Clinical trials: Respiratory Failure, ICU
Corona Virus Infection, Pneumonia
Epidemiological and Demographic Data From 150 Patients Diagnosed With Coronavirus Disease 2019 Pneumonia
In this study, the investigator examined epidemiological and demographic characteristics, risk factors and 28-day mortality of patients admitted to the intensive care unit with the diagnosis of coronavirus disease 2019 pneumonia.
- Conditions
- Corona Virus Infection, Pneumonia, Acute Respiratory Failure
- Trial name
- NCT04430023
- Testing
- epidemiological and demographic characteristics
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Ventilatory Failure
Individualised Weaning From Mechanical Ventilation in General ICU
Patients residing in the intensive care unit typically receive mechanical ventilatory support. Selecting the appropriate level of mechanical ventilation is not trivial, and it has been shown that lung protective settings can…
- Trial name
- iCareWean_CW (NCT03249623)
- Testing
- Beacon Caresystem
- Where
- United Kingdom
- Volunteers
- 274 people
- Sponsor
- Chelsea and Westminster NHS Foundation Trust
Acute Respiratory Failure, Shock
Impact of Early Enteral vs. Parenteral Nutrition on Preservation of Gut Mucosa Integrity in Patients Requiring Mechanical Ventilation and Catecholamine
To demonstrate that a strategy involving early first-line enteral nutrition is associated with improved preservation of gut mucosa integrity, as assessed based on the plasma citrulline level at H72, compared to a strategy…
- Trial name
- NCT03852940
- Testing
- Parenteral nutrition, Enteral Nutrition
- Where
- 6 sites in France
- Volunteers
- 169 people
- Sponsor
- Centre Hospitalier Departemental Vendee
Muscle Weakness, Renal Failure
Predictors of Respiratory Failure Following Extubation in the SICU
Respiratory failure following extubation causes significant morbidity and increases mortality in teh surgical intensive care unit (SICU). However the causes of respiratory failure following extubation remain poorly understood.
- Conditions
- Muscle Weakness, Renal Failure, Respiratory Comorbidities
- Trial name
- NCT01967056
- Where
- United States
- Volunteers
- 750 people
- Sponsor
- Massachusetts General Hospital
Respiratory Failure, Critical Illness
Double Triggering Asynchrony in Mechanically Ventilated Patients.
This observational study examined double triggering asynchrony in28ICU patients on mechanical ventilation. Researchers collected data on patient characteristics, health conditions, and outcomes to understand how this problem…
- Conditions
- Respiratory Failure, Critical Illness, Mechanical Ventilation
- Trial name
- NCT07380607
- Where
- Egypt
- Volunteers
- 28 people
- Sponsor
- Mansoura University
Respiratory Failure, Mechanical Ventilation Complication
Patient-ventilator Asynchrony During Mechanical Non-Invasive Assisted-ventilation in Pediatric Patients (NavPed-NI)
The purpose of this study is to document the prevalence and type of asynchronies incidence during non-invasive mechanical ventilation in pediatric patients breathing under pressure support.
- Trial name
- NavPed-NI (NCT01238757)
- Testing
- Non-invasive Ventilation under Pressure Support, Non-Invasive ventilation under NAVA
- Where
- Switzerland
- Volunteers
- 7 people
- Sponsor
- University Hospital, Geneva
Delirium, Respiratory Failure
How Your Patients' Non-REM Sleep Changes On Sedatives in the Intensive Care Units
The purpose of this study is to study the effect of two standard of care sedative medications on sleep stages and total sleep time.
- Trial name
- HYPNOS (NCT00826553)
- Testing
- Dexmedetomidine, GABA agonist
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Vanderbilt University Medical Center
Intensive Care Unit Acquired Weakness, Critical Care
TryCYCLE: A Pilot Study of Early In-bed Leg Cycle Ergometry in Mechanically Ventilated Patients
Background: Patients in the intensive care unit (ICU) are the sickest in hospital, and need advanced life-support. Survivors of critical illness are very vulnerable to weakness and disability.
- Conditions
- Intensive Care Unit Acquired Weakness, Critical Care, Mechanical Ventilation, Respiratory Failure
- Trial name
- TryCYCLE (NCT01885442)
- Testing
- In-bed leg cycle ergometry
- Where
- Canada
- Volunteers
- 33 people
- Sponsor
- McMaster University
ARDS, COVID19
Evaluation of Airway Pressure Release Ventilation in COVID-19 ARDS
The 2020 pandemic of the coronavirus (SARS-CoV2) has lead to an increase in ARDS cases requiring invasive mechanical ventilation in the ICU (Intensive Care Unit).
- Trial name
- APRV-COVID19 (NCT04386369)
- Testing
- Airway pressure release ventilation
- Where
- France
- Volunteers
- 17 people
- Sponsor
- Central Hospital, Nancy, France
Cardiovascular Diseases, Delirium
Absent Visitors: The Wider Implications of COVID-19 on Non-COVID Cardiothoracic ICU Patients, Relatives and Staff
Patients are part of a family network. When any person in a family becomes critically unwell and requires the assistance of an Intensive Care Unit (ICU), this has an impact on all members of that family.
- Conditions
- Cardiovascular Diseases, Delirium, Critical Illness, Intensive Care Unit Delirium
- Trial name
- VINCI (NCT04538469)
- Testing
- COVID visitation restrictions
- Volunteers
- 1,000 people
- Sponsor
- University of Glasgow
Respiratory Insufficiency, Wounds and Injuries
Humidification Effects on Airway Complications and Clinical Outcomes in Trauma ICU Patients on Mechanical Ventilation
This study compares the effects of two primary airway humidification methods-active heated humidifiers (HHs) and passive heat-and-moisture exchangers (HMEs)-on trauma intensive care unit (ICU) patients requiring prolonged…
- Conditions
- Respiratory Insufficiency, Wounds and Injuries, Critical Illness
- Trial name
- NCT07713238
- Testing
- Airway Humidification Device
- Where
- Egypt
- Volunteers
- 162 people
- Sponsor
- Assiut University
Abdominal Surgery, Respiratory Failure
Metabolites of Tramadol in the Postoperative Surgical Patients
Tramadol is opioid analgesic widely used to treat moderate to severe pain. It is metabolized by cytochrome CYP2D6 into two major metabolites: pharmacologically active metabolite O-desmethyltramadol (M1) and inactive…
- Conditions
- Abdominal Surgery, Respiratory Failure, Renal Failure, Liver Dysfunction
- Trial name
- METRAS (NCT04004481)
- Testing
- Postoperative analgesia using tramadol
- Where
- Croatia
- Volunteers
- 50 people
- Sponsor
- Osijek University Hospital
Acute Respiratory Failure
New Indirect Calorimetry Device for Energy Expenditure Measurement
Energy expenditure (EE) in critically ill patients is highly variable depending on the initial severity of the disease and treatments. Clinicians need to measure EE by indirect calorimetry (IC) to optimize nutritional support.
- Trial name
- ICALIC (NCT02024958)
- Where
- Switzerland
- Volunteers
- 182 people
- Sponsor
- University Hospital, Geneva
Acute Respiratory Failure, Shock
Psychological Trauma and Resilience After Critical Illness
Critically ill patients experience a severe physical disease, associated with a psychotrauma, which may lead to post-traumatic stress disorder (17 to 30% of patients after critical illness) and persistent symptoms of anxiety and…
- Trial name
- RESIREA (NCT05193123)
- Where
- 23 sites in France
- Volunteers
- 200 people
- Sponsor
- Nantes University Hospital