Clinical trials: Respiratory Distress Syndrome, Child
Multiple Osteochondroma, Osteogenesis Imperfecta
Resilience and Coping in a Rare Skeletal Disease Population to Face Coronavirus (COVID-19) Outbreak Distress: a Longitudinal Study
In the COVID-19 outbreak context, people living with rare diseases have been highly troubled with anxiety, loneliness, and depression.
- Conditions
- Multiple Osteochondroma, Osteogenesis Imperfecta, Ollier Disease, Maffucci Syndrome
- Trial name
- RELOAD (NCT04844697)
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Istituto Ortopedico Rizzoli
Pediatric Acute Respiratory Distress Syndrome (PARDS), Pediatric Respiratory Diseases
IPV and Lung Compliance in Invasively Ventilated Children
The goal of this observational study is to determine if Intrapulmonary Percussive Ventilation (IPV) improves lung compliance in children receiving conventional invasive mechanical ventilation.
- Conditions
- Pediatric Acute Respiratory Distress Syndrome (PARDS), Pediatric Respiratory Diseases, Lung Compliance
- Trial name
- NCT06836050
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Northwell Health
Respiratory Distress Syndrome, Adult
Understanding the Role of Genes and Biomarkers in the Inflammation and Blood Clotting Process in Children With Acute Lung Injury
Acute lung injury (ALI)/Acute Respiratory Distress Syndrome (ARDS) is a severe lung condition that causes respiratory failure. This study will examine if differences in genes and biomarkers involved in the inflammation and blood…
- Trial name
- PALI (NCT00605527)
- Where
- 5 sites in United States
- Volunteers
- 396 people
- Sponsor
- University of California, San Francisco
Respiratory Distress Syndrome
Effect of Postural Drainage With or Without Thoracic Squeezing on O2 and Respiratory Rate in Infant With RDS.
This study investigated whether adding thoracic squeezing to postural drainage improves immediate respiratory outcomes in preterm infants with Respiratory Distress Syndrome (RDS).
- Trial name
- NCT07579013
- Testing
- POSTURAL DRAINAGE TECHNIQUE
- Where
- Pakistan
- Volunteers
- 14 people
- Sponsor
- Riphah International University
Respiratory Distress Syndrome, Adult, Respiratory Distress Syndrome, Child
Pulmonary Pathophysiology and Inflammatory Response in Patients Treated With Ecmo for Severe Respiratory Failure
The purpose of this study is the observation of the course of the mechanics of the respiratory system the endexpiratory lung volume and the inflammatory response in patients undergoing treatment with extracorporeal life support…
- Trial name
- NCT01468142
- Where
- Sweden
- Volunteers
- 6 people
- Sponsor
- Karolinska University Hospital
Lung Diseases, Interstitial, Pulmonary Alveolar Proteinosis
European Management Platform for Childhood Interstitial Lung Diseases - chILD-EU Register and Biobank
Generation of a common European database and biobank Continous assessment and implementation of guidelines and treatment protocols Establishment of a large observational cohort of chILD patients Determination the value of…
- Conditions
- Lung Diseases, Interstitial, Pulmonary Alveolar Proteinosis, Pulmonary Eosinophilia, Pulmonary Fibrosis
- Trial name
- chILD-EU (NCT02852928)
- Where
- 3 sites in Germany, Turkey (Türkiye) and 1 more
- Volunteers
- 1,000 people
- Sponsor
- Matthias Griese
Acute Respiratory Distress Syndrome
EIT- Guided Lung Recruitment in pARDS
Study Title: EIT-Guided Lung Recruitment Maneuvers in Pediatric ARDS: Effects on Ventilation Distribution and Respiratory Mechanics Study Objective: The primary goal of this clinical trial is to determine whether lung recruitment…
- Trial name
- REMAV-EIT (NCT07402174)
- Testing
- Electrical Impedance Tomography (EIT)-Guided Lung Recruitment
- Where
- 2 sites in Italy
- Volunteers
- 8 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Respiratory Distress Syndrome
Prehospital Telemedicine Feasibility/Acceptability Pilot
Teleconsultation, or the use of video telecommunications technology to deliver expert recommendations for care remotely, has been used to improve the safety and quality of emergency care for children in hospital-based acute care…
- Trial name
- NCT05967624
- Testing
- Teleconsultation
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Boston Medical Center
Acute Respiratory Distress Syndrome, Acute Respiratory Distress Syndrome in Adult or Child
Effects of Extravascular Lung Water on Prone Position Efficacy in Patients With ARDS
The study will investigate the influence that extravascular lung water index (EVLWi) could have on the efficacy and persistance of efficacy of prone position in patients with acute respiratory distress syndrome.
- Trial name
- NCT04635267
- Testing
- Prone position in patients with ARDS
- Volunteers
- 200 people
- Sponsor
- Bicetre Hospital
COVID-19, SARS-CoV-2 Infection
Clinical Characteristics and Outcomes of Pediatric COVID-19
Rationale: The clinical manifestations of SARS-CoV-2 infection in children are poorly characterized. Preliminary findings indicate that they may be atypical.
- Conditions
- COVID-19, SARS-CoV-2 Infection, Pediatric ALL, Pneumonia, Viral
- Trial name
- PERN-COVID-19 (NCT04330261)
- Testing
- Exposure (not intervention) - SARS-CoV-2 infection
- Where
- Canada
- Volunteers
- 10,610 people
- Sponsor
- University of Calgary
Acute Lung Injury, Acute Respiratory Distress Syndrome
ALI (Acute Lung Injury) /ARDS (Acute Respiratory Distress Syndrome) in Oncologic Pediatric Patients
Identify pediatric oncologic patients with ALI/ARDS at GRAACC (Grupo de Apoio ao Adolescente e a Criança com Câncer) /IOP's (Instituto de Oncologia Pediátrica) Pediatric Intensive Care Unit and evaluate the mechanical ventilation…
- Conditions
- Acute Lung Injury, Acute Respiratory Distress Syndrome, Neoplasms
- Trial name
- NCT01304654
- Where
- Brazil
- Volunteers
- 29 people
- Sponsor
- Grupo de Apoio ao Adolescente e a Crianca com Cancer
Pediatric Acute Respiratory Distress Syndrome
Pediatric Positive End Expiratory Pressure (PEEP) Titration Using Electrical Impedence Tomography (EIT)
The goal of this clinical trial is to perform a PEEP titration protocol and use EIT to identify the optimal PEEP at which lung overdistention and collapse are most effectively balanced.
- Trial name
- NCT06684119
- Testing
- Electrical Impedance Tomography positive end-expiratory pressure titration
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Children's Hospital Los Angeles
Positive End-expiratory Pressure (PEEP), Oxygenation Index
Complications of the Alveolar Opening Maneuver in Children on Mechanical Ventilation
The objective of this research is to analyze the overall incidence of complications associated with a therapeutic maneuver known as alveolar opening and subsequent titration of positive end-expiratory pressure (PEEP) in pediatric…
- Conditions
- Positive End-expiratory Pressure (PEEP), Oxygenation Index, Pediatric Intensive Care Unit, Pediatric Acute Lung Injury
- Trial name
- NCT07233304
- Testing
- Alveolar Opening Maneuver and PEEP Titration (AOM+P)
- Where
- Argentina
- Volunteers
- 143 people
- Sponsor
- Hospital de Alta Complejidad en Red
Acute Respiratory Distress Syndrome
Restore Resilience in Critically Ill Children
The study design will allow investigators to describe usual care in each PICU and identify the facilitating and restraining factors impacting the implementation of R2 at each PICU.
- Trial name
- R2 (NCT04695392)
- Testing
- R2 Bundle
- Where
- 2 sites in United States
- Volunteers
- 56 people
- Sponsor
- University of Pennsylvania
Acute Lung Injury, Acute Respiratory Distress Syndrome
Acute Lung Injury in Children: Epidemiology and Natural History. PEDIATRIC ALIEN.
The investigators propose to perform a one-year prospective audit of all Acute lung injury (ALI)and cute respiratory distress syndrome (ARDS) pediatric patients managed in several ICUs in Spain.
- Trial name
- ALIEN (NCT01131598)
- Where
- Spain
- Volunteers
- 1 people
- Sponsor
- Hospital de Cruces
Acute Respiratory Distress Syndrome
Assessment of Acute Respiratory Distress in Children Presenting to the Emergency Department: Clinical, Epidemiological, and Etiological Insights
This study investigates the clinical and epidemiological characteristics of children with acute respiratory distress presenting to the emergency unit at Assiut University Children Hospital.
- Trial name
- NCT07149389
- Volunteers
- 70 people
- Sponsor
- Assiut University
Acute Respiratory Distress Syndrome
Long Term (1 Year) Respiratory Sequelae in Children Surviving an Acute Respiratory Distress Syndrome
The purpose of this study is to assess long term (1 year) respiratory sequelae in children surviving an acute respiratory distress syndrome
- Trial name
- NCT01435889
- Where
- 5 sites in Belgium, France
- Volunteers
- 38 people
- Sponsor
- University Hospital, Lille
Acute Respiratory Distress Syndrome (ARDS), Acute Lung Injury (ALI)
Trial of Steroids in Pediatric Acute Lung Injury/ARDS
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are devastating disorders associated with lung inflammation, low oxygen levels and respiratory failure in children.
- Trial name
- SPALIT (NCT01274260)
- Testing
- methylprednisolone, Normal Saline (0.9%)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Tennessee
Acute Respiratory Distress Syndrome in Children
PROSpect: Prone and Oscillation Pediatric Clinical Trial
Severe pediatric acute respiratory distress syndrome (PARDS) is a life-threatening and frequent problem experienced by thousands of children each year.
- Trial name
- NCT03896763
- Testing
- Either supine or prone positioning and either CMV or HFOV
- Where
- 49 sites in United States, Argentina and 13 more
- Volunteers
- 600 people
- Sponsor
- University of Pennsylvania
Acute Respiratory Distress Syndrome, Pneumonia in Children
Using Artificial Intelligence To Improve Ventilator Settings For Intensive Care Patients
This observational study aims to determine whether an AI-assisted decision support system can improve clinical outcomes for mechanically ventilated pediatric patients (aged 1 month to 18 years) in the PICU, compared to standard…
- Conditions
- Acute Respiratory Distress Syndrome, Pneumonia in Children, Respiratory Failure (Pediatric Patients)
- Trial name
- NCT07592039
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Wu Rongzhou