Clinical trials: Respiratory Distress Syndrome (RDS)
Acute Respiratory Distress Syndrome, Capnography
Dead Space Monitoring With Volumetric Capnography in ARDS Patients
This studies´ objective is to describe how different PEEP levels affect dead space measured by Bohr´s formula.
- Trial name
- NCT02889770
- Testing
- PEEP titration
- Volunteers
- 10 people
- Sponsor
- Hospital Italiano de Buenos Aires
Acute Respiratory Distress Syndrome (ARDS), Ventilator Management
Pediatric Acute Respiratory Distress Syndrome (ARDS) Management Trial
Acute respiratory distress syndrome (ARDS) is a serious and potentially life-threatening lung condition that can affect children.
- Conditions
- Acute Respiratory Distress Syndrome (ARDS), Ventilator Management, Lung-protective Ventilation, Pediatric Acute Respiratory Distress Syndrome (PARDS)
- Trial name
- PARMA (NCT07123961)
- Testing
- High Driving Pressure Mechanical Ventilation, Low Driving Pressure Mechanical Ventilation
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Children's Hospital of Philadelphia
Respiratory Distress Syndrome
Comparison in Pulmonary Compliance Between Curosurf and Survanta in Preterm Infants With Respiratory Distress Syndrome
This is a null hypothesis study. The investigators hypothesize that there will be no difference in changes in dynamic compliance when measured at 15, 30, 45 and 60 minute intervals after administration of either surfactant and…
- Trial name
- NCT01537354
- Testing
- Curosurf®, Survanta®
- Where
- United States
- Sponsor
- University of Michigan
Acute Respiratory Distress Syndrome
Diffuse Acute Respiratory Distress Syndrome (ARDS), Recruitment Maneuver, and sRAGE (DAMAGE Study)
RAGE, the receptor for advanced glycation end products, is a novel marker of alveolar epithelial type I cell injury, and soluble RAGE (sRAGE) is elevated in the plasma and in the pulmonary edema fluid from patients with ALI/ARDS.
- Trial name
- DAMAGE (NCT01600651)
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Clermont-Ferrand
Acute Respiratory Distress Syndrome
How to Predict Lung Recruitment at the Bedside in Patients Affected by Acute Lung Injury/Acute Respiratory Distress Syndrome (ALI/ARDS)
The investigators aim to compare four different lung recruitment techniques (described in literature) to Computed tomography scan analysis.
- Trial name
- NCT00682942
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Policlinico Hospital
Respiratory Distress Syndrome, Adult, Pneumonia
Comparison Study of High Frequency Percussive Ventilation With Conventional Ventilation
This study is designed to exam the effects of early management with high frequency percussive ventilation (HFPV) on patients with lung injury.
- Conditions
- Respiratory Distress Syndrome, Adult, Pneumonia, Mechanical Ventilation
- Trial name
- NCT00308022
- Testing
- High Frequency Percussive Ventilation
- Where
- United States
- Sponsor
- University of Texas Southwestern Medical Center
Respiratory Distress Syndrome in Premature Infant, RDS of Prematurity
Pragmatic Evaluation of Respiratory Distress Syndrome Treatment in Africa
The goal of this pragmatic clinical trial is to learn if the drug surfactant given by a less invasive technique works to treat respiratory distress in preterm infants in low- and middle-income African countries where invasive…
- Conditions
- Respiratory Distress Syndrome in Premature Infant, RDS of Prematurity, Surfactant Deficiency Syndrome Neonatal, Premature Birth
- Trial name
- NCT06554522
- Testing
- Surfactant
- Where
- 8 sites in Central African Republic, Ghana and 2 more
- Volunteers
- 1,512 people
- Sponsor
- Indiana University
Acute Respiratory Distress Syndrome
Efficacy and Safety of LEAF-4L6715 for Acute Respiratory Distress Syndrome
Acute Respiratory Distress Syndrome (ARDS) is a serious condition where people in hospital care suddenly have trouble breathing because of infection, pneumonia, COVID-19 or other disease.
- Trial name
- NCT06640777
- Testing
- LEAF-4L6715, Supportive Care
- Where
- France
- Volunteers
- 310 people
- Sponsor
- LEAF4Life, Inc.
Covid19, ARDS, Human
Exhaled Breath Particles as a Clinical Indicator for Lung Injury and Acute Respiratory Distress Syndrome (ARDS)
Acute Respiratory Distress Syndrome (ARDS) reflects the hallmark of the critical course of coronavirus (COVID19). The investigators have recently shown that Exhaled Breath Particles (EBP) measured as particle flow rate (PFR) from…
- Conditions
- Covid19, ARDS, Human, ALI
- Trial name
- NCT04503057
- Where
- Sweden
- Volunteers
- 300 people
- Sponsor
- Lund University Hospital
Infant, Newborn, Hypertension, Pulmonary
Inhaled Nitric Oxide Study for Respiratory Failure in Newborns
Respiratory failure in term newborns is associated with increased rates of death and long-term neurodevelopmental problems. This large international multicenter trial randomized newborns who had failed to respond to intensive…
- Conditions
- Infant, Newborn, Hypertension, Pulmonary, Persistent Fetal Circulation Syndrome, Pneumonia, Aspiration
- Trial name
- NINOS (NCT00005776)
- Testing
- Inhaled nitric oxide
- Where
- 20 sites in United States, Canada
- Volunteers
- 235 people
- Sponsor
- NICHD Neonatal Research Network
Fiberoptic Bronchoscopy (FOB), Bronchoalveolar Lavage (BAL)
Fiberoptic Bronchoscopy and Bronchoalveolar Lavage in Critically Ill Ventilated Patients
Fiberoptic bronchoscopy (FOB) is widely used as a diagnostic or therapeutic procedure in intensive care units. Patients with ARDS or COVID-19 disease often undergoes to these procedures.
- Conditions
- Fiberoptic Bronchoscopy (FOB), Bronchoalveolar Lavage (BAL), Respiratory Disease
- Trial name
- NCT04502368
- Testing
- Fiberoptic Bronchoscopy (FOB), Bronchoalveolar Lavage (BAL), Electrical Impedance Tomography (EIT)
- Where
- Belgium
- Volunteers
- 15 people
- Sponsor
- Erasme University Hospital
Neonatal Respiratory Distress, Oxygenation
Neonatal Oximeter Bias Study
The study aims to determine if there is a systematic difference (bias) between pulse oximeters used in control systems for automated oxygen delivery (A-FiO2) and those used in monitoring systems.
- Trial name
- NOB (NCT06817850)
- Where
- Czechia
- Volunteers
- 40 people
- Sponsor
- Czech Technical University in Prague
Corona Virus Disease 19 (COVID-19), COVID
Rehabilitation for People With COVID-19 in ICU
COVID-19 DISEASE Coronavirus disease 2019 (COVID-19) is a respiratory tract infection caused by a newly emergent coronavirus, severe acute respiratory syndrome from COVID-19, that was first recognized in Wuhan, China, in December…
- Conditions
- Corona Virus Disease 19 (COVID-19), COVID, Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS), Critical Illness
- Trial name
- COVID_REHAB (NCT04381338)
- Testing
- Pulmonary and Motor Rehabilitation
- Where
- 2 sites in Italy
- Volunteers
- 96 people
- Sponsor
- University of Padova
Acute Respiratory Distress Syndrome, Ventilator-Induced Lung Injury
Height Measurement Procedures Influence the Risk of Ventilator-induced Lung Injury in ARDS
Acute respiratory distress syndrome is characterized by heterogeneous lung injury, with dependent regions often collapsed and non-dependent regions relatively well-aerated, forming the so called "baby lung." Mechanical…
- Conditions
- Acute Respiratory Distress Syndrome, Ventilator-Induced Lung Injury, Tidal Volume, Predicted Body Weight
- Trial name
- SIZE-ARDS (NCT07595926)
- Testing
- height measured
- Where
- France
- Volunteers
- 39 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Acute Respiratory Distress Syndrome, Mechanical Ventilation Complication
Volatile Sedation for Patients With the Acute Respiratory Distress Syndrome
This study will investigate how different types of routine sedation may affect patient's breathing whilst on a ventilator in the Intensive Care Unit (ICU).
- Conditions
- Acute Respiratory Distress Syndrome, Mechanical Ventilation Complication, Sedation Complication
- Trial name
- ISO-DRIVE (NCT06014138)
- Testing
- Propofol, Isoflurane
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Acute Respiratory Distress Syndrome
Mechanical Ventilation With Neurally-Adjusted Ventilatory Assist in Patients With ARDS
Neurally-Adjusted Ventilatory Assist (NAVA) is a ventilatory mode that uses the electrical activity of the diaphragm to control the mechanical ventilator, offering inspiratory assistance in proportion to respiratory effort to…
- Trial name
- NCT01519258
- Testing
- Pressure Support ventilation, NAVA
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- University of Sao Paulo General Hospital
Acute Respiratory Distress Syndrome
Pulmonary and Ventilatory Effects of Bed Verticalization in Patients With Acute Respiratory Distress Syndrome
Acute respiratory distress syndrome (ARDS) is defined using the clinical criteria of bilateral pulmonary opacities on a chest radiograph, arterial hypoxemia (partial pressure of arterial oxygen [PaO2] to fraction of inspired…
- Trial name
- ERECTION (NCT04371016)
- Testing
- Verticalization (bed)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Clermont-Ferrand
Respiratory Distress Syndrome
A Multi-center Trial to Determine if Curosurf® Reduces the Duration of Mechanical Ventilation in Very Preterm Infants
The purpose of this study is to see if a medication called Curosurf can reduce the length of time that small premature babies with Respiratory Distress Syndrome (immature lungs) or RDS, stay on the ventilator, as compared to the…
- Trial name
- NCT01709409
- Testing
- Curosurf-Group1, BLES-group 2
- Where
- Canada
- Volunteers
- 88 people
- Sponsor
- Ottawa Hospital Research Institute
Respiratory Distress Syndrome, Preterm Pregnancy
Less Invasive Surfactant Administration in Late Preterm or Early Term Born Infants
The aim of this study is to see if giving less invasive surfactant administration (LISA) during high-flow nasal cannula (HFNC) oxygen treatment reduces the need for invasive ventilation in babies with breathing problems born 2-6…
- Conditions
- Respiratory Distress Syndrome, Preterm Pregnancy, Surfactant Deficiency Syndrome Neonatal
- Trial name
- NCT06421506
- Testing
- Less invasive surfactant administration during high flow nasal cannula treatment
- Where
- United Kingdom
- Volunteers
- 245 people
- Sponsor
- King's College Hospital NHS Trust
ARDS, Human
Extracorporeal Carbon Dioxide Removal Using PrismaLung in Reducing Ventilator Induced Lung Injury
Lung protective ventilation with low tidal volumes and low driving pressure are known to reduce mortality in mechanically ventilated patients with acute respiratory failure.
- Trial name
- NCT06321497
- Testing
- Extracorporeal carbon dioxide removal
- Where
- Australia
- Volunteers
- 15 people
- Sponsor
- Peninsula Health
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