Clinical trials: Respiratory Tract Disease
COPD
TRIMBOW® and RELVAR® on Lung Stiffness Reduction Assessed Through Forced Oscillation Technique in Patients With COPD
Efficacy of TRIMBOW® pMDI and RELVAR® ELLIPTA® DPI on lung stiffness reduction assessed through area under the reactance curve (AX) using oscillometry in chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT04671355
- Testing
- Beclometasone Dipropionate / Formoterol Fumarate / Glycopyrronium 100/6/10 mcg, Fluticasone Furoate / Vilanterol Trifenatate 100/25 mcg
- Sponsor
- Chiesi Farmaceutici S.p.A.
Chronic Obstructive Pulmonary Disease (COPD)
Lung Ultrasound With Acute Exacerbation and Stable COPD
This cross-sectional study aims to compare lung ultrasound findings, functional capacity, and dyspnea among patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD), patients with stable COPD, and…
- Trial name
- NCT07757126
- Where
- Turkey (Türkiye)
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Cancer, Respiratory Failure
Multi-Disciplinary Treatment on the Anthropomorphism of Large Language Models
This retrospective clinical trial aims to better explore the potential of large language models in medicine by comparing the effectiveness of MDT consultations conducted by human doctors with those conducted by large language…
- Conditions
- Cancer, Respiratory Failure, Heart Diseases, Infections
- Trial name
- MDTALLM (NCT06627985)
- Testing
- GPT-4o, GPT-4o mini, MedicalGPT
- Where
- China
- Volunteers
- 300 people
- Sponsor
- North Sichuan Medical College
Pleural Effusion, Malignant, Lung Cancer
Prognostic Factors on Malignant Pleural Effusion
Malignant pleural effusion can occur in up to half of the patients with metastatic disease. It can cause shortness of breath to patients and so far there is no protocol on its management.
- Trial name
- NCT03276715
- Where
- Hong Kong
- Volunteers
- 233 people
- Sponsor
- The University of Hong Kong
Influenza A Virus Infection
Interferon Alpha Lozenges Plus Oseltamivir for Influenza Treatment
This study aims to evaluate the safety and effect of interferon-alpha lozenges when used in combination with oseltamivir (Tamiflu) to treat influenza.
- Trial name
- NCT01146535
- Testing
- Interferon-alpha, Oseltamivir, maltose
- Where
- 4 sites in Taiwan
- Volunteers
- 40 people
- Sponsor
- Ainos, Inc. (f/k/a Amarillo Biosciences Inc.
Surgery, Immune System and Related Disorders
Immune Modulation by Enhanced vs Standard Prehabilitation Program Before Major Surgery
Over 30 million surgeries are performed annually in the US. Up to 30% of surgical patients experience delayed surgical recovery, marked by prolonged post-surgical pain, opioid consumption, and functional impairment, which…
- Conditions
- Surgery, Immune System and Related Disorders, Preoperative Care, Gastrointestinal Disease
- Trial name
- NCT04498208
- Testing
- Physical Prehabilitation, Stress Reduction Prehabilitation, Cognitive Prehabilitation
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Stanford University
Acute Respiratory Distress Syndrome
Effect of APRV and LTV on Lung Ventilation and Perfusion in Patients With Moderate-to-severe ARDS
Low tidal volume ventilation (LTV) has been proposed and widely used in patients with acute respiratory distress syndrome (ARDS) to prevent ventilator-induced lung injury (VILI) and mitigate its effects.
- Trial name
- NCT05767125
- Testing
- APRV, LTV
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Carcinoma, Non-small-cell Lung Cancer
Circulating Tumor DNA Detection in Surveillance of Surgical Lung Cancer Patients
Conduct a prospective study to confirm blood and urine ctDNA detection value in non-small-cell lung cancer patients.
- Conditions
- Carcinoma, Non-small-cell Lung Cancer, Lung Neoplasms
- Trial name
- NCT02696525
- Where
- 3 sites in China
- Volunteers
- 145 people
- Sponsor
- Peking University People's Hospital
Apnea
Fraction of Oxygen on Induction of Anesthesia in Infants
Invesetigators evaluated the effect of positive end-expiratory pressure during anaesthesia induction on nonhypoxic apnoea time in infants.
- Trial name
- PEEP (NCT04722276)
- Testing
- positive end expiratory pressure, fraction of inspired oxygen 80%
- Where
- South Korea
- Volunteers
- 84 people
- Sponsor
- Seoul National University Hospital
Asthma
TRIple in Asthma hiGh strenGth vErsus Ics/Laba hs and tiotRopium (TRIGGER)
Evaluate the superiority of CHF 5993 200/6/12.5 µg pressurised metered dose inhaler (pMDI) (fixed combination of extrafine beclometasone dipropionate plus formoterol fumarate plus glycopyrronium bromide) versus CHF 1535 200/6 µg…
- Trial name
- TRIGGER (NCT02676089)
- Testing
- CHF 5993 200/6/12.5 µg, CHF 1535 200/6 µg, CHF 1535 200/6 µg + Tiotropium Respimat 2.5 µg
- Where
- 244 sites in Argentina, Belarus and 15 more
- Volunteers
- 1,437 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
Critical Illness, Hypoxia
End-Tidal Oxygen for Intubation in the Emergency Department
Rapid Sequence Intubation (RSI) is a high-risk procedure in the emergency department (ED). Patients are routinely preoxygenated (given supplemental oxygen) prior to RSI to prevent hypoxia during intubation.
- Conditions
- Critical Illness, Hypoxia, Respiratory Failure
- Trial name
- PREOXED (NCT06578468)
- Testing
- End-tidal oxygen monitor
- Where
- 9 sites in United States, Australia
- Volunteers
- 1,400 people
- Sponsor
- Sydney Local Health District
Non Small Cell Lung Cancer
A Study of Alimta/Cisplatin/Gefitinib for Asian Non-smoking Participants With Non Small Cell Lung Cancer
The purpose of this study is to compare two different approaches to treating non-small cell lung cancer (NSCLC) in East Asian never-smoker participants.
- Trial name
- NCT01017874
- Testing
- Pemetrexed, Cisplatin, Gefitinib
- Where
- 12 sites in Hong Kong, Singapore and 3 more
- Volunteers
- 236 people
- Sponsor
- Eli Lilly and Company
Solid Tumor
Neo-T in Treating Patients With Advanced Solid Tumors(GI-NeoT-03)
The primary objective of this study is to evaluate the safety of Neo-T in combination with anti-PD1 in patients with solid tumors.
- Trial name
- NCT05798533
- Testing
- Neo-T, Toripalimab, Tislelizumab
- Where
- 2 sites in China
- Volunteers
- 6 people
- Sponsor
- BGI, China
Influenza
A Phase 1/2 Study of a Intramuscular Injection of TAK-850 in Healthy Adult Subjects
This clinical trial is a phase 1/2 study of a single intramuscular injection of TAK-850 in healthy Japanese adult participants
- Trial name
- NCT02111252
- Testing
- TAK-850
- Where
- Japan
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Takeda
Non-small Cell Lung Cancer
Functional Lung Avoidance for Individualized Radiotherapy (FLAIR): A Randomized, Double-Blind Clinical Trial
Concurrent chemoradiotherapy is the standard treatment for locally advanced, unresectable non-small cell lung cancer, but carries a risk of radiation pneumonitis of approximately 30%, and is associated with a decline in pulmonary…
- Trial name
- FLAIR (NCT02002052)
- Testing
- Concurrent platinum-based chemotherapy, Standard Radiotherapy, 60 Gy in 30 fractions., Functional Lung Avoidance Radiotherapy, 60 Gy in 30 fractions
- Where
- Canada
- Volunteers
- 29 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Constrictive Bronchiolitis
4DX for the Diagnosis of Constrictive Bronchiolitis
Constrictive bronchiolitis is an uncommon lung disease that has been described in Veterans of conflicts in Iraq and Afghanistan.
- Trial name
- NCT04489758
- Testing
- X-ray velocimetry analyzed by 4Dx XV Ventilation Analysis
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Vanderbilt University Medical Center
Pulmonary Fibrosis, Interstitial Lung Disease (ILD)
Implementation of Home Monitoring in Patients With Pulmonary Fibrosis
The objective of this study is to evaluate the impact of structurally replacing half of the outpatient clinic visits for patients with pulmonary fibrosis by home monitoring and video consultations on patient self-management and…
- Trial name
- SUITS (NCT06883448)
- Testing
- Home monitoring care
- Where
- 11 sites in Netherlands
- Volunteers
- 220 people
- Sponsor
- Erasmus Medical Center
Chronic Obstructive Pulmonary Disease, Respiratory Failure
Investigating Health Related Quality of Life in Patients With Chronic Respiratory Failure
To determine the quality of life of patients living with chronic respiratory failure and the impact interventions have on it.
- Conditions
- Chronic Obstructive Pulmonary Disease, Respiratory Failure, Neuromuscular Diseases, Ventilatory Failure
- Trial name
- CRF-QoL (NCT04236726)
- Testing
- Questionnaire
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Pneumococcal Pneumonia
Pharmacist Impact on Pneumococcal Polysaccharide Vaccination Rates in Patients With Diabetes in a Supermarket Pharmacy Chain
The goals of the study are to determine the pneumococcal polysaccharide vaccination rate in patients with diabetes before and after community pharmacist education and intervention.
- Trial name
- NCT03851978
- Testing
- Pharmacist Vaccine Education
- Where
- 4 sites in United States
- Volunteers
- 431 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Obstructive Sleep Apnea, Vascular Aneurysm
OSA as a Remote Ischemic Preconditioning in Vascular Surgery
Ischemia and reperfusion (I/R) injury during abdominal aortic aneurysm (AAA) repair is inevitable and may lead to postoperative multi-organ failure.
- Conditions
- Obstructive Sleep Apnea, Vascular Aneurysm, Ischemia Reperfusion Injury
- Trial name
- NCT04630535
- Testing
- aorto-bifemoral bypass surgery
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- St. Anne's University Hospital Brno, Czech Republic
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.