Clinical trials: Respiratory Disorder
COPD (Chronic Obstructive Pulmonary Disease), Chronic Obstructive Pulmonary Disease (COPD)
Nebulizer Versus Handheld Maintenance Therapy for Patients With COPD
Multi-site, randomized controlled trial to determine whether patients who report NO symptomatic benefit with their maintenance hand-held inhaler(s), benefit upon switching to nebulized therapy using comparable classes of…
- Trial name
- DELIVERY (NCT07816835)
- Testing
- Nebulized therapy of similar medication solutions, Continue handheld therapy
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- COPD Foundation
Bronchiolitis
Co-infections in Children Hospitalised for Bronchiolitis
Observational cohort study in children hospitalized for acute bronchiolitis. Patients are nursed in cohort isolation. Aim is to investigate the incidence and clinical impact of co-infections in this group.
- Trial name
- NCT01714076
- Testing
- cohort isolation
- Where
- Netherlands
- Volunteers
- 172 people
- Sponsor
- Princess Amalia Children's Clinic
COPD, Respiratory Acidosis
Evaluation of the Effects on Carbon Dioxide (paCO2) of a New Oronasal Mask in Patients With Severe COPD Exacerbation Requiring Non-Invasive Mechanical Ventilation
This single-center, crossover study aims to investigate the effects of the new OptiNIV oronasal mask used during NIV in COPD patients with respiratory acidosis following an exacerbation.
- Trial name
- OPTIMUS-MASK (NCT07081776)
- Testing
- OptiNIV, Visairo
- Where
- Italy
- Volunteers
- 21 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Respiratory Disease, Lung Cancer
Evaluate Efficacy of Respiratory Rehabilitation Personalized Mobile Services for Respiratory Diseases
This trial is multicenter prospective study to evaluate clinical efficacy of respiratory rehabilitation personalized mobile services for respiratory disease.
- Conditions
- Respiratory Disease, Lung Cancer, COPD
- Trial name
- NCT03432117
- Testing
- Fixed respiratory rehabilitation, Responsive respiratory rehabilitation
- Where
- 5 sites in South Korea
- Volunteers
- 179 people
- Sponsor
- Asan Medical Center
Asthma
National Survey on Asthma
To evaluate the concordance of the most frequently used words by the patients and the physicians to express asthma symptoms, according to the patient's level of asthma control.
- Trial name
- SYMPTOMES (NCT00770250)
- Where
- 905 sites in France
- Volunteers
- 1,704 people
- Sponsor
- AstraZeneca
Carcinoma, Non-Small-Cell Lung
Predictive Assay for Decision Making in Adjuvant Therapy
Prospective Registrational Trial to Define Real World Outcomes of Patients with Completely Resected Stage I or IIA (tumor < or = 5cm, node negative) Non-squamous Non-Small Lung Cancer (NSCLC) Identified as High, Intermediate, or…
- Trial name
- PADMA (NCT05032352)
- Testing
- Adjuvant, Observation
- Where
- 18 sites in United States
- Volunteers
- 55 people
- Sponsor
- Insight Molecular Diagnostics
COPD, Anxiety
Intervention Strategy in Chronic Obstructive Pulmonary Disease With Anxiety and Depression
Anxiety and depression have negative effect on outcomes of chronic obstructive pulmonary disease (COPD). Intervention strategy including behavioral-cognitive therapy and pulmonary rehabilitation are promising in improving life…
- Conditions
- COPD, Anxiety, Depression
- Trial name
- NCT03187249
- Testing
- Cognitive Behavioral Therapy, Pulmonary Rehabilitation Therapy, Combined Therapy
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Carcinoma, Non-Small-Cell Lung
Neoadjuvant MPDL3280A, Nab-paclitaxel and Carboplatin (MAC) in NSCLC
This is a research study to test the effectiveness of nab-paclitaxel + carboplatin + MPDL3280A for treatment of non-small-cell lung carcinoma (NSCLC), which is a type of lung cancer.
- Trial name
- NCT02716038
- Testing
- MPDL3280A, Carboplatin, Nab-paclitaxel
- Where
- 3 sites in United States
- Volunteers
- 39 people
- Sponsor
- Columbia University
COVID-19
A Phase 2 Trial of Infliximab in Coronavirus Disease 2019 (COVID-19).
The investigators hypothesize that early institution of TNFα inhibitor therapy in patients with severe COVID-19 infections will prevent further clinical deterioration and reduce the need for advanced cardiorespiratory support and…
- Trial name
- NCT04425538
- Testing
- Infliximab
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Tufts Medical Center
Patient/Ventilator Asynchrony
Study to Measure the Prevalence of Asynchrony In Mechanically Ventilated Patients
This study will examine the prevalence of patient-ventilator asynchrony and its determinants. Mechanically ventilated trauma patients often experience asynchrony when their pattern of breathing does not match the triggering of a…
- Trial name
- Asynchrony (NCT01049958)
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Cincinnati
COVID 19, Influenza
COVID-19 Booster and IIV Schedule in Immunocompromised Hosts
The goal of this pragmatic embedded open-label, 2 x 2 factorial phase II randomized controlled trial is to evaluate strategies to improve COVID-19 booster and influenza vaccine immunogenicity in people living with…
- Conditions
- COVID 19, Influenza, Rheumatoid Arthritis (RA), Systemic Lupus Erthematosus
- Trial name
- CO2I2 (NCT06599658)
- Testing
- Inactivated influenza vaccine (IIV) at baseline, COVID-19 Vaccines at a 3-month interval, Inactivated influenza vaccine at Month 1
- Where
- 3 sites in Canada
- Volunteers
- 660 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Chronic Obstructive Pulmonary Disease
Chronic Obstructive Pulmonary Disease Transcription Factor and Cytokine Study
Chronic Obstructive Pulmonary Disease Transcription Factor and Cytokine Study.
- Trial name
- NCT02557958
- Testing
- Azithromycin
- Volunteers
- 19 people
- Sponsor
- NYU Langone Health
Extensive-stage Small-cell Lung Cancer
Low-dose Radiotherapy Combined With Concurrent Chemotherapy, Toripalimab and Tifcemalimab in the Treatment of ES-SCLC
To evaluate the tolerability and safety of Low-dose radiotherapy combined with concurrent Chemotherapy, Toripalimab and Tifcemalimab in first-line treatment of Extensive-Stage Small Cell Lung Cancer, and to determine the RP2D.
- Trial name
- NCT06732258
- Testing
- Low-dose radiotherapy, Tifcemalimab injection, Toripalimab
- Sponsor
- Sichuan University
Pulmonary Disease, Chronic Obstructive, Breathing Exercises
Effects of an Exercise Rehabilitation Programme With a Nasal Inspiratory Restriction Device in COPD Patients
This study evaluates the effects of a nasal restriction device for inspiratory muscle training (FeelBreathe) after 8 weeks of exercise intervention on exercise capacity, quality of life, dyspnea and inspitarotory muscle strength…
- Conditions
- Pulmonary Disease, Chronic Obstructive, Breathing Exercises, Exercise Tolerance
- Trial name
- EPOC_2_0 (NCT03936348)
- Testing
- Exercise training program with and without FB
- Volunteers
- 16 people
- Sponsor
- University of Cadiz
SARS-CoV 2
Lung Irradiation for COVID-19 Pneumonia
In this research study the investigators want to learn more about the potential benefit of radiation to the lung to improve the health of patients who are hospitalized with Coronavirus-19 (COVID-19) due to infection with a virus…
- Trial name
- NCT04393948
- Testing
- Phase 1, Phase 2
- Where
- United States
- Sponsor
- Brigham and Women's Hospital
Ventilator Associated Pneumonia
Prognostic Biomarkers in Predicting Mortality in Respiratory Patients With Ventilator-Associated Pneumonia
The aim of this study is to evaluate prognostic efficiency RDW and NLR for mortality prediction in respiratory patients with VAP.
- Trial name
- NCT04739748
- Testing
- complete blood picture
- Where
- Egypt
- Volunteers
- 136 people
- Sponsor
- Assiut University
SARS-CoV-2
Seroprevalence of Coronavirus Disease 2019 (COVID-19) Antibodies in a Vulnerable Neighbourhood, Buenos Aries Argentina
Background The study aimed to establish the seroprevalence of SARS-COV-2 in an Argentinian slum three months after the first case was reported.
- Trial name
- NCT04472078
- Testing
- Serological Assay or IgG for SARS-CoV-2
- Where
- Argentina
- Volunteers
- 873 people
- Sponsor
- Hospital Italiano de Buenos Aires
Shy-Drager Syndrome, Orthostatic Hypotension
Droxidopa in Treating Patients With Neurogenic Hypotension
Please note that the continuation study can be found at http://clinicaltrials.gov/show/NCT00633880. RATIONALE: Neurogenic hypotension is a fall in blood pressure that occurs when one moves from a lying down to a standing position…
- Trial name
- NCT00004478
- Testing
- droxidopa
- Where
- United States
- Sponsor
- Icahn School of Medicine at Mount Sinai
COVID-19
Analysis of Suicide Dynamics in Link to the COVID-19 Pandemic
Covid is a virus that first appeared in China in 2019 and was quickly described as a pandemic virus by its globalized nature. The unprecedented occurrence of the virus has led to several health and restrictive government…
- Trial name
- DSL-Covid-19 (NCT06084143)
- Where
- France
- Volunteers
- 2,500 people
- Sponsor
- University Hospital, Strasbourg, France
Ovarian Neoplasms, Breast Neoplasms
Establishment of a Tumor Bank for Blood Samples
Establishment of a tumor bank, consisting of blood samples of tumor patients and healthy people as controls. The blood samples will be collected systematically together with the corresponding clinical data.
- Conditions
- Ovarian Neoplasms, Breast Neoplasms, Colorectal Neoplasms, Neoplasms of the Female Genitalia
- Trial name
- NCT01763125
- Testing
- Blood collection
- Where
- 6 sites in Austria, Belgium and 2 more
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
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