Clinical trials: Respiratory Dysfunction
Burn Pit Exposure, Airborne Hazard Exposure
Project PHOENIX: Molecular Signatures of Burn Pit Exposure
Project PHOENIX is an observational clinical research study designed to characterize molecular, genomic, cellular, and functional features in blood specimens from former U.S.
- Conditions
- Burn Pit Exposure, Airborne Hazard Exposure, Veteran Health, Deployment-Related Toxic Exposure
- Trial name
- PHOENIX (NCT07562243)
- Testing
- Prior Burn Pit Exposure, No Known Burn Pit Exposure
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Creative Medical Technology Holdings Inc
Obstructive Sleep Apnoea, Obesity
Obstructive Sleep Apnoea and Adipose Tissue Dysfunction
Dysfunctional adipose tissue predisposes to cardiovascular disease. Similarly, the risk of cardiovascular disease appears to be increased in subjects with obstructive sleep apnoea.
- Conditions
- Obstructive Sleep Apnoea, Obesity, Hypoxia
- Trial name
- NCT02518633
- Testing
- Continuous positive airway pressure devices
- Where
- 2 sites in United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
Down Syndrome, Polyendocrinopathies, Autoimmune
Depressed AIRE Gene Expression Causes Immune Cell Dysfunction & Autoimmunity in Down Syndrome
This study plans to learn more about Down syndrome. The investigators think there is a different level of the AIRE gene in individuals with Down syndrome.
- Conditions
- Down Syndrome, Polyendocrinopathies, Autoimmune, Respiratory Tract Infections, Autoimmunity
- Trial name
- NCT02421276
- Testing
- Phlebotomy
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Sleep Apnea
Mechanisms of Pharyngeal Collapse in Sleep Apnea, Study C
In obstructive sleep apnea (OSA), the upper airway recurrently closes during sleep. The mechanisms that lead to airway closure are not completely understood. Models to study mechanisms of airway collapse have been proposed.
- Trial name
- NCT01738022
- Testing
- Administration of gas mixtures
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Drug Resistant Epilepsy
Circulating microRNAs as Biomarkers of RESPIratory Dysfunction in Patients With Refractory epilePSY
Sudden and unexpected death in epilepsy (SUDEP) has become a major issue for patients with epilepsy and their physicians. SUDEP is a nontraumatic and non-drowning death in patients with epilepsy, unrelated to a documented status…
- Trial name
- MIRESPILEPSY (NCT03419000)
- Testing
- blood sample
- Where
- 2 sites in France
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
COPD
Effects of Combined Cognitive Rehabilitation in COPD Patients
This study was to examine the effect of endurance training combined with cognitive training in patients with COPD. The intervention group underwent Cognitive Training added to Endurance Training and the control group underwent…
- Trial name
- NCT03907839
- Testing
- clinical trials
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Faculty of Medicine, Sousse
COPD
Muscle Function After Lung Transplantation in Patients With Chronic Obstructive Pulmonary Disease (COPD)
The purpose of the project is to investigate changes in the quadriceps muscle and cardiovascular regulation during exercise in relation to improved lung function after lung transplantation in patients with COPD.
- Trial name
- COPD (NCT03548857)
- Testing
- Lung transplantation
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Anorexia Nervosa, Major Depressive Disorder
Neural Basis of Meal Related Interoceptive Dysfunction in Anorexia Nervosa
This study aims to identify the brain regions responsible for encoding cardiorespiratory 'interoceptive' sensations and determine whether they are dysfunctional in individuals affected by eating disorders, anxiety, depression, or…
- Conditions
- Anorexia Nervosa, Major Depressive Disorder, Generalized Anxiety Disorder, Panic Disorder
- Trial name
- NCT02615119
- Testing
- Isoproterenol, Normal saline
- Where
- United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Laureate Institute for Brain Research, Inc.
Primary Graft Dysfunction, Lung Transplantation
This Study is Assessing the Safety and Efficacy of Immune Inhibition as a Treatment to Prevent Primary Graft Dysfunction
Lung transplant recipient survival lags other solid organ recipients, with the main early cause of death being primary graft dysfunction (PGD).
- Conditions
- Primary Graft Dysfunction, Lung Transplantation, Acute Lung Injury(ALI), Natural Killer Cell Mediated Immunity
- Trial name
- MARAVIROC (NCT06853223)
- Testing
- Maraviroc
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Subarachnoid Hemorrhage, Delayed Cerebral Ischemia
MicroRNA Diagnostics in Subarachnoid Hemorrhage 2
The purpose of this study is to validate results from a related trial (NCT01791257) and to compare the profile of microRNA in blood from patients suffering subarachnoid hemorrhage with and without systemic complications.
- Conditions
- Subarachnoid Hemorrhage, Delayed Cerebral Ischemia, Acute Lung Injury, Cardiac Dysfunction
- Trial name
- NCT02320539
- Where
- Denmark
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Cystic Fibrosis
Mechanisms for Vascular Dysfunction and Exercise Tolerance in CF
Cystic fibrosis has many health consequences. A reduction in the ability to perform exercise in patients with CF is related to greater death rates, steeper decline in lung function, and more frequent lung infections.
- Trial name
- CF-AOX (NCT02690064)
- Testing
- Acute Antioxidant, Chronic Antioxidant
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Augusta University
Acute Lung Injury (ALI), Acute Respiratory Distress Syndrome (ARDS)
Effect of R-spondin3 on Sepsis Induced Endothelial Dysfunction
Sepsis is the most frequent risk factor for ALI/ARDS. Meanwhile, Pulmonary is the most vulnerable organ to fail in response to sepsis, vascular endothelial dysfunction is a central event in the pathophysiology of sepsis.
- Trial name
- NCT04546919
- Testing
- sepsis
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Ventricular Dysfunction, Right, Hypoxia
Impact of Hypoxia on Resting and Exertional Right Ventricular Performance
The purpose of this study is to better understand how hypoxia (low oxygen) affects resting and exertional right ventricular function in healthy individuals.
- Trial name
- NCT05272514
- Testing
- Hypoxia
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Obstructive Sleep Apnea of Adult, Mild Cognitive Impairment
The Relationship Between Obstructive Sleep Apnea and Alzheimer's Disease: Evidence and Effectiveness
The research plan to enroll 15 simple snoring patients (apnea/hypopnea <5, control group), 30 severe OSA patients (apnea/hypopnea >30, treatment group), and 15 mild cognitive impairment patients (comparative group).
- Trial name
- OSA (NCT05433883)
- Testing
- sleep surgery
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Mild Cognitive Impairment
Effects of Thai Dance With Twenty-five Squares in Elderly With Mild Cognitive Impairment
The objective of this study was to determine the effects of Thai dance with twenty-five squares on cerebrovascular and cognitive function in elderly with mild cognitive impairment
- Trial name
- NCT06236646
- Testing
- Thai dance with twenty-five squares (TDT), Control (CON)
- Where
- 2 sites in Thailand
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Seasonal Allergic Rhinitis
Treatment of Olfactory Dysfunction in Seasonal Allergic Rhinitis
People with allergies frequently complain of a loss or reduction in the sense of smell. In this study, the investigators propose to perform a randomized, double blind, placebo controlled parallel study of subjects with nasal…
- Trial name
- NCT00361439
- Testing
- Mometasone
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Asthma, Small Airway Disease
The Prevalence Of Small Airways Dysfunction In Asthma Patients And The Impact On The Asthma Control
Asthma, which are one of the most important causes of morbidity and mortality both in the world and in our country, constitute a very serious social and economic burden.
- Trial name
- NCT04375995
- Testing
- Impulse oscillometry, Spirometric pulmonary function test, Fractional exhaled nitric oxide (FENO) test
- Where
- Turkey (Türkiye)
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Sibel Naycı
SARS CoV-2 Post-Acute Sequelae
Positron Emission Tomography (PET) Imaging of Neuroinflammation in Patients With Neurological Dysfunction After Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV 2) Infection
This clinical imaging study will use the small molecule translocator protein (TSPO) ligand, Fluorodeoxyglucose(18F)-labeled DPA-714, to visualize and quantify neuroinflammation in individuals with post-acute sequelae of…
- Trial name
- NCT05656105
- Testing
- DPA-714 PET/MRI
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Covid19, Arterial Stiffness
Covid-19 Effects on Arterial Stiffness and Vascular Aging (CARTESIAN)
The purpose of the study is to evaluate the presence of early vascular aging 6 months and 12 months after COVID-19 infection.
- Conditions
- Covid19, Arterial Stiffness, Endothelial Dysfunction, Diastolic Dysfunction
- Trial name
- CARTESIAN (NCT04558450)
- Testing
- carotid-femoral pulse-wave velocity
- Where
- 3 sites in France
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Obstructive Sleep Apnea, Pathophysiology
Mechanisms of Pharyngeal Collapse in Sleep Apnea, Study A
In obstructive sleep apnea, the upper airway recurrently closes during sleep. The mechanisms that lead to airway closure are not completely understood.
- Trial name
- NCT01728974
- Testing
- Pharyngeal topical anesthesia
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital