Clinical trials: Respiratory Distress Syndrome (RDS) of Neonate
Neonates and Preterm Infants, Infant Respiratory Distress Syndrome
Duration of Surfactant Administration and Impact on Stabilisation of Vital Parameters in Very Preterm Neonates: 1 Minutes Versus 5 Minutes
Respiratory distress syndrome (RDS) is common in very preterm infants due to surfactant deficiency. Surfactant replacement therapy is lifesaving, and current guidelines recommend the less invasive surfactant administration (LISA)…
- Conditions
- Neonates and Preterm Infants, Infant Respiratory Distress Syndrome, Surfactant Deficiency Syndrome Neonatal, Surfactant
- Trial name
- SurfStab I (NCT07261787)
- Testing
- Poractant alfa (Curosurf®) - 1-minute administration, Poractant alfa (Curosurf®) - 5-minute administration
- Where
- Austria
- Volunteers
- 76 people
- Sponsor
- Medical University of Graz
Respiratory Distress Syndrome, Newborn, Respiratory Distress Syndrome in Premature Infant
Speed of Lung Inflation During Ventilation of Extremely Preterm Infants
Babies born extremely preterm (<28 weeks of pregnancy) require support to breathe. Some babies require help to breathe from a breathing machine (mechanical ventilator). While this keeps babies alive, it may damage their lungs.
- Trial name
- FLOW-VENT (NCT07101419)
- Testing
- Long PRT, Short PRT
- Where
- 3 sites in Australia
- Volunteers
- 68 people
- Sponsor
- Murdoch Childrens Research Institute
Respiratory Distress Syndrome of Newborn
A Clinical Pharmacological Study of Dose Halving of Dexamethasone in Pregnant Women With Preterm Labour With Preterm Birth at Greater Than or Equal to 34 Gestational Weeks (34GW+)
This study plans to conduct a DEX dose halving study and a normal dose study in 34+0-35+6 GW women with preterm preterm labour. In addition, this study plans to conduct a DEX dose halving study and a normal dose study in 34-38+6…
- Trial name
- NCT06350565
- Testing
- Dexamethasone
- Volunteers
- 48 people
- Sponsor
- Peking University Third Hospital
Neonatal Respiratory Distress Syndrome
Effect of Antenatal Corticosteroids on Neonatal Morbidity.
It will be a randomized controlled trial. There will be two study groups. Study group 1 will be given dexamethasone while study group 2 will be given betamethasone. The control group will be given placebo.
- Trial name
- NCT03446937
- Testing
- Dexamethasone Sodium Phosphate Injection, Betamethasone Sodium Phosphate Injection (Medication), Water for injection
- Where
- Nigeria
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Ahmadu Bello University Teaching Hospital
Prematurity, Respiratory Distress Syndrome
Curosurf and Survanta Treatment(CAST)of RDS in Very Premature Infants
Approval of surfactant by the FDA in 1989 for the treatment of Respiratory Distress Syndrome (RDS) in premature infants greatly improved survival rates.
- Conditions
- Prematurity, Respiratory Distress Syndrome, Patent Ductus Arteriosus
- Trial name
- CAST (NCT00767039)
- Testing
- Survanta (beractant), Curosurf (poractant)
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Alan Fujii
Respiratory Insufficiency of Prematurity
Nasal Intermittent Positive Pressure Ventilation in Premature Infants (NIPPV)
The machines and oxygen used to help very premature babies breathe can have side-effects, such as bronchopulmonary dysplasia (BPD).
- Trial name
- NIPPV (NCT00433212)
- Testing
- nCPAP, NIPPV
- Where
- 35 sites in United States, Austria and 8 more
- Volunteers
- 1,011 people
- Sponsor
- McMaster University
Neonatal Respiratory Distress, Preterm Birth
Study of the Feasibility of Early Lung Ultrasound in Neonatal Respiratory Distress in Premature Newborns Born Between 32 Weeks of Amenorrhea and 36 Weeks Plus 6 Days of Amenorrhea, Hospitalized in the Neonatal Pediatrics and Intensive Care Units of the Dijon University Hospital
Monocentric study carried out in the Neonatal and Intensive Care Units of the Dijon University Hospital. The objective is to evaluate the feasibility of performing a pulmonary ultrasound within 6 hours after admission in…
- Trial name
- REchoPP (NCT05737095)
- Testing
- Pulmonary ultrasound
- Where
- France
- Volunteers
- 69 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Diaphragm Ultrasound, Electrical Cardiometry
Diaphragmatic Ultrasound and Thoracic Fluid Content for Prediction of Non-Invasive Ventilation Failure in Neonates
This research assessed diaphragmatic ultrasound and thoracic fluid content (TFC) as potential early predictive tools for detecting NIV failure in preterm neonates.
- Conditions
- Diaphragm Ultrasound, Electrical Cardiometry, Non Invasive Ventilation (NIV), RDS of Prematurity
- Trial name
- NCT07148102
- Testing
- Diaphragmatic US, EC
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Lamiaa Khaled Zidan
Transient Tachypnea Newborn, Cesarean Delivery Affecting Fetus
Misoprostol Before Elective Caesarean Section for Decreasing the Neonatal Respiratory Morbidity
Neonatal respiratory distress may occur in either term or preterm newborns with a higher relative risk in preterm, and whether born vaginally or through caesarean section, but in a higher percentage after elective caesarean…
- Trial name
- NCT03031353
- Testing
- Misoprostol
- Where
- Egypt
- Volunteers
- 170 people
- Sponsor
- Ain Shams University
Prematurity, BPD - Bronchopulmonary Dysplasia
Feasibility and Impact of Volume Targeted Ventilation in the Delivery Room
Despite significant improvement in preterm infant survival, the incidence of bronchopulmonary dysplasia (BPD) in infants born < 28 weeks gestational age (GA) has been relatively stable at ~40%, with 10,000-15,000 new cases…
- Conditions
- Prematurity, BPD - Bronchopulmonary Dysplasia, Respiratory Distress Syndrome, Newborn
- Trial name
- NCT03938532
- Testing
- Volume Targeted Ventilation (VTV) using the Philips Respironics NM3 monitor, Tidal Volume Measurement using the Philips Respironics NM3 monitor
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Baystate Medical Center
Respiratory Distress Syndrome, Newborn
Comparison of CPAP Machines With Reusable vs Disposable Circuits
The study aims to assess the basic functionality of a newly designed CPAP machine with reusable circuits to existing machines with disposable circuits, for treatment of newborn infants diagnosed with respiratory distress…
- Trial name
- NCT03121612
- Testing
- CPAP
- Where
- India
- Volunteers
- 51 people
- Sponsor
- Medical Technology Transfer and Services Hong Kong Ltd
Neonatal Respiratory Distress, Lung Ultrasound Score
Predictive Value of Lung Ultrasound Combined With Serum ANGPL4 Levels for NICU Admission Needs in Late Preterm and Term Neonates With Respiratory Distress In The Transion Period
The aim of this study is to evaluate the validity of point-of-care lung ultrasound (POC-LUS) and serum ANGPL4 levels for predicting NICU admission needs in late preterm and full-term neonates with respiratory distress shortly…
- Trial name
- NCT07809971
- Testing
- Point of care lung ultrasound (POC-LUS), Serum ANGPTL4
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Tanta University
Hyaline Membrane Disease
MISurf Versus InSurE. A Comparison of Minimally Invasive Surfactant Application Techniques in Preterm Infants
The lungs of infants born too early are extremely underdeveloped. Respiratory Distress Syndrome (RDS) is a condition that frequently develops in infants born more than 10 weeks early and leads to the collapse of their lungs.
- Trial name
- MIsurf (NCT01615016)
- Testing
- Minimally invasive endotracheal surfactant application
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- Hamilton Health Sciences Corporation
Respiratory Distress Syndrome, Newborn, Neonatal Respiratory Distress
Chest Ultrasound as Diagnostic and Prognostic Tool in Neonatal RDS
This cross-sectional study aims to evaluate the diagnostic accuracy of chest ultrasound in neonatal respiratory distress syndrome and to assess its potential prognostic value compared with chest X-ray.
- Trial name
- NCT07857304
- Volunteers
- 82 people
- Sponsor
- Assiut University
Neonatal Respiratory Distress Syndrome, Prematurity
Breathing Variability and NAVA in Neonates
The current study is a crossover trial, aiming at evaluating the effect of NAVA -NIV compared to Nasal Intermittent Positive Pressure Ventilation (PC-NIV) at the same level of peak inspiratory pressure, in terms of…
- Trial name
- BRAVe NANO (NCT04000568)
- Testing
- Respiratory support: NAVA -NIV and PC-NIV
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Neonatal Respiratory Distress Syndrome
The Use of Maternal Serum Unconjugated Estriol for Monitoring the Prevention of Neonatal Respiratory Distress Syndrome
The objective of this project is to evaluate clinical significance of measuring maternal blood estriol levels, after the administration of antenatal corticosteroids to enhance lung maturity.
- Trial name
- NCT02112513
- Where
- 2 sites in United States
- Volunteers
- 160 people
- Sponsor
- Indiana University
Transient Tachypnoea of the Newborn
Study Protocol Evaluating Transient Tachypnoea of the Newborn in Term and Near Term Neonates
Transient tachypnoea of the newborn (TTN) is a common cause of hospitalisation in the neonatal period, complicating 1 to 1,5 per cent life birth.
- Trial name
- NCT00213941
- Testing
- Echocardiography
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Neonatal Respiratory Distress, Very Low Birth Weight Infant
PRICO: OPTI Target Range
The aim of the study is to determine if a narrower SpO2 Target Range setting automated control of FiO2 (A-FiO2) is more effective than a wider SpO2 Target Range
- Trial name
- POSTR (NCT06207994)
- Testing
- Narrow TR, Shifted TR
- Where
- Czechia
- Volunteers
- 11 people
- Sponsor
- Czech Technical University in Prague
Respiratory Distress Syndrome RDS, Preterm Birth
Early Prediction of Lung Injury in Preterm Infants Score
The main hypothesis is that even preterm infants considered "stable" receiving non-invasive ventilation may be at risk of developing BPD due to an inhomogeneous distribution of ventilation.
- Trial name
- EPLIPS (NCT07265583)
- Where
- Italy
- Volunteers
- 104 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Hyaline Membrane Disease, Preterm Infant
Evaluation of the Neonatal Autonomic Stress During Intubations Under Propofol in a Population of Premature Infants Under 33 w'GA
Hyaline membrane disease is one of the leading causes of morbidity and mortality in premature newborns in industrialized countries.
- Trial name
- PROPOSURF (NCT03721640)
- Testing
- electrocardiogram
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne