Clinical trials: Respiratory Distress Syndrome, Newborn
COVID, Acute Respiratory Distress Syndrome
Efficacy and Safety of Angiotensin II Use in Coronavirus Disease(COVID)-19 Patients With Acute Respiratory Distress Syndrome
This study aims to find out whether the use of angiotensin II, which is a drug to raise blood pressure has been approved by European Medical Agency in August 2019, as an add-on medication to increase blood pressure in patients…
- Trial name
- ACES (NCT04408326)
- Testing
- Angiotensin II, Interleukin-1 receptor antagonist
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Respiratory Distress Syndrome, Bronchopulmonary Dysplasia
Post-extubation Pressures in Preterm Neonates: A CER Study
The optimal post-extubation pressure level on non-invasive respiratory support modes - irrespective of the choice of the specific non-invasive mode - that optimizes extubation success and improves clinical outcomes remains…
- Conditions
- Respiratory Distress Syndrome, Bronchopulmonary Dysplasia, Preterm Birth
- Trial name
- NCT06552455
- Volunteers
- 1,050 people
- Sponsor
- McMaster Children's Hospital
Lung Injury, ARDS
Point-of-care Lung Ultrasound (POCUS)-Integrated Study of Admitted Patients With COVID-19
This study seeks to define the ultrasound profile of patients with COVID-19, and document the progression of these ultrasound findings to develop prognostication and clinical decision instruments that can help guide management of…
- Conditions
- Lung Injury, ARDS, Acute Cardiac Event, Covid19
- Trial name
- PIOS-COVID (NCT05228717)
- Testing
- Point of Care Ultrasound
- Where
- 4 sites in United States
- Volunteers
- 240 people
- Sponsor
- Olive View-UCLA Education & Research Institute
ARDS, Human
Advisory Lead ARDS Respirator Management
A advisory will be activated in the ICUs patient data management system. The trial will be conducted as observational cohort trial. During the first six month all patients with a LIPS ≥ 4 will be included in the control group.
- Trial name
- ALARM (NCT04274296)
- Testing
- Activation of Advisory
- Where
- Austria
- Volunteers
- 472 people
- Sponsor
- Mathias Maleczek
Acute Respiratory Distress Syndrome, Septic Shock
Organ-substituting Technologies in the Treatment of Heart and Pulmonary Failure
The implementation of this project will improve the effectiveness of surgical treatment and reduce the level of complications and mortality among patients with heart failure and heart failure in the terminal stage.
- Conditions
- Acute Respiratory Distress Syndrome, Septic Shock, Sepsis
- Trial name
- OST (NCT05042622)
- Testing
- Cytokine adsorber filter, Extracorporeal hemoperfusion cartridge
- Where
- Kazakhstan
- Volunteers
- 90 people
- Sponsor
- National Research Center for Cardiac Surgery, Kazakhstan
Acute Respiratory Distress Syndrome, Lung Diseases
Molecular Epidemiology of Acute Respiratory Distress Syndrome (ARDS)
To examine the possible relationship between genetic factors and the acute respiratory distress syndrome (ARDS).
- Trial name
- NCT00006496
- Where
- United States
- Volunteers
- 4,000 people
- Sponsor
- Massachusetts General Hospital
Respiratory Distress Syndrome, Adult, Ventilator-Induced Lung Injury
Asynchrony During Mechanical Ventilation in Patients With Acute Respiratory Distress Syndrome
Asynchrony during mechanical ventilation has been poorly described in patients suffering from acute respiratory distress syndrome.
- Trial name
- NCT02732041
- Where
- 5 sites in Argentina
- Volunteers
- 103 people
- Sponsor
- Centro de Educación Medica e Investigaciones Clínicas Norberto Quirno
Respiratory Distress Syndrome, Adult
Evaluating Health Outcomes and QOL After ALI Among Participants of the ALTA, OMEGA, EDEN, and SAILS ARDS Network Trials
Acute lung injury (ALI) is a severe lung condition that causes respiratory failure. The ARDS Network (ARDSNet) is a National Heart, Lung, and Blood Institute-sponsored network that is focused on improving treatments for people…
- Trial name
- ALTOS (NCT00719446)
- Where
- 6 sites in United States
- Volunteers
- 922 people
- Sponsor
- Johns Hopkins University
Acute Respiratory Distress Syndrome (ARDS)
Pirfenidone to Prevent Fibrosis in Ards.
Acute respiratory distress syndrome (ARDS) is a severe form of acute lung injury and a major cause of Intensive Care Unit (ICU) admission worldwide.
- Trial name
- PIONEER (NCT05075161)
- Testing
- Pirfenidone
- Where
- 17 sites in Italy, Kazakhstan
- Volunteers
- 130 people
- Sponsor
- Università Vita-Salute San Raffaele
Respiratory Failure, Ventilatory Failure
Non-Invasive Monitoring of Respiratory Function in Spontaneously Breathing Patients With COVID-19 Infection
This study uses the AirGo band to monitor changes in tidal ventilation in spontaneously breathing patients with COVID-19 associated respiratory failure.
- Conditions
- Respiratory Failure, Ventilatory Failure, COVID-19, Pneumonia
- Trial name
- NCT04356443
- Testing
- AirGo Respiratory Monitor
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Massachusetts General Hospital
Chronic Lung Disease of Prematurity, Respiratory Distress Syndrome in Premature Infant
PAL to Improve Oral Feeding for Infants With Chronic Lung Disease
The purpose of this study is to investigate the effects of the Pacifier Activated Lullaby (PAL) intervention on the transition to oral feeding for preterm infants with chronic lung disease and respiratory distress syndrome that…
- Conditions
- Chronic Lung Disease of Prematurity, Respiratory Distress Syndrome in Premature Infant, Bronchopulmonary Dysplasia, Preterm Birth
- Trial name
- NCT05446389
- Testing
- Pacifier Activated Lullaby ®
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Missouri-Columbia
ARDS
Extracorporeal Membrane Oxygenation (ECMO) in Non-intubated Patients With Acute Respiratory Distress Syndrome (ARDS)
Proof-of-concept study addressing the feasibility of awake ECMO (v/v) in patients with acute respiratory failure
- Trial name
- NCT01669863
- Testing
- ECMO, ECMO in non-intubated patients
- Where
- Germany
- Volunteers
- 6 people
- Sponsor
- Hannover Medical School
Lung Diseases, Mechanical Ventilation
Mitochondrial Dysfunction of Alveolar and Circulating Immune Cells During Acute Respiratory Distress Syndrome: Impact of Infectious Aggression and Alveolar Stretching as a Result of Mechanical Ventilation.
Sepsis leads to a deregulated host response that can lead to organ failure. During sepsis, experimental and clinical data suggest the occurrence of mitochondrial dysfunctions, particularly in circulating muscle and monocytes…
- Conditions
- Lung Diseases, Mechanical Ventilation, Bronchoalveolar Lavage
- Trial name
- PNEUMOCHONDRIE (NCT03955887)
- Testing
- bronchoalveolar lavage fluid (BAL), Venous blood
- Where
- France
- Volunteers
- 28 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Infant Respiratory Distress Syndrome
Umbilical Vein Needle Catheterization for Endotracheal Intubation.
The investigators describe a simple and efficient method to give a premedication in the delivery room, using the umbilical vein, directly punctured through Wharton's jelly.
- Trial name
- Intubation (NCT03359993)
- Testing
- Premedication of intubation
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Hôpital NOVO
Covid19, Corona Virus Infection
Expanded Access to Zofin for Patients With COVID-19
This expanded access protocol will provide access to the investigational product Zofin for patients in outpatient facilities infected with SARS-CoV-2 who have mild to moderate COVID-19, or who are judged by a healthcare provider…
- Conditions
- Covid19, Corona Virus Infection, SARS (Severe Acute Respiratory Syndrome), Acute Respiratory Distress Syndrome
- Trial name
- NCT04657406
- Testing
- Zofin
- Sponsor
- ZEO ScientifiX, Inc.
COVID, SARS-CoV-2
European/Euro-ELSO Survey on Adult and Neonatal/ Pediatric COVID-19 Patients in ECMO
In the last 10 years, severe acute respiratory infection (SARI) was responsible of multiple outbreaks putting a strain on the public health worldwide.
- Conditions
- COVID, SARS-CoV-2, ARDS, Human, Refractory Hypoxemia
- Trial name
- EuroECMO-COVID (NCT04366921)
- Where
- 97 sites in Austria, Belgium and 17 more
- Volunteers
- 150 people
- Sponsor
- Maastricht University Medical Center
ARDS, Right Ventricle
Speckle Tracking and Inhaled Nitric Oxide in Acute Respiratory Distress Syndrome
Acute cor pulmonale is one of deadly complications of mechanically ventilated acute respiratory distress syndrome (ARDS), which can lead to right ventricular dysfunction and worsen the hemodynamics of the patient.
- Trial name
- NOSPECKLE (NCT05104606)
- Testing
- TEE, TTE
- Where
- France
- Volunteers
- 64 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Respiratory Distress Syndrome
Effects of Volume Guarantee With Pressure Supported vs. Synchronized Intermittent Mandatory Ventilation in VLBW Infants
Studies in preterm infants have shown that adding volume guarantee (VG) to synchronized modes of ventilation is not only feasible but also advantageous for providing more constant and desirable mechanical breath size.
- Trial name
- NCT00295230
- Testing
- PSV+VG mode versus SIMV+VG mode
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Children's Hospitals and Clinics of Minnesota
Acute Necrotizing Pancreatitis, Acute Respiratory Distress Syndrome
Risk Factors for ARDS in Patients With Acute Necrotizing Pancreatitis
Try to collect about 350 cases of acute necrotizing pancreatitis at the First Affiliated Hospital with Nanjing Medical University and Nanjing General Hospital of Nanjing Military Command.
- Trial name
- NCT02641964
- Volunteers
- 350 people
- Sponsor
- Nanjing Medical University
Ards, Mechanical Ventilation Pressure High
Prognostic Value of Respiratory System Compliance Under VV-ECMO on 180-day Mortality in COVID-19 ARDS.
Mortality of patients with COVID-19 associated acute respiratory distress syndrome (CARDS) treated with veno-venous extra-corporal membrane oxygenation (vv-ECMO) is increasing over time since the beginning of the COVID-19…
- Conditions
- Ards, Mechanical Ventilation Pressure High, Extracorporeal Membrane Oxygenation
- Trial name
- COMPLIECMO (NCT05341687)
- Testing
- No applicable
- Where
- France
- Volunteers
- 122 people
- Sponsor
- Central Hospital, Nancy, France
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