Clinical trials: Respiratory Distress Syndrome of Newborn
Respiratory Distress Syndrome
Early CPAP in Respiratory Distress Syndrome
The purpose of this study is to establish if a strategy of EBCPAP application in a subgroup of VLBWI, 800 to 1500g birthweight, decreases the need for mechanical ventilation in this group, without affecting mortality.
- Trial name
- NCT00368680
- Testing
- Early Bubble CPAP
- Where
- 14 sites in Argentina, Chile and 3 more
- Volunteers
- 256 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Respiratory Distress Syndrome, Adult
High Flow Nasal Oxygen for Acute Hypoxemic Respiratory Failure in the Emergency Room
The aim of this multicenter, randomized, controlled, open-label trial is to investigate the efficacy of early treatment with HFNO compared with SOT in preventing early deterioration of patients admitted to the ER because of acute…
- Trial name
- GLAMOUR (NCT06489379)
- Testing
- high flow nasal cannula, standard oxygen
- Volunteers
- 234 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Acute Respiratory Distress Syndrome, Acute Lung Injury
Non-invasive Vagal Neurostimulation (nVNS) for Traumatic Brain Injury (TBI)-Induced Acute Respiratory Distress
This is a prospective, randomized, two-arm, controlled 30-day investigational pilot trial using the gammaCore Sapphire S non-invasive vagus nerve stimulation (nVNS) device + standard of care (SOC) in newly-hospitalized patients…
- Conditions
- Acute Respiratory Distress Syndrome, Acute Lung Injury, Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS), Traumatic Brain Injury
- Trial name
- NCT04935697
- Testing
- nVNS, SOC
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Transient Tachypnea of Newborn and Fetal Acidosis
Impact Of Maternal Spinal Anesthesia-Induced Hypotension At Scheduled Cesarean Delivery On Risk Development Of Transient Tachypnea Of Newborn And Fetal Acidosis
We will evaluate the association between transient tachypnea of newborns and fetal acidosis development to the degree and duration of maternal hypotension and anesthesia to delivery time during spinal anesthesia at scheduled…
- Trial name
- NCT06383624
- Where
- Egypt
- Volunteers
- 115 people
- Sponsor
- Benha University
Respiratory Distress Syndrome
Proper Pressure and Duration of Sustained Lung Inflation in Preterm Infants
The appropriate pressure and duration needed for sustained lung inflation in preterm infants at risk of respiratory distress syndrome have not been well evaluated.
- Trial name
- NCT02846597
- Testing
- Sustained lung inflation in preterms (SLI).
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Mansoura University Children Hospital
Respiratory Distress Syndrome, Newborn, Transient Tachypnea of the Newborn
Efficacy of Antenatal Steroids in Reducing Respiratory Morbidities in Late Preterm Infants
The hypothesis of the study is that administration of antenatal steroid to women at high risk of preterm birth after 34 weeks of gestation would reduce the risk of respiratory complications, specifically Respiratory Distress…
- Trial name
- NCT01206946
- Testing
- Betamethasone, Normal Saline
- Where
- 5 sites in Lebanon
- Volunteers
- 700 people
- Sponsor
- American University of Beirut Medical Center
Sepsis and Septic Shock
Proteinuria During Sepsis and Septic Shock: Characterization and Association With ARDS
ARDS is a pulmonary edema injury. Among its etiologies, it can be secondary to septic shock. Managing septic shock involves hemodynamic optimization with significant fluid and sodium inputs.
- Trial name
- ALBUREA (NCT06476860)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Intercommunal André Grégoire
Acute Respiratory Distress Syndrome (ARDS)
Application of Electrical Impedance Tomography in Evaluating Pulmonary Function Improvement After High Lateral Recumbent Position Therapy in ARDS Patients
This randomized controlled trial investigates the effects of prone positioning versus lateral positioning at different angles (30°, 90°, 120°) on pulmonary function improvement in patients with acute respiratory distress syndrome…
- Trial name
- NCT07375849
- Testing
- Place the patient in the 90-degree high lateral position., Place the patient in the 30-degree low lateral position., Place the patient in the 120-degree high lateral position.
- Volunteers
- 140 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
RDS of Prematurity, Preterm Birth
Pivotal Study to Assess Safety and Performance of Neola®, a Novel Lung Monitoring Device for Neonates
Pivotal study to assess safety and performance of Neola®, a novel lung monitoring device for neonates
- Conditions
- RDS of Prematurity, Preterm Birth, Lung Diseases
- Trial name
- NCT07060911
- Testing
- Lung monitoring with the Neola device
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- Neola Medical Inc
Multi-organ Failure After Severe Trauma
Metabolic Reprogramming in Renal Tubular Cells in Acute Kidney Injury Following Severe Trauma
Severe trauma remains the leading cause of death in people under 50, and is associated with high morbidity, including severe disability, with a substantial socio-economic impact.
- Trial name
- METAKIT (NCT06167512)
- Where
- 2 sites in France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Respiratory Distress Syndrome of Newborn
A Clinical Pharmacological Study of Dose Halving of Dexamethasone in Pregnant Women With Preterm Labour With Preterm Birth at Greater Than or Equal to 34 Gestational Weeks (34GW+)
This study plans to conduct a DEX dose halving study and a normal dose study in 34+0-35+6 GW women with preterm preterm labour. In addition, this study plans to conduct a DEX dose halving study and a normal dose study in 34-38+6…
- Trial name
- NCT06350565
- Testing
- Dexamethasone
- Volunteers
- 48 people
- Sponsor
- Peking University Third Hospital
Acute Respiratory Distress Syndrome
Macrophage Programing in Acute Lung Injury
The histologic hallmarks of lung inflammation and in the extreme, acute respiratory distress syndrome (ARDS), include intense accumulation of inflammatory cells in the airspaces and interstitium, injury to alveolar epithelial and…
- Trial name
- NCT03844893
- Testing
- Mini bal
- Volunteers
- 56 people
- Sponsor
- National Jewish Health
Moderate to Severe Acute Respiratory Distress Syndrome
Effects on Biotrauma of NMBAs and PP Association During ARDS
The improved survival of patients with acute respiratory distress syndrome (ARDS) over the last decades is related to the use of so-called "protective" mechanical ventilation.
- Trial name
- CURA-PRONE (NCT06212492)
- Testing
- NMBAs, Prone positioning
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
ARDS, Human, Ventilator-Induced Lung Injury
Non-invasive Phrenic Nerve Stimulation in ARDS Patient
Reduced diaphragmatic activity during mechanical ventilation can lead to diaphragmatic disuse atrophy, atelectasis, increased lung stress and strain, and hemodynamic impairment.
- Conditions
- ARDS, Human, Ventilator-Induced Lung Injury, Diaphragm Injury
- Trial name
- NCT06572280
- Testing
- PNS group
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Southeast University, China
ARDS, Prone Position
Determine the Effect of Prone Positioning in Adults With ARDS by Electrical Impedance Tomography
determine the effect of prone positioning on ventilation and perfusion distribution in adults with acute respiratory distress syndrome by electrical impedance tomography
- Conditions
- ARDS, Prone Position, Electrical Impedance Tomography
- Trial name
- NCT04725227
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shanghai Zhongshan Hospital
Pressure Ulcer, Respiratory Distress Syndrome, Acute
Extended Prone Position Duration COVID-19-related ARDS: a Retrospective Study
Prone position (PP) is standard of care for mechanically ventilated patients with severe acute respiratory distress syndrome in the intensive care unit (ICU). Recommendations suggest PP durations of at least 16 hours.
- Conditions
- Pressure Ulcer, Respiratory Distress Syndrome, Acute, Hypoxemic Respiratory Failure, COVID-19 Acute Respiratory Distress Syndrome
- Trial name
- NCT05124197
- Testing
- prone position
- Where
- France
- Volunteers
- 81 people
- Sponsor
- Hôpital Louis Mourier
ARDS, Human, COVID
Ruxolitinib for Treatment of Covid-19 Induced Lung Injury ARDS
The purpose of this study is to evaluate the efficacy and safety of ruxolitinib in the treatment of patients with COVID-19 severe pneumonia.
- Trial name
- RuXoCoil (NCT04359290)
- Testing
- Ruxolitinib administration
- Where
- Germany
- Volunteers
- 15 people
- Sponsor
- Philipps University Marburg
Lung Collapse, Lung Diseases
The Accuracy of Pediatric Air Test as a Non-invasive Atelectasis Diagnostic Tool
HYPOTHESIS: During anesthetic pre-oxygenation with high FiO2, pulmonary atelectasis occur, especially in patients < 6 years old, where FRC and pulmonary closing volume may overlap.
- Conditions
- Lung Collapse, Lung Diseases, Atelectasis, Atelectasis Without Respiratory Distress Syndrome
- Trial name
- NCT04506203
- Testing
- Air test
- Where
- 3 sites in Argentina, Spain
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario La Paz
ARDS (Acute Respiratory Distress Syndrome)
Effect of EIT-guided PEEP in ARDS Patients
Acute respiratory syndrome distress (ARDS) is a clinical common syndrome with high mortality. Mechanical ventilation (MV) is the cornerstone of management of ARDS but can lead to ventilator-induced lung injury.
- Trial name
- NCT06990477
- Testing
- EIT-guided PEEP
- Where
- 17 sites in China, South Korea and 1 more
- Volunteers
- 2,400 people
- Sponsor
- Southeast University, China
Acute Respiratory Distress Syndrome (ARDS)
Surviving ARDS: The Influence of Quality of Care and Individual Patient Characteristics on Quality of Life
The purpose of the DACAPO study ("Surviving ARDS: the influence of quality of care and individual patient characteristics on quality of life") is to investigate the role of quality of care and individual patient characteristics…
- Trial name
- DACAPO (NCT02637011)
- Where
- 3 sites in Germany
- Volunteers
- 2,000 people
- Sponsor
- University Hospital Regensburg