Clinical trials: Respiratory Function Impaired
Respiratory Failure, Diaphragm Injury
Diaphragm Ultrasound as a Powerful Tool in Managing Acute Hypoxemic Respiratory Failure in Hematological Patients
Acute hypoxemic respiratory failure due to parenchymal disfunction is one of the main complications of immunocompromised hematological patients.
- Conditions
- Respiratory Failure, Diaphragm Injury, Ultrasound, Mechanical Ventilation Complication
- Trial name
- NCT04026217
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Azienda Sanitaria-Universitaria Integrata di Udine
Airway Obstruction, Obstructive Sleep Apnea
Relationship Between STOP BANG Score and Airway Management
Nowadays, anesthetists may encounter many patients who are not diagnosed with obstructive sleep apnea syndrome (OSAS) to undergo elective surgery.
- Conditions
- Airway Obstruction, Obstructive Sleep Apnea, Hypoxia
- Trial name
- NCT05640856
- Testing
- intubation
- Where
- Turkey (Türkiye)
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Zonguldak Bulent Ecevit University
Respiratory Failure, Infant
Inhaled Nitric Oxide by Oxygen Hood in Neonates
Inhaled nitric oxide (iNO) improves oxygenation in term infants with respiratory failure. However, iNO has been primarily used in infants receiving mechanical ventilation.
- Conditions
- Respiratory Failure, Infant, Persistent Fetal Circulation
- Trial name
- NCT00732537
- Testing
- inhaled Nitric Oxide, Oxygen (>90% by hood) - standard therapy
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Alabama at Birmingham
Pneumocystis Pneumonia
Effects and Safety of Caspofungin and Corticosteroids in Pneumocystis Pneumonia in Non-HIV Patients
Pneumocystis Pneumonia is increasing in Immunocompromised Non-HIV Infected Patients. The effects and safety of caspofungin and corticosteroids is not certain in this population.
- Trial name
- NCT02603575
- Testing
- caspofungin, corticosteroids, Sulfanilamides
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Beijing Chao Yang Hospital
Pleural Effusions, Respiratory Failure
Drainage Of Pleural Effusions in the Intensive Care Unit (DOPE-ICU) - Feasibility Trial
This trial evaluates the feasibility of ultrasound-guided pleural drainage versus no drainage in adult ICU patients with pleural effusions (fluid buildup around the lungs) and respiratory failure.
- Trial name
- NCT06709456
- Testing
- Ultrasonography-guided pleural drainage
- Where
- 6 sites in Denmark
- Volunteers
- 88 people
- Sponsor
- Olav Schjørring
Impaired Glucose Tolerance, Obstructive Sleep Apnea
Effects of Treatment of Sleep Apnea on Metabolic Syndrome
The investigators performed a randomized, cross-over controlled clinical trial comparing 8 weeks of Continuous Positive Airway Pressure (CPAP) to 8 weeks of sham-CPAP in patients with moderate to severe Sleep Disordered Breathing…
- Trial name
- NCT01385995
- Testing
- Continuous Positive Airway Pressure (CPAP) (Philips-Respironics RemStar Pro® CPAP)
- Volunteers
- 50 people
- Sponsor
- Brigham and Women's Hospital
Respiratory Failure
Effect of Different Proprioceptive Neuromuscular Facilitation Techniques Versus Flow Trigger Sensitivity on Weaning Off Mechanical Ventilation
Weaning is a critical stage in respiratory care, requiring strategies to optimize breathing muscle function and reduce patient dependence on ventilatory support.
- Trial name
- PNF techniques (NCT06831201)
- Testing
- Flow trigger sensitivity group, Active proprioceptive facilitation technique ( active PNF) technique, Passive proprioceptive facilitation technique ( passive PNF) technique
- Where
- Egypt
- Volunteers
- 84 people
- Sponsor
- Beni-Suef University
Sleep Apnea, Obstructive
Virtual Surgery of the Upper Airways
Obstructive sleep apnea (OSA) is a sleep related breathing disorder caused by repetitive collapses of the upper airways resulting in impaired breathing, oxygen desaturation and sleep disturbances.
- Trial name
- VirtuOSA (NCT04829201)
- Testing
- functional septorhinoplasty or oropharyngeal/orthognathic surgery
- Where
- 2 sites in Norway
- Volunteers
- 30 people
- Sponsor
- Norwegian University of Science and Technology
Nasal Congestion
Functional Magnetic Resonance Imaging (fMRI) Study of Nasal Strips in Nasal Congestion
The aim of the study is to evaluate the effect of the nasal strip (relative to the placebo strip) on the nasal passages using anatomical MRI scans and to demonstrate the effect of the strip on breathing correlated cortical…
- Trial name
- NCT02275364
- Testing
- Test strip, Nasal spray
- Where
- United Kingdom
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Lung Disease, Brain Injury
Genomics, Single Nucleotide Polymorphisms (SNPs), and Clinical Neonatology
This research seeks to establish a neonatal DNA Tissue Bank to find out if differences in small segments of DNA predispose babies to Chronic Lung Disease (CLD), Periventricular Brain Injury (PVI), Necrotizing Enterocolitis (NEC)…
- Conditions
- Lung Disease, Brain Injury, Necrotizing Enterocolitis, Respiratory Failure
- Trial name
- NCT00315263
- Where
- 2 sites in United States
- Volunteers
- 63 people
- Sponsor
- Children's Mercy Hospital Kansas City
Critical Illness, Corona Virus Infection
Long Term Outcomes of Patients With COVID-19
The investigators hypothesize that those with respiratory failure due to COVID-19 will have different burdens of mental and physical disability than those with respiratory failure who do not have COVID-19.
- Conditions
- Critical Illness, Corona Virus Infection, Respiratory Failure, Covid-19
- Trial name
- COVID19 LTFU (NCT04360538)
- Testing
- Quality of Life, Impact Event Score, Hospital anxiety and depression scale
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- University of Chicago
Respiratory Insufficiency
High Flow Nasal Oxygen at Extubation for Adults Requiring a Breathing Tube for Treating Severe Breathing Difficulties
The goal of this feasibility study is to learn whether a new approach to breathing tube removal within the Intensive Care Unit is safe and acceptable to participants who require a breathing tube for the management of severe…
- Trial name
- Pre-SAFEx (NCT05904652)
- Testing
- Fisher and Paykel "HealthCare Airvo™ 3" high flow system, Conventional Oxygen Therapy
- Where
- United Kingdom
- Volunteers
- 2 people
- Sponsor
- NHS Greater Glasgow and Clyde
Dry Nose, Nose Irritation
Pilot Study to Assess Performance and Safety of SULFEX 13081.22 Nasal Spray in Patients With Dry or Irritated Nose
As the medical device is CE marked, the objective of this study is to provide performance and safety data on SULFEX 13081.22 nasal spray as close as possible to the routine care.
- Trial name
- NCT05499078
- Testing
- SULFEX 13081.22
- Where
- 2 sites in France
- Volunteers
- 40 people
- Sponsor
- Church & Dwight Company, Inc.
Systolic Heart Failure, Respiratory Failure
A Trial Comparing High-Flow Nasal Cannula Versus Noninvasive Ventilation on Reintubation and Post-Extubation Respiratory Failure in High-Risk Patients With Systolic Heart Failure
This prospective, open-label randomized controlled pilot trial will enroll participants at the Yale New Haven Hospital. Patients with systolic heart failure, defined as an ejection fraction ≤40%, who require invasive mechanical…
- Trial name
- EXTUBATE-HF (NCT06671015)
- Testing
- Airvo 3
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Yale University
Respiratory Failure
Quantification of Inspiratory Effort Through Nasal Pressure in Patients Undergoing Weaning From Invasive Mechanical Ventilation and Correlation With Clinical Outcomes
Weaning from invasive mechanical ventilation (MV) constitutes a fundamental procedure in intensive care, covering up to 50% of time spent on ventilation (1).
- Trial name
- NAIVE (NCT05282238)
- Testing
- Nasal pressure assessment
- Where
- Italy
- Volunteers
- 175 people
- Sponsor
- University of Modena and Reggio Emilia
Acute Hypoxemic Respiratory Failure
Intravenous L-Citrulline Influence on the Need for Invasive Mechanical Ventilation for Acute Hypoxemic Respiratory Failure in Patients With COVID-19
Prospective, Randomized, Double-Blind, Placebo-Controlled Phase II Trial of Intravenous L-Citrulline (Turnobi) to Delay and Potentially Prevent the Need for Invasive Mechanical Ventilation for Acute Hypoxemic Respiratory Failure…
- Trial name
- NCT04570384
- Testing
- L-Citrulline
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Asklepion Pharmaceuticals, LLC
Hypoxemic Respiratory Failure, Oxygen Toxicity
Handling Oxygenation Targets in the Intensive Care Unit
Handling oxygenation targets (HOT) is standard of care in the intensive care unit (ICU), however the quality and quantity of evidence is low and potential harm has been reported.
- Trial name
- HOT-ICU (NCT03174002)
- Testing
- Oxygen
- Where
- 37 sites in Denmark, Finland and 5 more
- Volunteers
- 2,928 people
- Sponsor
- Aalborg University Hospital
Premature Baby 26 to 32 Weeks, Bronchopulmonary Dysplasia
Respiratory Outcome at Adolescence of Very Low Birthweight Infants
EPIPAGEADO is an observational study. Respiratory symptoms and lung function will be evaluated in very low birth weight and term infants, born in 1997 and included in the French EPIPAGE cohort.
- Trial name
- EPIPAGEADO (NCT01424553)
- Testing
- Prevention and follow-up of the patients pulmonary parameters
- Where
- France
- Volunteers
- 355 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Respiratory Insufficiency
Sedation Versus No Sedation in a Spontaneous Breathing Trial
An important part of how we decide when a patient is ready to have their breathing tube removed is to have a person breathe without any machine breaths while the breathing tube is still in place.
- Trial name
- NCT00366353
- Testing
- Sedation during SBT, No sedation
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Memorial Medical Center
Patients With COVID-19 Pneumonia Will Allow to Detect an Absolute Reduction in the Rate of Respiratory-failure
Defibrotide in COVID-19 Pneumonia
Phase II, prospective, interventional, single-arm, multicentric, open label trial, with a parallel retrospective collection of data on not treated patients from IRCCS, San Raffaele Scientific Institute included in the…
- Trial name
- DEFI-VID19 (NCT04335201)
- Testing
- Defibrotide Injection
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- IRCCS San Raffaele