Clinical trials: Respiratory Disorder
Non-small Cell Lung Cancer
Neoadjuvant Finasteride for Patients With Non-small Cell Lung Cancer
The purpose of this study is to study the effect of hormone therapies (androgen pathway modification) on the outcomes of patients with lung cancer.
- Trial name
- NCT02055170
- Testing
- finasteride 5mg oral daily
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- CancerCare Manitoba
Smell Loss, Chronic Rhinosinusitis (CRS)
Cognitive and Immunologic Profiles of Patients With Olfactory Dysfunction After Smell Training
A research study to assess the baseline olfactory function, mental health status, clinical severity, and immunological profile in patients with smell loss.
- Trial name
- CIPOD (NCT07681973)
- Testing
- Smell Training
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Asthma
Ciclesonide for the Treatment of Airway Hyperresponsiveness
The study objective is to investigate in a placebo-controlled, double-blind manner the effect of inhaled corticosteroid (ciclesonide) on airway hyperresponsiveness measured as having PD15 mannitol.
- Trial name
- NCT00826969
- Testing
- Ciclesonide
- Where
- Switzerland
- Volunteers
- 64 people
- Sponsor
- AstraZeneca
Unilateral Vocal Cord Paralysis, Central Auditory Processing Disorder
Early UVFP Management Based on Neurological Evidences (ION-UVFP) - Preliminary Study
The purpose of this preliminary study is to help clarify our hypotheses for the longitudinal study by investigating the relationship between vocal cord paralysis and central auditory processes and thus the interpretation of…
- Trial name
- NCT03966183
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Covid19
TOcilizumab and Covid-19 : Risk of Severe INfection
SARS-CoV2 is responsible for a pandemic that has been evolving for approximately 18 months. The virus' capacity for dissemination and its virulence are responsible for significant morbidity and mortality.
- Trial name
- TOCSIN (NCT05017441)
- Where
- France
- Volunteers
- 1,200 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Pulmonary Disease, Chronic Obstructive
The Effect of Spa Treatment on Chronic Obstructive Pulmonary Disease
The primary objective of this study is to measure and compare the number of exacerbations (moderate or severe) between the two groups of randomized patients with and without thermal treatment).
- Trial name
- BPCeaux (NCT01296854)
- Testing
- Spa therapy
- Where
- 6 sites in France
- Volunteers
- 39 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Diaphragm Thickness, Dyspnoea
Abdominal Air-Pressure Resistance Versus Abdominal Weight Training for Improving Diaphragm Function in Healthy Young Adults
This study aims to compare the effects of abdominal air pressure resistance training, abdominal weight training, and breathing exercises on diaphragmatic strength, endurance, and physiological responses in young healthy adults.
- Trial name
- NCT07795905
- Testing
- Abdominal Air Pressure Resistance Training, Abdominal Weight Training (AWT), Breathing Exercise Control (BE)
- Where
- United Arab Emirates
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Sharjah
Influenza, COVID-19
Routine Application of Point-of-care PCR Test to Identify and Direct Therapy for Acute Respiratory Infection in the Emergency Department Trial
The RAPID-ARIED Trial is a pragmatic, single-centre, parallel group, open-label, randomised controlled trial to be conducted in the Accident and Emergency Department of Queen Mary Hospital in Hong Kong.
- Conditions
- Influenza, COVID-19, Acute Respiratory Infections (ARIs)
- Trial name
- RAPID-ARIED (NCT06780566)
- Testing
- Point-of-care PCR testing for respiratory viruses, Laboratory PCR testing for respiratory viruses
- Where
- Hong Kong
- Volunteers
- 1,050 people
- Sponsor
- The University of Hong Kong
Healthy, Asthma
A Study in Healthy Subjects and Mild Asthmatics to Investigate Pharmacokinetics of AZD5423 When Administered in Different Ways
A study in healthy subjects and mild asthmatics to investigate Pharmacokinetics of AZD5423 when administered in different ways.
- Trial name
- NCT01310322
- Testing
- AZD5423
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Pulmonary Arterial Hypertension
Combination Therapy in Pulmonary Arterial Hypertension
An open label, non-comparative study design is appropriate for this Phase 4 study designed to assess whether a core therapy of bosentan, either as monotherapy or with the addition of sildenafil, enables patients with pulmonary…
- Trial name
- COMPASS 3 (NCT00433329)
- Testing
- Bosentan, Sildenafil
- Volunteers
- 100 people
- Sponsor
- Actelion
Radiographic Axial Spondyloarthritis
Respiratory Function and S-index in Radiographic Axial Spondyloarthritis
Radiographic axial spondyloarthritis (r-axSpA) is a chronic inflammatory disease that may lead to reduced chest expansion and impaired respiratory function due to thoracic involvement.
- Trial name
- NCT07515131
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Gazi University
Non Small Cell Lung Cancer
A Study to Assess Efficacy and Safety of Pembrolizumab With or Without Sacituzumab Tirumotecan (MK- 2870) in Adult Participants With Resectable Non Small Cell Lung Cancer (NSCLC) Not Achieving Pathological Complete Response (pCR) (MK-2870-019)
This study will assess if adding sacituzumab tirumotecan with pembrolizumab after surgery is effective in treating NSCLC for participants not achieving pathological complete response.
- Trial name
- TroFuse-019 (NCT06312137)
- Testing
- Sacituzumab tirumotecan, Pembrolizumab, Cisplatin
- Where
- 270 sites in United States, Argentina and 29 more
- Volunteers
- 780 people
- Sponsor
- Merck Sharp & Dohme LLC
Systemic Sclerosis Pulmonary, Pulmonary Hypertension
Infusion of Allogeneic Mesenchymal Stem Cells in Patients With Diffuse Cutaneous Systemic Sclerosis With Refractory Pulmonary Involvement
Progressive SSc is an entity with limited therapeutic alternatives and with asurvival rate of less than 45% in the first 3 to 5 years.
- Conditions
- Systemic Sclerosis Pulmonary, Pulmonary Hypertension, Pulmonary Fibrosis
- Trial name
- NCT04432545
- Testing
- Mesenchymal Stem Cells from Wharton ́s jellyintravenous infusion of Mesenchymal Stem Cells from Wharton ́s jelly
- Where
- Colombia
- Sponsor
- Universidad de la Sabana
COVID-19
Study on Safety and Clinical Efficacy of AZVUDINE in Initial Stage COVID-19 Patients (SARS-CoV-2 Infected)
Phase III, single-center with co-participating units, randomized, double-blind, parallel, placebo-controlled clinical study
- Trial name
- NCT05033145
- Testing
- AZVUDINE
- Where
- 7 sites in Brazil
- Volunteers
- 312 people
- Sponsor
- HRH Pharmaceuticals Limited
Chronic Obstructive Pulmonary Disease, Pulmonary Rehabilitation
Profile of COPD Patients Refusing Educational Program in Pulmonary Rehabilitation and Impact on the Benefits
Pulmonary rehabilitation (PR) has proven its efficacy to improve dyspnea, health status, exercise tolerance and quality of life for patients with stable Chronic Obstructive Pulmonary Disease (COPD).
- Trial name
- NCT04301245
- Testing
- Educational program
- Where
- France
- Volunteers
- 201 people
- Sponsor
- ADIR Association
Community Acquired Pneumonia
Comparative Study of NXL103 Versus Comparator in Adults With Community Acquired Pneumonia
The purpose of this study is to compare the efficacy, safety and tolerance of 2 different dose levels of oral NXL103 with oral comparator in the treatment of community acquired pneumonia in adults
- Trial name
- NCT00653172
- Testing
- NXL103, comparator
- Where
- 60 sites in Chile, Croatia and 7 more
- Volunteers
- 302 people
- Sponsor
- Novexel Inc
Sleep Apnea Syndrome
Treatment of Sleep Apnea Syndrome With nCPAP Versus Oral Appliance
This prospective randomized cross over study aims to compare nCPAP with mandibular advancement device for the treatment of sleep apnea syndrome.The effectiveness of nCPAP and oral appliance on apnea-hypopnea index, daytime…
- Trial name
- NCT00152672
- Testing
- nCPAP vs oral appliance
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Angers
Covid19
Impact of Spectacles on Compliance to Mask-wearing Directives
Primary objective of this study is to identify the compliance of Greek people in mask-wearing directive and explore potential associations with refractive errors, spectacles and contact lenses use.
- Trial name
- NCT04501172
- Testing
- Questionnaire completion
- Where
- Greece
- Volunteers
- 1,214 people, healthy volunteers welcome
- Sponsor
- Democritus University of Thrace
Exercise
Sex Differences in Cold-Induced Changes in Maximal Fat Oxidation
The purpose of this research study is to determine if the cold-induced change in fat burning during exercise is different between females and males.
- Trial name
- NCT07297823
- Testing
- Cold temperature, Room Temperature
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Influenza
Safety and Immunogenicity of Different Dosages of High-Dose Quadrivalent Influenza Vaccine in Children 6 Months to 17 Years of Age
The objectives of this study were: To describe the safety of each dosage of high-dose quadrivalent influenza vaccine (QIV-HD) used in the study during the 28 days following each vaccination, and serious adverse events (including…
- Trial name
- QHD04 (NCT03698279)
- Testing
- High-Dose Quadrivalent Influenza Vaccine (QIV-HD) 30 μg (split-virion, inactivated), High-Dose Quadrivalent Influenza Vaccine (QIV-HD) 45 μg, (split-virion, inactivated), High-Dose Quadrivalent Influenza Vaccine (QIV-HD) 60 µg (split-virion, inactivated)
- Where
- 16 sites in United States, Canada
- Volunteers
- 665 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
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