Clinical trials: Respiratory Disorder
Pulmonary Arterial Hypertension
Study of the Initial Combination of Bosentan With Iloprost in the Treatment of Pulmonary Hypertension Patients
Previous studies suggest that combinations of existing therapies may be effective for pulmonary arterial hypertension (PAH). However, all of these studies are sequential combination therapy, for example, by adding sildenafil to…
- Trial name
- BIPH (NCT01712997)
- Testing
- Iloprost, Bosentan
- Where
- 2 sites in China
- Volunteers
- 90 people
- Sponsor
- Air Force Military Medical University, China
Bronchiolitis Acute
Bronchiolitis Clearance Airways With Seaserum
The objective of this study is to show that the use of electrodialyzed seawater reduces the duration (in days) of symptoms in acute infant bronchiolitis compared with the use of saline solution in infants aged 1 month to less…
- Trial name
- B-CLASS (NCT06177197)
- Testing
- Physiomer, Saline solution
- Where
- 8 sites in France
- Volunteers
- 458 people
- Sponsor
- University Hospital, Brest
Respiratory Tract Infections
Safety, Tolerability and Blood Sampling of GSK3923868 Administered Via Dry Powder Inhaler to Healthy Participants of Chinese, Japanese and European Ancestry
This study is designed to understand how the drug GSK3923868 works in the bodies of healthy people from Japanese, Chinese, and European ancestries.
- Trial name
- NCT06577597
- Testing
- GSK3923868
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Small Cell Lung Cancer, Small Cell Lung Cancer Recurrent
BIBF 1120 as Second Line Treatment for Small Cell Lung Cancer
Although chemotherapy is the primary treatment option for small cell lung cancer (SCLC), longterm survival is rare. SCLC is initially chemosensitive, but rapidly relapses in a chemoresistant form with an overall survival of <5%.
- Trial name
- NCT01441297
- Testing
- BIBF 1120
- Where
- South Korea
- Volunteers
- 24 people
- Sponsor
- Ji-youn Han
COVID - 19, Diabetes Mellitus
DIFFERENT SARS-COV-2 VARIANTS' EFFECT ON THE COURSE OF COVID-19 IN ESTONIAN CHILDREN
The study focuses on Estonian children under 18 who had COVID-19 from 27.02.2020 to 01.03.2023. The main aim is to find out the risk factors for severe COVID-19 in children.
- Conditions
- COVID - 19, Diabetes Mellitus, Post-COVID Conditions, MIS-C Associated With COVID-19
- Trial name
- NCT06784713
- Where
- Estonia
- Volunteers
- 127,277 people
- Sponsor
- University of Tartu
Obstructive Sleep Apnea (OSA)
A Comparative Effectiveness Study of Positive Airway Pressure (PAP) Therapy, Dental Device, and Atomoxetine-Oxybutynin for Treatment of Obstructive Sleep Apnea in Adults
Researchers want to identify which treatments for obstructive sleep apnea (OSA) work best and are easiest for patients to use consistently.
- Trial name
- ADAPT-OSA (NCT07679282)
- Testing
- Positive airway pressure (PAP) therapy, Sleep dental device, Atomoxetine-oxybutynin
- Where
- 4 sites in United States
- Volunteers
- 2,400 people
- Sponsor
- Sairam Parthasarathy
Electric Impedance Tomography, Bronchoscopy
Bronchoscopy and Electric Impedance Tomography (EIT) Pilot Study
Electrical Impedance Tomography (EIT)is a technique based on the injection of small currents and voltage measurements using electrodes on the skin surface generating cross-sectional images representing impedance change in a slice…
- Conditions
- Electric Impedance Tomography, Bronchoscopy, Change in Lung Impedance Due to Ventilation, Recruitment
- Trial name
- Broncho-EIT (NCT01294813)
- Testing
- Electrical Impedance Tomography (EIT)
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- RWTH Aachen University
Chronic Obstructive Pulmonary Disease, Acute Coronary Syndromes
Screening for Chronic Obstructive Pulmonary Disease in Patients With Acute Coronary Syndromes
Several studies and registries suggested that the concomitant presence of acute coronary syndromes (ACS) and chronic obstructive pulmonary disease (COPD) is significantly associated with poor prognosis.
- Trial name
- SCAP (NCT02324660)
- Testing
- screening test
- Where
- Italy
- Volunteers
- 137 people
- Sponsor
- University Hospital of Ferrara
Non-small-cell Lung Cancer (NSCLC)
Camrelizumab Combined With Albumin-bound Paclitaxel and Platinum in Neoadjuvant Treatment of Resectable NSCLC
Explorative study, which evaluates the effect of Camrelizumab combined with albumin-bound paclitaxel and platinum in neoadjuvant treatment of resectable non-small-cell lung carcinoma.
- Trial name
- NCT04338620
- Testing
- camrelizumab、albumin-bound paclitaxel and platinum, albumin-bound paclitaxel and platinum
- Where
- China
- Volunteers
- 94 people
- Sponsor
- Tang-Du Hospital
Prematurity, RSV
The Impact of a Short Intervention During RSV Prophylaxis on Influenza Vaccination Rate.
Premature infants (born before 34 wk) are routinely vaccinated against RSV but vaccination rate against influenza are low in spite of national programs.
- Conditions
- Prematurity, RSV, Influenza, Upper Respiratory Tract Infection
- Trial name
- NCT01985620
- Testing
- Educational intervention
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Acute Lung Injury, Acute Respiratory Distress Syndrome
The Specific Lung Elastance in Acute Lung Injury/Acute Respiratory Distress Syndrome (ALI/ARDS) Patients in Supine and Prone Position
The investigators aim is to study the specific lung elastance in ALI/ARDS patients during invasive mechanical ventilation, in supine and prone position.
- Trial name
- NCT00568659
- Testing
- specific elastance
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Policlinico Hospital
Inadequate or Impaired Breathing Pattern or Ventilation
Weaning Using Noninvasive Positive Pressure Ventilation by Means of Helmet in Patients With Acute Respiratory Failure
The purpose of this study is to determine whether helmet is effective as device for noninvasive positive pressure ventilation in the weaning from mechanical ventilation.
- Trial name
- NCT01322659
- Testing
- Helmet, Endotracheal tube
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- University of Padova
COVID19
Assessment the Activity Value of Isotretinoin (13- Cis-Retinoic Acid ) in the Treatment of COVID-19 ( Isotretinoin in Treatment of COVID-19) (Randomized)
Assessment the Activity Value of Isotretinoin (13- Cis-Retinoic Acid ) in the Treatment of COVID-19 Mahmoud ELkazzaz(1),Tamer Haydara(2), Mohamed Abdelaal(3), Abedelaziz Elsayed(4) ,Yousry Abo-amer(5), Hesham Attia(6), Quan…
- Trial name
- Isotretinoin (NCT04353180)
- Testing
- Drug Isotretinoin (13 cis retinoic acid ) capsules+standard treatment, Isotretinoin(Aerosolized 13 cis retinoic acid) +standard treatment, Isotretinoin (13 cis retinoic acid ) capsules
- Where
- 2 sites in Egypt
- Volunteers
- 100,000 people
- Sponsor
- Kafrelsheikh University
Cardiovascular Diseases, Coronary Disease
Honolulu Heart Program
To investigate coronary heart disease and stroke among American men of Japanese ancestry who were living on the island of Oahu in 1965. Morbidity and mortality surveillance of the original cohort is continuing.
- Conditions
- Cardiovascular Diseases, Coronary Disease, Cerebrovascular Accident, Heart Diseases
- Trial name
- NCT00005123
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Lung Cancer
VX-710, Doxorubicin, and Vincristine for the Treatment of Patients With Recurrent Small Cell Lung Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00003847
- Testing
- biricodar dicitrate, doxorubicin hydrochloride, vincristine sulfate
- Where
- 9 sites in United States
- Volunteers
- 36 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Allergic Rhinitis (Disorder)
Effectiveness Of Therapy With A Thermal Water Nasal Aerosol In Children With Seasonal Allergic Rhinitis
The purpose of this study was to evaluate the effects of Ischia thermal waters nasal irrigation on allergic rhinitis and airway inflammation during the period of natural exposure to parietaria pollen in children with allergic…
- Trial name
- NCT01326247
- Testing
- thermal waters nasal irrigation
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Federico II University
Community-acquired Pneumonia, Air Pollution
The Impact of Air Pollution on the Consumption of Antimicrobials in the General Population
Objectives: To test the hypothesis that certain levels of air pollution may lead to increases in 1) antimicrobial consumption in the general population and 2) the presence of antibiotic resistance genes.
- Conditions
- Community-acquired Pneumonia, Air Pollution, Drug Resistance, Microbial
- Trial name
- ONAIR (NCT04662047)
- Where
- Spain
- Volunteers
- 3,249,128 people
- Sponsor
- Hospital Universitari de Bellvitge
Respiratory Distress Syndrome (&Amp; [Hyaline Membrane Disease])
Early Surfactant Administration at FiO₂ >0.25 Under NIPPV for RDS in Very Preterm Infants
This multicenter randomized controlled trial investigates whether initiating pulmonary surfactant (PS) at a lower oxygen threshold (FiO₂ >0.25) during nasal intermittent positive pressure ventilation (NIPPV) for very preterm…
- Trial name
- NCT07100652
- Testing
- Threshold FiO₂
- Where
- China
- Volunteers
- 384 people
- Sponsor
- Jiulongpo No.1 People's Hospital
Bronchiolitis, Pneumonitis
Utility of Lung Clearance Index Score as a Noninvasive Marker of Deployment Lung Disease
The purpose of this study is to learn more about new noninvasive ways of detecting lung disease in US Military personnel and people who worked as contractors during military operations in Iraq and Afghanistan.
- Conditions
- Bronchiolitis, Pneumonitis, Dyspnea
- Trial name
- LCI (NCT03012958)
- Testing
- Lung clearance index (LCI)
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- National Jewish Health
Long-term Outcome, Extracorporeal Membrane Oxygenation
Long Term Outcome of Extracorporeal Membrane Oxygenation Patients in China
Outcomes and Long-term Quality-of-life of Patients requiring Extracorporeal Membrane Oxygenation are not known in china. A prospective study survey will be performed to assess the long-term outcome of these patients.
- Trial name
- ECMO (NCT03345758)
- Testing
- outcome
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Southeast University, China
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