Clinical trials: Respiratory Distress Syndrome, Newborn
ARDS, Human, Extracorporeal CO2 Removal
ECCO2R - Mechanical Power Study
Although mechanical ventilation remains the cornerstone of ARDS treatment, several experimental and clinical studies have undoubtedly demonstrated that it can contribute to high mortality through the developing of ventilator…
- Conditions
- ARDS, Human, Extracorporeal CO2 Removal, Mechanical Power
- Trial name
- NCT03939260
- Testing
- Extracorporeal CO2 Removal
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- University of Milan
Transient Tachypnea of the Newborn
Dexamethasone in Prevention of Respiratory Morbidity in Elective Caesarean Section in Term Fetus
Introduction: Babies born at term by elective caesarean section (CS) and before onset of labor are more likely to develop respiratory complications than babies born vaginally.
- Trial name
- NCT01772381
- Testing
- Dexamethasone
- Where
- Egypt
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
Community-Acquired Pneumonia (CAP), Acute Respiratory Distress Syndrome (ARDS)
Study of Nogapendekin Alfa Inbakicept and iNKT Cells in Critically Ill Adults With Severe Community-Acquired Pneumonia
This is a Phase 3, randomized, blinded, and placebo-controlled clinical trial investigating a new combination treatment for critically ill adults who have severe community-acquired pneumonia, especially if they also have sepsis…
- Conditions
- Community-Acquired Pneumonia (CAP), Acute Respiratory Distress Syndrome (ARDS), Sepsis, Lymphopenia
- Trial name
- NCT07492875
- Testing
- Nogapendekin alfa inbakicept (NAI), agenT-797
- Sponsor
- ImmunityBio, Inc.
ARDS (Acute Respiratory Distress Syndrome), Respiratory Failure
Development and Prospective Validation of the AutoEIT Foundation Model for ARDS
Acute Respiratory Distress Syndrome (ARDS) is a highly heterogeneous condition, making precision mechanical ventilation challenging.
- Conditions
- ARDS (Acute Respiratory Distress Syndrome), Respiratory Failure, Mechanical Ventilation, Ventilator-induced Lung Injury (VILI)
- Trial name
- NCT07898319
- Testing
- AutoEIT Model Training, AutoEIT Blinded Validation
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Ruijin Hospital
COVID-19 Acute Respiratory Distress Syndrome
When to Apply to Which Patient in MSC?
Mesenchymal stem cell (MSC) therapy is among the promising treatments for acute respiratory distress syndrome (ARDS). Our study aimed to investigate the clinical efficacy of MSC treatment in COVID-19 patients, to determine when…
- Trial name
- MSC (NCT05240430)
- Testing
- Mesenchymal Stem Cell Antigen-1, Human
- Where
- Turkey (Türkiye)
- Volunteers
- 1 people
- Sponsor
- Trabzon Kanuni Education and Research Hospital
Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS)
VExUS in Ards Patients and Association with AKI
A single-center prospective observational study will be conducted with the aim of determining the prevalence of venous congestion during ARDS using venous Doppler and the VExUS score.
- Trial name
- VEXAKI (NCT06805409)
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Oxygenation, Driving Pressure
Clinical Impact of Different Duration Prone Postition Treatment for Patients With ARDS.
Acute respiratory distress syndrome (ARDS) is a life-threatening disease, patients with ARDS usually need mechanical ventilation.
- Trial name
- NCT04391387
- Testing
- prone position
- Where
- Taiwan
- Volunteers
- 45 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Acute Respiratory Distress Syndrome
Extravascular Lung Water and Pulmonary Vascular Permeability After Minimally Invasive Cardiac Surgery
The use of cardiopulmonary bypass (CPB) combined with one lung ventilation (OLV) allows to perform minimally invasive cardiac surgery (MICS) through small incisions.
- Trial name
- NCT02155387
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University Hospital Freiburg
Acute Respiratory Distress Syndrome, ARDS (Moderate or Severe)
Multiple Dosing of Mesenchymal Stromal Cells in Patients With ARDS (COVID-19)
This is a multi-center, randomized, placebo controlled, interventional phase 2A trial to evaluate the safety profile and potential efficacy of multi-dosing of mesenchymal stromal cells (MSC) for patients with SARS-CoV-2…
- Conditions
- Acute Respiratory Distress Syndrome, ARDS (Moderate or Severe), COVID-19 Pneumonia
- Trial name
- NCT04466098
- Testing
- Mesenchymal stromal cells
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Acute Respiratory Distress Syndrome
The ARISE Study - Use of Vertical Positioning
The pilot study will randomize 40 ARDS patients who if proning were required would be randomized to upright bed positioning or to stand of care with bed in the head of bed elevation position
- Trial name
- ARISE (NCT07025421)
- Testing
- Intervention Upright Bed positioning
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Alabama at Birmingham
Respiratory Distress Syndrome in Premature Infant
Physiological Changes With High-Flow Nasal Cannula
To measure changes in physiologic parameters in extremely low birthweight (ELBW) infants on high-flow nasal cannula compared to nasal continuous positive airway pressure (nCPAP).
- Trial name
- NCT03700606
- Testing
- High flow nasal cannula, Nasal CPAP
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Sharp HealthCare
ARDS (Acute Respiratory Distress Syndrome)
Lung EIT Image Guide Ventilation in ARDS
The goal of this multi-center randomized controlled clinical trial is to learn if an individualized, bedside electrical impedance tomography (EIT)-guided ventilation strategy (including EIT-guided prone positioning and PEEP…
- Trial name
- NCT07309783
- Testing
- Recruitment maneuver and PEEP setting guided by EIT, PEEP setting according to routine practice, Prone positioning guided by EIT
- Where
- China
- Volunteers
- 574 people
- Sponsor
- Peking Union Medical College Hospital
Acute Respiratory Distress Syndrome
Comparison of Positive End Expiratory Pressure Titration Methods in ARDS Patients
This study aims at assessing the short-term physiological effects of 2 positive end expiratory pressure titration strategies in patients with ARDS.
- Trial name
- ELSE (NCT03281473)
- Testing
- Strategy 1, Strategy 2
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Angers
Lung Diseases, Respiratory Distress Syndrome
Human Surfactant Treatment of Respiratory Distress Syndrome Bicenter Trial
To determine if surfactant administration at birth in infants at high risk for respiratory distress syndrome (RDS) modified the clinical course of the syndrome.
- Trial name
- NCT00000570
- Testing
- pulmonary surfactant
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Prematurity, Respiratory Distress Syndrome, Newborn
Will CPAP Reduce Length Of Respiratory Support In Premature Infants?
In Canada each year, there are approximately 800 infants born between 28 and 32 weeks gestation. Up to 60% of these infants will require breathing tube placement for Respiratory Distress Syndrome or RDS.
- Trial name
- OLIVIA (NCT00486395)
- Testing
- CPAP, Mechanical ventilation
- Where
- 6 sites in Canada
- Volunteers
- 126 people
- Sponsor
- Children's & Women's Health Centre of British Columbia
ARDS, Human
Prone-Supine Study II: The Effect of Prone Positioning for Patients Affected by Acute Respiratory Distress Syndrome
The purpose of this study is to determine whether prone positioning is effective in improving survival in patients affected by acute respiratory distress syndrome (ARDS).
- Trial name
- NCT00159939
- Testing
- prone positioning
- Where
- 17 sites in Italy
- Volunteers
- 344 people
- Sponsor
- Policlinico Hospital
Bronchopulmonary Dysplasia (BPD)
Efficacy of Intrathecal Administration of Budesonide to Prevent Bronchopulmonary Dysplasia
The goal of this clinical trial is to learn if budesonide works to prevent bronchopulmonary dysplasia in newborn less than 32 weeks gestational age or birth weight less than 1500 g with respiratory distress syndrome who needs…
- Trial name
- NCT07725575
- Testing
- Experimental
- Where
- Indonesia
- Volunteers
- 86 people
- Sponsor
- Universitas Indonesia
Acute Respiratory Distress Syndrome
Glucocorticoid Therapy for Acute Respiratory Distress Syndrome
Acute respiratory distress syndrome (ARDS) is a clinical syndrome of inflammatory lung injury characterized by increased pulmonary vascular permeability, loss of aerated lung tissue, severe hypoxemia and impaired compliance.
- Trial name
- NCT05401812
- Testing
- Intravenous glucocorticoid therapy
- Sponsor
- National Taiwan University Hospital
Respiratory Failure
Regional Lung Inflammation and Expansion in Mechanically Ventilated Patients - a PET/CT Study
The goal of this study is to investigate acute respiratory distress syndrome (ARDS) and septic lung with positron emission tomography (PET) imaging and to examine the distribution of inflammation, as measured by neutrophil…
- Trial name
- NCT01806532
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital
Pneumonia, Viral
Characterization of Persistent Pulmonary Abnormalities Following COVID-19 Pneumonia
Severe Acute Respiratory Syndrome (SARS) SARS-CoV-2, name of the Coronavirus Group of international Committee on taxonomy of viruses, is an emerging virus from the family of coronaviridae, responsible for the COVID-19 pandemic.
- Trial name
- PULCO-19 (NCT04422613)
- Testing
- pulmonary anomalies 4 months after documented COVID-19 pneumonia
- Where
- France
- Volunteers
- 73 people
- Sponsor
- University Hospital, Toulouse
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