Clinical trials: Respiratory Failure with Hypoxia
Covid19, Hypoxemia
A Study of Micro Dose Ambrisentan in Hospitalized Patients With Respiratory Insufficiency Due to COVID-19
Patients with COVID-19 frequently develop lower respiratory complications. Difficulty breathing and a low concentration of oxygen in the blood are of concern in patients with COVID-19, as they indicate that the lungs may be…
- Trial name
- NCT04771000
- Testing
- Ambrisentan
- Where
- 13 sites in Croatia, Spain
- Volunteers
- 88 people
- Sponsor
- Noorik Biopharmaceuticals AG
Infant, Newborn, Hypertension, Pulmonary
Early Inhaled Nitric Oxide for Respiratory Failure in Newborns
This prospective, randomized controlled trial tested whether initiating iNO therapy earlier would reduce death and reduce the use of extracorporeal membrane oxygenation (ECMO) -- temporary lung bypass -- therapy compared with the…
- Conditions
- Infant, Newborn, Hypertension, Pulmonary, Persistent Fetal Circulation Syndrome, Pneumonia, Aspiration
- Trial name
- Early iNO (NCT00005773)
- Testing
- Inhaled Nitric Oxide, Standard iNO therapy
- Where
- 18 sites in United States
- Volunteers
- 302 people
- Sponsor
- NICHD Neonatal Research Network
SARS-CoV-2 Infections, Respiratory Failure With Hypoxia
Automated Quantification of Radiologic Pulmonary Alteration During Acute Respiratory Failure: Application to the COVID-19 Pandemic
Automated quantification of the pulmonary volume impaired during acute respiratory failure could be helpful to assess patient severity during COVID-19 infection or perioperative medicine, for example.
- Trial name
- QUANTICO-PRO (NCT05278390)
- Testing
- Thoracic CT scan
- Where
- 2 sites in France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Strasbourg, France
COVID-19
Sargramostim in Patients With Acute Hypoxic Respiratory Failure Due to COVID-19 (SARPAC)
Phase IV study to evaluate the effectiveness of additional inhaled sargramostim (GM-CSF) versus standard of care on blood oxygenation in patients with COVID-19 coronavirus infection and acute hypoxic respiratory failure.
- Trial name
- SARPAC (NCT04326920)
- Testing
- Sargramostim, Control
- Where
- 4 sites in Belgium
- Volunteers
- 87 people
- Sponsor
- University Hospital, Ghent
Pneumonia, Community-Acquired Infections
Helmet Continuous Positive Airway Pressure Versus Oxygen Venturi in Acute Respiratory Failure in CAP: CAPOVeRSO
The purpose of this study is to compare the efficacy of CPAP application by a helmet and O2 administration by a Venturi mask in terms of gas exchanges improvement in patients with acute respiratory failure due to…
- Conditions
- Pneumonia, Community-Acquired Infections, Respiratory Insufficiency, Acute Lung Injury
- Trial name
- CAPOVeRSO (NCT00603564)
- Testing
- Castar Starmed (CPAP) delivered by a helmet
- Where
- Italy
- Volunteers
- 47 people
- Sponsor
- University of Milan
SARS-CoV-2 Infection, Respiratory Failure With Hypoxia
Automated Quantification of Radiologic Pulmonary Alteration During Acute Respiratory Failure
Automated quantification of the pulmonary volume impaired during acute respiratory failure could be helpful to assess patient severity during COVID-19 infection or perioperative medicine, for example.
- Trial name
- QUANTICO-RETRO (NCT04534400)
- Testing
- thoracic CT-scan
- Where
- 2 sites in France
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Strasbourg, France
Acute Respiratory Failure With Hypoxia
High-flow Oxygen Therapy vs Non-invasive Ventilation: Comparison of Alveolar Recruitment in Acute Respiratory Failure
This physiological study showed an increase in regional ventilation with NIV but no difference in alveolar recruitment as compared to HFNC in patients with hypoxemic ARF.
- Trial name
- IRAvista (NCT04664322)
- Testing
- non invasive ventilation and high flow nasal canulae oxygen therapy
- Where
- France
- Volunteers
- 16 people
- Sponsor
- University Hospital, Rouen
Acute Respiratory Distress Syndrome (ARDS), Acute Respiratory Failure with Hypoxia
Physiologic Effects of Continuous Positive Airway Pressure and High Flow Nasal Oxygenation in Patients with Acute Respiratory Distress Syndrome.
The acute respiratory distress syndrome (ARDS) consists on a lack of breath due to fluid overload in the lungs that is not produced by a heart desease.
- Trial name
- NCT06694311
- Testing
- CPAP, HFNO 50 L/min
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Ricard Mellado Artigas
Respiratory Failure With Hypoxia
Clinical Comparison of Flow Regulated Nasal Oxygen Delivery System (FRNDS) Cannula and Plethysmography Belts
SUMMARY: This is a quantitative, non-inferiority study using healthy participants to compare tidal volumes at rest measured by both a standard RIP belt and a flow-regulated nasal oxygen delivery system FRNDS cannula.
- Trial name
- FRNDS (NCT06713213)
- Testing
- Flow-regulated nasal oxygen delivery system (FRNDS)
- Where
- 2 sites in United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Mechanical Ventilation Complication, Respiratory Failure
Effect of PEEP on Lung Regional Ventilation and Perfusion
Investigate effects of PEEP on pulmonary regional ventilation and perfusion assessed by EIT
- Conditions
- Mechanical Ventilation Complication, Respiratory Failure, Hypoxia
- Trial name
- PEEP (NCT04081155)
- Where
- China
- Volunteers
- 33 people
- Sponsor
- Yun Long
Acute Respiratory Tract Infection, Acute Respiratory Insufficiency
An Open Randomized Study of Dalargin Efectiveness in Combination With Leitragin Drug in Patients With Severe and Critical Manifestations of SARS-COVID-19
The purpose of the study is to evaluate an effectiveness of the drug Dalargin in combination with Leitragin for the prevention and treatment of severe pulmonary complications symptoms associated with severe and critical…
- Conditions
- Acute Respiratory Tract Infection, Acute Respiratory Insufficiency, Pneumonia, Septic Shock
- Trial name
- NCT04346693
- Testing
- Standard therapy recommended by the Ministry of Health of the Russian Federation., Standard therapy recommended by the Ministry of Health of the Russian Federation and Leitragin intramuscular injection, Standard therapy recommended by the Ministry of Health of the Russian Federation and Leitragin inhalation
- Where
- Russia
- Volunteers
- 320 people
- Sponsor
- Burnasyan Federal Medical Biophysical Center
PPHN, Hypoxic Respiratory Failure
Predictors of Inhaled Nitric Oxide Responsiveness in Patients With PPHN
To identify biochemical, clinical, or genetic biomarkers that may predict responsiveness to iNO in neonates with PPHN/HRF. The primary outcome will be identification of any biomarker(s) associated with response to iNO therapy.
- Trial name
- PINOR (NCT06043635)
- Sponsor
- Nationwide Children's Hospital
Altitude Intolerance, High-Altitude Illness
Relationship Between Succinate Dehydrogenase Mutations and High-Altitude Illness
This study is is the first step of a full study named CHEMOGENE because it explores the genetic determinant of an alteration of the chemoreflex.
- Trial name
- NCT00202683
- Where
- France
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Société Française de Cardiologie
Respiratory Failure, Hypoxemia
OxyGap : Comparison Between Different Pulse Oximeter and With the Arterial Blood Gase
The oximeter is used to monitor intensive care patients undergoing oxygen therapy. It indicates pulsed oxygen saturation (SpO2), a reflection of arterial oxygen saturation (SaO2) which enables detection of hypoxemia and…
- Conditions
- Respiratory Failure, Hypoxemia, Hyperoxemia
- Trial name
- OxyGap (NCT04772183)
- Testing
- SpO2 and SaO2 comparison
- Where
- 2 sites in Canada
- Volunteers
- 300 people
- Sponsor
- Laval University
Respiratory Failure With Hypoxia
Assessment of Tidal Volume During Non Invasive Oxygenation Techniques
High Tidal volume is one of the main mechanisms that lead to lung injuries under mechanical ventilation (ventilator induced lung injury: VILI).
- Trial name
- VOLHYPOX (NCT03445455)
- Testing
- Tidal volume measurement
- Volunteers
- 25 people
- Sponsor
- Henri Mondor University Hospital
COVID-19
Zilucoplan® in Improving Oxygenation, Short-, Longterm Outcome of COVID19 Patients With Acute Hypoxic Respiratory Failure
The study is a randomized controlled, open-label trial comparing subcutaneous Zilucoplan® with standard of care to standard of care alone.
- Trial name
- ZILU-COV (NCT04382755)
- Testing
- Zilucoplan®
- Where
- 9 sites in Belgium
- Volunteers
- 81 people
- Sponsor
- University Hospital, Ghent
Apgar; 0-3 at 1 Minute, Metabolic Acidosis
Autologous Stem Cells in Newborns With Oxygen Deprivation
The purpose of this study is to determine whether the plasticity of autologous intravenous application of cord blood stem cells would improve the clinical course of asphyxiated newborns.
- Conditions
- Apgar; 0-3 at 1 Minute, Metabolic Acidosis, Hypoxia, Brain, Multiple Organ Failure
- Trial name
- NCT01506258
- Testing
- Application of Stem Cells, Observation
- Where
- Mexico
- Volunteers
- 20 people
- Sponsor
- Hospital Universitario Dr. Jose E. Gonzalez
Acute Respiratory Failure With Hypoxia, Malnutrition
Supplemental Parenteral Nutrition in Pediatric Respiratory Failure
Optimal delivery of nutritional support during critical illness is central to appropriate intensive care unit management, and yet fundamental gaps in knowledge exist regarding timing, route, dose, and type of nutritional support…
- Trial name
- SuPPeR (NCT01937884)
- Testing
- Parenteral Nutrition
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Arizona
Acute Heart Failure, Pulmonary Congestion
Oxygen Targets in Acute Heart Failure With Pulmonary Congestion
REDOX-AHF compared two oxygen saturation targets in adults admitted with acute heart failure and clinical or radiological signs of congestion.
- Conditions
- Acute Heart Failure, Pulmonary Congestion, Hypoxemia
- Trial name
- REDOX-AHF (NCT05613218)
- Testing
- Oxygen
- Where
- 2 sites in Denmark
- Volunteers
- 135 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
COVID, Hypoxic Respiratory Failure
Incline Positioning in COVID-19 Patients for Improvement in Oxygen Saturation
COVID-19 is a respiratory illness caused by SARS-CoV-2 with a range of symptoms from mild, self-limiting respiratory tract infections to severe progressive pneumonia, multiorgan dysfunction and death.
- Trial name
- UPSAT (NCT04344561)
- Testing
- Postural Positioning
- Where
- 2 sites in United States
- Volunteers
- 7 people
- Sponsor
- Johns Hopkins University