Clinical trials: Respiratory Inflammation
COVID-19, SARS-CoV2 Infection
Effect of IMMUNEPOTENT-CRP on Serum Pro-Inflammatory Cytokines in Mild to Moderate COVID-19
In this study, the effects of IMMUNEPOTENT-CRP (I-CRP), a dialyzable leukocyte extract (DLE) derived from bovine spleen cells, on the levels of key inflammatory cytokines in outpatients with COVID-19 were examined.
- Trial name
- ICRPDLECOVID (NCT06676709)
- Testing
- IMMUNEPOTENT-CRP (I-CRP)
- Where
- 2 sites in Mexico
- Volunteers
- 80 people
- Sponsor
- Universidad Autonoma de Nuevo Leon
Asthma, Hypersensitivity
Phase II Efficacy Study of Aerosolized Recombinant Human IL-4 Receptor in Asthma
Asthma is a chronic inflammatory disorder of the airways characterized by reversible airflow obstruction. Fourteen million persons (6.4%) in the United States report having asthma, and from 1980 to 1994 the prevalence of…
- Trial name
- NCT00001909
- Testing
- Soluble recombinantly produced IL-4R
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Parapneumonic Pleural Effusion, Empyema
Clinical Trial Corticoids For Empyema And Pleural Effusion In Children
STUDY JUSTIFICATION 1. Scientific evidence of the usefulness of corticosteroid use for infectious diseases: Corticosteroids along with antibiotic use improve survival in some infectious processes provide long term benefits and…
- Trial name
- CORTEEC (NCT01261546)
- Testing
- Dexamethasone
- Where
- 8 sites in Spain
- Volunteers
- 60 people
- Sponsor
- Hospital Infanta Sofia
COPD, OSA
The Effect of Exercise on Systemic Inflammation in Veterans With COPD and OSA
The overlap syndrome (OS), i.e. the association of both Chronic Obstructive Pulmonary Disease (COPD) and Obstructive Sleep Apnea (OSA) in a single Veteran, is prevalent and associated with increased cardiovascular disease (CVD)…
- Conditions
- COPD, OSA, Home Exercise, Inflammation
- Trial name
- NCT03431103
- Testing
- Exercise
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Salem Veterans Affairs Medical Center
Sepsis, Respiratory Failure
Safety, Tolerability and Performance of the NucleoCapture Device in the Reduction of Circulating CfDNA/NETs in Subjects with Sepsis
This is a prospective, multinational, multicentre, randomised, parallel-group, open-label study to assess the safety, tolerability and performance of the NucleoCapture extracorporeal apheresis device in the reduction of…
- Trial name
- NUC-CAP (NCT05647096)
- Testing
- NucleoCapture device
- Where
- 9 sites in Germany, Switzerland and 1 more
- Volunteers
- 73 people
- Sponsor
- Santersus AG
Respiratory Distress Syndrome, Adult
Understanding the Role of Genes and Biomarkers in the Inflammation and Blood Clotting Process in Children With Acute Lung Injury
Acute lung injury (ALI)/Acute Respiratory Distress Syndrome (ARDS) is a severe lung condition that causes respiratory failure. This study will examine if differences in genes and biomarkers involved in the inflammation and blood…
- Trial name
- PALI (NCT00605527)
- Where
- 5 sites in United States
- Volunteers
- 396 people
- Sponsor
- University of California, San Francisco
Heart Failure, Congestive, Renal Failure Acute Chronic
Effect of a Focused Point-of-care Ultrasonography Screening Protocol in Hospitalized Patients
This research project aims to establish a real-time focused ultrasound examination protocol for routine assessment of hospitalized patients, including evaluations of the inferior vena cava (IVC), pericardial effusion…
- Conditions
- Heart Failure, Congestive, Renal Failure Acute Chronic, Liver Cirrhosis, Sepsis
- Trial name
- NCT07656428
- Where
- Taiwan
- Volunteers
- 9,000 people
- Sponsor
- National Taiwan University Hospital
Asthma
Study Of Asthma In Patients Of African Descent
This study will last up to 62 weeks. You will visit the clinic up to 17 times. Certain clinic visits will include physical examination, medical history review and lung function tests.
- Trial name
- NCT00102765
- Testing
- fluticasone propionate/salmeterol powder, fluticasone propionate powder
- Where
- 75 sites in United States
- Volunteers
- 479 people
- Sponsor
- GlaxoSmithKline
Health Knowledge, Attitudes, Practice, Sneezing
"Anticipatory Guidance in the Nursery and Its Impact on Non-urgent Emergency Department Visits"
Kennedy et al, in a study of pediatric Emergency Department (ED) use by newborns less than 14 days of age, revealed that half of all visits in this population were non-acute problems.
- Conditions
- Health Knowledge, Attitudes, Practice, Sneezing, Constipation, Nasal Congestion and Inflammations
- Trial name
- NCT01859065
- Testing
- Intensified anticipatory guidance, Routine
- Where
- United States
- Volunteers
- 323 people, healthy volunteers welcome
- Sponsor
- Bronx-Lebanon Hospital Center Health Care System
COPD, Inflammation
A Multi-Center Study of Rehabilitation to Stable Chronic Obstructive Pulmonary Disease (COPD) Patients
This is a multi-center prospective follow-up study. to choose the stable COPD patients in community to compare different modes of exercise (cycling and walking) to compare the effect of different exercises on the quality of…
- Trial name
- NCT00686660
- Testing
- cycling, walking, cycling, non-walking, walking, walking
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Beijing Chao Yang Hospital
Pulmonary Embolism
Diclofenac for Submassive PE
The primary objective is to demonstrate the clinical benefits of diclofenac (added to standard anticoagulant therapy) over placebo in normotensive patients with acute symptomatic pulmonary embolism and right ventricular…
- Trial name
- AINEP-1 (NCT01590342)
- Testing
- Diclofenac
- Where
- Spain
- Volunteers
- 34 people
- Sponsor
- Ministry of Health, Spain
Chronic Obstructive Pulmonary Disease
Changes in Inflammatory Markers During Pulmonary Rehabilitation Based on Exacerbation States in COPD
This study will examine the inflammatory response to exercise encompassed as part of a standard pulmonary rehabilitation programme in patients with chronic obstructive pulmonary disease (COPD).
- Trial name
- CIMPRES-COPD (NCT02740686)
- Testing
- Sample collection
- Where
- 6 sites in United Kingdom
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University of Lincoln
Vitamin D Deficiency, Cystic Fibrosis
Vitamin D and Microbiota in Cystic Fibrosis
The objective of this study is to assess the effects of a high-dose vitamin D3 on the composition of gut and lung microbiota in adolescents and adults with cystic fibrosis who are vitamin D deficient.
- Trial name
- NCT02589444
- Testing
- High-Dose Vitamin D3, Stool Sample, Sputum Sample
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Emory University
Chronic Obstructive Pulmonary Disease
Systemic Inflammation in Chronic Obstructive Pulmonary Disease (COPD)
COPD is ranked number 3 by the WHO list of important diseases worldwide and is the only disease with increasing mortality. The pathogenesis of cigarette smoke-induced COPD is obscure, therefore more insight is needed to design…
- Trial name
- NCT00850863
- Where
- Netherlands
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Top Institute Pharma
New Onset Atrial Fibrillation, Sepsis
Rapid Atrial Fibrillation Treatment Strategy
Prospective, randomized, open-label clinical trial studying the treatment of new onset atrial fibrillation in critically ill patients with septic shock.
- Conditions
- New Onset Atrial Fibrillation, Sepsis, Respiratory Failure
- Trial name
- RAFTS (NCT04092621)
- Testing
- Amiodarone in Parenteral Dosage Form, Amiodarone Pill, Direct Current Cardioversion (DCC)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Our Lady of the Lake Hospital
Chronic Obstructive Pulmonary Disease (COPD), Exacerbation Copd
Determinants of Lower Limb Muscle Atrophy Induced During an Hospitalization for Exacerbation of COPD
Chronic Obstructive Pulmonary Disease (COPD) is characterized by persistent airway obstruction and inflammatory response of the lungs and bronchi.
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Exacerbation Copd, Muscle Atrophy
- Trial name
- AMI-EX-BPCO (NCT03153826)
- Testing
- Comparison of clinical and biological characteristics of patients
- Where
- France
- Volunteers
- 9 people
- Sponsor
- University Hospital, Montpellier
Obstructive Chronic Pulmonary Disease, Emphysema
Effects of Exercise Training on Systemic Inflammation an Muscle Repair According to the Obstructive Chronic Pulmonary Disease (COPD) Phenotype
AIM: To identify those mechanisms involved in the systemic and muscular response to exercise treatment, in two different Obstructive Chronic Pulmonary Disease (COPD) phenotypes (emphysema and non-emphysema).
- Conditions
- Obstructive Chronic Pulmonary Disease, Emphysema, Chronic Bronchitis
- Trial name
- NCT01431625
- Testing
- Combined Training (endurance and strength exercises)
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Hospitales Universitarios Virgen del Rocío
Idiopathic Pulmonary Fibrosis, Obstructive Sleep Apnea
Effect of CPAP on Abnormal Gastroesophageal Reflux and Lung Inflammation in IPF
This study will evaluate the effect of CPAP therapy on esophageal pH and lung inflammation in patients with idiopathic pulmonary fibrosis (IPF) and sleep apnea.
- Conditions
- Idiopathic Pulmonary Fibrosis, Obstructive Sleep Apnea, Gastro Esophageal Reflux
- Trial name
- NCT05359965
- Testing
- Positive Airway Pressure
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Arizona
Myocardial Infarction, Inflammation
Inflammation in Type 2 Myocardial Infarction
Type 2 myocardial infarction (MI) is defined as myocardial necrosis that results from an imbalance of myocardial oxygen supply and demand.
- Conditions
- Myocardial Infarction, Inflammation, Critical Illness
- Trial name
- NCT02385487
- Where
- United States
- Sponsor
- NYU Langone Health
Sinusitis, Maxillary Sinusitis
A Study of the Safety and Effectiveness of Levofloxacin Compared With Amoxicillin/Clavulanate Potassium in the Treatment of Adults With Rapid Onset of Severe Inflammation/Infection of the Sinuses
The purpose of this study is to evaluate the safety and effectiveness of levofloxacin, an antibiotic, compared with amoxicillin/clavulanate potassium in the treatment of adults with rapid onset of severe inflammation/infection of…
- Trial name
- NCT00249210
- Testing
- levofloxacin
- Volunteers
- 614 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
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