Clinical trials: Respiratory Failure, ICU
Intensive Care Unit Syndrome, Hypercapnia
Hypercapnic Acute Respiratory Failure in the ICU : the YETI Study
Hypercapnia is a frequent clinical situation defined as an elevation of the partial pressure of carbon dioxide (PaCO2) above 45 mmHg.
- Conditions
- Intensive Care Unit Syndrome, Hypercapnia, Acute Respiratory Failure
- Trial name
- YETI (NCT04304339)
- Testing
- Hypercapnic respiratory failure
- Where
- 3 sites in France
- Volunteers
- 862 people
- Sponsor
- French Society for Intensive Care
Critically Ill, Respiratory Failure
A Randomized, Controlled Trial of Inspiratory Muscle Training (IMT)in the ICU and CCU
Inspiratory muscle training (IMT) is an intervention used with success in the outpatient setting within the COPD population. Use of IMT is also theoretically possible during mechanical ventilation.
- Trial name
- NCT02003053
- Testing
- Inspiratory Muscle Trainer
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Wake Forest University Health Sciences
Critical Illness, Respiratory Failure
Cerebral Oxygenation and Neurological Outcomes FOllowing CriticAL Illness-2
This study is designed to test the hypothesis that poor cerebral perfusion during critical illness is a risk factor for acute and long-term neurological dysfunction among survivors.
- Conditions
- Critical Illness, Respiratory Failure, Shock, Delirium
- Trial name
- CONFOCAL-2 (NCT03141619)
- Where
- Canada
- Volunteers
- 500 people
- Sponsor
- Dr. Gordon Boyd
Respiratory Failure
Preoxygenation in the Intensive Care Unit Using a Nose-mouth Mask Versus High-flow Nasal Cannula Oxygen.
Preoxygenation is routinely performed before endotracheal intubation. In the intensive care unit, preoxygenation is often accomplished using a nose-mouth mask.
- Trial name
- NCT01994928
- Testing
- Nose-mouth mask, High flow nasal cannula oxygen, Intubation
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Respiratory Failure
Closed-loop FiO2 Controller During High Flow Oxygen Treatment In Pediatric Patients (COFICOHFOT)
Recently, high flow oxygen therapy (HFOT) is becoming more popular in the treatment of any kind of respiratory failure. Pediatric mechanical ventilation consensus conference (PEMVECC) guidelines suggest measuring oxygen…
- Trial name
- COFICOHFOT (NCT05032365)
- Testing
- Close-loop FiO2 controller, Conventional
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 23 people
- Sponsor
- Dr. Behcet Uz Children's Hospital
Airway Extubation, Pneumonia, Bacterial
Relation Between the Volume of Subglottic Secretion and Risk of Extubation Failure in ICU Patients (SEGEX)
This study evaluates the relation between the volume of subglottic secretion before airway extubation and the risk of extubation failure in the ICU patient.
- Conditions
- Airway Extubation, Pneumonia, Bacterial, Aspiration of Subglottic Secretions
- Trial name
- SEGEX (NCT03946371)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Premature Birth, Respiration Failure
Predictors of Prolonged Mechanical Ventilation in Preterm Infants
This prospective cohort study aims to identify the independent predictors of prolonged mechanical ventilation in preterm infants admitted to the Neonatal Intensive Care Unit of Assiut University Children Hospital.
- Conditions
- Premature Birth, Respiration Failure, Bronchopulmonary Dysplasia
- Trial name
- NCT07821632
- Volunteers
- 100 people
- Sponsor
- Assiut University
Respiratory Insufficiency, Ventilator Weaning
Correlation of Two Methods for Cough Peak Flow Measurement in Intubated Patients
Cough Peak Flow (CPF) seems to be an efficient tool to assess cough capacity for the intensive care unit (ICU) ventilated patient.
- Trial name
- COUGH-ICU (NCT03357198)
- Where
- France
- Volunteers
- 62 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Bronchiolitis, Respiratory Failure (Pediatric Patients)
Nurse-led High-flow Nasal Cannula Weaning Protocol in Pediatric Intensive Care Unit
Bronchiolitis is a leading cause of pediatric hospital admissions. Despite its limited clinical benefits, the use of HFNC in children with bronchiolitis is increasing.
- Conditions
- Bronchiolitis, Respiratory Failure (Pediatric Patients), High Flow Nasal Cannula
- Trial name
- NCT06621641
- Testing
- The new HFNC weaning protocol
- Where
- 6 sites in Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Dr. Behcet Uz Children's Hospital
Acute Hypoxemic Respiratory Failure, Acute Respiratory Distress Syndrome
EndotyPIng PreHospitAl de Novo Acute hYpoxemic Respiratory Failure
We attempt to perform dynamic endotyping of critically ill patients presenting in the emergency department with de novo acute hypoxemic respiratory failure (AHRF).
- Trial name
- EPIPHANY (NCT05150483)
- Where
- Greece
- Volunteers
- 350 people
- Sponsor
- Evangelismos Hospital
Covid19, Myocardial Infarction
Outcomes of Patients Who Survived Treatment on an Intensive Care Unit for COVID-19 in England and Wales
This retrospective cohort study aims to characterise outcomes for patients treated on an intensive care unit (ICU) with COVID-19 in England and Wales, one year after discharge from hospital.
- Conditions
- Covid19, Myocardial Infarction, Stroke, Critical Illness
- Trial name
- OPTIC-19 (NCT04838106)
- Testing
- Not applicable as observational study
- Where
- United Kingdom
- Volunteers
- 319,600 people
- Sponsor
- University of Oxford
High Flow Nasal Cannula, Oxygen Therapy
Closed-loop Oxygen Control for High Flow Nasal Therapy
In patients with acute hypoxemic respiratory failure (AHRF), High Flow Nasal Therapy (HFNT) improves oxygenation, tolerance, and decrease work of breathing as compared to standard oxygen therapy by facemask.
- Conditions
- High Flow Nasal Cannula, Oxygen Therapy, Hypoxemia, Hyperoxemia
- Trial name
- HILOOP (NCT04965844)
- Testing
- Oxygen close-loop, No intervention
- Where
- Spain
- Volunteers
- 53 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Acute Respiratory Failure, Intratracheal Intubation
Comparison of Pre-oxygenation of NIV and HFNC Therapy for Intubation of ICU Patients With Acute Respiratory Failure
The aim of the study is to evaluate the incidence of severe hypoxemia episodes during the intubation procedure with two methods of pre-oxygenation: 1. NIV (Non Invasive Ventilation) 2. HFNC (High-flow nasal canula oxygen therapy)
- Trial name
- FLORALI2 (NCT02668458)
- Testing
- High Flow nasal canula oxygen therapy, Noninvasive ventilation
- Where
- 27 sites in France
- Volunteers
- 320 people
- Sponsor
- Poitiers University Hospital
SARS-CoV-2 Pneumonia
Predictors of Respiratory Failure in SARS-Cov-2 Infection
The emergence of SARS-CoV-2 is currently engaging and consuming most of resources of efficient healthcare systems in Europe, and several hospitals are currently experiencing a shortage of ICU beds for critically-ill patients with…
- Trial name
- NCT04316949
- Where
- Italy
- Volunteers
- 350 people
- Sponsor
- University of Bologna
Coronavirus Infection, Pneumonia, Viral
HFNC Treatment in COVID-19 Pneumonia
coronavirus disease 2019 related pneumonia is causing acute respiratory failure and this is the most common reason for ICU admission. We have several different way for respiratory support.
- Conditions
- Coronavirus Infection, Pneumonia, Viral, Acute Respiratory Failure
- Trial name
- NCT04424836
- Testing
- high flow nasal cannula device
- Where
- Turkey (Türkiye)
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Acute Respiratory Failure
Study on Ventilation Distribution With Electrical Impedance Tomography for Paediatric Respiratory Failure
Electrical impedance tomography (EIT) is a non-invasive, bedside monitoring technique that provides continuous, real-time information about the regional distribution of the ventilation.
- Trial name
- PELUCHE1 (NCT05347563)
- Testing
- Electrical impedance tomography
- Where
- 4 sites in France
- Volunteers
- 250 people
- Sponsor
- Hospices Civils de Lyon
Critical Illness, Respiratory Failure
Treatment of Muscle Weakness in Critically Ill Patients
Patients who are admitted to the intensive care unit and require mechanical ventilation frequently develop profound respiratory and limb muscle weakness.
- Conditions
- Critical Illness, Respiratory Failure, Myopathy, Weakness
- Trial name
- NCT02247895
- Testing
- Electrical stimulation
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Gerald Supinski
Critical Illness, Sepsis
The Checklist for Early Recognition and Treatment of Acute Illness (CERTAIN)
The purpose of the study is to test whether the health care provider access and training in CERTAIN (Checklist for Early Recognition and Treatment of Acute Illness), would facilitate timely and error free best-practice delivery…
- Conditions
- Critical Illness, Sepsis, Respiratory Failure, Shock
- Trial name
- NCT01973829
- Testing
- Checklist for Early Recognition and Treatment of Acute Illness (CERTAIN)
- Where
- 30 sites in Belarus, Bosnia and Herzegovina and 15 more
- Volunteers
- 5,215 people
- Sponsor
- Mayo Clinic
Respiratory Failure
Re- Admission Rate Among Survived Patients With Acute Respiratory Failure
Readmission to the intensive care unit (ICU) results in increased consumption of medical resources and costs, and has been proposed as a marker for quality of care.
- Trial name
- NCT06291636
- Where
- Egypt
- Volunteers
- 994 people
- Sponsor
- Mansoura University
Acute Respiratory Failure With Hypoxia, Hypoxemia
Conduct of Nasal High Flow Oxygen in Acute Respiratory Failure
Although many studies have investigated the clinical benefits of nasal high flow during acute hypoxemic respiratory failure, there is no data (and even less so recommendations) on how to best conduct this technique, including its…
- Trial name
- DECIPHEROBS (NCT03311087)
- Where
- 10 sites in France
- Volunteers
- 100 people
- Sponsor
- Hôpital Louis Mourier