Clinical trials: Respiratory Disorder
Diabetes, Type 1 Diabetes
The Effects of Alpha-1 Antitrypsin (AAT) on the Progression of Type 1 Diabetes
The purpose of this study is to determine if the drug Alpha-1 Antitrypsin (AAT, Aralast NP) will preserve beta-cell function and help slow the progression of type 1 diabetes.
- Trial name
- NCT01319331
- Testing
- Alpha 1-Antitrypsin (AAT, Aralast NP)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Colorado, Denver
Atopic Dermatitis, Atopic
Dietary Intervention on Atopy
Diet is a key determinant of overall health, with growing evidence associating dietary patterns with allergic diseases. Among these, atopic dermatitis (AD) is of particular interest as it often represents the earliest…
- Conditions
- Atopic Dermatitis, Atopic, Allergic Diseases, Allergic Rhinitis
- Trial name
- NCT06547372
- Testing
- Dietary Intervention on Atopy
- Where
- Singapore
- Volunteers
- 110 people
- Sponsor
- National University of Singapore
Chronic Obstructive Pulmonary Disease, COPD
Tele Health Monitoring Service for Patients With Chronic Obstructive Pulmonary Disease
The aim of this study is to evaluate the effect of monitoring patients with chronic obstructive pulmonary disease (COPD) after a hospitalization for COPD exacerbation or pneumonia.
- Trial name
- NCT02615795
- Testing
- Tele Monitoring, using Tunstall monitoring device
- Where
- Denmark
- Volunteers
- 160 people
- Sponsor
- University of Aarhus
Pulmonary Embolism, Covid-19
Prevalence and Characteristics of Pulmonary Embolism on COVID-19 Patients Presenting Respiratory Symptoms
Multicentric case-control study that is aims at: evaluating the prevalence of pulmonary embolism among a large population of consecutive patients admitted for COVID-19 pneumonia into two large university hospitals in Paris…
- Trial name
- COVID-EP (NCT04420312)
- Where
- France
- Volunteers
- 1,024 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Brain and Central Nervous System Tumors, Breast Cancer
Carboxyamidotriazole and Paclitaxel in Treating Patients With Advanced Solid Tumors or Refractory Lymphomas
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells.
- Conditions
- Brain and Central Nervous System Tumors, Breast Cancer, Kidney Cancer, Lung Cancer
- Trial name
- NCT00019019
- Testing
- carboxyamidotriazole, paclitaxel
- Where
- 2 sites in United States
- Volunteers
- 70 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Pulmonary Atelectasis, Postoperative
Effect of Different Inspired Oxygen Concentrations on Intraoperative Recruitment Outcomes in Patients Undergoing Abdominal Surgery
This study intends to evaluate the effect of different inhaled oxygen concentrations on the effect of lung recruitment in patients undergoing abdominal surgery.
- Trial name
- NCT06746181
- Testing
- Fraction of inspiration O2(FiO2)
- Where
- China
- Volunteers
- 95 people
- Sponsor
- Northern Jiangsu People's Hospital
Non Small Cell Lung Cancer
Erlotinib as Neoadjuvant Treatment in Patients With Stage ⅢA N2 NSCLC With Activating EGFR Mutation.
This is a single arm, one center, phaseⅡ study evaluating efficacy and safety of erlotinib as neoadjuvent treatment in patients with EBUS confirmed stage ⅢA N2 NSCLC with activating EGFR mutation in exon 19 or 21.
- Trial name
- ML25444 (NCT01217619)
- Testing
- erlotinib
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Baohui Han
Non-small-cell Lung Cancer
E7080 in Combination With Carboplatin and Paclitaxel in Patients With Non-small Cell Lung Cancer (NSCLC)
The purpose of this study is to determined the maximum tolerated dose (MTD), safety and tolerability, pharmacokinetics, pharmacodynamics, and anti-tumor effect of E7080 administered continually twice daily in combination with…
- Trial name
- NCT00832819
- Testing
- E7080, Paclitaxel, Carboplatin
- Where
- 3 sites in Japan
- Volunteers
- 28 people
- Sponsor
- Eisai Co., Ltd.
Lung Injury, Acute
a Study Conducted About a New Mode of Ventilation in Laparoscopic Surgeries
Carbon dioxide insufflations of abdomen are integral part of laparoscopic operations in minimally invasive surgery era. It does cause splinting effect on diaphragm movement and set it high inside thoracic cavity too.
- Trial name
- NCT03637530
- Testing
- inverse ratio ventilation
- Volunteers
- 128 people
- Sponsor
- All India Institute of Medical Sciences, Rishikesh
Carcinoma, Small Cell Lung
Study of Low-Dose Radiotherapy (LDRT) Concurrent Cisplatin/Carboplatin Plus Etoposide With Atezolizumab for Patients With Extensive-Stage Small Cell Lung Cancer
This is a Phase II, single arm, multicenter study designed to evaluate the safety and efficacy of low-dose radiotherapy (LDRT) concurrent cisplatin/carboplatin plus etoposide with atezolizumab in participants who have…
- Trial name
- Match (NCT04622228)
- Testing
- Atezolizumab, Cisplatin, Carboplatin
- Where
- 8 sites in China
- Volunteers
- 56 people
- Sponsor
- Hoffmann-La Roche
Covid19
Pulmonary Rehabilitation in COVID-19 Patients
It was aimed to evaluate the respiratory functions of patients who were given respiratory rehabilitation, bed positioning and early mobilization, and the time of leaving the hospital.
- Trial name
- NCT04832867
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
COVID-19
Physical Activity and the Course of COVID-19
Being active has a beneficial effect on human immunology. Patients hospitalized for COVID-19 (coronavirus disease 2019) will be surveyed for their prior physical activity.
- Trial name
- NCT05200767
- Testing
- completing surveys
- Where
- 2 sites in Poland
- Volunteers
- 140 people
- Sponsor
- Wroclaw Medical University
Sleep Apnea, Nasal Obstruction
Turbinate Cauterization in Pediatric Patients With Nasal Obstruction
patients will be placed in 2 groups, with or without turbinate cautery ( a surgical method to reduce the size of the skin covered bones in the nose), at the time of adenoidectomy and tonsillectomy.
- Trial name
- NCT01695967
- Testing
- turbinate cauterization
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Eastern Virginia Medical School
Postural Orthostatic Tachycardia Syndrome
Efficacy and Safety Study of Efgartigimod in Adults With Post-COVID-19 POTS
The study aims to investigate the safety, tolerability, efficacy, pharmacodynamics (PD), pharmacokinetics (PK), and immunogenicity of efgartigimod compared to placebo in participants with post-COVID-19 postural orthostatic…
- Trial name
- POTS (NCT05633407)
- Testing
- Efgartigimod
- Where
- 11 sites in United States
- Volunteers
- 53 people
- Sponsor
- argenx
Lung Neoplasm
Reader Study of DeltaView™ Chest Radiograph Software
A new software product takes two chest radiographs, aligns them, and then subtracts one image from the other. The resulting image represents an image showing any differences between them.
- Trial name
- NCT01261507
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Georgetown University
Cystic Fibrosis
Safety and Efficacy Study of Aztreonam for Inhalation Solution (AZLI) in Cystic Fibrosis (CF) Patients With Pseudomonas Aeruginosa (PA)
The purpose of this study was to evaluate the safety and efficacy of multiple courses of AZLI in patients with cystic fibrosis (CF) and lung infection due to Pseudomonas aeruginosa (PA).
- Trial name
- AIR-CF3 (NCT00128492)
- Testing
- AZLI 75 mg two times a day (BID)/ three times a day (TID)
- Where
- 65 sites in United States, Australia and 2 more
- Volunteers
- 274 people
- Sponsor
- Gilead Sciences
Pneumonia, Covid19
Prone Position to Improve Oxygenation in COVID-19 Patients Outside Critical Care
Prone positioning is known to improve the PaO2/FiO2 ratio and reduce mortality in patients with ARDS managed in the critical care setting.
- Trial name
- PRONE-COVID (NCT04589936)
- Testing
- Prone positioning
- Where
- United Kingdom
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Tuberculosis, Lower Respiratory Infection
Host Blood RNA Signatures for Diagnosis of TB
Tuberculosis (TB) is the biggest infectious cause of death worldwide, and the biggest cause of death in Sub-Saharan Africa among HIV-positive patients.
- Trial name
- RADIANT (NCT05542511)
- Where
- South Africa
- Volunteers
- 1,458 people
- Sponsor
- University of Stellenbosch
Community-acquired Pneumonia, Sepsis
Anti-inflammatory Action of Oral Clarithromycin in Community-acquired Pneumonia
Traditional management of community-acquired pneumonia (CAP) relies on the prompt administration of antimicrobials that target the most common causative pathogens.
- Conditions
- Community-acquired Pneumonia, Sepsis, Inflammatory Response, Mortality
- Trial name
- ACCESS (NCT04724044)
- Testing
- Tablets, Clarithromycin 500mg
- Where
- 18 sites in Greece
- Volunteers
- 278 people
- Sponsor
- Hellenic Institute for the Study of Sepsis
Chronic Obstructive Pulmonary Disease (COPD), Obstructive Sleep Apnea Syndrome (OSAS)
Endothelial Function Study Before Cardiovascular Surgery
The aim of this clinical trial is to evaluate the effect of chronic obstructive pulmonary disease (COPD) and/or obstructive sleep apnea syndrome (OSAS) on the endothelial function, before cardiovascular surgery, compared to non…
- Trial name
- COPD-OSAS (NCT01195064)
- Where
- 3 sites in France
- Volunteers
- 109 people
- Sponsor
- University Hospital, Grenoble
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