Clinical trials: Respiratory Distress Syndrome, Newborn
Respiratory Distress Syndrome, Intraventricular Hemorrhage
Antenatal Betamethasone Compared to Dexamethasone - "BETACODE TRIAL"
Antenatal corticosteroids result in substantial decrease in neonatal morbidity and mortality by specifically reducing the risk of respiratory distress syndrome, intraventricular hemorrhage and neonatal death among premature…
- Conditions
- Respiratory Distress Syndrome, Intraventricular Hemorrhage, Neonatal Mortality
- Trial name
- NCT00418353
- Testing
- Betamethasone(Celestone soluspan) and Dexamethasone
- Where
- United States
- Sponsor
- University of Oklahoma
Acute Respiratory Distress Syndrome
Diffuse Acute Respiratory Distress Syndrome (ARDS), Recruitment Maneuver, and sRAGE (DAMAGE Study)
RAGE, the receptor for advanced glycation end products, is a novel marker of alveolar epithelial type I cell injury, and soluble RAGE (sRAGE) is elevated in the plasma and in the pulmonary edema fluid from patients with ALI/ARDS.
- Trial name
- DAMAGE (NCT01600651)
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Clermont-Ferrand
Respiratory Distress Syndrome, Adult
Effect of Positive Expiratory Pressure on Right Ventricular Function in Patients With Respiratory Distress Syndrome
The objective of this study is to analyze by trans-oesophageal echocardiography the effect on the right ventricle of positive expiratory pressure (PEP) level variations with constant plate pressure among patients with syndrome of…
- Trial name
- NCT00236262
- Testing
- ventilatory strategies with pressure
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
COVID-19, ARDS, Human
The Critical Care Response to the COVID-19 Pandemic in Madrid
Description of the adaptation of ICUs in the region of Madrid to que surge in demand of critical care due to COVID-19
- Trial name
- Tetrix (NCT04393324)
- Where
- Spain
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Hospital San Carlos, Madrid
COVID-19 Pneumonia, COVID-19 Respiratory Infection
Therapeutic Plasma Exchange Followed by Convalescent Plasma Transfusion in Severe and Critically Ill COVID-19 Patients
Therapeutic plasma exchange (TPE) has been proposed as a rescue therapy in critically ill COVID-19 patients. The aim of this study is to determine whether combining TPE with convalescent plasma (CVP) transfusion early during the…
- Conditions
- COVID-19 Pneumonia, COVID-19 Respiratory Infection, Acute Respiratory Failure, Acute Respiratory Distress Syndrome
- Trial name
- NCT04973488
- Testing
- Therapeutic plasma exchange
- Where
- Romania
- Volunteers
- 38 people
- Sponsor
- Novacescu Alexandru
COVID-19, Acute Respiratory Distress Syndrome
Treatment of Lung Injury From COVID-19 Infection With Intravenous Sodium Nitrite
This multicenter, randomized, double-blind, placebo-controlled clinical trial will evaluate the efficacy and safety of intravenous Sodium Nitrite Injection for treatment of patients infected with COVID-19 who develop lung injury…
- Conditions
- COVID-19, Acute Respiratory Distress Syndrome, Acute Respiratory Failure
- Trial name
- NCT04401527
- Testing
- Sodium Nitrite, Normal Saline
- Where
- 2 sites in United States
- Sponsor
- Hope Pharmaceuticals
Respiratory Distress Syndrome
Medium vs Low Oxygen Threshold for the Surfactant Administration
The aim of this study will be to assess the better fraction inspired oxygen (FiO2) threshold for the surfactant treatment in preterm infants with respiratory distress syndrome (RDS) randomized to receive exogenous surfactant at…
- Trial name
- NCT04199364
- Testing
- Poractant Alfa 80 mg/mL Intratracheal Suspension
- Volunteers
- 200 people
- Sponsor
- Virgilio Paolo Carnielli
Corona Virus Disease (COVID-19), Respiratory Distress Syndrome
Fenofibrate for Patients With COVID-19 Requiring Hospitalization
This is an open-label run-in followed by a randomized, double-blind drug treatment study of COVID-19 infected patients requiring inpatient hospital admission.
- Conditions
- Corona Virus Disease (COVID-19), Respiratory Distress Syndrome, SARS-CoV-2 Infection
- Trial name
- FENOC (NCT04661930)
- Testing
- TriCor® 145mg tablets, Usual care
- Where
- 3 sites in Israel
- Volunteers
- 55 people
- Sponsor
- Yaakov Nahmias
COVID-19, Mechanical Ventilation Complication
Clinical Trial of Efficacy and Safety of Oral Drug in Adult Patients With COVID-19
This is a Phase 1, multi-center, dose escalation study that is followed by a Phase 2 randomized, double-blind, placebo-controlled study of the safety and efficacy of WP1122 administered q12h ±1 hr PO in adult patients with…
- Conditions
- COVID-19, Mechanical Ventilation Complication, COVID-19 Acute Respiratory Distress Syndrome
- Trial name
- WP1122 (NCT05365321)
- Testing
- WP1122
- Where
- Brazil
- Volunteers
- 75 people
- Sponsor
- Andrei Carvalho Sposito
Acute Respiratory Distress Syndrome After Cardiac Surgery Under Cardiopulmonary Bypass
Transpulmonary Gradient After Cardiac Surgery Under Cardiopulmonary Bypass
Get a better understanding of the pathophysiological processes of acute respiratory failure following cardiopulmonary bypass to initiate timely therapies targeted on a cell line.
- Trial name
- NCT01723930
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Strasbourg, France
Acute Respiratory Distress Syndrome
Extracorporeal Lung Assist Device in Acute Lung Impairment
The purpose of this study is to compare the effect of interventional Lung Assist iLA activve to standard therapy in mechanically ventilated patients with severe acute lung impairment.
- Trial name
- EXODUS (NCT02550600)
- Testing
- iLA activve treatment, Control group
- Where
- 8 sites in Austria, Germany and 2 more
- Volunteers
- 300 people
- Sponsor
- Technical University of Munich
Positive Expiratory Pressure, Acute Respiratory Distress Syndrome
Determination of the Best Positive End-expiratory Pressure (PEEP)
Determination of the best positive end-expiratory pressure (PEEP) based on oxygenation or driving pressure in patients with acute respiratory distress syndrome (ARDS) after cardiothoracic surgery The use of a positive…
- Trial name
- DROP (NCT03969407)
- Where
- France
- Volunteers
- 118 people
- Sponsor
- Centre Chirurgical Marie Lannelongue
Respiratory Infection Virus, Respiratory Failure
Sivelestat for Acute Respiratory Distress Syndrome Due to COVID-19
A randomized, double-Blind, placebo-controlled trial aimed to investigate the safety and efficacy of sivelestat on treating adult patients with COVID-19-related acute respiratory distress syndrome (ARDS)
- Trial name
- NCT05697016
- Testing
- Sivelestat Sodium for Injection
- Volunteers
- 238 people
- Sponsor
- Beijing Tiantan Hospital
Bronchiolitis, Viral
Efficacy and Safety of Curosurf® in Patients Invasively Ventilated for Severe Bronchiolitis Under 12 Months of Age
Background. Viral bronchiolitis is a common cause of hospitalization for acute respiratory insufficiency in young infants. Despite several RCT have tested the effectiveness of various agents, currently there is no proven specific…
- Trial name
- NCT03959384
- Testing
- Curosurf 80Mg/Ml Intratracheal Suspension, Ambient Air
- Where
- Italy
- Volunteers
- 9 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Acute Lung Injury, Acute Respiratory Distress Syndrome
Ganciclovir/Valganciclovir for Prevention of CMV Reactivation in Acute Injury of the Lung and Respiratory Failure
To evaluate whether administration of ganciclovir reduces serum IL-6 levels (i.e. reduction between baseline and 14 days post-randomization) in immunocompetent adults with severe sepsis or trauma associated respiratory failure.
- Conditions
- Acute Lung Injury, Acute Respiratory Distress Syndrome, Respiratory Failure
- Trial name
- GRAIL (NCT01335932)
- Testing
- IV Ganciclovir
- Where
- 14 sites in United States
- Volunteers
- 160 people
- Sponsor
- Fred Hutchinson Cancer Center
Respiratory Distress Syndrome, Chronic Lung Disease of Prematurity
Prevention of Chronic Lung Disease (CLD) in Preterm Infants
Pulmonary inflammation plays an important role in the early development of CLD. Postnatal glucocorticoids have been shown effective in the prevention or treatment of CLD with various success.
- Trial name
- NCT00883532
- Testing
- budesonide
- Where
- China
- Volunteers
- 300 people
- Sponsor
- China Medical University, China
Acute Respiratory Distress Syndrome, Intensive Care
Liberal Oxygenation Versus Conservative Oxygenation in ARDS
No clear recommendation exists for the level of oxygenation of intensive care patients. In Acute Respiratory Distress Syndrome (ARDS), pulsed oxymetry (SpO2) have to be kept between 88 and 95 percent and oxygen alveolar pressure…
- Trial name
- LOCO2 (NCT02713451)
- Testing
- Modulation of Inspired Fraction of Oxygen (FiO2)
- Where
- France
- Volunteers
- 206 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
ARDS, Human, Lung Ultrasound
Personalized Mechanical Ventilation Guided by UltraSound in Patients With Acute Respiratory Distress Syndrome
Rationale Acute respiratory distress syndrome (ARDS) is a frequent cause of hypoxemic respiratory failure with a mortality rate of approximately 30%.
- Conditions
- ARDS, Human, Lung Ultrasound, Mechanical Ventilation
- Trial name
- NCT05492344
- Testing
- Personalized ventilation, Standard care
- Where
- 11 sites in Belgium, China and 6 more
- Volunteers
- 538 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Acute Hypoxemic Respiratory Failure, Sepsis
EARLY-SARDS: Early AlveolaR Lung biologY Underling Sepsis-Associated ARDS
Sepsis-associated acute respiratory distress syndrome (ARDS) remains a major cause of respiratory failure and mortality in critically ill patients.
- Conditions
- Acute Hypoxemic Respiratory Failure, Sepsis, ARDS (Acute Respiratory Distress Syndrome)
- Trial name
- EARLY-SARDS (NCT07281911)
- Testing
- Serial bronchoalveolar lavage and biological-physiological assessment
- Where
- Spain
- Volunteers
- 145 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Acute Kidney Injury, ARDS, Human
Renal Doppler to Predict Acute Kidney Injury (AKI) in ARDS Patients. (RED-AKI Study)
This is a multicenter international observational prospective cohort study. The main questions it aims to answer are: PRIMARY AIM: To describe the capability of IRVF demodulation at diagnosis of ARDS to predict development of AKI…
- Trial name
- RED-AKI (NCT06302192)
- Testing
- ARDS+AKI
- Volunteers
- 164 people
- Sponsor
- Policlinico Hospital
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