Clinical trials: Respiratory Failure With Hypoxia, active
Hypoxic Respiratory Failure
Effect of FAST HUGS WITH ICU Approach on Length of Intensive Care Unit Stay in Patients With Hypoxic Respiratory Failure
This study will investigate the effect of the FAST HUGS WITH ICU approach on the length of stay in the intensive care unit in patients with hypoxic respiratory failure.
- Trial name
- NCT06901050
- Testing
- FAST HUGS WITH ICU approach
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Muş Alparslan University
Acute Respiratory Failure With Hypoxia
PEEP in Patients With Acute Respiratory Failure
Positive end-expiratory pressure (PEEP) has become an essential component of the care of critically ill patients who require ventilatory support.
- Trial name
- NCT04912960
- Testing
- Mechanical ventilation
- Where
- 3 sites in Spain
- Volunteers
- 15 people
- Sponsor
- Jesus Villar
Pulmonary Hypertension, Hypoxic Respiratory Failure
Inhaled Nitric Oxide for the Treatment of Neonatal Hypoxic Respiratory Failure With Pulmonary Hypertension
This is a prospective, open-label, single-arm, multicenter Phase IV clinical study to evaluate the safety of INOmax for the treatment of hypoxic respiratory failure with pulmonary hypertension in newborns (≥ 34 weeks gestational…
- Trial name
- INOFTTONHRFWPH (NCT07099144)
- Testing
- Inhaled nitric oxide (NO)
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Lee's Pharmaceutical Limited
Acute Respiratory Failure
Correlation Between Trans Esophageal Pressure and Non-invasive Respiratory Support Failure in Patients With Acute Hypoxic Respiratory Failure
This study aims at assessing the correlation between trans esophageal pressure and related respiratory mechanics (including, among others, nasal pressure-Pnose) and non-invasive respiratory support failure in patients with acute…
- Trial name
- TEMPO (NCT03826797)
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- University of Modena and Reggio Emilia
Hypoxia, Airway Obstruction, Postoperative
Endotracheal Tube Suctioning Versus No Suctioning During Emergence From General Anesthesia
The goal of this study is to determine whether omitting tracheal suctioning immediately prior to extubation is non-inferior to routine tracheal suctioning with respect to early postoperative oxygenation among adult surgical…
- Conditions
- Hypoxia, Airway Obstruction, Postoperative, Sore Throat, Cough, Postoperative
- Trial name
- NCT07287293
- Testing
- Routine Endotracheal Suctioning, Omission of Endotracheal Suctioning
- Where
- Thailand
- Volunteers
- 408 people
- Sponsor
- Mahidol University
Choledocholithiasis With Cholecystitis With Obstruction, Obstructive Jaundice
Feasibility and Safety of Supraglottic Oxygen Delivery Via an Endotracheal Tube for Non-intubated ERCP Anesthesia: A Two-Stage Phase II Clinical Study
Endoscopic retrograde cholangiopancreatography (ERCP) is a technique for evaluating the bile duct, pancreatic duct, and ampulla.
- Conditions
- Choledocholithiasis With Cholecystitis With Obstruction, Obstructive Jaundice, Pancreatitis, Cholelithiasis
- Trial name
- NCT07051980
- Testing
- Supraglottic Oxygen Delivery via an Endotracheal Tube
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Zhejiang University
Covid19, Hypoxic Respiratory Failure
SedAting With Volatile Anesthetics Critically Ill COVID-19 Patients in ICU: Effects On Ventilatory Parameters And Survival
Patients suffering lung failure, possibly from COVID-19 or hypoxic lung failure, will need life-saving support from a breathing machine.
- Trial name
- SAVE-ICU (NCT04415060)
- Testing
- Isoflurane Inhalant Product, Sevoflurane inhalant product
- Where
- 13 sites in Canada
- Volunteers
- 800 people
- Sponsor
- Sunnybrook Health Sciences Centre
Chronic Respiratory Failure, Hypoxemia
Effects of Oxygen Supplementation During the 6-Minute Walk Test in Chronic Respiratory Failure or Exertional Hypoxemia
The aim of this multicenter crossover trial is to describe the effect of adding a therapeutic dose of exertional oxygen therapy, in terms of exercise performance, gas exchange, heart rate, symptoms perception and subjective…
- Conditions
- Chronic Respiratory Failure, Hypoxemia, Chronic Obstructive Pulmonary Disease (COPD), Interstitial Lung Disease
- Trial name
- NCT07451977
- Testing
- Usual Oxygen During 6-Minute Walk Test, Supplemental Oxygen During 6-Minute Walk Test
- Where
- 6 sites in Italy
- Volunteers
- 114 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Extubation Readiness, Respiratory Failure With Hypoxia
Identifying the Best Flow Setting Strategy for High-Flow Nasal Cannula
The goal of this randomized trial is to compare four different flow-setting approaches for post-extubation use of high-flow nasal cannula (HFNC).
- Trial name
- NCT07007715
- Testing
- Flow of 40L/min, Peak tidal inspiratory flow (PTIF) guided, PaO2/FiO2 ratio guided
- Where
- Taiwan
- Volunteers
- 480 people
- Sponsor
- National Taiwan University Hospital
Acute Hypoxemic Respiratory Failure
Awake Prone Positioning in Spontaneous Breathing Patients With Acute Hypoxic Respiratory Failure Due to Pneumonia
Prone positioning has shown beneficial effects in intubated patients with severe respiratory failure and positive effects in awake patients with COVID-19 pneumonia.
- Trial name
- PROSA (NCT06931938)
- Testing
- Awake Prone Positioning
- Where
- Germany
- Volunteers
- 342 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Choledocholithiasis With Cholecystitis With Obstruction, Obstructive Jaundice
COMBO Endoscopy Oropharyngeal Airway in Sedated Endoscopic Retrograde Cholangiopancreatography for Patients
Hypoxia represents the prevailing adverse occurrence during the sedation of patients undergoing Endoscopic Retrograde Cholangiopancreatography (ERCP) with propofol.
- Conditions
- Choledocholithiasis With Cholecystitis With Obstruction, Obstructive Jaundice, Pancreatitis, Cholelithiasis
- Trial name
- NCT07012772
- Testing
- The COMBO Endoscopy Oropharyngeal Airway
- Where
- 2 sites in China
- Volunteers
- 50 people
- Sponsor
- Zhejiang University
Respiratory Failure, Hypoxemia
Comparison of Pulse Oximetry (SpO2) With Different Oximeters and Arterial Saturation (SaO2): Oxygap2 Study
The oximeter is used to monitor intensive care patients undergoing oxygen therapy. It indicates pulsed oxygen saturation (SpO2), a reflection of arterial oxygen saturation (SaO2) which enables detection of hypoxemia and…
- Conditions
- Respiratory Failure, Hypoxemia, Hyperoxemia
- Trial name
- Oxygap 2 (NCT06102499)
- Testing
- SpO2 and SaO2 comparison
- Where
- 5 sites in Canada, Guadeloupe and 1 more
- Volunteers
- 250 people
- Sponsor
- Laval University
Respiratory Failure With Hypoxia
Physiological Study of High PEEP in Noninvasive Ventilation
To investigate the physiological effects of high positive end-expiratory pressure (PEEP) during noninvasive ventilation in patients with hypoxemic respiratory failure, and to elucidate the mechanisms underlying high PEEP-induced…
- Trial name
- NCT07503509
- Testing
- high PEEP
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Chongqing Medical University
Pulmonary Embolism (Diagnosis), Respiratory Failure With Hypoxia
Screening for Pulmonary Embolism Using Single-channel Electrocardiogram
It is a prospective, controlled, single-center, observational, non-randomized study. The study is planned to include at least 500 patients 18 years old and older (300 patients in the training sample and 200 patients in the test…
- Conditions
- Pulmonary Embolism (Diagnosis), Respiratory Failure With Hypoxia, Chronic Obstructive Pulmonary Disease (COPD)
- Trial name
- NCT07412418
- Where
- Russia
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Respiratory Failure with Hypoxia
Comparison Between Four Weaning Methods from High-velocity Nasal Insufflation Device in Acute Hypoxemic Respiratory Failure
High-flow nasal oxygen therapy (HFNO) is an innovative high-flow system that allows for delivering up to 60 liters/ min of heated and fully humidified gas with a fraction of inspired oxygen (FIO2) ranging between 21% and 100% .
- Trial name
- HVNI (NCT06746636)
- Testing
- High velocity nasal insufflation
- Volunteers
- 120 people
- Sponsor
- Assiut University
Respiratory Failure With Hypoxia, Respiratory Failure, ICU
Weaning From High Flow Nasal Oxygen in Acute Respiratory Failure : a Target Trial Emulation
Acute respiratory failure is a frequent reason for admission to the intensive care unit (ICU). It is associated with high healthcare consumption and mortality.
- Conditions
- Respiratory Failure With Hypoxia, Respiratory Failure, ICU, High-Flow Nasal Oxygen Therapy
- Trial name
- HFNO-Weaning (NCT07030413)
- Where
- 3 sites in France
- Volunteers
- 2,000 people
- Sponsor
- Poitiers University Hospital
Pleural Effusions, Respiratory Failure
Drainage Of Pleural Effusions in the Intensive Care Unit (DOPE-ICU) - Feasibility Trial
This trial evaluates the feasibility of ultrasound-guided pleural drainage versus no drainage in adult ICU patients with pleural effusions (fluid buildup around the lungs) and respiratory failure.
- Trial name
- NCT06709456
- Testing
- Ultrasonography-guided pleural drainage
- Where
- 6 sites in Denmark
- Volunteers
- 88 people
- Sponsor
- Olav Schjørring
Acute Respiratory Distress Syndrome (ARDS), Acute Respiratory Failure with Hypoxia
Physiologic Effects of Continuous Positive Airway Pressure and High Flow Nasal Oxygenation in Patients with Acute Respiratory Distress Syndrome.
The acute respiratory distress syndrome (ARDS) consists on a lack of breath due to fluid overload in the lungs that is not produced by a heart desease.
- Trial name
- NCT06694311
- Testing
- CPAP, HFNO 50 L/min
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Ricard Mellado Artigas
IVH- Intraventricular Hemorrhage, Extreme Prematurity
Delayed Cord Clamping With Oxygen In Extremely Low Gestation Infants
This study is being conducted to compare the incidence of preterm infants (up to 28+6 weeks GA) who achieve a peripheral oxygen saturation of 80 percent by 5 minutes of life (MOL) given mask CPAP/PPV with an FiO2 of 1.0 during…
- Conditions
- IVH- Intraventricular Hemorrhage, Extreme Prematurity, Hypoxia Neonatal, Hyperoxia
- Trial name
- DOXIE (NCT04413097)
- Testing
- Delayed Cord Clamping with Low Oxygen concentration, Delayed Cord Clamping with High Oxygen concentration
- Where
- 3 sites in United States
- Volunteers
- 140 people
- Sponsor
- Sharp HealthCare
Critical Illness, Respiratory Failure
High-flow Nasal Oxygenation for Apnoeic Oxygenation During Intubation of the Critically Ill
Intubation in the intensive care unit is a standard procedure with a high risk of adverse events such as hypoxaemia and cardiovascular instability.
- Conditions
- Critical Illness, Respiratory Failure, Multi Organ Failure, Hypoxia
- Trial name
- HiPOXIC (NCT05883137)
- Testing
- Optiflow Switch
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Region Stockholm