Clinical trials: Respiratory Inflammation
Asthma
Comparison of Combination Therapy: Montelukast and Inhaled Steroid on Exercise Induced Bronchoconstriction
The purpose of this study is to compare the effects of 2 weeks therapy of montelukast, budesonide, their combination on exercise induced bronchoconstriction (EIB) and airway inflammation in children and young adults, not on…
- Trial name
- NCT00462592
- Testing
- budesonide, montelukast
- Where
- 2 sites in Canada
- Volunteers
- 18 people
- Sponsor
- Hamilton Health Sciences Corporation
Acute Respiratory Tract Infections, Diarrhea
Home Based Child Care to Reduce Mortality and Malnutrition in Tribal Children of Melghat, India: CRCT
Melghat is poorly developed tribal area in India with very high child mortality \& malnutrition prevalence (grossly inadequate medical facilities). Important health problems.
- Conditions
- Acute Respiratory Tract Infections, Diarrhea, Malaria, Neonatal Sepsis
- Trial name
- HBCC (NCT02473796)
- Testing
- Home based child care
- Where
- India
- Volunteers
- 7,594 people
- Sponsor
- MAHAN Trust
Healthy, Lung Disease
Effects of Endotoxin in Normal Human Volunteers
Bacterial infections can progress to a life-threatening illness called septic shock, characterized by low blood pressure and vital organ damage.
- Conditions
- Healthy, Lung Disease, Sepsis, Septic Shock
- Trial name
- NCT00001303
- Testing
- Reference Endotoxin, Inhaled Nitric Oxide
- Where
- United States
- Volunteers
- 198 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Carbapenem-Resistant Acinetobacter Baumannii Infection, Bloodstream Infection
Sulbactam-Durlobactam in CRAB Infection: A Real-World Cohort Study
This is a multicenter real-world observational cohort study designed to evaluate the effectiveness and safety of sulbactam-durlobactam in patients with carbapenem-resistant Acinetobacter baumannii (CRAB) infections.
- Conditions
- Carbapenem-Resistant Acinetobacter Baumannii Infection, Bloodstream Infection, Pneumonia, Sepsis
- Trial name
- SD-CRAB (NCT07601711)
- Testing
- Sulbactam-Durlobactam
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Sichuan Provincial People's Hospital
SARS-CoV-2 Acute Respiratory Disease, Covid19
Pandemic Triage Score in Patients With Known or Suspected Severe Acute Respiratory Syndrome (SARS) CoronaVirus (CoV) 2 Infection
During this pandemic period, the goal of the health care system is to optimize the use of intensive care services for patients infected with SARS-CoV-2, given the frequency of complications that can lead to high mortality.
- Trial name
- STC-19 (NCT04371471)
- Testing
- STC-19 score
- Where
- France
- Volunteers
- 91 people
- Sponsor
- Groupe Hospitalier de la Rochelle Ré Aunis
Community-acquired Pneumonia, Sepsis
Anti-inflammatory Action of Oral Clarithromycin in Community-acquired Pneumonia
Traditional management of community-acquired pneumonia (CAP) relies on the prompt administration of antimicrobials that target the most common causative pathogens.
- Conditions
- Community-acquired Pneumonia, Sepsis, Inflammatory Response, Mortality
- Trial name
- ACCESS (NCT04724044)
- Testing
- Tablets, Clarithromycin 500mg
- Where
- 18 sites in Greece
- Volunteers
- 278 people
- Sponsor
- Hellenic Institute for the Study of Sepsis
Severe Sepsis, Respiratory Failure
Muscle Atrophy in Patients With Severe Sepsis
This study is being done to help determine whether patients with severe sepsis (overwhelming inflammation in the body as a result of an infection) lose muscle and become weak more rapidly than patients with other severe…
- Trial name
- NCT01717651
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Ohio State University
Bronchopulmonary Ignition, Condensate of Exhaled Air
Development of a Noninvasive Method of Evaluation of Pulmonary Inflammation in the Condensates of Exhaled Air
The aim of the study is identify biological parameters reflecting proteolytic activity in the exhaled condenstaes which might be useful to follow up pulmonary inflammation in various conditions including cystic fibrosis, COPD…
- Conditions
- Bronchopulmonary Ignition, Condensate of Exhaled Air, Mucoviscidosis, Asthma
- Trial name
- NCT00356629
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Sepsis, Respiratory Failure
Inert Gas Rebreathing in Ventilated Patients
Measuring hemodynamic parameters in ventilated patients is important yet still complicated to perform. Inert gas rebreathing (IGR) showed promising results when being compared to other invasive as well as non-invasive techniques…
- Conditions
- Sepsis, Respiratory Failure, Heart Failure, Renal Failure
- Trial name
- VIGR (NCT01891253)
- Testing
- non-invasive determination of cardiac output
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Universitätsmedizin Mannheim
Covid19, Cytokine Storm
Intramuscular Effect of Polymerized Type I Collagen on the Cytokine Storm in COVID-19 Patients
SARS-CoV-2 infection induces a hyperinflammatory syndrome, causing the acute respiratory distress syndrome, massive lung cell destruction and, as a plausible sequelae, pulmonary fibrosis in COVID-19 patients.
- Conditions
- Covid19, Cytokine Storm, Regulation of Inflammatory Response, Pulmonary Fibrosis
- Trial name
- NCT04517162
- Testing
- Collagen-Polyvinylpyrrolidone
- Where
- Mexico
- Volunteers
- 90 people
- Sponsor
- Janette Furuzawa Carballeda
Asthma, Late-Onset Asthma
General Risk Factors and Inflammatory Determinants in Older Patients With Asthma
A cross-sectional study in asthma patients to determine if a late age of onset asthma (start symptoms >18 years old), is associated with more persistent airway/systemic inflammation, worse asthma control, more co-morbidity, a…
- Conditions
- Asthma, Late-Onset Asthma, Childhood Asthma
- Trial name
- GRANDMA (NCT03278561)
- Testing
- Sputum induction, Blood sample
- Where
- Netherlands
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Gerdien Tramper
Anemia, Iron Deficiency
Iron and Prebiotics Fortification in Kenyan Infants
Iron deficiency and anemia are health issues affecting mainly infants and women in developing countries. Iron deficiency in infancy can have long-lasting impact on cognitive and motor development of the child.
- Conditions
- Anemia, Iron Deficiency, Diarrhea, Malaria
- Trial name
- Iro'n'Pre (NCT02118402)
- Testing
- Fortified maize porridge
- Where
- Kenya
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Sepsis
Molecular Diagnosis and Risk Stratification of Sepsis
Background: Sepsis is a major cause of in-hospital morbidity and mortality. Current tools available to the clinician to initiate therapy of patients with sepsis mainly comprise of symptom classification systems and culture…
- Trial name
- MARS (NCT01905033)
- Where
- 2 sites in Netherlands
- Volunteers
- 7,500 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Asthma, Inflammation
Pathogenesis and Genetics of Environmental Asthma Ozone Study
The goals of the research are designed to accomplish genetic association studies of candidate genes in healthy normal individuals exposed to 0.2 ppm for 2.25 hours with intermittent exercise in order to search for associations…
- Trial name
- NCT00574158
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Bronchiolitis Obliterans
Bronchial Inflammation in Patients With Bronchiolithis Obliterans
The investigators plan to study the variability of lung function parameters and bronchial inflammatory markers in 20 patients with bronchiolitis obliterans at the age of 6 to 25 years compared with an age- and sex-matched control…
- Trial name
- FRABO-02 (NCT01633385)
- Where
- Germany
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Johann Wolfgang Goethe University Hospital
Inflammation, Death, Sudden, Cardiac
The Effects of Enzymes and Flavonoids on Inflammation and Coagulation After Marathon
The aim of the present study is to investigate changes in inflammatory status and incidence of infection after extreme aerobic physical stress (participation in a marathon).
- Conditions
- Inflammation, Death, Sudden, Cardiac, Death, Heart Diseases
- Trial name
- Enzy-MagIC (NCT01916408)
- Testing
- Wobenzym plus, PL 1
- Where
- Germany
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Asthma; Eosinophilic
Dupilumab Efficacy on Bronchial Inflammation, Small Airways Disfunction and Mucous Secretion
Unicentric prospective real life study designed to analyse the efficacy of Dupilumab to reduce bronchial inflammation of asthma measured by inflammatory cell counts obtained in induced sputum and other related characteristics…
- Trial name
- DEBORA (NCT05787678)
- Testing
- Dupilumab
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Critical Illness, Sepsis
Point-of-Care AI Assistance and Critical Care Outcomes: A Randomized Trial
This is a prospective, unmasked, randomized, multicenter clinical trial evaluating the impact of point-of-care large language model (LLM)-based decision support on diagnostic accuracy and clinical outcomes in adult medical…
- Conditions
- Critical Illness, Sepsis, Acute Respiratory Failure (ARF), Multi-organ Failure
- Trial name
- POC-AI-ICU (NCT07293078)
- Testing
- Point-of-care large language model decision support (ChatGPT-5)
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- MetroWest Artificial Intelligence Research Workgroup
COPD, Exacerbation
CRP-guided Antibiotic Treatment in COPD Exacerbations Admitted to the Hospital
Rationale: Acute exacerbations are key events in chronic obstructive pulmonary disease (COPD), resulting in poorer quality of life. Causes include irritants, viruses and bacterial pathogens.
- Conditions
- COPD, Exacerbation, Bronchitis, Sputum
- Trial name
- CATCH (NCT01232140)
- Testing
- CRP-guided antibiotic treatment
- Where
- Netherlands
- Volunteers
- 220 people
- Sponsor
- Medical Center Alkmaar
COVID - 19
Vitamin E Supplementation As Adjunctive Therapy To Lower Inflammation In COVID-19 Patients
Since the first reported case of the novel coronavirus (SARS-CoV-2) in humans at the end of 2019 in Wuhan, the virus had infected approximately 100 million individuals.
- Trial name
- VITEC (NCT07412574)
- Testing
- Patients were randomly assigned, under a double-blind design, α-Tocopherol group (n = 22)
- Where
- Mexico
- Volunteers
- 56 people
- Sponsor
- Universidad Veracruzana
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