Clinical trials: Respiratory Distress Syndrome (RDS)
Respiratory Distress Syndrome, Newborn
High Flow Nasal Cannula Versus Nasal Continuous Positive Airway Pressure for Respiratory Support of Preterm Neonates
This work is designed to: 1. Evaluate the efficacy of HHHFNC in comparison with nCPAP in preterm neonates. 2. Investigate hemodynamic changes associated with HHHFNC in comparison to nCPAP in preterm neonates during periods of…
- Trial name
- NCT04238273
- Testing
- Functional Echocardiography
- Where
- Egypt
- Volunteers
- 123 people
- Sponsor
- Ain Shams University
Respiratory Distress Syndrome
High Flow Nasal Cannula in Comparison With Nasal Continuous Positive Airway Pressure in the Management of Respiratory Distress Syndrome
To compare the primary outcome, failure of extubation defined by the need for re-intubation and mechanical ventilation within 5 days of initial extubation and secondary outcomes, morbidities and mortality after using of heated…
- Trial name
- NCT02587832
- Testing
- HHHFNC, NCPAP
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Sidra Medicine
Respiratory Distress Syndrome, Premature Infants
Effects of Non-invasive Ventilation With Helium-oxygen Mixture in Premature Infants With Respiratory Distress Syndrome
The use of a mixture of helium with oxygen (heliox) as a breathing gas may be beneficial due to its unique physical properties, such as low density and high carbon dioxide (CO2) diffusion coefficient.
- Trial name
- NCT04404816
- Testing
- heliox
- Where
- Poland
- Volunteers
- 23 people
- Sponsor
- Poznan University of Medical Sciences
COVID19, Oxygen Therapy
Impact of Prone Position in Patients Under Spontaneous Breathing on Intubation or Non-invasive Ventilation or Death Incidence During COVID-19 Acute Respiratory Distress
The SARS-Cov2 viral pandemic is responsible for a new infectious disease called COVID-19 (CoronaVIrus Disease), is a major health problem.
- Conditions
- COVID19, Oxygen Therapy, Prone Position, Spontaneous Ventilation
- Trial name
- PROVID-19 (NCT04363463)
- Testing
- prone position
- Where
- 19 sites in France, Monaco
- Volunteers
- 268 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Sepsis, Corona Virus Infection
The Impact of Premorbid Illnesses on the Risk of ICU Admission and Short-term Outcome
The Corona virus disease 2019 (COVID-19) pandemic is currently involving all parts of the world. Several risk factors for critical illness and death from the disease have been proposed.
- Conditions
- Sepsis, Corona Virus Infection, ARDS, Human
- Trial name
- NCT04542538
- Testing
- No intervention, observational study
- Where
- Sweden
- Volunteers
- 9,905 people
- Sponsor
- Uppsala University
Acute Respiratory Distress Syndrome, Critical Illness
A Study Promoting Critical Illness Recovery in the Elderly
This proposal will test the hypothesis that EARLY application of a novel early rehabilitation therapy in critically ill patients will improve functional outcomes, and change the functional trajectory of this population.
- Conditions
- Acute Respiratory Distress Syndrome, Critical Illness, Critical Care
- Trial name
- ASPIRE (NCT02963558)
- Testing
- cycle ergometry
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Wake Forest University Health Sciences
Acute Respiratory Distress Syndrome
Epidemiology of Acute Respiratory Distress Syndrome in Chinese ICUs
The acute respiratory distress syndrome(ARDS)has a high morbidity and mortality in patients admitted to intensive care units(ICUs). It represents a significant public health issue.
- Trial name
- NCT02490215
- Where
- 26 sites in China
- Volunteers
- 2,530 people
- Sponsor
- Peking Union Medical College Hospital
Developing Acute Respiratory Distress Syndrome
Advanced Respiratory Monitoring for Safer Mechanical Ventilation in Patients Without Respiratory Failure
Patients admitted to the intensive care unit (ICU) and mechanically ventilated for reasons other than acute respiratory failure, such as coma, trauma, or sepsis, are at risk of developing acute respiratory distress syndrome…
- Trial name
- ADAPT (NCT07686315)
- Testing
- Advanced Non-Invasive Respiratory Monitoring
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Istituto Clinico Humanitas
Lung Diseases, Respiratory Distress Syndrome
Clinical Interventions in Respiratory Distress Syndrome and Neonatal Lung Injury - SCOR in Lung Biology and Diseases in Infants and Children
To conduct clinical interventions directed at neonatal lung disease and injury, with a focus on infants having surfactant-deficiency or inactivation as a component of pathophysiology.
- Conditions
- Lung Diseases, Respiratory Distress Syndrome, Bronchopulmonary Dysplasia
- Trial name
- NCT00005683
- Sponsor
- University of Rochester
Respiratory Distress, Acute Lung Injury
Lung Injury Prediction Study
The purpose of the study is to externally validate the acute lung injury/acute respiratory distress syndrome (ALI/ARDS) prediction model (Lung Injury Prediction Score - LIPS) in a multicenter sample of patients at risk presented…
- Trial name
- USCTG-LIPS1 (NCT00889772)
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Mayo Clinic
COVID, ARDS, Human
Compassionate Use Open-Label Anti-CD14 Treatment in Patients With SARS-CoV-2 (COVID-19)
This protocol proposes to use IC14, a recombinant chimeric monoclonal antibody (mAb) recognizing human CD14, to block CD14-mediated cellular activation in patients early in the development of ARDS.
- Conditions
- COVID, ARDS, Human, Ards, SARS-CoV2
- Trial name
- NCT04346277
- Testing
- IC14, a monoclonal antibody against CD14
- Where
- Italy
- Sponsor
- Implicit Bioscience
ARDS (Acute Respiratory Distress Syndrome), Respiratory Acidosis
Clinical Study to Determine the Optimal Operation Parameters During CO2 Removal With the Abylcap® System
This prospective study includes 5 patients with ARDS (Acute Respiratory Distress Syndrome) treated by mechanical ventilation. In case of respiratory acidosis, extracorporeal CO2 (carbon dioxide)removal might be necessary.
- Trial name
- NCT01913977
- Testing
- Abylcap® System: blood flow (QB): 200mL/min; gas flow (QG):7L/min, Abylcap® System: blood flow (QB): 300mL/min; gas flow (QG):7L/min, Abylcap® System: blood flow (QB): 400mL/min; gas flow (QG):7L/min
- Where
- Belgium
- Volunteers
- 4 people
- Sponsor
- University Hospital, Ghent
Lung Disease, Acute Respiratory Distress Syndrome
Palliative Use of High-flow Oxygen Nasal Cannula in End-of-life Lung Disease Patients
The prevalence of severe dyspnoea among terminally ill patients has been reported as 70% and 90% for lung cancer and chronic obstructive pulmonary disease (COPD) patients, respectively.
- Trial name
- NCT02253667
- Testing
- HFONC, Conventional oxygen therapy
- Where
- Portugal
- Sponsor
- Hospital Sao Joao
Preterm Birth, Respiratory Distress Syndrome
Surfactant Nebulization for the Early Aeration of the Preterm Lung
Respiratory distress syndrome is the most common cause of respiratory failure in preterm infants. Treatment consists of respiratory support and exogenous surfactant administration.
- Conditions
- Preterm Birth, Respiratory Distress Syndrome, Surfactant Deficiency Syndrome Neonatal
- Trial name
- SUNSET (NCT04315636)
- Testing
- Surfactant nebulisation
- Where
- Switzerland
- Volunteers
- 32 people
- Sponsor
- University of Zurich
Acute Respiratory Distress Syndrome
Discovery of New Early Detection Biomarkers From Peripheral Blood of Acute Respiratory Distress Syndrome(ARDS)
Acute respiratory distress syndrome (ARDS) has a very poor prognosis and high mortality. To improve the early diagnosis of ARDS, there is an urgent need for novel biomarkers of ARDS.
- Trial name
- NCT02967471
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The Third Affiliated Hospital of Southern Medical University
Respiratory Distress Syndrome, Adult
Treprostinil Sodium Inhalation for Patients At High Risk for ARDS
Acute Respiratory Distress Syndrome (ARDS) is a rapidly progressing lung disease caused by a number of factors including pneumonia, sepsis and acute trauma that leads to reduced lung function and breathlessness.
- Trial name
- NCT02370095
- Testing
- Treprostinil Inhalation Solution
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of North Carolina, Chapel Hill
Acute Respiratory Distress Syndrome (ARDS)
LIPS-B: Lung Injury Prevention Study With Budesonide and Beta
This study tested whether inhaled budesonide and formoterol were able to alleviate or prevent pulmonary injury when administered early in hospital course to the patients at risk for developing acute respiratory distress syndrome…
- Trial name
- LIPS-B (NCT01783821)
- Testing
- Budesonide, Formoterol
- Where
- 5 sites in United States
- Volunteers
- 61 people
- Sponsor
- Mayo Clinic
Respiratory Distress Syndrome, Pediatric, Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS)
Continuous Infusion Versus Intermittent Boluses of Cisatracurium in the Early Management of Pediatric ARDS
The aim of this work is to compare continuous infusion vs on need intermittent boluses of Cisatracurium in the early management of pediatric acute respiratory distress syndrome
- Trial name
- NCT05153525
- Testing
- Intermittent boluses of Cisatracurium, Intravenous infusion of Cisatracurium for 24 hours
- Where
- 2 sites in Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
Acute Respiratory Distress Syndrome (ARDS)
Clinical Features, Treatments, and Outcomes in Acute Respiratory Distress Syndrome (ARDS-CTO)
The goal of this observational prospective cohort study is to explore the clinical characteristics, treatment strategies, and outcomes of adult patients with acute respiratory distress syndrome (ARDS) admitted to the medical…
- Trial name
- ARDS-CTO (NCT07186140)
- Where
- South Korea
- Volunteers
- 800 people
- Sponsor
- Jee Hwan Ahn
RDS, Infant, Newborn
Intratracheal Vitamin A Administration With Surfactant for Newborn Respiratory Distress Syndrome
To research the effect of vitamin A to newborn respiratory distress syndrome by intratracheal administration with surfactant.
- Conditions
- RDS, Infant, Newborn, Vitamin A, Surfactant
- Trial name
- RDS (NCT01265589)
- Testing
- surfactant, surfactant+vitamin A
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Third Military Medical University
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