Clinical trials: Respiratory Inflammation
Chronic Obstructive Pulmonary Disease
Short Antibiotic Treatment Versus Duration Guided by Markers of Inflammation in the Treatment of AECOPD
Chronic obstructive pulmonary disease (COPD) is one of the most common diseases in the world. In a recent study, we showed that administration of levofloxacin is superior to placebo in the treatment of decompensation of COPD; it…
- Trial name
- AECOPD (NCT02067780)
- Testing
- Levofloxacin 500mg
- Where
- Tunisia
- Volunteers
- 310 people
- Sponsor
- University of Monastir
Respiratory Tract Infections, Urinary Tract Infections
HostDx Sepsis in the Diagnosis and Prognosis of Emergency Department Patients With Suspected Infections: a Multicenter Pilot Study
This study will analyze gene expression data (HostDx Sepsis test) from blood samples collected from participants with suspected infections.
- Conditions
- Respiratory Tract Infections, Urinary Tract Infections, Skin and Soft Tissue Infections, Intraabdominal Infections
- Trial name
- NCT03744741
- Testing
- HostDx Sepsis
- Where
- 7 sites in United States, Greece
- Volunteers
- 585 people
- Sponsor
- Inflammatix
Acute Lung Injury (ALI) Associated With COVID-19, Lung Inflammation Associated With COVID-19
TD-0903 for ALI Associated With COVID-19
This Phase 2 study will evaluate the efficacy, safety, pharmacodynamics and pharmacokinetics of inhaled TD-0903 compared with a matching placebo in combination with standard of care (SOC) in hospitalized patients with confirmed…
- Trial name
- NCT04402866
- Testing
- TD-0903
- Where
- 24 sites in United States, Brazil and 5 more
- Volunteers
- 235 people
- Sponsor
- Theravance Biopharma
Asthma
Airflow Obstruction and Biomarkers of Airway Inflammation During and Following Acute Exacerbations of Childhood Asthma
This study is a longitudinal single-center pilot study designed to describe changes in lung function and levels of noninvasive biomarkers of airway inflammation in children ages 6-18 years over two months following…
- Trial name
- NCT01227070
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Seattle Children's Hospital
Chronic Obstructive Pulmonary Disease
An Investigation of the Mechanism of Action of Seretide in Chronic Obstructive Pulmonary Disease
This study is investigating the possible mechanisms of action of an inhaled treatment (Seretide), currently used worldwide in millions of patients with COPD (Chronic Obstructive Pulmonary Disease) and how it improves the symptoms…
- Trial name
- IMAS (NCT00974805)
- Testing
- Seretide 500 Accuhaler
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Southampton
Critical Illness, Sepsis
Peer Support for Post Intensive Care Syndrome Self-Management
A prospective, 2-arm, single-blind, randomized controlled clinical feasibility trial design is planned. Forty CCI survivors will be randomized (1:1) to either the PS-PICS (peer support) intervention or usual care (control) group.
- Conditions
- Critical Illness, Sepsis, Shock, Septic, Shock
- Trial name
- PS-PICS (NCT03788096)
- Testing
- Peer Support with Motivational Interviewing, Usual Care Group
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Texas at Austin
Asthma, Exercise-Induced Bronchoconstriction
Effect of a Component of Fish Oil on Exercise-Induced Bronchoconstriction and Airway Inflammation in Asthma
The primary aim of this study will be to evaluate the effects of Lyprinol® supplementation on airway inflammation and the bronchoconstrictor response to dry air hyperpnea in individuals with asthma.
- Trial name
- NCT01504646
- Testing
- Lyprinol
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Indiana University
Nasal Congestion and Inflammations
Sonu Nasal Congestion Relief Study in Patients Suffering From Moderate to Severe Nasal Congestion
To demonstrate the safety and effectiveness of Sonu for the treatment of patients suffering from moderate to severe nasal congestion.
- Trial name
- SCORE (NCT05821842)
- Testing
- Sonu
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Third Wave Therapeutics
Inflammation, Community Acquired Pneumonia (CAP)
Targeting Vascular INflammation in Patients With Community-Acquired Pneumonia
The goal of this clinical trial is to learn if icosapent ethyl (Vascepa) works to lessen the amount of inflammation in adults diagnosed with Community-Acquired Pneumonia (CAP).
- Conditions
- Inflammation, Community Acquired Pneumonia (CAP), Inflammation Plaque, Atherosclerotic
- Trial name
- TIN-CAP (NCT06710080)
- Testing
- Icosapent Ethyl 1000 MG Oral Capsule [Vascepa]
- Where
- Canada
- Volunteers
- 168 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Oxygen Toxicity, Pulmonary Injury
Hyperoxia Induced Pulmonary Inflammation and Organ Injury: a Human in Vivo Model
Oxygen is the most commonly administered therapy in critical illness. Accumulating evidence suggests that patients often achieve supra-physiological levels of oxygenation in the critical care environment.
- Conditions
- Oxygen Toxicity, Pulmonary Injury, Acute Lung Injury
- Trial name
- NCT05414370
- Testing
- Liquid oxygen, medical air
- Where
- United Kingdom
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Belfast Health and Social Care Trust
Coronavirus, COVID
A Phase 2 Study to Evaluate Axatilimab for Hospitalized Participants With Respiratory Involvement Secondary to COVID-19
This was a randomized, double-blind, placebo-controlled, 29-day study to assess the efficacy and safety of axatilimab plus standard of care (SOC), compared with placebo plus SOC, in participants with respiratory signs and…
- Conditions
- Coronavirus, COVID, ARDS, Cytokine Storm
- Trial name
- NCT04415073
- Testing
- SNDX-6352
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- Syndax Pharmaceuticals
Intestinal Inflammation, Rhinosinusitis
the Prevalence of Chronic Rhinosinusitis Associated With Inflammatory Bowel Disease and Association With Biomarkers of Epithelial Barrier Damage
The goal of this observational study is to define the prevalence of chronic rhinosinusitis in patients with intestinal bowel disease.
- Trial name
- PRIME (NCT06149949)
- Testing
- Observational study
- Volunteers
- 100 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Pulmonary Arterial Hypertension
Testing of HIV Protease Inhibitors to Suppress Inflammation and Improve Cardio Pulmonary Hemodynamics in Subjects With Pulmonary Arterial Hypertension
Study Rationale:There is recent evidence that HIV protease inhibitors (HIV-PI) can improve pulmonary hemodynamics in experimental models of pulmonary arterial hypertension (PAH).
- Trial name
- NCT02023450
- Testing
- saquinavir and ritonavir
- Where
- China
- Volunteers
- 20 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Hypoxia, Normoxia
Effects of Oxygen Status on Endotoxemia Induced Inflammation and Hypoxia Inducible Factor-1α
Oxygen is a widely available gas that is cheap, easy to get and extensively used in medicine. From animal studies it has become apparent that increasing or lowering the degree of oxygen in the blood, the inflammatory response can…
- Conditions
- Hypoxia, Normoxia, Hyperoxia
- Trial name
- NCT01978158
- Testing
- Lipopolysaccharide
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Cystic Fibrosis
Modulation by Sex Hormones of Inflammation and Susceptibility to Pseudomonas Aeruginosa in Cystic Fibrosis Airways
The general objective is to elucidate the mechanisms whereby sex hormones may modulate the severity of respiratory disease. An important component of this proposal is a systematic and intensive approach to characterize how the…
- Trial name
- NCT00700050
- Testing
- Hypertonic saline
- Where
- Canada
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Allergic Rhinitis, Asthma
Allergic Inflammation in Rhinitis Patients Following Nasal Allergen Challenge
Allergic rhinitis is a common condition caused by inflammation of nasal mucosa. The study was performed to gain information on this inflammation, including effect of intranasal corticosteroid treatment hereupon and potential…
- Trial name
- NCT01657097
- Testing
- INCS
- Where
- Denmark
- Volunteers
- 24 people
- Sponsor
- University of Aarhus
COVID-19, Acute Respiratory Distress Syndrome
Low-Level Laser Therapy Treatment of Lung Inflammation in Post-COVID-19 Recovery
An informational evaluation of COVID-19 patients who receive low-level laser therapy in addition to a normal regimen of treatment for symptoms associate with COVID-19.
- Trial name
- NCT05258617
- Testing
- LLLT Photobiomodulation
- Where
- 7 sites in United States
- Volunteers
- 5 people
- Sponsor
- Ward Photonics LLC
Lung Inflammation, Experimental Lung Inflammation
Pulmonary and Inflammatory Responses Following Exposure to a Low Concentration of Ozone or Clean Air at Rest
The primary purpose of this study is to measure pulmonary function, symptoms, and pulmonary inflammatory responses in healthy young adults during and immediately after exposure to a low concentration of ozone (0.070 ppm) or clean…
- Trial name
- LOCONOZ3 (NCT06943989)
- Testing
- Ozone Exposure, Clean air (0.0 ppm ozone)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Environmental Protection Agency (EPA)
COVID 19
Oral 25-hydroxyvitamin D3 and COVID-19
The goal of this clinical trial is to investigate the therapeutic efficacy of rapidly correcting vitamin D deficiency in adults with the use of 25-hydroxyvitamin D3 [25(OH)D3] for reducing the risk of acquiring the SARS-CoV-2…
- Trial name
- NCT04386850
- Testing
- Oral 25-Hydroxyvitamin D3
- Where
- Iran
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Tehran University of Medical Sciences
Chronic Obstructive Pulmonary Disease (COPD)
Impact of Systemic Manifestations/Comorbidities on Clinical State, Prognosis, Utilisation of Health Care Resources in Patients With COPD
The purpose of this study is to determine the prevalence and severity of extrapulmonary disorders and to quantify the impact of extrapulmonary organ manifestations on morbidity and mortality of COPD patients.
- Trial name
- COSYCONET (NCT01245933)
- Where
- 22 sites in Germany
- Volunteers
- 2,741 people
- Sponsor
- Philipps University Marburg
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