Clinical trials: Respiratory Failure with Hypoxia
Acute Hypoxic Respiratory Failure
Analysis of Advanced Physiological Ventilatory Parameters During Spontaneous Breathing Effort in Patients with Acute Hypoxemic Respiratory Failure
The aim of this prospective physiological cohort study conducted in a medical intensive care unit (ICU) at Hospital del Mar in Barcelona, Spain, was to analyze the proportion of time spent within the "safe" range of respiratory…
- Trial name
- NCT06490523
- Where
- Spain
- Volunteers
- 31 people
- Sponsor
- Hospital del Mar Research Institute (IMIM)
Respiratory Failure With Hypoxia
Non Invasive and Invasive Ventilation Post Extubation
Patients and methods: It is a prospective double blind study done on total 300 patients. Admitted with respiratory failure ARDS due to severe lung contusion. All of them selected to be ventilated for one week or more.
- Trial name
- NCT04402320
- Testing
- Midazolam, ventilator
- Where
- Saudi Arabia
- Volunteers
- 300 people
- Sponsor
- King Abdul Aziz Specialist Hospital
Acute Respiratory Failure With Hypoxia
Positive Pressure During Bronchoscopy
It has been demonstrated the application of noninvasive positive pressure ventilation (NPPV) to assist spontaneous breathing through a face mask during fiberoptic bronchoscopy (FOB) with bronchoalveolar lavage (BAL) in severely…
- Trial name
- NCT02167542
- Testing
- Noninvasive Positive Pressure Ventilation, CPAP valve (Boussignac)
- Where
- Portugal
- Volunteers
- 24 people
- Sponsor
- Hospital Sao Joao
Respiratory Failure With Hypoxia, Respiratory Failure, ICU
Weaning From High Flow Nasal Oxygen in Acute Respiratory Failure : a Target Trial Emulation
Acute respiratory failure is a frequent reason for admission to the intensive care unit (ICU). It is associated with high healthcare consumption and mortality.
- Conditions
- Respiratory Failure With Hypoxia, Respiratory Failure, ICU, High-Flow Nasal Oxygen Therapy
- Trial name
- HFNO-Weaning (NCT07030413)
- Where
- 3 sites in France
- Volunteers
- 2,000 people
- Sponsor
- Poitiers University Hospital
COVID -19, Respiratory Failure
Use of Oxygen Hoods in Patients Failing on Conventional High-flow Oxygen Delivery Systems, Effects on Oxygenation in Hypoxic COVID-19 Patients. Prospective Cohort Study.
To determine whether the use of oxygen hoods as compared to conventional high-flow oxygen delivery systems, and the effects on oxygenation, mechanical ventilation and mortality rates in hypoxic patients with COVID-19.
- Conditions
- COVID -19, Respiratory Failure, Hypoxia
- Trial name
- NCT04407260
- Testing
- Oxygen Hood
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- Northwell Health
Oxygen Deficiency, Coronavirus Infection
Awake Proning in COVID-19 Patients With Hypoxemic Respiratory Failure
The purpose of this study is to retrospectively review clinical data to determine whether awake proning improves oxygenation in spontaneously breathing patients with COVID-19 severe hypoxemic respiratory failure.
- Trial name
- NCT04408222
- Testing
- Awake proning
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Columbia University
COVID-19 Pneumonia, Non-invasive Ventilation
The Difference Between Non-invasive High-frequency Oscillatory Ventilation and Non-invasive Continuous Airway Pressure Ventilation in COVID-19 With Acute Hypoxemia
High frequency oscillatory ventilation (HFOV), as an ideal lung protection ventilation method, has been gradually applied to neonatal intensive care treatment, and is currently recommended as a rescue method for neonatal acute…
- Trial name
- NCT05706467
- Testing
- Non-invasive high-frequency oscillatory ventilation, Non-invasive continuous positive airway pressure ventilation
- Volunteers
- 20 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Hypoxic Respiratory Failure, Ventilators, Mechanical
Two Modes of Mechanical Ventilation for Intensive Care Patients With Low Blood Oxygen Due to Breathing Difficulties
The study examines individuals admitted to the intensive care unit due to breathing difficulties resulting in not getting enough oxygen into their bodies.
- Trial name
- NCT06140056
- Testing
- Airway pressure release ventilation, Volumen controlled mechanical ventilation
- Where
- 2 sites in Denmark
- Volunteers
- 45 people
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Respiratory Failure, Respiratory Failure With Hypoxia
Preventing Hypoxemia With Manual Ventilation During Endotracheal Intubation (PreVent) Trial
Complications are common during endotracheal intubation of critically ill adults. Manual ventilation between induction and intubation ("bag-valve-mask" ventilation) has been proposed as a means of preventing hypoxemia, the most…
- Conditions
- Respiratory Failure, Respiratory Failure With Hypoxia, Endotracheal Intubation
- Trial name
- PreVent (NCT03026322)
- Testing
- Manual Ventilation, No Manual Ventilation
- Where
- 5 sites in United States
- Volunteers
- 401 people
- Sponsor
- Vanderbilt University Medical Center
Acute Respiratory Failure With Hypoxia, Oxygen Inhalation Therapy
Prehospital High-Flow Nasal Oxygen Therapy
The purpose of the present project is to compare High-Flow Nasal Oxygen therapy with Standard Oxygen therapy, initiated in the prehospital setting in patients with acute hypoxemia respiratory failure, in terms of oxygenation at…
- Conditions
- Acute Respiratory Failure With Hypoxia, Oxygen Inhalation Therapy, Prehospital Setting
- Trial name
- PRHOXY-1 (NCT03326830)
- Testing
- High-flow nasal oxygen, Standard oxygen therapy
- Where
- 2 sites in France
- Volunteers
- 58 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Acute Respiratory Failure With Hypoxia
ARDS Caused by COVID-19
Patients with the acute respiratory distress syndrome (ARDS) have markedly varied clinical presentations. Main characteristics of mechanically ventilated ARDS caused by COVID-19, and adherence to lung-protective ventilation…
- Trial name
- NCT04368975
- Where
- Spain
- Volunteers
- 500 people
- Sponsor
- Hospital Clinic of Barcelona
Hypoxemic Respiratory Failure, Hypercapnic Respiratory Failure
Evaluation of Conventional Non-invasive Mechanical Ventilation (NIV) Versus an Automatic Ventilation Mode.
To evaluate the polysomnographic performance of an automatic ventilatory mode compared with the gold standard (manual polysomnographic titration) to adjust chronic non-invasive ventilation by means of a randomized cross-over…
- Trial name
- NCT03872167
- Testing
- BIPAP, Intelligent automatic mode defined by assured volume with pressure support, BIPAP, manual tritration.
- Where
- Spain
- Volunteers
- 26 people
- Sponsor
- Hospital Clinic of Barcelona
Respiratory Failure With Hypoxia
Role of High Flow Nasal Oxygen as a Strategy for Weaning From Invasive Mechan
evaluate the Efficacy of high flow nasal oxygen as a weaning strategy in mechanically ventilated patients with respiratory failure.
- Trial name
- NCT04657796
- Testing
- High Flow Nasal Cannula
- Volunteers
- 84 people
- Sponsor
- Assiut University
Leukemia
Ultrafiltration (Aquapheresis) in Patients With Leukemia and Severe Fluid Overload
The goal of this clinical research study is to learn about the safety and level of effectiveness of aquapheresis compared to diuretic drugs. Diuretic drugs are designed to help the kidneys to form more urine.
- Trial name
- NCT01508260
- Testing
- Aquapheresis, Furosemide
- Sponsor
- M.D. Anderson Cancer Center
COVID-19
Sargramostim in Patients With Acute Hypoxic Respiratory Failure Due to COVID-19 (SARPAC)
Phase IV study to evaluate the effectiveness of additional inhaled sargramostim (GM-CSF) versus standard of care on blood oxygenation in patients with COVID-19 coronavirus infection and acute hypoxic respiratory failure.
- Trial name
- SARPAC (NCT04326920)
- Testing
- Sargramostim, Control
- Where
- 4 sites in Belgium
- Volunteers
- 87 people
- Sponsor
- University Hospital, Ghent
Respiratory Failure with Hypoxia
Comparison Between Four Weaning Methods from High-velocity Nasal Insufflation Device in Acute Hypoxemic Respiratory Failure
High-flow nasal oxygen therapy (HFNO) is an innovative high-flow system that allows for delivering up to 60 liters/ min of heated and fully humidified gas with a fraction of inspired oxygen (FIO2) ranging between 21% and 100% .
- Trial name
- HVNI (NCT06746636)
- Testing
- High velocity nasal insufflation
- Volunteers
- 120 people
- Sponsor
- Assiut University
Hypoventilation, Hypoxia
Using Capnography to Reduce Hypoxia During Pediatric Sedation
The investigators hypothesize that the addition of capnography during moderate sedation will improve recognition of hypoventilation and apnea.
- Trial name
- NCT01463527
- Testing
- Nellcor NPB-70 Capnograph
- Where
- United States
- Volunteers
- 167 people
- Sponsor
- Yale University
Corona Virus Infection, Hypoxic Respiratory Failure
Timed Awake Prone and Repositioning for Patients With Covid-19-induced Hypoxic Respiratory Failure.
Awake prone positioning has been reported to improve oxygenation for patients with COVID-19. Awake timed and repositioning is a novel method to improve patients' compliance and prolong the prone time.
- Trial name
- NCT05689216
- Testing
- Awake timed prone and repositioning
- Where
- 3 sites in China
- Volunteers
- 286 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Early Acute Respiratory Failure
Early Non-invasive Ventilation Outside the Intensive Care Unit
A large multicentre, randomized, controlled trial to demonstrate that non invasive ventilation given at an early stage of acute respiratory failure (ARF) outside the intensive care unit (ICU) can prevent the deterioration of ARF…
- Trial name
- NAVIGATE (NCT01572337)
- Testing
- Non-invasive ventilation, Standard care
- Where
- 14 sites in Greece, Italy and 1 more
- Volunteers
- 520 people
- Sponsor
- Università Vita-Salute San Raffaele
Covid19, Hypoxic Respiratory Failure
SedAting With Volatile Anesthetics Critically Ill COVID-19 Patients in ICU: Effects On Ventilatory Parameters And Survival
Patients suffering lung failure, possibly from COVID-19 or hypoxic lung failure, will need life-saving support from a breathing machine.
- Trial name
- SAVE-ICU (NCT04415060)
- Testing
- Isoflurane Inhalant Product, Sevoflurane inhalant product
- Where
- 13 sites in Canada
- Volunteers
- 800 people
- Sponsor
- Sunnybrook Health Sciences Centre