduction Versus Spontaneous Breathing Trials in Weaning From Ventilation
This study is a comparison of two most commonly used modes of weaning and the outcomes in the two groups.
- Trial name
- NCT00911378
- Testing
- Pressure support ventilation, Spontaneous breathing trials
- Where
- India
- Volunteers
- 130 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Healthy
Inspiratory Support Improves Preoxygenation in Healthy Subjects
Preoxygenation optimizes oxygen content in the functional residual capacity (FRC). Adequate preoxygenation is defined by an expiratory oxygen fraction (FEO2) > 90%.
- Trial name
- NCT00922753
- Testing
- VS, AI-4/PEEP-4, AI-6/PEEP-4
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Maisonneuve-Rosemont Hospital
Critically Ill, Enteral Nutrition
Prokinetic Drugs and Enteral Nutrition
The purpose of this study is to compare the effect of two drugs that can help in the prevention of regurgitation during the administration of enteral nutrition and define which one is the most effective.
- Trial name
- prokinetics (NCT00916591)
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Universitair Ziekenhuis Brussel