Clinical trials: Respiratory Disorder
COVID - 19
Vitamin E Supplementation As Adjunctive Therapy To Lower Inflammation In COVID-19 Patients
Since the first reported case of the novel coronavirus (SARS-CoV-2) in humans at the end of 2019 in Wuhan, the virus had infected approximately 100 million individuals.
- Trial name
- VITEC (NCT07412574)
- Testing
- Patients were randomly assigned, under a double-blind design, α-Tocopherol group (n = 22)
- Where
- Mexico
- Volunteers
- 56 people
- Sponsor
- Universidad Veracruzana
Pulmonary Hypertension, Heart Failure With Preserved Ejection Fraction
A Study of TX000045 in Patients With Pulmonary Hypertension Secondary to Heart Failure With Preserved Ejection Fraction (the APEX Study)
TX000045-003 is a double-blind, randomized, parallel group, placebo-controlled, proof- of-concept (POC) study, evaluating 2 dose regimens of TX000045 over the course of a 24-week treatment period (the APEX study).
- Trial name
- NCT06616974
- Testing
- TX000045- Dose A, TX000045- Dose B
- Where
- 72 sites in United States, Armenia and 15 more
- Volunteers
- 191 people
- Sponsor
- Tectonic Therapeutic
Respiratory Tract Diseases, Lung Diseases
What is an Important Change in the Short Physical Performance Battery (SPPB)?
The purpose of this study is to determine the important change in the Short Physical Performance Battery (SPPB) when used in patients with lung disease.
- Trial name
- NCT01649193
- Testing
- Pulmonary rehabilitation
- Where
- United Kingdom
- Volunteers
- 400 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Lung Carcinoma
Lung Cancer Risk Assessment and Etiology
This study examines the biological and social determinants that may increase the risk for lung cancer in patients and never-smoking individuals.
- Trial name
- NCT06328621
- Testing
- Biospecimen Collection, Computed Tomography, Electronic Health Record Review
- Where
- United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Lung Cancer
Efficacy and Safety of Omega 3 Fatty Acid Supplements on Heavy Smokers
The study duration is 12 months. The initial enrollment visit will take approximately one hour. The Month 1, 3, 6, 7, 9 and 12 visits will take approximately 30 minutes each.
- Trial name
- Omega (NCT03936621)
- Testing
- Omega 3 fatty acid
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- British Columbia Cancer Agency
Acute Pulmonary Embolism
A Phase II Study to Evaluate the Efficacy of ThromboView® in the Detection of Pulmonary Emboli
The aim of the study is to determine the diagnostic accuracy of 99mTc ThromboView® SPECT imaging for the detection of acute pulmonary embolism (PE) in patients for whom there is a moderate to high clinical suspicion for PE.
- Trial name
- NCT00519506
- Testing
- ThromboView
- Where
- 6 sites in United States, Canada
- Volunteers
- 61 people
- Sponsor
- Agen Biomedical
Pneumonia, Bacterial
Blinded Efficacy and Safety Study of CAL02 IV Plus SOC in Subjects With Severe Community-Acquired Bacterial Pneumonia
This is a placebo-controlled study to evaluate the addition of CAL02 to standard of care in treating hospitalized subjects diagnosed with severe community acquired bacterial pneumonia (SCABP) requiring critical care measures
- Trial name
- NCT05776004
- Testing
- CAL02
- Where
- 90 sites in United States, Argentina and 17 more
- Volunteers
- 276 people
- Sponsor
- Eagle Pharmaceuticals, Inc.
Cough Variant Asthma
Validity of Fractional Exhaled Nitric Oxide and Impulse Oscillometry in Patients With Cough Variant Asthma
The aim of the research is to evaluate the clinical value of fractional exhaled nitric oxide(FeNO) ,impulse oscillometry(IOS) and mid-expiratory flow (MEF) in patients with cough variant asthma.
- Trial name
- NCT03573284
- Testing
- fractional exhaled nitric oxide(FeNO), impulse oscillometry(IOS)
- Where
- China
- Volunteers
- 146 people
- Sponsor
- Zhujiang Hospital
COVID-19, Pulmonary Fibrosis
Comparison of Pulmonary Telerehabilitation and Physical Activity Recommendations in Patients With Post Covid Fibrosis
Rehabilitation plays a very important role in the management of patients with COVID-19, focusing on respiratory and motor functions, and therefore the importance of establishing treatment strategies to ensure optimal recovery of…
- Trial name
- NCT05299333
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Istanbul University - Cerrahpasa
Neoplasms
A Study of the Safety and Effects of ADH-1 Given Intravenously as a Single Agent
N-cadherin, a protein involved in blood vessel cell binding, is increased as cancer progresses, and is on the surface of many tumor cells. ADH-1 blocks N-cadherin.
- Trial name
- NCT00264433
- Testing
- ADH -1 (Exherin™)
- Where
- 11 sites in United States, Canada
- Sponsor
- Adherex Technologies, Inc.
Cystic Fibrosis
Streamlined Treatment of Pulmonary Exacerbations in Pediatrics
The STOP PEDS RCT is a multicenter, parallel, open label randomized controlled trial evaluating the long-term (one year) and short-term safety and efficacy of two antibiotic treatment strategies for the management of outpatient…
- Trial name
- STOP PEDS RCT (NCT06654752)
- Testing
- Immediate Oral Antibiotics, Tailored Treatment: Oral Antibiotics only if Additional Treatment needed
- Where
- 33 sites in United States, Canada
- Volunteers
- 430 people
- Sponsor
- University of Washington, the Collaborative Health Studies Coordinating Center
Pneumocystis Jirovecii Infection
Pneumocystis Jirovecii Pneumonia in Non-HIV-infected Immunocompromised Patients
Pneumocystis jirovecii pneumonia (PjP) is a rare infectiouse disease with a high level of mortality. PjP is a classical opportunistic infection which concern HIV infected and immunocompromised patients.
- Trial name
- PnP-HIV-Free (NCT05458752)
- Where
- France
- Volunteers
- 133 people
- Sponsor
- Central Hospital, Nancy, France
Snoring, Apnea, Obstructive
Dental Appliance to Treat SDB in Children
The clinical hypothesis of this study is that a currently marketed mouthguard may also be able to reduce the symptoms of sleep-disordered breathing in children.
- Conditions
- Snoring, Apnea, Obstructive, Upper Airway Resistance Syndrome, Sleep-Disordered Breathing
- Trial name
- NCT05661747
- Testing
- Vivos Grow/Vivos Way Device
- Where
- 4 sites in United States
- Volunteers
- 50 people
- Sponsor
- Vivos BioTechnologies, Inc.
Lung Cancer
NGS-based Comprehensive Genomic ctDNA Panel in NSCLC With Immunotherapy
Liquid biopsy based on next-generation sequencing (NGS) method has become an increasingly powerful detection tool for clinical research and practice.
- Trial name
- NCT04636047
- Testing
- The method of gene mutation detection
- Where
- China
- Volunteers
- 450 people
- Sponsor
- Shanghai Chest Hospital
Chest Wall Mechanics, Chest Wall Deformity
Institutional Experience With Chest Wall Reconstruction Using Sternal Steel Wires: A Case Series Study
Chest wall resections, often performed for tumors, infections, or trauma, result in significant defects that require reconstruction to restore structural integrity and functionality. The use of twisted stainless steel wires (No.
- Conditions
- Chest Wall Mechanics, Chest Wall Deformity, Chest Wall Tumor, Chest Wall Disease
- Trial name
- NCT07148648
- Testing
- Chest Wall Reconstruction
- Where
- Pakistan
- Volunteers
- 38 people
- Sponsor
- University of Health Sciences Lahore
Non-small Cell Lung Cancer
A Prospective Study of Constructing Immune Repertoire to Monitor the Therapeutic Effect in NSCLC Patients
This study is designed to evaluate the untreated NSCLC patients. After participants have accepted chemotherapy, radiotherapy, and immunotherapy, the investigators used the next generation sequence technology (NGS) to construct…
- Trial name
- NCT03373955
- Testing
- pembrolizumab
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sichuan University
Obstructive Sleep Apnea
Effect of Added Varnum Mouthpiece on Pharyngeal Collapsibility and Sleep Apnea Severity in Mouth Breathers.
Test the effect of added a single-use Varnum mouthpiece on pharyngeal collapsibility and obstructive sleep apnea (OSA) severity in patients who identify themselves as mouth breathers.
- Trial name
- NCT02738255
- Testing
- Varnum mouthpiece
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- David Andrew Wellman
Lung Cancer
Trial of RAD001 in Patients With Operable Non-Small Cell Lung Cancer (NSCLC)
This is a Phase 1b pre-operative lung cancer trial wherein patients with operable lung cancer will be treated with RAD001 to evaluate the target effects of this compounds on relevant molecular pathways and on the…
- Trial name
- NCT00401778
- Testing
- RAD001
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Emory University
Infant, Premature, Respiratory Disease
Extremely Preterm Respiratory Outcome Cohort
This study examines the respiratory outcomes of preterm infants born at gestational ages less than 29 weeks, spanning from birth to 24 months corrected age.
- Trial name
- NCT06726226
- Testing
- Standard care for preterm infants
- Where
- South Korea
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Pulmonary Embolism
Point-of-Care Ultrasound in Predicting Adverse Outcomes in Emergency Department Patients With Acute Pulmonary Embolism
This study is an observational, prospective study examining the role point-of-care echocardiography of predicting short term adverse outcomes in emergency department patients with acute pulmonary embolism.
- Trial name
- NCT05050617
- Testing
- Point-of-care echocardiography
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- WellSpan Health
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