Clinical trials: Respiratory Inflammation
ASTHMA
Exhaled Air Temperature (TAE) As A Marker Of Airway Inflammation In Asthma
The goals : to develop and computerize equipment for measuring ITAE , compare the results with TAEP Itae study the possible relationship between different markers of inflammation: sputum eosinophils , FeNO , the ITAE and TAEP and…
- Trial name
- NCT02064686
- Testing
- Exhaled breath temperature
- Where
- Spain
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Airway Inflammation
Airborne Ultrafine and Fine Particulate Matter: A Cause for Endothelial Dysfunction in Man?
The purpose of this study is to examine biological pathways of altered blood vessel function resulting from breathing airborne particulate.
- Trial name
- NCT00814281
- Testing
- Montelukast
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Marywood University
Covid19, Sepsis
Feasibility Study of Hematology Parameters in COVID-19 Disease
The purpose of this study is to evaluate the potential for MDW and other CPD parameters (measured with CBC-DIFF) to identify COVID-19 diseased adult individuals presenting to the hospital with symptoms suggestive of COVID-19 or…
- Conditions
- Covid19, Sepsis, Adults, Emergency Department
- Trial name
- NCT04816630
- Testing
- CBC-Diff Monocyte Volume Width Distribution
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Beckman Coulter, Inc.
Empyema, Pleural, Pleural Infections
VATS or Intrapleural Enzymatic Therapy for Patients With Empyema.
A parapneumonic pleural infection is a frequently encountered and serious medical emergency with high morbidity and mortality in specific patient groups (especially in the elderly and immunocompromised).
- Trial name
- VIETS (NCT07886541)
- Testing
- VATS group, IET
- Where
- Netherlands
- Volunteers
- 164 people
- Sponsor
- Amsterdam UMC
Acute Lung Injury, Systemic Inflammatory Response Syndrome
Study of Sivelestat Sodium Hydrate in Acute Lung Injury (ALI) Associated With Systemic Inflammatory Response Syndrome (SIRS) in Japan
The purpose of this study is to confirm the efficacy and safety of sivelestat in patients with acute lung injury associated with systemic inflammatory response syndrome.
- Trial name
- NCT00219375
- Testing
- Sivelestat sodium hydrate
- Where
- 9 sites in Japan
- Volunteers
- 649 people
- Sponsor
- Ono Pharmaceutical Co., Ltd.
Pneumonia, Peritonitis
Functional Genomic Influences on Disease Progression and Outcome in Sepsis
The proposal is aimed at identifying genetic factors that determine the incidence and severity of, and the outcome from life-threatening infections (severe sepsis/septic shock) in patients admitted to High Dependency Units (HDUs)…
- Trial name
- GAinS (NCT00131196)
- Where
- 50 sites in United Kingdom
- Volunteers
- 4,000 people
- Sponsor
- University of Oxford
Neurokinin 1 Receptor, Substance P, Respiratory Illness, Inflammation, Covid-19, Coronavirus
To Determine the Efficacy of Neurokinin 1 Receptor Antagonist as a Therapeutic Tool Against Cytokine Storm and Respiratory Failure in Covid-19 Patients
This is a randomized, randomized controlled trial to investigate the efficacy and safety of Neurokinin-1 Receptor (NK-1R) 80 mg orally given daily to treat cytokine storm causing inflammatory lung injury and respiratory failure…
- Trial name
- NCT04468646
- Testing
- NK-1R antagonist
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Prof. Dr. Fridoon Jawad Ahmad
Noninvasive Ventilation
The Effects of Nocturnal Non-invasive Ventilation in Stable COPD
Rationale: Application of long-term non-invasive ventilation (NIV) in chronic obstructive pulmonary disease (COPD) patients with chronic hypercapnic respiratory failure (CHRF) has recently been shown to improve outcomes.
- Trial name
- RECAPTURE (NCT03053973)
- Testing
- nocturnal noninvasive ventilation, Standard Care
- Where
- Netherlands
- Volunteers
- 116 people
- Sponsor
- University Medical Center Groningen
Asthma, Diabete Type 2
Bronchial Asthma and Diabetes: Impact on Bronchial Inflammation and Exercise Capacity
Type 2 diabetes is the most common form of diabetes and according to several studies, even lung can represent another target of the diabetic disease.
- Trial name
- NCT04448262
- Testing
- data collection
- Where
- Italy
- Volunteers
- 39 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Idiopathic Granulomatous Mastitis, Granulomatous Mastitis
GRAnulomatous MAstitis REGistry Study
Idiopathic granulomatous mastitis (IGM) is a rare benign inflammatory breast condition with unknown cause, affecting approximately 2.4 per 100,000 women aged 20-40 years.
- Trial name
- GRAMAREG (NCT07422870)
- Where
- 2 sites in Germany
- Volunteers
- 1,000 people
- Sponsor
- European Breast Cancer Research Association of Surgical Trialists
Ventilator Associated Pneumonia
GRam Stain-guided Antibiotics ChoicE for Ventilator-Associated Pneumonia (GRACE-VAP) Trial
Background: Optimising the use of antibiotic agents is a pressing challenge to overcoming the rapid emergence and spread of multidrug-resistant pathogens in intensive care units (ICUs).
- Trial name
- NCT03506113
- Testing
- Gram stain-guided antibiotic choice, Guidelines-based antibiotics choice
- Where
- 12 sites in Japan
- Volunteers
- 206 people
- Sponsor
- Osaka General Medical Center
Immune Response, Upper Respiratory Tract Infection
Walnut and Immunity Study
The main objective of the study is to determine if eating walnuts enhances immune function, in older free-living men and postmenopausal women with overweight.
- Trial name
- walnutimmune (NCT05915390)
- Testing
- walnuts, Habitual diet
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Covid19, Inflammation
Brazilian Green Propolis Extract (EPP-AF) as an Adjunct Treatment for Hospitalized COVID-19 Patients (BeeCovid2)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) promotes challenging immune and inflammatory phenomena. Though various therapeutic possibilities have been tested against coronavirus disease 2019 (COVID-19), the most…
- Trial name
- BeeCovid2 (NCT04800224)
- Testing
- Standardized Brazilian Green Propolis Extract
- Where
- Brazil
- Volunteers
- 200 people
- Sponsor
- D'Or Institute for Research and Education
Asthma
Neural Mechanisms in Asthma
Asthma is a chronic disease that affects nearly 13% of adults in the U.S., causing substantial impairment that is reflected in the tens of millions of missed days of work, and doctors' and emergency room visits it leads to…
- Trial name
- NCT01155843
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Community-Acquired Pneumonia (CAP), Acute Respiratory Distress Syndrome (ARDS)
Study of Nogapendekin Alfa Inbakicept and iNKT Cells in Critically Ill Adults With Severe Community-Acquired Pneumonia
This is a Phase 3, randomized, blinded, and placebo-controlled clinical trial investigating a new combination treatment for critically ill adults who have severe community-acquired pneumonia, especially if they also have sepsis…
- Conditions
- Community-Acquired Pneumonia (CAP), Acute Respiratory Distress Syndrome (ARDS), Sepsis, Lymphopenia
- Trial name
- NCT07492875
- Testing
- Nogapendekin alfa inbakicept (NAI), agenT-797
- Sponsor
- ImmunityBio, Inc.
Sepsis, Critical Illness
Indirect Calorimetry Usage and Effect in Ventilator-free Days and Muscle Thickness in Septic Ventilated Patients
Patients admitted to the ICU with diagnosis of sepsis and requiring mechanical ventilation for at least 24-hours and receiving enteral or parenteral nutrition will be prospectively randomized to one of two arms.
- Conditions
- Sepsis, Critical Illness, Respiratory Failure, Nutrition Disorders
- Trial name
- NCT03440593
- Testing
- Caloric delivery will target results of IC measurement.
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Baylor Research Institute
Acute Respiratory Distress Syndrome, ARDS (Moderate or Severe)
Multiple Dosing of Mesenchymal Stromal Cells in Patients With ARDS (COVID-19)
This is a multi-center, randomized, placebo controlled, interventional phase 2A trial to evaluate the safety profile and potential efficacy of multi-dosing of mesenchymal stromal cells (MSC) for patients with SARS-CoV-2…
- Conditions
- Acute Respiratory Distress Syndrome, ARDS (Moderate or Severe), COVID-19 Pneumonia
- Trial name
- NCT04466098
- Testing
- Mesenchymal stromal cells
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Non-small Cell Lung Cancer, Progression, Disease
Energy for Lymphocytes
CERTIM is a cohort created in July 2015 to set up a multidisciplinary follow-up of cancer patients treated with immune checkpoint inhibitors.
- Trial name
- ELY (NCT04879316)
- Testing
- Resting Energy Expenditure measurement
- Where
- France
- Volunteers
- 144 people
- Sponsor
- Hôpital Cochin
Asthma, Allergic, Rhinitis,Allergic
Effects of Intranasal Fluticasone Plus Azelastine on Airway Inflammation in Patients With Asthma & Allergic Rhinitis
Single centre, double-blind, placebo controlled, adaptive design, cross-over trial. The primary objective is to assess the additive effects of using combined intranasal fluticasone propionate plus azelastine nasal spray on airway…
- Conditions
- Asthma, Allergic, Rhinitis,Allergic, Allergy
- Trial name
- MAN06 (NCT02953106)
- Testing
- Azelastine-Fluticasone Nasal
- Where
- United Kingdom
- Volunteers
- 7 people
- Sponsor
- University of Dundee
COVID 19, SARS-CoV 2
Mavrilimumab to Reduce Progression of Acute Respiratory Failure in COVID-19 Pneumonia and Systemic Hyper-inflammation
The purpose of this prospective, Phase 2, multicenter, blinded, randomized placebo controlled study is to demonstrate that early treatment with mavrilimumab prevents progression of respiratory failure in patients with severe…
- Conditions
- COVID 19, SARS-CoV 2, Pneumonia
- Trial name
- NCT04492514
- Testing
- Mavrilimumab
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Kristin Hudock
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