Clinical trials: Respiratory Disorder
Asthma
Comparing Bronchodilation of Symbicort With and Without Valved Holding Chamber (Aerochamber Plus)
This study will compare the amount of bronchial tube relaxation from the Formoterol medicine contained in the Symbicort pressure Metered Dose Inhaler(pMDI)(a combination of Budesonide, a steroid, and Formoterol, a drug which…
- Trial name
- WSMR2 (NCT00915538)
- Testing
- pMDI budesonide/formotrol 160/4.5 is in group 1, Symbicort 160/4.5 plus Aerochamber Plus included in group 2
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Western Sky Medical Research
Carcinoma, Non-Small-Cell Lung, Sleep Wake Disorders
Low-Frequency rTMS for In-Hospital Sleep Disturbance in Advanced NSCLC
This randomized, double-blind, sham-controlled trial will evaluate whether low-frequency repetitive transcranial magnetic stimulation (rTMS) can improve in-hospital sleep quality in adults with advanced non-small cell lung cancer…
- Trial name
- NCT07796438
- Testing
- Active Low-Frequency Repetitive Transcranial Magnetic Stimulation
- Volunteers
- 160 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Sinusitis
Immunologic Aspects of the Pathogenesis of Chronic Sinusitis in Children
Chronic sinusitis is a common pediatric disease; it ranks among the top five infectious diseases of the upper respiratory tract. Its treatment is limited and may be due largely in part to a lack of understanding of its cause.
- Trial name
- NCT00004638
- Testing
- pathogenesis study
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Center for Research Resources (NCRR)
Cystic Fibrosis
Safety, Tolerability, and Pharmacokinetics of ARCT-032 in Healthy Adult Subjects and Adults With Cystic Fibrosis.
Determine the safety, tolerability and pharmacokinetics of single doses of ARCT-032 in healthy adult subjects (Phase 1) and of two doses in Adults with Cystic Fibrosis (Phase 1b).
- Trial name
- NCT05712538
- Testing
- ARCT-032
- Where
- New Zealand
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Arcturus Therapeutics, Inc.
Asthma
Single and Multiple Ascending Dose Study of TD-8236 by Inhalation
This is a Phase 1, randomized, double-blinded, placebo controlled study. The study consists of 3 parts: Part A is a single ascending dose (SAD) study in healthy subjects, Part B is a multiple ascending dose (MAD) study in…
- Trial name
- NCT03652038
- Testing
- TD-8236
- Where
- 2 sites in United Kingdom
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Theravance Biopharma
COPD - Chronic Obstructive Pulmonary Disease, Healty Controls
Hemodynamic Responses and Brain Activity During Dual Tasks in COPD Patients Versus Healthy Individuals
Abstract Cognitive dysfunction is joint in patients with chronic obstructive pulmonary disease (COPD). In particular, there are effects in tasks that require attention, executive functions, and working memory related to the…
- Trial name
- NCT06974448
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Fatigue, Dyspnea
TaiChi-DTx for Treating Long Covid Symptoms
The randomized controlled trial will be conducted to evaluate the effectiveness of a Multi-domain Tai Chi Digital Therapy for treating the individuals suffering from the long term COVID-19 syndrome (Long COVID).
- Conditions
- Fatigue, Dyspnea, Cognitive Impairment, Muscle Pain
- Trial name
- TaiChi-DTx (NCT05419219)
- Testing
- the multi-domain Tai Chi Digital therapy Software Application
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Tim Shi
Bronchiolitis, Viral
High Flow Oxygen Therapy vs Standard Care in Infants With Viral Bronchiolitis
A randomized control trial of 130 infants admitted to the paediatric high care admission ward will be enrolled, and randomized to either "high flow humidified oxygen" or "standard therapy".
- Trial name
- NCT03252119
- Testing
- High flow humidified oxygen therapy
- Where
- South Africa
- Volunteers
- 28 people
- Sponsor
- Chris Hani Baragwanath Academic Hospital
Extensive-Stage Small Cell Lung Cancer
Maintenance Lurbinectedin in Combination With Serplulimab for Patients With ES-SCLC
This is a single-arm, open-lable exploratory study of Lurbinectedin in combination with Serplulimab as maintenance therapy in participants with extensive-stage small-cell lung cancer (ES-SCLC) after first-line induction therapy…
- Trial name
- NCT06497530
- Testing
- Serplulimab, Lurbinectedin, Carboplatin
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Pulmonary Arterial Hypertension
Long-Term, Open Label Extension Study of Pemziviptadil (PB1046) in PAH Subjects Following Completion of Study PB1046-PT-CL-0004
This is a multi-center, Phase 2 Long-Term, Open Label Extension (OLE) Study to assess the safety and tolerability of pemziviptadil (PB1046) at an optimally titrated dose.
- Trial name
- VIP Extend (NCT03795428)
- Testing
- Pemziviptadil (PB1046) Injection
- Where
- 16 sites in United States
- Volunteers
- 25 people
- Sponsor
- PhaseBio Pharmaceuticals Inc.
COVID-19
Provide Pre-approval Single-patient Expanded Access (Compassionate Use) of VYD222 for Patients With Symptomatic COVID-19 Refractory to Other Treatments
Provide pre-approval single-patient Expanded Access (Compassionate Use) of VYD222 for patients with symptomatic COVID-19 refractory to other treatments.
- Trial name
- NCT06004128
- Testing
- VYD222
- Sponsor
- Invivyd, Inc.
Rhinitis, Allergic, Perennial and Seasonal
Regulatory AVAMYS Nasal Spray PMS
Non-interventional, open-label, single group, multicentric post-marketing surveillance to monitor the safety and effectiveness of AVAMYS nasal spray administered in Korean patients according to the prescribing information.
- Trial name
- NCT01001130
- Testing
- fluticasone furoate group
- Where
- South Korea
- Volunteers
- 3,244 people
- Sponsor
- GlaxoSmithKline
Respiratory Insufficiency
Evaluation of the Therapeutic Usability of RESPIRA ADVANCED Device in Patients Under Invasive Mechanical Ventilation
The objective of the clinical investigation presented is to guarantee the safety and usability of the RESPIRA ADVANCED medical device in patients undergoing mechanical ventilation in the ICU, both stable patients and in the…
- Trial name
- RESPIRA-02 (NCT05174130)
- Testing
- RESPIRA device.com® Advanced
- Where
- 3 sites in Spain
- Volunteers
- 30 people
- Sponsor
- Fundacion Clinic per a la Recerca Biomédica
Nasal Congestion and Inflammations, Sinus Congestion Chronic
Effects of SinuSonic on Psychological and Physical Well-Being
The goal of this clinical trial is to evaluate the effects of using the SinuSonic on psychological and physical well-being in adults who have nasal/sinus congestion.
- Trial name
- NCT06268730
- Testing
- SinuSonic
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of North Carolina, Chapel Hill
Lung Cancer
Neoadjuvant IRESSA As Single Agent PreopTherapy for NSCLC With Molecular Correlates
RATIONALE: Gefitinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving gefitinib before surgery may shrink the tumor so it can be removed.
- Trial name
- NCT00104728
- Testing
- ZD1839
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Respiratory Failure With Hypoxia, Respiratory Failure Without Hypercapnia
Prone Positioning During High Flow Oxygen Therapy in Acute Hypoxemic Respiratory Failure
Background High-flow nasal cannula (NHF) are a promising tool for administering oxygen to critically ill patients with high respiratory demand.
- Trial name
- Optiprone (NCT03095300)
- Testing
- Prone position
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Catholic University of the Sacred Heart
Chronic Obstructive Pulmonary Disease
Bufei Jianpi Granule for Delaying Pulmonary Function Decline in Early-Stage COPD
This study aims to establish the treatment scheme of Bufei Jianpi granule for early-stage (GOLD stage 1 or 2) chronic obstructive pulmonary disease (COPD), delaying pulmonary function decline and forming high quality evidence.
- Trial name
- NCT03976700
- Testing
- Bufei Jianpi granule
- Where
- China
- Volunteers
- 612 people
- Sponsor
- Henan University of Traditional Chinese Medicine
Covid19
Elderly Patients and COVID-19 Infection: a Cohort of Fifty Patients Over Ninety Years of Age
SARS-CoV2 or CoVid19 disease is a newly described pathology linked to a subtype of the coronavirus family identified in China in December 2019.
- Trial name
- NCT04499300
- Testing
- Data collection from medical files
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Murielle Surquin
Wheezing, Asthma in Children
Impedance Pneumography in Assessment of Asthma Control in Preschool Children
This study evaluates the value of impedance pneumography, used as overnight home recordings during a longitudinal design, in assessing asthma control in preschool children
- Trial name
- IPAAC (NCT03377192)
- Where
- 2 sites in Finland
- Volunteers
- 53 people
- Sponsor
- HUS Skin and Allergy Hospital
Chronic Respiratory Failure
Adaptation to Nocturnal Noninvasive Ventilation in Patients With Chronic Respiratory Failure (ROOMILA)
BACKGROUND: Adaptation to noninvasive ventilation (NIV) is a critical step for acceptability and efficacy of this treatment during sleep in patients with chronic respiratory failure.
- Trial name
- ROOMILA (NCT01255111)
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Groupe de Recherche sur le Handicap Respiratoire
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