Clinical trials: Respiratory Physiological Phenomena
Asthma Acute, Asthma in Children
User-Friendly Spirometer and Mobile App for Self-Management and Home Monitoring of Asthma Patients
The primary goal of this proposal is to use an in-home, smartphone-enabled, hand-held spirometer to determine the FEV1% predicted ranges that predict the Yellow Zone threshold.
- Conditions
- Asthma Acute, Asthma in Children, Asthma Chronic, Asthma Attack
- Trial name
- NCT03642418
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Francisco
Idiopathic Pulmonary Fibrosis
NAL ER IPF Respiratory Function and Safety Study
The primary purpose of this study is to assess the safety and tolerability of escalating doses of NAL ER and to evaluate its effect on respiratory function in participants with IPF.
- Trial name
- NCT07036029
- Testing
- NAL ER
- Where
- 2 sites in United States, United Kingdom
- Volunteers
- 9 people
- Sponsor
- Trevi Therapeutics
Heart Failure
CHANges iN skEletal muscLe in Heart Failure
The mechanisms behind heart failure are largely unknown. Despite an increasing arsenal of pharmacological therapies, cardiovascular disease is still the most common cause of death in the western world, which demonstrates a…
- Trial name
- Channel-HF (NCT03401151)
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Karolinska Institutet
Asthma
Zileuton and Exhaled Nitric Oxide in Asthmatics
Evaluate the additive role of zileuton 600mg qid to clinically stable asthmatics on Advair 250/50 bid. Since asthma is an endogenous inflammatory disease there usually is increased total exhaled, bronchial and alveolar nitric…
- Trial name
- NCT00575861
- Testing
- zileuton
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Gelb, Arthur F., M.D.
Lung Cancer, Pneumonitis
Incentive Spirometry to Improve Outcomes in Lung Cancer Patients Undergoing Concurrent Chemotherapy and Radiation Therapy
The goal of this clinical trial is to learn if using an incentive spirometer can reduce lung problems in people with advanced lung cancer who are receiving chemotherapy and radiation therapy.
- Conditions
- Lung Cancer, Pneumonitis, Radiation-Induced Lung Injury, Immunotherapy-Induced Pneumonitis
- Trial name
- INSPIRE-CRT (NCT06688422)
- Testing
- incentive spirometry
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- The Cooper Health System
Respiratory Muscle, Exercise
The Effect of Functional Respiratory Muscle Training on Respiratory Function and Physical Performance
The study aims to investigate the effects of core stabilization exercise, which includes functional respiratory muscle training, on respiratory function, aerobic capacity, trunk stabilization, and physical performance in football…
- Trial name
- NCT06494930
- Testing
- F-IMT, Core Stabilization Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Istinye University
Core Stability, Respiratory Function
Effects of Diaphragmatic Breathing During Equipment-Based Pilates in Women
This randomized controlled study aims to investigate the effects of diaphragmatic breathing exercises on core stabilization muscle strength, peak expiratory flow (PEF), and chest expansion in women performing equipment-based…
- Conditions
- Core Stability, Respiratory Function, Diaphragmatic Breathing
- Trial name
- NCT07652229
- Testing
- Diaphragmatic Breathing Exercise, Equipment-Based Pilates Training
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Istanbul Aydın University
Pulmonary Ventilation
Exposure of Taxi Drivers to Ultrafine Particles and Black Carbon Within Their Vehicles
Brief Summary Short description of the protocol intended for the lay public. Include a brief statement of the study hypothesis. (Limit: 5000 characters) Example: The purpose of this study is to determine whether prednisone…
- Trial name
- PUF-TAXI (NCT03839537)
- Testing
- Exposure measurement, Spirometry test, Exhaled carbon monoxide test
- Where
- France
- Volunteers
- 56 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Organ Protection
Effects of Dexmedetomidine on Respiratory Function and Inflammatory Responses in Patient With Sepsis Undergoing Cleaning Focus of Infection
The purpose of this study is to assess the efficacy of dexmedetomidine on lung protection in patient with sepsis undergoing cleaning focus of infection.
- Trial name
- NCT02842437
- Testing
- dexmedetomidine, normal saline
- Where
- China
- Volunteers
- 50 people
- Sponsor
- General Hospital of Ningxia Medical University
Laparoscopic Renal Surgery, Laparoscopy
Effects of Deep Neuromuscular Blockade on Intraoperative Respiratory Mechanics
The primary objective of the current study is to compare intraoperative respiratory mechanics in patients receiving laparoscopic renal surgery under deep neuromuscular blockade (dNMB) and under moderate neuromuscular blockade…
- Conditions
- Laparoscopic Renal Surgery, Laparoscopy, Muscle Relaxation
- Trial name
- NCT02185339
- Testing
- Rocuronium
- Where
- South Korea
- Volunteers
- 61 people
- Sponsor
- Seoul St. Mary's Hospital
Analgesia
ESP Versus PIFB for Analgesia in Open Cardiac Surgery: a Randomized Control Trial
This clinical trial compares analgesia efficiency and recovery outcomes between two different fascial plane block techniques (ESPB vs.PIFB) in cardiac surgery patients participant population/health conditions].
- Trial name
- NCT06322810
- Testing
- Erector spinae plane block (ESPB), Pecto-intercostal fascial plane blok (PIFB)
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Taichung Veterans General Hospital
Chronic Obstructive Pulmonary Disease
Computed Tomography (CT) and Lung Function Data Collection for Computational Fluid Dynamics (CFD) in Chronic Obstructive Pulmonary Disease (COPD) Patients
In this study, 20 COPD patients will undergo a high-resolution/multi slice CT scan and lung function tests to obtain patient specific geometries of the central and peripheral small airways and patient specific boundary…
- Trial name
- NCT00966459
- Testing
- Computed Tomography
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- University Hospital, Antwerp
Cystic Fibrosis
Effectiveness of Respiratory Physiotherapy on Frequency of Exacerbations, Lung Function and Quality of Life After 6 Months in Children With Cystic Fibrosis
Daily respiratory physiotherapy is a fundamental part of cystic fibrosis treatment, however, patients adherence is low. Thus, there is a need for studies that evaluate the impact of physiotherapy supervision in patients with…
- Trial name
- NCT07088614
- Testing
- Remote respiratory physiotherapy
- Where
- Chile
- Volunteers
- 9 people
- Sponsor
- University of Americas - Chili
PET/CT, COVID-19
Study for Quantitative Analysis of the Recovered COVID-19 Patients by 18F-FDG-PET/CT
In this study, clinically cured patients with severe COVID-19 were used to evaluate the therapeutic effect of COVID-19 and the recovery and health status of patients over time with highly sensitive PET/CT imaging technology.
- Conditions
- PET/CT, COVID-19, Respiratory Function, Inflammatory Lesions
- Trial name
- NCT04519255
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fifth Affiliated Hospital, Sun Yat-Sen University
Stroke
Effects of Inspiratory Muscle Training on Stroke Rehabilitation Outcomes
This study is designed to explore the effects of a 4-week protocol of inspiratory muscle training (IMT) at 50% maximum inspiratory pressure (MIP) on respiratory function, diaphragm thickness, balance control, exercise capacity…
- Trial name
- NCT06640101
- Testing
- IMT-stable group (sitting on a stable surface), IMT-unstable group (sitting on an unstable surface), Conventional treatment
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Hong Kong Metropolitan University
Esophageal Cancer
Effect of Concurrent Chemoradiation Therapy on Respiratory Muscle Performance, Lung Function and Functional Capacity in Patients With Local Esophagus Cancer
The purpose of this study is to investigate the effect of concurrent chemoradiation therapy on respiratory muscle performance, lung function and functional capacity in patients with local esophagus cancer.
- Trial name
- NCT03120572
- Where
- Taiwan
- Volunteers
- 45 people
- Sponsor
- Mackay Memorial Hospital
Aging
Effects of Exergames on Muscle and Lung Function in Elderly
The goal of this study is to examine the effects of 8-weeks exergames program on pulmonary function, muscle strength and cognitive function in elderly.
- Trial name
- NCT06921057
- Testing
- exergame
- Where
- Taiwan
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Chang Gung University
Asthma
Mechanism(s)of Airflow Limitation in Moderate-severe Persistent Asthma
The purpose of this study is to evaluate the site and mechanisms responsible for expiratory airflow limitation in chronic, treated, non-smoking, stable asthmatics with moderate to severe persistent expiratory airflow obstruction.
- Trial name
- NCT00576069
- Testing
- budesonide/formoterol, fluticasone/salmeterol, mometasone/formoterol
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Gelb, Arthur F., M.D.
Disorder Related to Lung Transplantation, Bronchiolitis Obliterans
Aerosol Liposomal Cyclosporine for Chronic Rejection in Lung Transplant Recipients
This is a single-center pilot study to investigate the efficacy and safety of aerosolized liposomal cyclosporine A in the treatment of chronic rejection in lung transplant recipients with bronchiolitis obliterans syndrome (BOS).
- Conditions
- Disorder Related to Lung Transplantation, Bronchiolitis Obliterans, Decreased Immunologic Activity, Chronic Rejection of Lung Transplant
- Trial name
- NCT01650545
- Testing
- Liposomal aerosol cyclosporine, standard immune suppression, oral
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Maryland, Baltimore
Growth Hormone Deficiency
Observational Longitudinal Study in Children Affected by Idiopathic Growth Hormone Deficiency (GHD)
The aim of this study is to assess the developmental patterns of lung function in children affected by growth hormone deficiency after one year of GH therapy.The assessment by specific questionnaires of quality of life and of…
- Trial name
- GHD (NCT02507245)
- Testing
- Growth Hormone-Releasing Hormone
- Volunteers
- 48 people
- Sponsor
- Stefania La Grutta, MD
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