Clinical trials: Respiratory Failure, completed
Airway Obstruction, Dyspnea
Heliox in Experimental Upper Airway Obstruction
Currently it is common medical wisdom that HELIOX (mixture of Helium in Oxygen) with a fraction of Helium below 60% is not effective in reducing airway obstruction.
- Trial name
- NCT00788788
- Testing
- HELIOX
- Where
- Germany
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Witten/Herdecke
Heart Failure, Cardiovascular Diseases
Nene Remote Monitoring Proof of Concept
This feasibility study is being conducted to investigate the practicalities and potential benefits of equipping patients with wearable monitoring devices.
- Conditions
- Heart Failure, Cardiovascular Diseases, Respiratory Disease, Stroke
- Trial name
- NCT04598659
- Where
- United Kingdom
- Volunteers
- 180 people
- Sponsor
- Doccla UK
Hypercapnia, Ventilatory Depression
Clinical Study to Investigate the Effect of the Combination of Psychotropic Drugs and an Opioid on Ventilation
Opioids can decrease breathing and co-administration of benzodiazepines with opioids can further decrease breathing. It is unknown whether certain other drugs also decrease breathing when co-administered with opioids.
- Trial name
- NCT04310579
- Testing
- Oxycodone and Midazolam, Oxycodone, Paroxetine, and Quetiapine
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Food and Drug Administration (FDA)
Acute Hypoxic - Hypercapnic Respiratory Failure (ARF)
Diaphragmatic Ultrasound in Acute Hypoxic - Hypercapnic Respiratory Failure (ARF)
Mortality of acute hypoxic - hypercapnic respiratory failure (ARF) patients underwent invasive mechanical ventilation is demonstrated to be higher than in patients who underwent only non invasive mechanical ventilation (NIV).
- Trial name
- DiaDea (NCT03314883)
- Testing
- D-US ARF
- Where
- Italy
- Volunteers
- 21 people
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
Chronic Respiratory Failure
Assist Control Versus Pressure Support Modes for Domiciliary Noninvasive Ventilation in Chronic Respiratory Failure
Noninvasive ventilation is a therapeutic option in some patients with chronic respiratory failure. Patients usually ventilate during nightime with a domiciliary ventilator either in assist control or in pressure support mode.
- Trial name
- NCT00189527
- Testing
- respiratory settings
- Volunteers
- 100 people
- Sponsor
- Association Nationale pour les Traitements A Domicile, les Innovations et la Recherche
COPD Exacerbation, Hypoxia
Oxygen Control and Weaning by O2matic to Patients Admitted With an Exacerbation of COPD
The aim of the study is to examine if automated oxygen delivery with O2matic allows for faster weaning from oxygen and better oxygen control than manually controlled oxygen therapy for patients admitted with an exacerbation of…
- Conditions
- COPD Exacerbation, Hypoxia, Hypoxemia, Hyperoxia
- Trial name
- O2MATIC-WEAN (NCT03661086)
- Testing
- O2matic
- Where
- 5 sites in Denmark
- Volunteers
- 157 people
- Sponsor
- Hvidovre University Hospital
Noninvasive Ventilation, Nutrition Therapy
Nutrition Under Noninvasive Ventilation
Even though nutrition is a fundamental component of Intensive care unit (ICU) therapy, critically ill patients are frequently malnourished, a factor well known for its strong association with a higher risk of complications…
- Conditions
- Noninvasive Ventilation, Nutrition Therapy, Respiratory Insufficiency
- Trial name
- NUTRINIV (NCT06260202)
- Where
- Italy
- Volunteers
- 112 people
- Sponsor
- Università degli Studi del Piemonte Orientale Amedeo Avogadro
Chronic Obstructive Pulmonary Disease, Chronic Respiratory Hypercapnic Failure
A Study to Investigate the Effects of Heated Humidification During Non-Invasive Ventilation
Noninvasive ventilation (NIV) is a form of ventilation delivered by a mask and is an important mode of treatment in patients with both acute and chronic respiratory (breathing) failure.
- Conditions
- Chronic Obstructive Pulmonary Disease, Chronic Respiratory Hypercapnic Failure, Neuromuscular Disease, Obesity Hypoventilation Syndrome
- Trial name
- NCT01372072
- Testing
- non-invasive ventilation heated humidification (Fisher-Paykel MR810 and MR850 humidifiers)
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
ARDS, COVID19
Evaluation of Airway Pressure Release Ventilation in COVID-19 ARDS
The 2020 pandemic of the coronavirus (SARS-CoV2) has lead to an increase in ARDS cases requiring invasive mechanical ventilation in the ICU (Intensive Care Unit).
- Trial name
- APRV-COVID19 (NCT04386369)
- Testing
- Airway pressure release ventilation
- Where
- France
- Volunteers
- 17 people
- Sponsor
- Central Hospital, Nancy, France
Critical Illness
Prevalence and Predictors of CCI in Patients With Acute Respiratory Failure (CCI)
Chronic Critical Illness (CCI) is a condition associated to patients surviving an acute phase of disease and respiratory failure (ARF) although remaining dependent on mechanical ventilation (MV).
- Trial name
- CCI (NCT03851822)
- Volunteers
- 127 people
- Sponsor
- University of Modena and Reggio Emilia
Critical Illness, Acute Respiratory Failure
Feasibility of Upright Bed Position in ARDS Patients
Lower lobe atelectasis of the lung is common in Acute Respiratory Distress Syndrome (ARDS) and has the potential to adversely impact lung compliance and intra-pulmonary shunt.
- Conditions
- Critical Illness, Acute Respiratory Failure, Adult Syndrome
- Trial name
- NCT02160561
- Testing
- Intervention Arm
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Wake Forest University Health Sciences
Infection, Heart Failure
Prediction of Patient Deterioration Using Machine Learning
This is a retrospective observational study drawing on data from the Brigham and Women's Home Hospital database. Sociodemographic and clinic data from a training cohort were used to train a machine learning algorithm to predict…
- Conditions
- Infection, Heart Failure, Chronic Obstructive Pulmonary Disease, Asthma
- Trial name
- NCT05045742
- Testing
- Traditional vital sign alarms versus the BioVitals Index vs the National Early Warning Score 2
- Where
- 2 sites in United States
- Volunteers
- 526 people
- Sponsor
- Brigham and Women's Hospital
Preterm Birth, Premature
Comparison of the Acute Effects of Chest Physiotherapy Methods Applied in Different Positions in Preterm Newborns
Infants in the neonatal intensive care unit (NICU) may be lost due to risks such as being sensitive, frequent exposure to birth complications and being prone to infection.
- Conditions
- Preterm Birth, Premature, Bronchopulmonary Dysplasia, Respiratory Distress Syndrome
- Trial name
- therapy (NCT05036603)
- Testing
- chest physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Sanko University
Tetraplegia
Diaphragmatic Reinnervation of Tetraplegic Patients With Respiratory Insufficiency
This study evaluates the diaphragmatic reinnervation by inferior laryngeal nerve in tetraplegic patients with ventilatory insufficiency.
- Trial name
- TETRADIA-UNI (NCT01350297)
- Testing
- reinnervation
- Where
- France
- Volunteers
- 5 people
- Sponsor
- University Hospital, Rouen
Non-small Cell Lung Cancer
Sintilimab Combined With Docetaxel for Standard Chemotherapy Failure Non-driver Gene Mutation Metastatic Non-small Cell Lung Cancer
The purpose of this study is to assess the safety and effectiveness of Sintilimab Combined With Docetaxel in Non-driver Gene Mutation NSCLC patients who failed with double platinum-based chemotherapy
- Trial name
- NCT04144582
- Testing
- Sintilimab Combined With Docetaxel Monotherapy
- Where
- 2 sites in China
- Volunteers
- 30 people
- Sponsor
- Yongchang Zhang
Acute Hypoxic Respiratory Failure
Noninvasive Ventilation Breathing Test Guiding Weaning in Patients With Acute Hypoxic Respiratory Failure
SBT, as a routine extubation strategy for invasive mechanical ventilation, has been widely recognized. However, in recent years, studies have found that SBT may lead to delayed extubation, which has been confirmed in COPD…
- Trial name
- NCT06574659
- Testing
- Noninvasive ventilation breathing test guiding sequential invasive Ventilation and noninvasive ventilation weaing protocol, The standard SBT guiding weaning group
- Where
- China
- Volunteers
- 160 people
- Sponsor
- West China Hospital
Nasal Congestion
To Determine if Diphenhydramine Works for Nasal Congestion at Two Different Doses
The study was to determine if the drug worked to relieve nasal congestion experienced by people with seasonal allergies.
- Trial name
- NCT00648973
- Testing
- Diphenhydramine 50 mg, Diphenhydramine 25 mg, Pseudoephedrine 120 mg
- Where
- 12 sites in United States
- Volunteers
- 1,021 people
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Sleep Apnea
Mapping for Acute Transvenous Phrenic Nerve Stimulation Study
The Mapping for Transvenous Phrenic Nerve Stimulation Study (MAPS) is being conducted to evaluate the feasibility of transvascular stimulation of phrenic nerves via an electrophysiology (EP) catheter advanced into the great veins.
- Trial name
- MAPs (NCT01981590)
- Testing
- Stimulating the phrenic nerve intravenously using high frequency electrical pulses using an EP catheter connected to external pulse stimulator.
- Where
- 2 sites in Netherlands, Sweden
- Volunteers
- 15 people
- Sponsor
- Medtronic BRC
Acute Respiratory Failure With Hypoxia, Acute Respiratory Distress Syndrome
The Acute Respiratory Intervention StudiEs in Africa (ARISE-AFRICA) Study
The dearth of Intensive care units in low resource settings portends for poor outcomes amongst patients with acute hypoxemic respiratory failure (AHRF) .
- Conditions
- Acute Respiratory Failure With Hypoxia, Acute Respiratory Distress Syndrome, Acute Lung Injury
- Trial name
- ARISE-AFRICA (NCT04693403)
- Testing
- HFNC, CPAP, Standard Oxygen
- Where
- 17 sites in Uganda
- Volunteers
- 705 people
- Sponsor
- Makerere University
Atelectasis, Pulmonary Infection
Bi-PAP vs Sham Bi-PAP on Pulmonary Function in Morbidly Obese Patients After Bariatric Surgery
The effect of biphasic positive airway pressure (Bi-PAP) at individualized pressures on the postoperative pulmonary recovery of morbidly obese patients (MOP) undergoing open bariatric surgery (OBS) and possible placebo…
- Conditions
- Atelectasis, Pulmonary Infection, Chronic Obstructive Pulmonary Disease (COPD), Pulmonary Disease
- Trial name
- NCT03438383
- Testing
- Bi-PAP
- Volunteers
- 48 people
- Sponsor
- Evangelismos Hospital