Clinical trials: Respiratory Distress Syndrome of Newborn
Acute Respiratory Distress Syndrome (ARDS)
Metoprolol in Acute Respiratory Distress Syndrome (MAIDEN)
Randomised, double-blind, placebo-controlled clinical trial to evaluate the efficacy of intravenous metoprolol in patients with Acute Respiratory Respiratory Distress Syndrome (ARDS).
- Trial name
- MAIDEN (NCT05847517)
- Testing
- Metoprolol Injection, saline 0.9%
- Where
- 12 sites in Spain
- Volunteers
- 14 people
- Sponsor
- Consorcio Centro de Investigación Biomédica en Red (CIBER)
Acute Respiratory Distress Syndrome, Ventilator-Induced Lung Injury
Height Measurement Procedures Influence the Risk of Ventilator-induced Lung Injury in ARDS
Acute respiratory distress syndrome is characterized by heterogeneous lung injury, with dependent regions often collapsed and non-dependent regions relatively well-aerated, forming the so called "baby lung." Mechanical…
- Conditions
- Acute Respiratory Distress Syndrome, Ventilator-Induced Lung Injury, Tidal Volume, Predicted Body Weight
- Trial name
- SIZE-ARDS (NCT07595926)
- Testing
- height measured
- Where
- France
- Volunteers
- 39 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Respiratory Distress Syndrome, Adult, Head Injuries, Closed
Hypertonic Saline With Dextran for Treating Hypovolemic Shock and Severe Brain Injury
The purpose of this study is to evaluate the clinical outcome of patients following blunt traumatic injury with hypovolemic shock, who receive either lactated ringer's solution or hypertonic saline with dextran (HSD)…
- Conditions
- Respiratory Distress Syndrome, Adult, Head Injuries, Closed, Shock, Shock, Traumatic
- Trial name
- NCT00113685
- Testing
- Hypertonic Saline-Dextran Solution, Lactated Ringer's Solution
- Where
- United States
- Volunteers
- 209 people
- Sponsor
- University of Washington
Transfusion-related Acute Lung Injury, Chronic Liver Disease
Predicting Lung Injury From Transfusion in Patients With Liver Disease
A certain molecule floating in the blood may represent a risk of lung injury after a transfusion. We are determining whether detection of this molecule on a simple blood clotting test will predict the development of lung injury…
- Conditions
- Transfusion-related Acute Lung Injury, Chronic Liver Disease, Gastrointestinal Bleeding
- Trial name
- NCT01756690
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- University of Colorado, Denver
Transient Tachypnea of the Newborn, TTN
Lung Ultrasound to Diagnose Transient Tachypnea of the Newborn (TTN) Versus Respiratory Distress Syndrome (RDS) in Neonates
The investigators hypothesize that ultrasonography of the newborn lung can be used as an effective diagnostic tool in neonates ≥ 28 weeks gestation with early symptoms of respiratory distress.
- Conditions
- Transient Tachypnea of the Newborn, TTN, Respiratory Distress Syndrome, RDS
- Trial name
- NCT01517958
- Testing
- Respiratory Distress Group, Control Group
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Moderate to Severe Acute Respiratory Distress Syndrome Associated With COVID-19
Intermediate-size Expanded Access Program (EAP), Mesenchymal Stromal Cells (MSC) for Acute Respiratory Distress Syndrome (ARDS) Due to COVID-19 Infection
The objectives of this intermediate-size expanded access protocol are to assess the safety and efficacy of remestemcel-L in participants with ARDS due to coronavirus infection 2019 (COVID-19).
- Trial name
- NCT04366830
- Testing
- Remestemcel-L
- Where
- United States
- Sponsor
- Mesoblast International Sàrl
Preterm Birth, Distress Respiratory Syndrome
Adverse Neonatal Outcomes With a Shortened Clinical Regimen of Dexamethasone.
Respiratory morbidity, including respiratory distress syndrome (RDS), is a serious complication of preterm birth and the leading cause of early neonatal mortality and disability.
- Trial name
- UNODEXA (NCT06569251)
- Testing
- Dexamethasone 12 mg QD, Dexamethasone 6 mg BID
- Where
- Honduras
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Ricardo A Gutierrez Ramirez, MD, MSc, FACOG
Transient Tachypnea of the Newborn
Fluid Management in Transient Tachypnea of the Newborn
Transient tachypnea of the newborn (TTN) is a diagnosis given to infants born between 34 and 42 weeks gestation who develop difficulty breathing during the first days of life when no specific cause of the breathing difficulty can…
- Trial name
- NCT01225029
- Testing
- Amount of total fluids
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
COVID-19 Pneumonia, Superinfection
The Diagnosis of Superinfections in Mechanically Ventilated Covid-19 Patients
Patients with severe Coronavirus Disease 2019 (Covid-19) pneumonia depending on mechanical ventilation are at risk of superinfections, especially infections of respiratory tract.
- Conditions
- COVID-19 Pneumonia, Superinfection, ARDS, Human
- Trial name
- SUPER-BAL (NCT05148975)
- Testing
- Bronchoalveolar lavage fluid diagnostics
- Where
- 2 sites in Czechia
- Volunteers
- 150 people
- Sponsor
- Brno University Hospital
Respiratory Distress Syndrome in Premature Infant, Bronchopulmonary Dysplasia
Efficacy of Recombinant Human Clara Cell 10 Protein (rhCC10) Administered to Premature Neonates With Respiratory Distress Syndrome
Bronchopulmonary Dysplasia (BPD) is a multi-factorial disease process that is the end result of an immature, surfactant deficient lung that has been exposed to hyperoxia, mechanical ventilation and infection.
- Trial name
- NCT01941745
- Testing
- Half normal saline, Low Dose rhCC10, High dose rhCC10
- Where
- 3 sites in United States
- Volunteers
- 88 people
- Sponsor
- Tufts Medical Center
Lung Disease, Acute Respiratory Distress Syndrome
Palliative Use of High-flow Oxygen Nasal Cannula in End-of-life Lung Disease Patients
The prevalence of severe dyspnoea among terminally ill patients has been reported as 70% and 90% for lung cancer and chronic obstructive pulmonary disease (COPD) patients, respectively.
- Trial name
- NCT02253667
- Testing
- HFONC, Conventional oxygen therapy
- Where
- Portugal
- Sponsor
- Hospital Sao Joao
Infant, Premature, Diseases, Respiratory Distress Syndrome
Functional Residual Capacity During Different Levels of High-flow in Preterm Infants
Although there is a widespread use of HighFlow therapy around the world, there is still uncertainty about the most appropriate initial HighFlow level after nasal continuous positive airway pressure therapy.
- Trial name
- FunkFlow (NCT05237622)
- Testing
- High Flow
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University of Zurich
Ventilation Therapy; Complications, Ventilator-Induced Lung Injury
Clinical Decision Support Tool in PARDS Pilot Study
Previous clinical trials in adults with acute respiratory distress syndrome (ARDS) have demonstrated that ventilator management choices can improve Intensive Care Unit (ICU) mortality and shorten time on mechanical ventilation.
- Conditions
- Ventilation Therapy; Complications, Ventilator-Induced Lung Injury, Ards
- Trial name
- NCT04068012
- Testing
- Ventilator protocol
- Where
- 8 sites in United States, Canada and 1 more
- Volunteers
- 180 people
- Sponsor
- Children's Hospital Los Angeles
Premature Birth, Respiratory Distress Syndrome
Non-invasive Ventilation in Preterm Infants
This is a prospective, observational cohort study. For the study part on noninvasive neurally adjusted ventilatory assist (NIV-NAVA) the design is interventional.
- Conditions
- Premature Birth, Respiratory Distress Syndrome, Ventilator Lung; Newborn
- Trial name
- NCT05987800
- Testing
- Titration procedure, Electrical impedance tomography, Lung and diaphragm ultrasound
- Where
- Belgium
- Volunteers
- 136 people
- Sponsor
- Universitair Ziekenhuis Brussel
Shock, Preterm Birth Complication
Early Hydrocortisone Versus Regular Treatment in Shock in Extremely Preterm Neonates - an Open Randomized Controlled Trial
The goal of this clinical trial is to determine the effectiveness of early use of hydrocortisone (since the diagnosis of shock) for its resolution within the first 72 hours in premature infants under 1,500 g.
- Conditions
- Shock, Preterm Birth Complication, Preterm Intraventricular Hemorrhage, Asphyxia Perinatal
- Trial name
- NCT07248761
- Testing
- Intravascular Hydrocortisone (stress dosage): 1 mg/k/dose each 8 hours for 5 days, Vasoactive drug therapies
- Where
- Mexico
- Volunteers
- 76 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Acute Respiratory Distress Syndrome, Respiratory Failure
Precision Ventilation vs Standard Care for Acute Respiratory Distress Syndrome
The goal of this interventional study is to compare standard mechanical ventilation to a lung-stress oriented ventilation strategy in patients with Acute Respiratory Distress Syndrome (ARDS).
- Trial name
- PREVENT VILI (NCT06066502)
- Testing
- Precision ventilation, Guided usual care ventilation
- Where
- 33 sites in United States
- Volunteers
- 1,100 people
- Sponsor
- Beth Israel Deaconess Medical Center
COVID, Corona Virus Infection
Intensive Care Associated Complications and Outcome of Acute Respiratory Distress Syndrome Due to COVID-19
COVID-19 patients with a severely symptomatic progression with development of an Acute respiratory distress syndrome (ARDS) due to SARS-CoV-2 need prolonged intensive care treatment involving pharmacological immobilization…
- Conditions
- COVID, Corona Virus Infection, Sars-CoV2
- Trial name
- NCT04397172
- Testing
- Study Arm
- Where
- Switzerland
- Volunteers
- 48 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Acute Respiratory Distress Syndrome
A Strategy to Improve Implementation of LTVV for Patients w/ ARDS
The primary objective of this study is to evaluate whether a multi-component implementation strategy/quality improvement intervention comprised of 1) clinical decision support that couples a natural language processing (NLP)…
- Trial name
- NCT03051139
- Testing
- Multi-component LTVV implementation strategy
- Where
- United States
- Sponsor
- Northwestern University
Respiratory Distress Syndrome in Premature Infants
First In Human Study on Synthetic Surfactant CHF 5633 in Respiratory Distress Syndrome
The aim of this study is to investigate the safety and tolerability of intratracheal administration of two different single doses of CHF 5633 in preterm neonates with RDS in terms of adverse events, adverse drug reactions…
- Trial name
- NCT01651637
- Testing
- synthetic surfactant (CHF5633)
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
Respiratory Distress Syndrome, Newborn
Efficacy Evaluation of Surfactant Administration Via Laryngeal Mask Airway
With the development of the Intubation Surfactant Extubation technic, in which surfactant is administered during a brief intubation followed by immediate extubation, surfactant therapy can be given during nasal continuous…
- Trial name
- NCT01173237
- Testing
- Use tracheal intubation for surfactant therapy, Use of Proseal laryngeal mask airway for surfactant therapy
- Where
- 2 sites in Brazil
- Volunteers
- 60 people
- Sponsor
- Federal University of Minas Gerais
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