Clinical trials: Respiratory Distress Syndrome, Newborn
Acute Respiratory Distress Syndrome
Stress Index to Individualize Mechanical Ventilation in ARDS
Acute respiratory distress syndrome (ARDS) is a widely prevalent and morbid disease for which the current standard treatment is supportive care and avoidance of complications with lung-protective ventilation.
- Trial name
- NCT02871102
- Testing
- Recruitment Maneuver with PEEP and Tidal Volume Optimization
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Vanderbilt University
Respiratory Distress Syndrome in Premature Infant
REspiratory MEchanics for Delivering Individualised Exogenous Surfactant
This study is an interventional, non-pharmacological, multicentric, randomized, controlled, superiority, non-profit study. Its primary objective is to evaluate if the administration of surfactant based on FOT assessment will…
- Trial name
- REMEDIES (NCT05791331)
- Testing
- Surfactant administration following lung mechanics assessment in addition to clinical assessment, Surfactant administration following clinical assessment
- Volunteers
- 458 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Respiratory Disease, Respiratory Distress Syndrome
Oxygenation Efficacy of "Intrinseque Health" Non-Rebreathing Mask ("IHNRM")
Based on early bench-testing data and subsequent clinical case studies in the U.S., "Intrinseque Health" non-rebreathing mask (IHNRM) has delivered virtual elimination of air entrainment and preferential delivery of all available…
- Conditions
- Respiratory Disease, Respiratory Distress Syndrome, Respiratory Failure
- Trial name
- NCT06310629
- Testing
- High Flow Nasal Cannula, "Intrinseque Health" Non-Rebreathing Mask ("IHNRM")
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- China Medical University Hospital
Pneumonia, Diaphragm; Movement
Evaluation of the Relevance of Diaphragmatic Stroke Ultrasound for the Etiological Diagnosis of Acute Respiratory Distress in an Emergency Department.
The goal of this Prospective interventional multicenter diagnostic study is to investigate the use of diaphragmatic ultrasound (DE) as a diagnostic tool in an adult emergency department for patients in acute respiratory distress.
- Conditions
- Pneumonia, Diaphragm; Movement, Diaphragmatic Ultrasound, Emergency Medical Services
- Trial name
- EchoDiaph (NCT06650137)
- Testing
- diaphragmatic ultrasound
- Where
- 2 sites in France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Montpellier
Respiratory Distress Syndrome, Premature Birth
nCPAP Versus High-Flow Nasal Cannula in Preterm Infants With RDS
This randomized controlled trial aims to compare the efficacy and safety of nasal continuous positive airway pressure versus high-flow nasal cannula as initial non-invasive respiratory support in preterm infants with respiratory…
- Trial name
- NCT07869719
- Testing
- Non-invasive respiratory support
- Volunteers
- 94 people
- Sponsor
- Assiut University
Respiratory Distress Syndrome, Newborn
Comparison of Methods of Weaning From Nasal CPAP in Preterm Infants: A Randomized Controlled Trial
This study aimed to determine the efficacy of different NCPAP weaning strategies in pre-term infants presenting with respiratory distress, and ultimately establishing the best method to withdraw from NCPAP.
- Trial name
- NCT07009366
- Testing
- Sudden weaning of NCPAP, Gradual weaning with increasing the time off NCPAP, Pressure weaning of NCPAP
- Where
- Pakistan
- Volunteers
- 75 people
- Sponsor
- RESnTEC, Institute of Research
COVID-19 Acute Respiratory Distress Syndrome
Positive End Espiratory Pressure Trial in Coronavirus Disease 19 Treated With Continuous Positive Airway Pressure
Consecutive patients with hypoxemic respiratory failure, CT evidence of bilateral pneumonia and diagnosis of Coronavirus Disease 19 (COVID-19) with molecular nasopharyngeal swab consecutively admitted to the COVID Care Unit of…
- Trial name
- NCT05178160
- Testing
- PEEP Standard Protocol
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Santa Maria delle Grazie Hospital
ARDS (Acute Respiratory Distress Syndrome)
Lung Injury is One of the Primary Causes of Morbidity and Mortality in Critically Ill Patients. These Patients Will be Monitored for: 1) Immune Cell Activation 2) Blood-based Biomarkers. In Vitro Models Derived From These Samples Will be Treated With Novel Agent PIP-2 to Evaluate Its Efficacy.
Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS) is a condition where high levels of inflammation damage the lung. This is a highly morbid condition with no specific pharmacologic therapies.
- Trial name
- ALI/ARDS (NCT07125079)
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Pennsylvania
Mechanical Ventilation, Respiratory Distress Syndrome, Adult
Practice of Ventilation in Middle-Income Countries
The purpose of this international, multicenter service review is to describe and compare ventilation management in patients at risk of acute respiratory distress syndrome (ARDS) versus patients not at risk and patients with…
- Conditions
- Mechanical Ventilation, Respiratory Distress Syndrome, Adult, Acute Respiratory Failure
- Trial name
- PRoVENT-iMIC (NCT03188770)
- Where
- 51 sites in Bangladesh, India and 8 more
- Volunteers
- 1,315 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Acute Respiratory Distress
The ARCTIC Trial: Aerosolized Inhaled Adenosine Treatment in Patients With Acute Respiratory Distress Syndrome (ARDS) Caused by COVID-19
This is a phase II study to test adenosine efficacy for down-regulation of the overwhelming inflammation of COVID-19 in the lungs as reflected by clinical recovery of lung function; resolution of clinically relevant markers of…
- Trial name
- NCT04588441
- Testing
- Adenosine
- Sponsor
- University of Florida
Acute Respiratory Distress Syndrome
Influence of NEP Inhibition on Vascular Leak and Inflammation (NEPi-INFLAMMATION)
Acute Respiratory Distress Syndrome (ARDS) is a severe type of lung injury that affects 10% of patients admitted to Intensive Care Units worldwide, with an unacceptably high mortality of up to 48% in those with the most severe…
- Trial name
- NCT05600062
- Testing
- Racecadotril 100 milligram (MG) Oral Capsule
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Severe Acute Respiratory Distress Syndrome, Refractory Hypoxemia
ECMO for Critically Ill Patients With Respiratory Failure and/or Circulatory Failure
Extracorporeal membrane oxygenation (ECMO) had been used to treat refractory hypoxemia associated with acute respiratory distress syndrome (ARDS).
- Trial name
- NCT04031794
- Testing
- Extra Corporeal Membrane Oxygenator (ECMO)
- Where
- Thailand
- Volunteers
- 250 people
- Sponsor
- Mahidol University
Acute Respiratory Distress Syndrome (ARDS), Acute Lung Injury (ALI)
Trial of Steroids in Pediatric Acute Lung Injury/ARDS
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are devastating disorders associated with lung inflammation, low oxygen levels and respiratory failure in children.
- Trial name
- SPALIT (NCT01274260)
- Testing
- methylprednisolone, Normal Saline (0.9%)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Tennessee
PPROM, Respiratory Distress Syndrome in Premature Infants
Does a Rescue Course of Betamethasone in Pregnant Women With PPROM Decrease Neonatal Morbidity?
The purpose of this study is to determine if a repeat course of betamethasone given to pregnant women with preterm premature rupture of membranes (PPROM) will decrease the infant's length of stay in the neonatal intensive care…
- Trial name
- NCT02939742
- Testing
- Betamethasone
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Respiration, Artificial, Respiratory Distress Syndrome, Adult
Adaptive Support Ventilation in Acute Respiratory Distress Syndrome (ARDS)
Prospective randomized controlled trial to be conducted in the Respiratory Intensive Care Unit (RICU) of Post Graduate Institute of Medical Education And Research (PGIMER),Chandigarh.
- Trial name
- NCT01165528
- Testing
- type of mechanical ventilation
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
COVID-19
Evaluation of the Efficacy and Safety of Sarilumab in Hospitalized Patients With COVID-19
Phase 2: The primary objective of the study is to evaluate the clinical efficacy of sarilumab relative to the control arm in adult patients hospitalized with COVID-19 regardless of disease severity strata.
- Trial name
- NCT04315298
- Testing
- Sarilumab
- Where
- 62 sites in United States
- Volunteers
- 1,912 people
- Sponsor
- Regeneron Pharmaceuticals
Coronavirus
Cyclo-Ergometry in the Patient With Acute Respiratory Distress Syndrome
In March 2020 the World Health Organization declares the Coronavirus disease pandemic 2019. Intensive Care Units deal entirely with patients with pneumonia complicated by Acute Respiratory Distress Syndrome, requiring aggressive…
- Trial name
- NPIDRA2021 (NCT06226428)
- Testing
- Bed cyclo-ergonometry, Bed mobility activities (turning, pelvic elevation and sitting), standing, transfers and walking., Progressive upper and lower limb strength training
- Where
- Spain
- Volunteers
- 35 people
- Sponsor
- Biogipuzkoa Health Research Institute
Fluid Loss
The Effect of Negatively Fluid Balancing Speed for ICU Patients With Acute Respiratory Distress Syndrome
Previous studies have shown that a positive fluid balance was an independent factor of worse prognosis in ICU patients with acute respiratory distress syndrome (ARDS), and negative fluid balance has been demonstrated to increase…
- Trial name
- NCT03552601
- Testing
- traditional speed, faster speed
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Qingdao University
Respiratory Distress Syndrome, Newborn
Randomized Controlled Trial of Surfactant Delivery Via Laryngeal Mask Airway (LMA) Versus Endotracheal Intubation
In this study, newborn babies with respiratory distress syndrome (RDS), receiving oxygen via nasal CPAP, and needing surfactant treatment will be randomized to standard delivery of surfactant via and endotracheal tube…
- Trial name
- NCT01042600
- Testing
- Endotracheal tube insertion, Laryngeal mask airway insertion
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Albany Medical College
Acute Respiratory Distress Syndrome
The Effects of Different Ventilator Strategies on Inflammation and Injury in Normal Lungs
This research is being done to determine if there is a way the investigators can improve the techniques that they use to assist patients with their breathing during surgery.
- Trial name
- NCT01003730
- Testing
- Ventilator settings
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
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