Clinical trials: Respiratory Inflammation
COPD, Inflammation
A Multi-Center Study of Rehabilitation to Stable Chronic Obstructive Pulmonary Disease (COPD) Patients
This is a multi-center prospective follow-up study. to choose the stable COPD patients in community to compare different modes of exercise (cycling and walking) to compare the effect of different exercises on the quality of…
- Trial name
- NCT00686660
- Testing
- cycling, walking, cycling, non-walking, walking, walking
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Beijing Chao Yang Hospital
Acute Lung Injury, Sepsis
Oral Administration or Nasal Feeding of Huzhangxiefei Decoction for Treatment in Sepsis Induced Acute Lung Injury
Hypothesis 1A: Oral Administration or Nasal Feeding of Huzhangxiefei Decoction will significantly attenuate sepsis-induced systemic organ failure as measured by overall response rate.
- Trial name
- NCT04940676
- Testing
- Huzhangxiefei Decoction, 10% Huzhangxiefei Decoction
- Where
- China
- Volunteers
- 58 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
COVID-19 Virus Infection, Cytokine Storm
High-Dose Corticosteroid or Tocilizumab for Clinical Worsening of COVID-19
COVID-19 pandemic has spread all over the world, and hospitalization of the patients with COVİD-19 Pneumonia has become a great burden to the Intensive Care Units.
- Conditions
- COVID-19 Virus Infection, Cytokine Storm, Corticosteroid, Tocilizumab
- Trial name
- NCT05133635
- Testing
- Methylprednisolone, Tocilizumab
- Sponsor
- Marmara University
COVID-19, Acute Respiratory Distress Syndrome
Study of Immunomodulation Using Naltrexone and Ketamine for COVID-19
Ideal new treatments for Novel Coronavirus-19 (COVID-19) would help halt the progression disease in patients with mild disease prior to the need for artificial respiration (ventilators), and also provide a rescue treatment for…
- Conditions
- COVID-19, Acute Respiratory Distress Syndrome, Severe Acute Respiratory Syndrome (SARS), Coronavirus Infections
- Trial name
- SINK COVID-19 (NCT04365985)
- Testing
- Naltrexone, Ketamine
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Corewell Health East
Long COVID-19 Syndrome, Long COVID Symptoms
Epigenetic Changes in Long COVID Patients
The goal of this observational study is to improve the understanding of the biological mechanisms underlying long COVID and to identify molecular biomarkers that may support its diagnosis, prognosis, and future precision medicine…
- Trial name
- ECLIPSE (NCT07757620)
- Where
- 3 sites in Italy
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
COVID19, Sepsis or Other Causes, Acute Respiratory Distress Syndrome
A Study of Liposomal Trans Crocetin, LEAF-4L6715, in Patients With Acute Respiratory Distress Syndrome Due to COVID-19, Sepsis or Other Causes
This is an open label phase II study of treatment with LEAF-4L6715 in patients who experience severe acute respiratory distress syndrome (ARDS) due to COVID-19, Sepsis or other Causes.
- Trial name
- NCT04378920
- Testing
- LEAF-4L6715
- Where
- 2 sites in France
- Volunteers
- 37 people
- Sponsor
- Institut de cancérologie Strasbourg Europe
Malignant Pleural Mesothelioma (MPM)
Multidimensional Omics Analysis in Malignant Pleural Mesothelioma
Malignant pleural mesothelioma (MPM) is a rare and incurable cancer. Most patients are diagnosed with unresectable disease for which treatment options are limited.
- Trial name
- OMIM (NCT07561190)
- Where
- 4 sites in Italy
- Volunteers
- 300 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Cytokine Release Syndrome
Safety and Tolerability Study of IV ST266 in COVID-19 Subjects
The primary aim of the study is to evaluate the safety and tolerability of open-label ST266 given to subjects with confirmed COVID-19 infection through IV administration once a day of 5 consecutive days.
- Trial name
- NCT04720378
- Testing
- ST266
- Where
- 3 sites in United States
- Volunteers
- 12 people
- Sponsor
- Noveome Biotherapeutics, formerly Stemnion
Asthma
Asthma (and Dietary) Inflammation Reduction
The purpose of this study is to evaluate the effects of a diet that is low in glycemic load and abundant in fiber, fruits, vegetables, legumes and omega-3 fatty acids ("anti-inflammatory diet") on pulmonary function in pediatric…
- Trial name
- AIR (NCT01996891)
- Testing
- Anti-Inflammatory Diet
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Boston Children's Hospital
COVID-19
A Study to Assess the Efficacy and Safety of Gimsilumab in Subjects With Lung Injury or Acute Respiratory Distress Syndrome Secondary to COVID-19 (BREATHE)
Study KIN-1901-2001 is a multi-center, adaptive, randomized, double-blind, placebo-controlled study to assess the efficacy and safety of gimsilumab in subjects with lung injury or acute respiratory distress syndrome (ARDS)…
- Trial name
- NCT04351243
- Testing
- Gimsilumab
- Where
- 33 sites in United States
- Volunteers
- 227 people
- Sponsor
- Kinevant Sciences GmbH
Asthma, Allergic, Rhinitis,Allergic
Effects of Intranasal Fluticasone Plus Azelastine on Airway Inflammation in Patients With Asthma & Allergic Rhinitis
Single centre, double-blind, placebo controlled, adaptive design, cross-over trial. The primary objective is to assess the additive effects of using combined intranasal fluticasone propionate plus azelastine nasal spray on airway…
- Conditions
- Asthma, Allergic, Rhinitis,Allergic, Allergy
- Trial name
- MAN06 (NCT02953106)
- Testing
- Azelastine-Fluticasone Nasal
- Where
- United Kingdom
- Volunteers
- 7 people
- Sponsor
- University of Dundee
Empyema, Pneumonia
Urokinase Versus Video-assisted Thoracoscopic to Treat Complicated Parapneumonic Empyema in Childhood
A great controversy exists about which is the best method to perform the evacuation of the collection. The purpose of this study is to evaluate which is the best initial treatment to drain complicated parapneumonic empyema…
- Trial name
- NCT00798278
- Testing
- Urokinase, Video-Assisted Thoracoscopic
- Where
- 6 sites in Spain
- Volunteers
- 200 people
- Sponsor
- Spanish Society of Pediatric Surgery
Critical Illness
Optimization Dose Study on Pharmacokinetics and Pharmacodynamics of Colistin in Critically Ill Patients
Phase II clinical trial, open-labelled, prospective and single-center study directed to obtain blood samples in experimental detailed conditions in order to compare and optimize the dose of colistin in critically ill patients…
- Trial name
- COLPHAR (NCT02408185)
- Testing
- Colistin 6 million units + 240mg/8h, Colistin 6 million units + 360mg/12h
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Pulmonary Disease, Chronic Obstructive, Airway Disease
Innate Immunity in Ozone-induced Airway Inflammation in COPD
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death in the United States. Patients with COPD are routinely exposed to indoor and outdoor air pollution, which appears to cause escalation of their…
- Conditions
- Pulmonary Disease, Chronic Obstructive, Airway Disease, COPD Exacerbation, Pollution; Exposure
- Trial name
- CO3PD (NCT04669743)
- Testing
- Ozone exposure
- Where
- 3 sites in United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Asthma
Neural Mechanisms in Asthma
Asthma is a chronic disease that affects nearly 13% of adults in the U.S., causing substantial impairment that is reflected in the tens of millions of missed days of work, and doctors' and emergency room visits it leads to…
- Trial name
- NCT01155843
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Empyema, Pleural, Pleural Infection
Chest Drain Regular Flushing in Complicated Parapneumonic Effusions and Empyemas
Infections of the pleural space are common, and patients require antibiotics and chest drain placement to evacuate the chest from the infected fluid. Chest drains can get blocked by the drainage fluid and material.
- Trial name
- RELIEF (NCT06427538)
- Testing
- Saline Flush
- Where
- 5 sites in United States
- Volunteers
- 96 people
- Sponsor
- Vanderbilt University Medical Center
Asthma
Exhaled Breath Condensate as a Measure of Airway Inflammation in Children With Asthma
This study will evaluate the usefulness of a new procedure for evaluating asthma in children. The method measures the pH (a measure of acidity and alkalinity) of exhaled breath condensate (water vapor created by the lungs).
- Trial name
- NCT00078208
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Chronic Obstructive Pulmonary Disease
Efficacy of Simvastatin for the Treatment of COPD
To evaluate in patients with stable Chronic Obstructive Pulmonary Disease (COPD) the efficacy of statins (simvastatin) on: (1) endothelial function; (2) systemic inflammation; (3)BODE (B: body mass , O: bronchial obstruction, D…
- Trial name
- NCT02070133
- Testing
- Simvastatin
- Where
- 2 sites in Spain
- Volunteers
- 18 people
- Sponsor
- Hospital Universitari Son Dureta
Sepsis, Pneumonia
Benefit of Clarithromycin in Patients With Severe Infections Through Modulation of the Immune System
High mortality associated with sepsis and Multiple Organ Dysfunction Syndrome (MODS) calls for alternative, individualized therapies in selected patients that might benefit form specific interventions.
- Conditions
- Sepsis, Pneumonia, Gram-Negative Bacteria Infection, Multiple Organ Failure
- Trial name
- INCLASS (NCT03345992)
- Testing
- Clarithromycin, Water for injection
- Where
- 12 sites in Belgium, Greece
- Volunteers
- 110 people
- Sponsor
- Hellenic Institute for the Study of Sepsis
Sex Differences in Immune Response, Acute Inflammatory Diseases in Children
Study of the Sex Differences in Inflammatory Diseases in Children
Sexual differences in innate immune response have been demonstrated and were mainly attributed to the influence of the sex steroids (1-18).
- Trial name
- SepsiX (NCT04815811)
- Testing
- Blood collection, Stool collection
- Where
- Belgium
- Volunteers
- 160 people
- Sponsor
- Queen Fabiola Children's University Hospital
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