Clinical trials: Respiratory System
Chronic Neck Pain
Effects of Respiratory Muscle Training on Pulmonary Function
The study was conducted to determine the effects of respiratory muscle training on pulmonary function and musculoskeletal parameters in patients with chronic neck pain.
- Trial name
- NCT05588765
- Testing
- Neck stretching exercises
- Where
- Pakistan
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Lahore
Allergic Rhinitis
Clinical Validation of Birch Pollen in the EEU
The EEU has proven effective in multiple studies evaluating various aspects of seasonal allergic rhinitis. All previous EEU clinical trials have utilized ragweed or grass pollen as the allergen of choice for dispersal, due to the…
- Trial name
- NCT02351830
- Testing
- Birch Pollen, Nasal Brushing
- Where
- Canada
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Queen's University
Apnea, Sleep
Remifentanil in Adults With OSA
Obstructive Sleep Apnea (OSA) is the most common problem that affects sleep. People with this problem have their airway blocked or minimized, causing snoring or gasping while sleeping.
- Trial name
- AROSA (NCT02898792)
- Testing
- Targeted infusion of remifentanil
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Pandemic, COVID-19, Demodex Infestation
Could Wearing Face Mask Have Affected Demodex Parasite
This study aimed to examine whether wearing masks by healthy individuals during the Covid-19 pandemic created an environment for Demodex mites, by comparing it with the control group.
- Trial name
- NCT06185699
- Testing
- standard superficial skin biopsy (SSSB)
- Where
- Turkey (Türkiye)
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Nurhan Döner Aktaş
Thyroid Diseases, Hypocalcemia
Use of Prophylactic Steroids in the Prevention of Post-thyroidectomy Hypocalcaemia and Voice Dysfunction
Total thyroidectomy for benign surgical pathologies is associated with risks related to temporary hypocalcaemia and vocal quality dysfunction.
- Conditions
- Thyroid Diseases, Hypocalcemia, Vocal Cord Dysfunction
- Trial name
- NCT04752852
- Testing
- Dexamethasone
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Holy Family Hospital, Pakistan
Asthma
Comparison of Methacholine Bronchial Provocation With Wright and Devilbiss646 Nebulizers
The purpose of this study is to compare the diagnostic validity (sensitivity and specificity) and evaluate the safety of 2-min Tidal Breathing methacholine bronchial provocation tests with the Wright and Devilbiss646 nebulizers…
- Trial name
- NCT02502825
- Testing
- methacholine, Wright Nebulizer, Devilbiss646 Nebulizer
- Where
- China
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Guangzhou Institute of Respiratory Disease
Respiratory Insufficiency
Evaluation of Leak-free Bronchoscope Adapter
Patients who develop respiratory failure require the assistance of mechanical ventilation while recovering from their respiratory injury.
- Trial name
- NCT05288218
- Testing
- Leak-free Bronchoscope Adapter, Standard Bronchoscope Adapter
- Volunteers
- healthy volunteers welcome
- Sponsor
- Columbia University
Severe Acute Respiratory Syndrome
Study of Alferon® LDO (Low Dose Oral) in Normal Volunteers
The purpose of this trial is to conduct a randomized dose-ranging study to evaluate the safety and activity of orally administered low dose interferon alfa-n3 as an antiviral and immunomodulator in asymptomatic subjects with…
- Trial name
- NCT00215826
- Testing
- Alferon LDO
- Where
- Hong Kong
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- AIM ImmunoTech Inc.
Influenza
Study to Evaluate the Immunogenicity and Safety of GlaxoSmithKline (GSK) Biologicals' Quadrivalent Influenza Vaccine (GSK2282512A) Compared to Fluzone® Quadrivalent in Children 6 to 35 Months of Age
The purpose of this study is to assess the immunogenicity and safety of GSK Biologicals' quadrivalent influenza vaccine (GSK2282512A) compared to Sanofi Pasteur's Fluzone® Quadrivalent in children 6 to 35 months of age.
- Trial name
- NCT02242643
- Testing
- FluLaval™ Quadrivalent, Fluzone® Quadrivalent
- Where
- 66 sites in United States, Mexico
- Volunteers
- 2,432 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Covid19
Relative Bioavailability, Safety, and Tolerability of Single-dose Sotrovimab Injection in Adults (COSMIC)
This clinical pharmacology study will evaluate the relative bioavailability, safety, and tolerability of two different concentrations of sotrovimab injections administered at different injection sites in male or female healthy…
- Trial name
- COSMIC (NCT05280717)
- Testing
- sotrovimab
- Where
- 10 sites in United States
- Volunteers
- 316 people, healthy volunteers welcome
- Sponsor
- Vir Biotechnology, Inc.
Sleep, Pregnancy
Halifax PrenaBelt Trial
Back and right-sided sleeping position in pregnant women has recently emerged as a potential risk factor for low birthweight (LBW) and stillbirth (SB) in the medical literature.
- Conditions
- Sleep, Pregnancy, Stillbirth, Infant, Low Birth Weight
- Trial name
- NCT02377817
- Testing
- PrenaBelt
- Where
- Canada
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Allan Kember
Ventilation, End-Tidal Carbon Dioxide
End-tidal Carbon Dioxide Monitoring in Low Tidal Volume Ventilation
In cases where there is no ventilation-perfusion problem, the end-tidal carbon dioxide (ETCO2) value is closely associated with partial arterial carbon dioxide pressure (PaCO2); therefore, the PaCO2 value can be estimated using…
- Trial name
- ETCO2 (NCT04281589)
- Testing
- if the ventilation parameter caused desaturation or hypercapnia we will change the parameter
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
COVID-19, Corona Virus Infection
Hydroxychloroquine as Prophylaxis for COVID-19 in Healthcare Workers (HCQPreP)
This a double-blind, randomized, placebo-controlled clinical trial to determine if primary prophylaxis with hydroxychloroquine in healthcare workers reduces symptomatic COVID-19 infection.
- Conditions
- COVID-19, Corona Virus Infection, Wuhan Coronavirus, Prophylaxis
- Trial name
- HCQPreP (NCT04363450)
- Testing
- Hydroxychloroquine
- Where
- 2 sites in United States
- Volunteers
- 1,700 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Influenza
T-cell And General Immune Response to Seasonal Influenza Vaccine (SLVP018) - Year 1, 2009
This study will compare influenza vaccine responses in monozygotic and dizygotic twins.
- Trial name
- NCT01987349
- Testing
- Fluzone® (intramuscular), FluMist® (intranasal)
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Stanford University
Dexmedetomidine, Sedation
Safety Exploration and Evaluation of Dexmedetomidine Hydrochloride Nasal Spray for Pre-anesthesia Sedation in Low-Monitoring Settings
The goal of this clinical trial is to assess the viability of dexmedetomidine hydrochloride nasal spray under minimal or no supervision and to further investigate novel clinical applications for this medication.
- Conditions
- Dexmedetomidine, Sedation, Safety, Preanesthetic Medication
- Trial name
- NCT07298525
- Testing
- Dexmedetomidine hydrochloride nasal spray
- Volunteers
- 564 people, healthy volunteers welcome
- Sponsor
- Sichuan Provincial People's Hospital
Periodontitis, Gingivitis
Extending Dental Care to Nursing Home Residents to Reduce Mouth Infections and Incidence of Pneumonia and Improve Diabetic Glucose Control
The goal of this study is to learn if dental infection control treatment delivered to older adult nursing home residents at their place of residence will result in : improved dental health reduced risk of pneumonia better glucose…
- Conditions
- Periodontitis, Gingivitis, Periodontal Disease, Periodontal Infections
- Trial name
- NHOralHealth (NCT06890676)
- Testing
- Comprehensive Oral Evaluation, Intraoral Complete Radiographic Series, • Teledentistry-synchronous and asynchronous
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Missouri Department of Health and Senior Services
Influenza
Safety and Immunogenicity of Co-administration of Candidate Influenza Vaccine MVA-NP+M1 and Viroflu® Seasonal Influenza Vaccine
This is a single blinded placebo controlled phase I study, to assess the safety and immunogenicity of co-administration of the candidate influenza vaccine MVA-NP+M1 with the Viroflu® seasonal influenza vaccine.
- Trial name
- NCT02014168
- Testing
- Viroflu® and MVA-NP+M1
- Where
- United Kingdom
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Nitrous Oxide, Dentistry
Demand-Driven Method for Gas Delivery in a Dental Setting
This study compares two methods of gas delivery in a dental setting: 1) demand-driven (DD) and 2) free-flow (FF). Nitrous oxide and oxygen sedation (NOS) is a common form of minimal sedation for adult and paediatric patients…
- Conditions
- Nitrous Oxide, Dentistry, Drug Delivery System, Comfort
- Trial name
- NCT04305990
- Testing
- Demand-driven delivery method, Free-flow delivery method
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Toronto
COVID-19
Phase I/II Clinical Trial of Recombinant Novel Coronavirus Vaccine (Adenovirus Type 5 Vector) in Canada
This study is a phase I /II adaptive clinical trial to evaluate the safety, tolerability and the Immunogenicity of Ad5-nCoV in healthy adults from 18 to <55 and 65 to <85 years of age，with the randomized, observer-blind…
- Trial name
- NCT04398147
- Testing
- Recombinant Novel Coronavirus Vaccine (Adenovirus Type 5 Vector)
- Where
- Canada
- Volunteers
- 696 people, healthy volunteers welcome
- Sponsor
- CanSino Biologics Inc.
Influenza
Heterosubtypic Immune Responses to Influenza in Older People
Vaccination is the principal means of combating epidemic and pandemic influenza. As vaccines induce relatively strain-specific and short-lived antibody responses, annual immunisation with regularly updated vaccine is recommended…
- Trial name
- NCT00798343
- Testing
- Seasonal vaccine, H5 vaccine
- Where
- United Kingdom
- Volunteers
- 292 people, healthy volunteers welcome
- Sponsor
- University Hospitals, Leicester
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