Clinical trials: Respiratory System
Ventilation
Bispectral Index (BIS) on Ventilated Patients in the Prehospital Setting
To evaluate the effectiveness of use of the bispectral index for monitoring of depth of sedation in ventilated patients during their prehospital management by a physician- staffed EMS.
- Trial name
- OHBIS (NCT00919971)
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Beaujon Hospital
Lung Cancer Stage IA
Transthoracic vs Transbronchial Radiofrequency Ablation for Lung Cancer
The aim of this study is to investigate the efficacy and safety of transthoracic versus transbronchial ablation in the treatment of early stage peripheral lung cancer.
- Trial name
- NCT06503744
- Testing
- ablation
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Shanghai Chest Hospital
Frail Elderly Syndrome, Elderly Infection
Effect of Alfacalcidol to Respiratory Infection and Immune Response of Indonesian Elderly
Vitamin D has been known to influence immune response through Vitamin D Receptor in Immune Cells, but only few has been known about the effect alfacalcidol, a vitamin D analog to immune system.
- Trial name
- NCT03292744
- Testing
- Alfacalcidol
- Where
- Indonesia
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
COVID-19, Telerehabilitation
Teletechnology-assisted Home-based Exercise Program for Severe COVID-19
The aim of this study was to investigate the efficacy of a home-based pulmonary rehabilitation program with the support of teletechnology in COVID-19 survivors.
- Trial name
- NCT05778344
- Testing
- Teletechnology-assisted home-based pulmonary rehabilitation
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- National Taiwan University Hospital
Morbid Obesity, Hypertension
Prevention of Coronary Heart Disease in Morbidly Obese Patients
The changes in risks of developing coronary heart disease in patients with morbid obesity after different weight loss interventions have not been extensively studied.
- Conditions
- Morbid Obesity, Hypertension, Type 2 DM, Obstructive Sleep Apnea
- Trial name
- SphCor (NCT00626964)
- Testing
- Bariatric Surgery, Conservative Treatment:
- Where
- Norway
- Volunteers
- 200 people
- Sponsor
- The Hospital of Vestfold
Non-small Cell Lung Cancer, Quality of Life
LIFE - Lung Cancer, Immunotherapy, Frailty, Effect
The LIFE study (Lung cancer, Immunotherapy, Frailty, Effect) is investigating the unselected 'real life' non-small cell lung cancer (NSCLC) population treated with immune checkpoint inhibition.
- Conditions
- Non-small Cell Lung Cancer, Quality of Life, Brain Metastases, Venous Thromboembolism
- Trial name
- NCT03870464
- Testing
- CT-scans extended, MRI scan of the brain, Prospective registration of irAEs
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- University of Southern Denmark
Chronic Obstructive Pulmonary Disease
Study to Investigate the Dose Response, Safety and Efficacy of Nebulized EP-101(SUN101) in Patients With Chronic Obstructive Pulmonary Disease (COPD): GOLDEN-1 Study
The purpose of this study is to determine steady-state efficacy and dose response profile and to assess safety and pharmacokinetic profile of nebulized EP-101(SUN101) after 7-day dosing using an investigational high efficiency…
- Trial name
- NCT01426009
- Testing
- EP-101 via nebulizer (eFlow®) 25 ug, EP-101 via nebulizer (eFlow®) 50 ug, EP-101 via nebulizer (eFlow®) 100 ug
- Where
- 11 sites in United States, United Kingdom
- Volunteers
- 140 people
- Sponsor
- Sunovion Respiratory Development Inc.
Urticaria
Efficacy Study for the Symptomatic Treatment of Chronic Idiopathic Urticaria
The objective of the study is to evaluate the efficacy and tolerability of Bilastine 20 mg Q.D., compared to Levocetirizine 5 mg Q.D. and placebo for the treatment of Chronic Idiopathic Urticaria.
- Trial name
- NCT00421109
- Testing
- Bilastine, Levocetirizine
- Where
- 50 sites in Argentina, Belgium and 5 more
- Volunteers
- 522 people
- Sponsor
- Faes Farma, S.A.
Chronic Obstructive Pulmonary
Involvement of Plasmatic Factors in the Peripheral Muscle Dysfunction of COPD Patients - In Vitro Study
Chronic Obstructive Pulmonary Patients is a defined by persistent airflow limitation that is usually progressive and associated with an enhanced chronic inflammatory response in the airways and the lung to noxious particles or…
- Trial name
- NCT03197909
- Testing
- Determination of pro-inflammatory plasma factors
- Where
- France
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Long COVID Syndrome
Does Taurine Supplementation Improve Vascular Function and Orthostatic Responses in Long COVID?
Millions have developed Long COVID (LC), and recent findings show an association between taurine deficiency (an amino acid) and symptoms in LC.
- Trial name
- NCT07312409
- Testing
- Taurine supplementation
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- York University
Obstructive Sleep Apnea, Snoring
Novel Myofunctional Water Bottle to Reduce OSA and Snoring Study
This research study is being done to determine whether the repetition and resistance from the daily use of the myofunctional therapy (MT) nozzle will improve obstructive sleep apnea and primary snoring.
- Trial name
- NCT05371509
- Testing
- Myofunctional therapy (MT) nozzle
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Mayo Clinic
Extracorporeal CO2 Removal, Acute Respiratory Distress Syndrome
Effects of Blood Pulsatility on Von Willebrand Factor During ECCO2R
The primary objective of the study is to demonstrate that the ECCO2R pulsatile configuration prevents the Willebrand factor high molecular weight multimers decrease observed under continuous blood flow configurations.
- Conditions
- Extracorporeal CO2 Removal, Acute Respiratory Distress Syndrome, Chronic Obstructive Pulmonary Disease Exacerbation, Pulmonary Disease
- Trial name
- FLOW-ECCO2R (NCT05079009)
- Testing
- ECCO2R pulsatile configuration
- Where
- France
- Volunteers
- 6 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Head and Neck Cancer, Oral Cavity Cancer
Immune Biomarker Study for Head and Neck Cancer
The aim of this prospective non-interventional multi-center trial is to study the prognostic value of intratumoral and systemic immune biomarkers in newly diagnosed non-metastatic head and neck cancer.
- Conditions
- Head and Neck Cancer, Oral Cavity Cancer, Oropharyngeal Cancer, Hypopharyngeal Cancer
- Trial name
- ImmunBio-KHT (NCT05375266)
- Testing
- Sampling
- Where
- 3 sites in Germany
- Volunteers
- 1,100 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Laparoscopic Cholecystectomy, Acute Post-operative Pain
The Effect of Erector Spinae Block on Diaphragma Movement
Laparoscopic cholecystectomy surgeries cause moderate/severe pain and thus can result in shallow breathing, atelectasis and increased opioid consumption in the early postoperative period which in turn cause a longer hospital…
- Conditions
- Laparoscopic Cholecystectomy, Acute Post-operative Pain, Respiratory Diaphragm
- Trial name
- NCT05021822
- Testing
- Erector spinae plane block
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Ufuk University
Asthma
Inhaled Corticosteroid Replacement Study - Efficacy and Safety of Ro 27-2441 (Test Drug) in Moderate Persistent Asthma
The primary objective of the study is to evaluate the anti-inflammatory action and safety of Ro 27-2441 (study drug) in asthmatic patients currently taking inhaled corticosteroids.
- Trial name
- NCT00048022
- Testing
- Dual Integrin Antagonist
- Where
- 60 sites in United States, Puerto Rico
- Sponsor
- Hoffmann-La Roche
Face Mask Squeeze, COVID-19
Face Mask Habits and COVID-19 Among University Students in Cairo
The World Health Organization officially declared the pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as a public health emergency.
- Conditions
- Face Mask Squeeze, COVID-19, Pandemic, COVID-19
- Trial name
- NCT05517629
- Testing
- It is an observational cross-sectional study
- Where
- Egypt
- Volunteers
- 1,455 people
- Sponsor
- Benha University
Acute Respiratory Distress Syndrome
Stress Index to Individualize Mechanical Ventilation in ARDS
Acute respiratory distress syndrome (ARDS) is a widely prevalent and morbid disease for which the current standard treatment is supportive care and avoidance of complications with lung-protective ventilation.
- Trial name
- NCT02871102
- Testing
- Recruitment Maneuver with PEEP and Tidal Volume Optimization
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Vanderbilt University
Influenza
To Identify the Immunogenicity and Safety of QIV in Children Aged 3-8 Years
To explore the immunogenicity and safety of quadrivalent split influenza virus vaccine in children aged 3-8 years with two doses and one dose.
- Trial name
- QIV (NCT05389137)
- Testing
- Inavtivated Quadrivalent Influenza Virus Split Vaccine
- Where
- China
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Wuhan Institute of Biological Products Co., Ltd
Deep Venous Thrombosis, Pulmonary Embolism
Drug Interaction Between Paracetamol and Warfarin
The objective of this study is to investigate whether paracetamol, given at therapeutic doses (2g/day and 3 g/day), may potentiate the anticoagulant effect of warfarin.
- Conditions
- Deep Venous Thrombosis, Pulmonary Embolism, Atrial Fibrillation, Stroke
- Trial name
- INPAWA2 (NCT01104337)
- Testing
- paracetamol
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Hopital Lariboisière
COVID-19
COVID-19 Endoscopy Survey
A questionnaire containing some critical questions about practice inside GI endoscopy units in different countries will be distributed via emails.
- Trial name
- COVID-19 Endo (NCT04342637)
- Testing
- Practice details
- Where
- 4 sites in United States, Egypt and 1 more
- Volunteers
- 163 people
- Sponsor
- Al-Azhar University
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