Clinical trials: Respiratory Distress Syndrome of Newborn
PreTerm Neonate, Respiratory Distress Syndrome (RDS)
Neonatologist-Performed Lung Ultrasound (NPLUS) to Guide Respiratory Therapy
The goal of this cross-over clinical trial is to evaluate whether Neonatologist-Performed Lung Ultrasound (NPLUS) can be used in preterm babies on non-invasive breathing support to reduce the amount of oxygen they need.
- Trial name
- NCT06901206
- Testing
- Neonatologist performed lung ultrasound
- Where
- Australia
- Volunteers
- 20 people
- Sponsor
- Royal Hospital For Women
ARDS, Covid19
Evaluating AVM0703 for Treatment of COVID-19 or Influenza-mediated ARDS
This is a randomized, double-blinded, placebo-controlled study of AVM0703 administered as a single intravenous (IV) infusion to patients with moderate or severe immediately life-threatening Acute Respiratory Distress Syndrome…
- Conditions
- ARDS, Covid19, Influenza, Human
- Trial name
- AVM0703 (NCT04366115)
- Testing
- AVM0703
- Volunteers
- 16 people
- Sponsor
- AVM Biotechnology Inc
Acute Respiratory Distress Syndrome
EPVent 2- A Phase II Study of Mechanical Ventilation Directed by Transpulmonary Pressures
This phase II multi-centered, randomized controlled trial of mechanical ventilation directed by esophageal pressure measurement will test the primary hypothesis that using a strategy of maintaining a minimal but positive…
- Trial name
- EPVent2 (NCT01681225)
- Testing
- Esophageal-pressure guided mechanical ventilation, High PEEP mechanical ventilation
- Where
- 14 sites in United States, Canada
- Volunteers
- 202 people
- Sponsor
- Beth Israel Deaconess Medical Center
ARDS
Electrical Impedance Tomography-Derived Dorsal Recruitment-to-Inflation Ratio Identifies PEEP Responsiveness and Risk Phenotypes in ARDS
In the treatment of critically ill patients, mechanical ventilation is a key link, and appropriate mechanical ventilation strategies can open the alveoli and improve oxygenation, while inappropriate mechanical ventilation can…
- Trial name
- NCT06823804
- Testing
- Electrical Impedance tomography Monitoring
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Ruijin Hospital
Sepsis, Pneumonia
Benefit of Clarithromycin in Patients With Severe Infections Through Modulation of the Immune System
High mortality associated with sepsis and Multiple Organ Dysfunction Syndrome (MODS) calls for alternative, individualized therapies in selected patients that might benefit form specific interventions.
- Conditions
- Sepsis, Pneumonia, Gram-Negative Bacteria Infection, Multiple Organ Failure
- Trial name
- INCLASS (NCT03345992)
- Testing
- Clarithromycin, Water for injection
- Where
- 12 sites in Belgium, Greece
- Volunteers
- 110 people
- Sponsor
- Hellenic Institute for the Study of Sepsis
Respiratory Distress Syndrome
Impact of Synchronized Nasal Intermittent Positive Pressure Ventilation Using NAVA in Preterm Infants With RDS
The nasal CPAP (continuous positive airway pressure), is a technique of noninvasive ventilation commonly used in neonatal intensive care units, and has recently been used in association with nasal intermittent mandatory…
- Trial name
- NCT02030652
- Testing
- Intermittent nasal positive pressure positive ventilation., CPAP
- Where
- Brazil
- Volunteers
- 56 people
- Sponsor
- Hospital Israelita Albert Einstein
ARDS, Human, Coronavirus Infection
Pilot Study of Single Dose Bevacizumab as Treatment for Acute Respiratory Distress Syndrome (ARDS) in COVID-19 Patients
Our hypothesis is that treating ARDS caused by COVID-19 with bevacizumab improves mortality. This is a phase II, multi-centered, randomized, open label, two-armed clinical trial to study the safety and efficacy of bevacizumab in…
- Trial name
- BEVACOR (NCT04954014)
- Testing
- Bevacizumab, BAT
- Where
- Spain
- Volunteers
- 21 people
- Sponsor
- Maimónides Biomedical Research Institute of Córdoba
Acute Respiratory Distress Syndrome
Stratification of the Acute Respiratory Distress Syndrome - A Second Phase Study
Current definitions of the Acute Respiratory Distress Syndrome (ARDS) could be adequate for epidemiological studies but are not adequate for inclusion of patients into therapeutic clinical trials.
- Trial name
- STANDARDS-2 (NCT02836444)
- Where
- 16 sites in Spain
- Volunteers
- 422 people
- Sponsor
- Hospital Universitario de Gran Canaria Doctor Negrín
ARDS (Acute Respiratory Distress Syndrome)
EIT Evaluation of the Impact of Inhaled Nitric Oxide on Ventilation/Perfusion Mismatch in ARDS Patients Receiving Noninvasive Respiratory Support
This study aimed to quantitatively evaluate the immediate effect of inhaled nitric oxide on the ventilation / perfusion ratio in ARDS patients receiving nasal high flow oxygen therapy or noninvasive ventilation using electrical…
- Trial name
- NCT07617298
- Testing
- Inhale different doses of nitric oxide
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Ming Zhong
ARDS, Lung Protective Ventilation
Effect of Different Depths of Neuromuscular Blockade on Respiratory Mechanics in Patients With Moderate-severe Acute Respiratory Distress Syndrome
Acute respiratory distress syndrome (ARDS) is characterized by acute diffuse alveolar injury caused by a variety of pulmonary and extrapulmonary factors, leading to refractory hypoxemia. It has high incidence and mortality rates.
- Trial name
- ARDS (NCT06514209)
- Testing
- cisatracurium
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Southeast University, China
Respiratory Distress Syndrome, Newborn, Infant, Premature, Diseases
Airway Flow of RAM Cannula With BCPAP in Infants
The RAM Cannula interface is used as routine interface for newborn infants receiving CPAP treatment for respiratory distress. Compared to the standard systems that have been used for more than 50 years, the interface has high…
- Conditions
- Respiratory Distress Syndrome, Newborn, Infant, Premature, Diseases, Infant, Newborn, Diseases
- Trial name
- NCT06697912
- Where
- Vietnam
- Volunteers
- 100 people
- Sponsor
- Karolinska Institutet
Covid-19
Coronavirus Response - Active Support for Hospitalised Covid-19 Patients
The CRASH-19 trial is a multinational, open-label, factorial, randomised trial in adults hospitalised with suspected or confirmed acute COVID-19 infection.
- Trial name
- CRASH-19 (NCT04343001)
- Testing
- Aspirin, Losartan, Simvastatin
- Where
- 2 sites in Nigeria, Pakistan
- Sponsor
- London School of Hygiene and Tropical Medicine
Severe Pneumonia, Acute Respiratory Distress Syndrome
Treatment of COVID-19 Positive/Negative Bangladeshi Adults With Severe Respiratory Complaints by a Locally Made bCPAP: Feasibility Study
Low and middle-income countries (LMICs) urgently need cost-effective adaptive technologies to provide CPAP. The lead investigator has designed a device that has already been approved by the Directorate General of Drug…
- Conditions
- Severe Pneumonia, Acute Respiratory Distress Syndrome, Covid19
- Trial name
- Adult-bCPAP (NCT05158842)
- Testing
- Adult bubble CPAP oxygen therapy device
- Where
- 2 sites in Bangladesh
- Volunteers
- 20 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Acute Respiratory Distress Syndrome, Coronavirus
Prone Position Improves End-Expiratory Lung Volumes in COVID-19 Acute Respiratory Distress Syndrome
Covid-19 associated Acute Respiratory Distress Syndrome (ARDS) may present with profound hypoxemia not fully explained with pulmonary infiltrates.
- Conditions
- Acute Respiratory Distress Syndrome, Coronavirus, Mechanical Ventilation Complication, Ventilation Perfusion Mismatch
- Trial name
- NCT04818164
- Where
- Turkey (Türkiye)
- Volunteers
- 43 people
- Sponsor
- Istanbul University - Cerrahpasa
ARDS, Human
Pulmonary Immune Cell-microbiome Interactions in ARDS
The overall aim is to compare the composition and spatial heterogeneity of the following in critically ill intensive care unit (ICU) patients: i) immune cell populations and their activation patterns, ii) the surrounding…
- Trial name
- ILLUMINA-1 (NCT05795257)
- Testing
- Bronchoalveolar lavage
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Hvidovre University Hospital
Pharmacological Action of Drug
the Incidence of Necrotizing Enterocolitis in Preterm With Respiratory Distress Syndrome Undergoing Caffeine Therapy
It is a randomized, prospective study; it will be carried out in the NICU at Alzahraa University Hospital including 50 newborn babies diagnosed with respiratory distress syndrome. The purpose of this study is to : 1.
- Trial name
- NCT06097767
- Testing
- Caffeine citrate, Amikacin
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Al-Azhar University
Respiratory Distress Syndrome (RDS), Bronchopulmonary Dysplasia (BPD)
Can Betamethasone Given After Birth Help Extremely Premature Babies Come Off Breathing Support Safely and Effectively?
The goal of this study is to determine if giving a steroid medication (specifically, betamethasone) after birth can help extremely premature babies (born before 28 weeks) come off breathing machines safely and reduce their risk…
- Trial name
- NCT07447739
- Testing
- Betamethasone
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Khang Nguyen
Acute Respiratory Distress Syndrome
This Study Collects Information on the Safety of Inhaled Pegylated Adrenomedullin (PEG-ADM), How the Drug is Tolerated and How it Affects Patients Suffering From a Type of Lung Failure That Cause Fluid to Build up in the Lungs Making Breathing Difficult (ARDS)
The study is composed of two parts. In part A of the study two active doses of inhaled pegylated adrenomedullin (PEG-ADM) will be compared regarding safety and efficacy to a substance that has no therapeutic effect (placebo) in…
- Trial name
- SEAL (NCT04417036)
- Testing
- BAY1097761 Active Dose 1, BAY1097761 Active Dose 2
- Where
- 22 sites in Austria, Czechia and 5 more
- Volunteers
- 90 people
- Sponsor
- Bayer
Acute Respiratory Distress Syndrome
A Multicenter, Random Control Study :Early Use of Airway Pressure Release Ventilation (APRVplus) Protocol in ARDS
Animal experimentals have shown that the more physiology-driven airway pressure release ventilation (APRV) methodologies in ARDS may significantly improve alveolar recruitment and gas exchange, increased homogeneity, and…
- Trial name
- NCT03549910
- Testing
- APRVplus protocol, Low tidal volume ventilation
- Where
- China
- Volunteers
- 840 people
- Sponsor
- West China Hospital
Respiratory Failure
Closed-Loop O2 Use During Invasive Mechanical Ventilation Of Pediatric Patients
During mechanical ventilation (MV) hypoxemic or hyperoxemic events should be carefully monitored and a quick response should be provided by the caregiver at the bedside.
- Trial name
- CLOUDIMPP (NCT05714527)
- Testing
- Close-loop FiO2 controller, Conventional
- Where
- 4 sites in Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Dr. Behcet Uz Children's Hospital
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