Clinical trials: Respiratory Support
COVID, Pregnancy Complications, Infectious
International Lung UltraSound Analysis (ILUSA) Study
Currently there is a great need for an accurately and rapid assessment of patients suspected for Covid-19. Like CT, Lung Ultrasound (LUS) examination can potentially help with the initial triage of patients but also help track…
- Conditions
- COVID, Pregnancy Complications, Infectious, Pregnancy Related, Pregnancy, High Risk
- Trial name
- ILUSA (NCT04353141)
- Testing
- standardized Lung Ultrasound (LUS) examination
- Where
- 7 sites in Belgium, Italy and 1 more
- Volunteers
- 1,850 people
- Sponsor
- KU Leuven
Respiratory Distress Syndrome, Adult
Ultra-protective Pulmonary Ventilation Supported by Low Flow ECCO2R for Severe ARDS
This study evaluates the use of ultra-protective ventilation, where very low ventilation volumes are used, in patients with severe acute respiratory distress syndrome (ARDS) meeting criteria to nurse in the prone position.
- Trial name
- U-Protect (NCT02252094)
- Testing
- Prismalung, Ultra-protective ventilation, Conventional Lung Protective Ventilation
- Where
- 2 sites in Singapore
- Volunteers
- 8 people
- Sponsor
- National University Health System, Singapore
Lung Cancer
Implementation of Up-front ctDNA Into Lung Cancer Care and Development of Liquid Biopsy-based Decision Support Models - LM² Study
Despite scientific evidence, use of liquid biopsy (LB) in diagnosis and monitoring of lung cancer (LC) is limited since it requires major changes in diagnostic and care pathways.
- Trial name
- LM2 (NCT06105177)
- Where
- 5 sites in Netherlands
- Volunteers
- 800 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
COVID-19
A Clinical Trial to Determine the Safety and Efficacy of HB-adMSCs to Provide Protection Against COVID-19
Hope Biosciences is conducting a research study of an investigational product called autologous adipose-derived mesenchymal stem cells (abbreviated as HB-adMSCs) to provide immune support against COVID-19.
- Trial name
- NCT04349631
- Testing
- HB-adMSCs
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Hope Biosciences Research Foundation
Sleep Disordered Breathing (SDB), Cerebral Palsy (CP)
Experiences of Managing Sleep Disordered Breathing in Children With Cerebral Palsy.
Cerebral palsy (CP) refers to a non-progressive movement disorder, which occurs due to damage to the developing brain around the time of birth.
- Conditions
- Sleep Disordered Breathing (SDB), Cerebral Palsy (CP), Respiratory Support
- Trial name
- QualSDB_CP (NCT06753370)
- Where
- 2 sites in United Kingdom
- Volunteers
- 24 people
- Sponsor
- University of Edinburgh
Asthma
Investigation of the Role of Pictorial Asthma Action Plans to Promote Self-management in Rural Youth With Asthma
The aim of this study is to investigate the potential benefit of Pictorial versus Written Asthma Action Plans (AAPs) to support asthma management among young people with persistent asthma.
- Trial name
- TAAC (NCT03187119)
- Testing
- Pictorial Asthma Action Plan, Written Asthma Action Plan
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- West Virginia University
Idiopathic Pulmonary Fibrosis
Homecare Integral Support Program for IPF Patients
Homecare patient support program especially designed for covering IPF patient needs, implemented for 12 months, for improving quality of life
- Trial name
- PSPi-IPF (NCT05173571)
- Testing
- Comprehensive patient support program (educational, physiotherapy, nutritional, emotional)
- Where
- Spain
- Volunteers
- 95 people
- Sponsor
- Institut d'Investigació Biomèdica de Bellvitge
Care, Palliative, Respiratory Failure
RENOVATE Palliative: HFNC vs. Standard Respiratory Support in Patients With Do-Not-Intubate Order and ARF
Randomized clinical trial in which the main objective is to compare High Flow Nasal Cannula (HFNC) versus the standard respiratory care in the alleviation of dyspnea perception in patients with do-not-intubate (DNI) order.
- Trial name
- NCT04269681
- Testing
- High Flow Nasal Cannula, Standard respiratory support
- Where
- Brazil
- Volunteers
- 3 people
- Sponsor
- Hospital do Coracao
Respiratory Insufficiency, Respiratory Failure
Entrainment-Based Mechanical Ventilation
BACKGROUND AND SIGNIFICANCE Entrainment-based ventilation is a new mode of mechanical ventilation based on the classical physics theory of mutual entrainment between coupled oscillators.
- Conditions
- Respiratory Insufficiency, Respiratory Failure, Mechanical Ventilation Complication
- Trial name
- NCT03512067
- Testing
- Patients given EMV Ventilation
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Brigham and Women's Hospital
Chronic Obstructive Pulmonary Disease (COPD), Respiration Disorders
Retrospective Evaluation of the Implementation of a Digital Solution Supporting the Delivery of Pulmonary Rehabilitation Programs in Private Physiotherapy Practice
Pulmonary rehabilitation improves exercise capacity, functional status, symptoms and quality of life in individuals with chronic respiratory diseases.
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Respiration Disorders, Pulmonary Rehabilitation, Chronic Respiratory Diseases
- Trial name
- DIGILIB-RR (NCT07687836)
- Testing
- TELEREHAPP-supported pulmonary rehabilitation
- Where
- France
- Volunteers
- 50 people
- Sponsor
- ADIR Association
Covid19
Determination of the Hemoadsorption Impact as Adjunctive Treatment Upon the Support Therapy of COVID-19
A) Comparing the % of change in each clearances of pro-, and anti-inflammatory mediators (cytokine, chemokines and complement) in the COVID-19 patients treated with CytoSorb as compared to the same patient population who do not…
- Trial name
- NCT04518969
- Testing
- CytoSorb
- Where
- Belgium
- Volunteers
- 24 people
- Sponsor
- Dr David DE BELS
Respiratory Tract Infections, Influenza, Human
Idylla IFV-RSV Panel Clinical Testing
This clinical study will collect fresh samples and perform laboratory testing on fresh and archived samples as described in the protocol.
- Conditions
- Respiratory Tract Infections, Influenza, Human, Respiratory Syncytial Virus Infections
- Trial name
- RP1 (NCT02786381)
- Where
- United States
- Volunteers
- 213 people
- Sponsor
- Janssen Pharmaceutica N.V., Belgium
Pulmonary Edema - Acute
Comparison of Respiratory Support for Acute Pulmonary Edema
This study is a retrospective study. The demographic and vital signs of patients with acute pulmonary edema are retrospectively collected to compare the prognosis of patients after receiving different respiratory support.
- Trial name
- NCT06820112
- Testing
- mechanical ventilation
- Volunteers
- 200 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Cardiopulmonary Resuscitation
Pilot Study Comparing Ventilation Modes During CPR With Mechanical Compression Device.
Comparison of three ventilation modes (volume controlled, BIPAP and CPAP) during cardiopulmonary re-suscitation with a mechanical compression device in the emergency room.
- Trial name
- COVME (NCT03347175)
- Testing
- Volume controlled ventilation, Pressure controlled ventilation, CPAP mode
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Technical University of Munich
Ischemic Heart Disease, Hopelessness
Reducing Hopelessness Through Improved Physical Activity in Adults With Heart Disease: With COVID-19 Considerations
After a 30-year decline, heart disease is projected to increase up to 18% by 2030. Participation rates in cardiac rehabilitation remain extremely low and hopeless individuals are less likely to participate.
- Conditions
- Ischemic Heart Disease, Hopelessness, Physical Activity, Motivation
- Trial name
- Heart Up! (NCT03907891)
- Testing
- Motivational social support from nurse, Motivational social support from nurse with additional support from significant other, Attention control
- Where
- United States
- Volunteers
- 224 people
- Sponsor
- University of Illinois at Chicago
Respiratory Failure, Hypotension and Shock
Using Vasopressor Medication to Support Blood Pressure During Intubation Procedure
The purpose of this study is to investigate whether protocolized vasopressor use for patients with normal blood pressure undergoing rapid sequence intubation improves hemodynamic parameters and mitigates adverse events.
- Conditions
- Respiratory Failure, Hypotension and Shock, Hypotension on Induction, Intubation Complication
- Trial name
- RAPID PRESS (NCT05355974)
- Testing
- Norepinephrine, Lactated Ringers, Intravenous, normal saline
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Wright State University
Heart Failure NYHA Class III, Heart Failure NYHA Class IV
Family Palliative and End-of-Life Care for Advanced Heart Failure
Overall objective is to test whether the 5-weekly family home palliative and end-of-life care (FamPALcare) intervention educational and supportive sessions will improve rural home end-of-life and palliative care (EOLPC) for…
- Trial name
- NCT04153890
- Testing
- FamPALcare
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- West Virginia University
Pulmonary Disease, Chronic Obstructive, Respiratory Tract Diseases
Post-hospitalisation Nutritional Support and Gait Speed in COPD
To determine the feasibility of delivering different community nutritional interventions to chronic obstructive pulmonary disease (COPD) patients at moderate or severe risk of malnutrition following a hospitalisation for an acute…
- Conditions
- Pulmonary Disease, Chronic Obstructive, Respiratory Tract Diseases, Lung Diseases, Obstructive, Bronchitis, Chronic
- Trial name
- NCT02261350
- Testing
- Food fortification, Oral Nutritional Supplements
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Cystic Fibrosis
Pressure Support Ventilation During CF Exacerbations
Chest physiotherapy is recognized as a mainstay of cystic fibrosis therapy, and is particularly important during treatment of pulmonary exacerbations.
- Trial name
- NCT00008775
- Testing
- Pressure support ventilation
- Where
- United States
- Sponsor
- National Center for Research Resources (NCRR)
Medical Condition Requiring Extracorporeal Organ Support
The University of Freiburg Medical Center Extracorporeal Organ Support Device Registry
A prospective registry collecting pseudonymized clinical and treatment data from all patients treated with extracorporeal organ support (i.e., VV ECMO, VA ECMO, ECPR, Impella, IABP, and others) on the wards of the Department of…
- Trial name
- NCT05811780
- Where
- Germany
- Volunteers
- 1,500 people
- Sponsor
- University Hospital Freiburg