Clinical trials: Respiratory Disorder
Chronic Obstructive Pulmonary Disease
Effects of Breathing Retraining in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Conventional pulmonary rehabilitation programs improve exercise tolerance, peripheral muscle strength, and health related quality of live but not pulmonary function in patients with chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT01175265
- Testing
- respiratory biofeedback
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University Hospital, Essen
Asthma
A Bronchoprovocation Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of CSJ117 in Adult Subjects With Mild Atopic Asthma
This is a non-confirmatory, randomized, subject and investigator blinded, placebo-controlled, parallel-design, multi-center bronchoprovocation study.
- Trial name
- NCT03138811
- Testing
- CSJ117
- Where
- 10 sites in Canada, Germany
- Volunteers
- 28 people
- Sponsor
- Novartis Pharmaceuticals
Premature Infants
Compliance to Synagis (Palivizumab) Under Daily Pediatrician´s Conditions in Premature Infants 33 - 35 wGA
Compliance to Synagis (palivizumab) is a key factor to obtain maximal protection against respiratory syncytial virus (RSV) infection as shown in the IMpact study.
- Trial name
- NCT01077271
- Where
- 45 sites in Austria
- Volunteers
- 124 people
- Sponsor
- Abbott
Lung Diseases
Data Collection Using Eko Devices in a Clinical Setting
The main objectives of the study are to: train and validate binary classifiers for wheeze, coarse crackle, fine crackle, rhonchus, stridor, rales, and cough, as well as determine correspondence between type/location of…
- Trial name
- NCT07270744
- Testing
- Eko digital stethoscopes
- Where
- India
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Eko Devices, Inc.
Critical Illness, Muscle Weakness
Correlation Between Muscle Strength and Thickness in Critically Ill Patients
Mechanical ventilation (MV) is associated with adverse outcomes in ventilated patients, and impact of MV-induced diaphragm changes are still unclear.
- Trial name
- NCT06289244
- Testing
- Ultrasound, Muscle strength measurement
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Pleural Effusion
Detection of Pleural Effusion by Internal Thoracic Impedance Method
Early detection of pleural effusion (PLE) would improve the treatment. However, preclinical detection of pleural effusion is often not possible.
- Trial name
- NCT01601444
- Testing
- Pletysmograph
- Volunteers
- 100 people
- Sponsor
- Michal Roll PhD,MBA
Asthma
Self-regulation for Older Adults With Asthma Through Remote Education
This research is studying whether changing an individual's behaviors may have an impact as a treatment or outcome for asthma. The purpose of this study is to implement and evaluate an asthma self-management intervention through…
- Trial name
- SOAR (NCT05722834)
- Testing
- SOAR intervention
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Michigan
Obstructive Sleep Apnea
A Study of Sex Differences in Neurocirculatory Control
The purpose of this study is to investigate potential sex differences in neurocirculatory control of blood pressure in patients with untreated obstructive sleep apnea (OSA).
- Trial name
- NCT06261034
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Mayo Clinic
Acute Coronary Syndromes, Heart Failure
Prospective Cohort of Acute Cardiology Referrals in an Ambulatory Day-Hospital Setting
Suspected acute or subacute cardiovascular diseases-including chest pain, dyspnea, and palpitations-are among the most common reasons for unscheduled emergency department visits and pre-hospital referrals.
- Conditions
- Acute Coronary Syndromes, Heart Failure, Pulmonary Embolism, Deep Vein Thrombosis, HTN-Hypertension
- Trial name
- CESAR (NCT07675434)
- Volunteers
- 25,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Advanced Solid Tumors, Non-small Cell Lung Cancer
Phase 1/2 Study of X-396, an Oral ALK Inhibitor, in Patients With ALK-positive Non-Small Cell Lung Cancer
This is the first human study to use X-396 (ensartinib), a drug being developed for treatment of advanced cancers. The initial purpose of the study is to determine the largest amount of X-396 that can be safely given to humans…
- Trial name
- NCT01625234
- Testing
- Phase I: X-396 (ensartinib), Phase II: X-396 (ensartinib)
- Where
- 14 sites in United States
- Volunteers
- 131 people
- Sponsor
- Xcovery Holdings, Inc.
COVID-19
#StayHome: Early Hydroxychloroquine to Reduce Secondary Hospitalisation and Household Transmission in COVID-19
BACKGROUND Despite drastic quarantine measures, COVID-19 continues to propagate and threatens global healthcare systems by saturating their capacity with high transmissibility and the particularly protracted length of stay needed…
- Trial name
- #StayHome (NCT04385264)
- Testing
- Hydroxychloroquine, Mannitol
- Where
- Switzerland
- Volunteers
- healthy volunteers welcome
- Sponsor
- Center for Primary Care and Public Health (Unisante), University of Lausanne, Switzerland
Insomnia, Sleep-Disordered Breathing
CPAP vs ASV for Insomnia
The study will determine which of two different types of positive airway pressure (PAP therapy) modes are more effective in reducing sleep breathing events in chronic insomnia patients and in decreasing insomnia severity.
- Trial name
- P2P (NCT02365064)
- Testing
- AirCurve 10 ASV
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- ResMed
Ventilator Associated Pneumonia
Microbial Etiology of Ventilator-associated Pneumonia in COVID-19 Infected Patients
National multicentric observational retrospective case-control study comparing the relative frequency of the various microorganisms responsible for VAP in patients infected or not by SARS-CoV-2 and their resistance to antibiotics.
- Trial name
- NCT04344509
- Testing
- Bacterial species isolated
- Volunteers
- 10,000 people
- Sponsor
- Poitiers University Hospital
PCOS, Sleep Apnea
The SNORES Randomized Clinical Trial
Randomized clinical trial among women with polycystic ovary syndrome (PCOS) who present for fertility treatment to evaluate the impact of screening for obstructive sleep apnea.
- Trial name
- SNORES (NCT02442999)
- Testing
- Screening for obstructive sleep apnea, CPAP - continuous positive airway pressure
- Where
- 6 sites in United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Allergic Rhinitis
Validation of Laser Doppler Flowmetry to Identify Allergic Rhinitis Patients With Pharmacogenetic Alterations in Histamine Metabolism
The hypothesis to be proven is that histamine iontophoresis with measurement of microvascular blood flow by laser Doppler flowmetry can be used as a reliable marker to characterize the normal microvascular cutaneous response to…
- Trial name
- NCT00362999
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Children's Mercy Hospital Kansas City
Post-COVID-19 Syndrome
Physiotherapy in Post COVID-19 Syndrome Patients
Patients who have undergone COVID-19 infection often have long-term sequelae. One of the most prevalent sequelae is pain. The main objective of this research is to investigate the efficacy of a cognitive behavioral…
- Trial name
- NCT05477199
- Testing
- Cognitive behavioral principles-based treatment program, Control intervention
- Where
- Spain
- Volunteers
- 54 people
- Sponsor
- Universidad de Granada
Healthy Adult, Sleep Apnea
Oura Ring OA15 Validation
The current study intends to collect data from Oura Ring time-locked to ground truth medical sleep diagnostic gold-standard polysomnography (PSG) for product research and development, investigational algorithm validation, and…
- Trial name
- NCT07908199
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ouraring Inc.
COPD, Chronic Obstructive Pulmonary Disease
GOLD 0 - DLCO 1: A Look Beyond the Obstruction. Is Spirometry Enough for COPD (Chronic Obstructive Pulmonary Disease) Screening?
This is a multicenter observational prospective study in smokers or ex-smokers with cumulative exposure ≥ 10 a / p (years / pack) with respiratory symptoms and presenting a normal spirometry.
- Trial name
- NCT05016466
- Testing
- Standard Care, Standard Care plus oxidative stress study plus inflammation biomarkers study
- Where
- Spain
- Volunteers
- 236 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Fetal Hypoxia, Fetal Distress
Gemini Flash 3.6 Versus Human Observers for FIGO-Based Interpretation of Intrapartum Cardiotocography
Cardiotocography (CTG) is the standard method for monitoring fetal heart rate and uterine contractions during labor to detect signs of fetal hypoxia.
- Conditions
- Fetal Hypoxia, Fetal Distress, Low Apgar Score, Neonatal Acidemia
- Trial name
- NCT07827222
- Volunteers
- 415 people
- Sponsor
- Assiut University
Interstitial Lung Disease, Lung Cancer
Assessment of Exhaled Breath Condensate Hydrogen Peroxide (EBC H2O2) as Measured Using a New Device (Inflammacheck™) in Patients With Interstitial Lung Disease, Lung Cancer and Healthy Volunteers.
A cross-sectional study of EBC H2O2 levels, as measured by a novel device, 'Inflammacheck™', and other markers of disease severity in patients with ILD and Lung Cancer.
- Trial name
- EXHALE 1B (NCT04061356)
- Where
- United Kingdom
- Volunteers
- 37 people
- Sponsor
- Portsmouth Hospitals NHS Trust
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