Clinical trials: Respiratory Physiological Phenomena
Exposure to Environmental Pollution, Non-occupational
Interaction Effects of Temperature and Ozone
Purpose: The purpose of this protocol is to understand how individuals respond to the air pollutant ozone at elevated temperatures.
- Trial name
- TROPICOZ (NCT01981135)
- Testing
- Clean Air, Ozone
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Environmental Protection Agency (EPA)
Lung Diseases, Obstructive, Postoperative Complications
Preoperative Diagnostic Tests for Pulmonary Risk Assessment in COPD
This prospective study intends to investigate the incidence of postoperative pulmonary complications (PPC) or in-hospital mortality in patients with COPD or at risk for COPD undergoing high-risk noncardiac major surgery and to…
- Trial name
- PredicT (NCT02566343)
- Where
- Germany
- Volunteers
- 365 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Chronic Obstructive Pulmonary Disorder
Study to Assess Efficacy and Safety of PT009 Compared to PT005, PT008, and Symbicort® Turbuhaler® on Lung Function Over 24-Weeks in Subjects With Moderate to Very Severe COPD
This is a Phase III randomized, double-blind, parallel group, multi-center, 24-week lung function study with BFF MDI (320/9.6 μg and 160/9.6 μg) compared to FF MDI 9.6 μg, BD MDI 320 μg, and open-label Symbicort® TBH (200/6 μg)…
- Trial name
- telos (NCT02766608)
- Testing
- BFF MDI 320/9.6 μg, BFF MDI 160/9.6 μg, FF MDI 9.6 μg
- Where
- 259 sites in United States, Canada and 6 more
- Volunteers
- 2,389 people
- Sponsor
- Pearl Therapeutics, Inc.
Fontan Operation
Pulmonary Functions Test in Patients After Fontan Operation
Developed in the early 1970s, Fontan Operation has provided palliative care for patients with single ventricle physiology. Single ventricle is a rare subclass of the atrioventricular (AV) alignment abnormalities double inlet and…
- Trial name
- NCT01413308
- Volunteers
- 15 people
- Sponsor
- Rambam Health Care Campus
Neuromuscular Diseases in Children
Mechanical Insufflator/Exsufflator Technique in Children With Neuromuscular Disease
In a randomized cross-over design, two different modes of a mechanical insufflator/exsufflator applied to pediatric subjects with neuromuscular disease will be compared with respect to their short term effect on lung function…
- Trial name
- MINEX-2 (NCT05454215)
- Testing
- Mechanical insufflation/exsufflation conventional, Mechanical insufflation/exsufflation modified
- Where
- Switzerland
- Volunteers
- 7 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Wheezing
Nebulized Beclomethasone Dipropionate Improves Respiratory Lung Function in Preschool Children With Recurrent Wheezing
This is a single-centre, open label study, aiming to evaluate the efficacy of beclomethasone dipropionate applied for 12 weeks with a dose of 400 µg twice a day (total dose 800 µg nebulized), on airway resistance and reactances…
- Trial name
- NCT02381158
- Testing
- Nebulized beclomethasone dipropionate
- Volunteers
- 12 people
- Sponsor
- Istituto per la Ricerca e l'Innovazione Biomedica
Asthma
The Effect of Single Dose Paracetamol on the Lower Airways of Asthmatic and Healthy Children
Asthma is a common inflammatory airway disease. Several researches have demonstrated a possible connection between asthma and exposure to paracetamol.
- Trial name
- NCT01073748
- Testing
- paracetamol
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Using Functional Lung MRI to Explore Pulmonary Perfusion Changes in Patients With Pulmonary Fibrosis and Emphysema Syndrome
Magnetic Resonance Lung Function Imaging Study of Pulmonary Fibrosis Combined With Emphysema Syndrome
This study intends to use magnetic resonance pulmonary function imaging technology to explore imaging markers for early diagnosis of patients with CPFE.
- Trial name
- NCT06431555
- Testing
- MRI
- Where
- China
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Beijing Chao Yang Hospital
COVID-19 Pneumonia
Exercise Training Six-Months After Discharge in Post-COVID-19 Syndrome
The goal of this study investigate the effects of 12-week exercise training on pulmonary function, symptoms, functional capacity, and quality of life (QoL) in patients with severe COVID 6 months after intensive care discharge.
- Trial name
- NCT05739032
- Testing
- Aerobic exercise and strength training
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Ukbe Sirayder
Hernias, Diaphragmatic, Congenital
Resistance Exercise in Children With Post-operative Congenital Diaphragmatic Hernia
Congenital diaphragmatic hernia (CDH) is a life-threatening condition with long-term complications including respiratory tract infections, respiratory muscle weakness, and abnormal lung functions.
- Trial name
- hernia (NCT04900649)
- Testing
- chest resistance exercise, chest expansion exercises
- Where
- Saudi Arabia
- Volunteers
- 32 people
- Sponsor
- Qassim University
Long-term Effects Secondary to Cancer Therapy in Children, Pulmonary Complications
Study of Lung Function in Children Who Have Undergone Bone Marrow Transplantation
RATIONALE: Assessing the long-term effects of bone marrow transplant on lung function in patients may improve the ability to plan treatment.
- Trial name
- NCT00009711
- Testing
- management of therapy complications
- Where
- United States
- Volunteers
- 280 people
- Sponsor
- Fred Hutchinson Cancer Center
Mild Persistent Asthma
Dose Response AMP Challenge Study With Beclometasone Dipropionate (BDP)/Formoterol Pressurised Metered Dose Inhaler (pMDI)
The aim of this exploratory investigation is to evaluate if the Forced Expiratory Volume in the 1st second (FEV1) measurements, fractional exhaled nitric oxide (FENO) and Provocative Concentration 20 (PC20) after Adenosine…
- Trial name
- NCT01343745
- Testing
- BDP/formoterol
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
Chronic Obstructive Pulmonary Disease, Nasal High Flow
Investigating the Effect of Nasal High Flow Oxygen Therapy on Regional Lung Function
This study aims to assess the effect of nasal high flow oxygen therapy on regional function measured by volumetric computed tomography, in patients with chronic obstructive pulmonary disease.
- Conditions
- Chronic Obstructive Pulmonary Disease, Nasal High Flow, Dynamic Volumetric Computed Tomography
- Trial name
- INVENT (NCT03821311)
- Testing
- Computed tomography
- Where
- France
- Volunteers
- 8 people
- Sponsor
- University Hospital, Grenoble
Spinal Cord Injury
Effect of Immersion Level on Respiratory Function of Spinal Cord Injury Patients During Balneotherapy
Balneotherapy is a physiotherapy technique which allows patients to work out in a weightless environment and which is often used in patients with spinal cord injury.
- Trial name
- BALNEORESPI (NCT01831414)
- Testing
- Water immersion at cervical level, Water immersion at xyphoid level
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Centre d'Investigation Clinique et Technologique 805
Heart Failure
REmoTe TelenURsiNg on Lung Function of Heart Failure Outpatients
Pulmonary dysfunction presented in patients with heart failure is observed as a decrease of maximal aerobic capacity compared to healthy people.
- Trial name
- RETURN-001 (NCT02387190)
- Testing
- Telenursing monitoring
- Where
- Brazil
- Volunteers
- 156 people
- Sponsor
- Federal University of Bahia
Spina Bifida
Motor Imagery-Supported Thoracic Expansion in Children With Spina Bifida
This study will investigate whether adding motor imagery to thoracic expansion exercises can improve respiratory function in children with spina bifida.
- Trial name
- NCT07846202
- Testing
- Thoracic Expansion Exercises, Motor Imagery-Supported Thoracic Expansion Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Karabuk University
Spinal Cord Injuries, Cervical Spinal Cord Injury
Neurostimulation for Respiratory Function After Spinal Cord Injury
The purpose of this research study is to learn more about the connections between the brain, nerves, and diaphragm after experiencing a cervical spinal cord injury (SCI).The main question it aims to answer is: Changes in…
- Conditions
- Spinal Cord Injuries, Cervical Spinal Cord Injury, Respiratory Function Impaired
- Trial name
- NCT05756894
- Testing
- Neurostimulation, Repiratory training
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Shirley Ryan AbilityLab
Pulmonary Fibrosis, COPD
Multiple Breath Washout as a Method for Diagnosing Lung Diseases
Comparison of the new multiple-breath washout method (ndd Medizintechnik Zürich, Trueflow™/Truecheck™) with established methods of lung function diagnostics in patients with idiopathic pulmonary fibrosis, chronic obstructive…
- Conditions
- Pulmonary Fibrosis, COPD, Asthma
- Trial name
- NCT06179342
- Testing
- Multiple-Breath-Washout
- Where
- Germany
- Volunteers
- 90 people
- Sponsor
- Wissenschaftliches Institut Bethanien e.V
Healthy, Body Weight
The Effect of Body Composition on Respiratory Parameters, Functional Capacity and Sleep in Healthy Young Adults
Body composition has a significant effect on the respiratory system. Both respiratory prediction of function and a prognostic tool evaluated in the cardiopulmonary system factor.
- Trial name
- NCT06507969
- Testing
- The Effect of Body Composition on Respiratory Parameters, Functional Capacity and Sleep in Healthy Young Adults
- Where
- Turkey (Türkiye)
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Istanbul Kent University
Cystic Fibrosis
Evaluation of Sit-to-stand Test in Patients With Cystic Fibrosis and Matched Controls.
Introduction: In recent years, since the discovery of the cystic fibrosis (CF) transmembrane conductance regulator gene in human skeletal muscle, there appears to be growing interest in the measurement of muscle function in CF.
- Trial name
- STS-CF (NCT03524859)
- Where
- Spain
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Universidad Católica San Antonio de Murcia