Clinical trials: Respiratory Tract Disease
Post COVID-19
Special Chinese Medicine Out-patient Programme for Discharged COVID-19 Patients
According to the ongoing observational studies and the Chinese Medicine practice guideline for COVID-19 patients, the discharged patients with COVID-19 still exhibits certain clinical symptoms such as fatigue, poor appetite…
- Trial name
- NCT04544605
- Testing
- Individualized-Chinese herbal medicine
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Hong Kong Baptist University
Chronic Obstructive Pulmonary Disease
A Multi-center,Prospective, OS to Evaluate the Effectiveness of 'NAC' Nebulizer Therapy in COPD (NEWEST)
To evaluate the effect of Mucomyst nebulizer therapy on improvement in symptoms and quality of life in COPD patients with difficulty of expectoration.
- Trial name
- NCT05102305
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Boryung Pharmaceutical Co., Ltd
COVID-19
Administration of Chlorpromazine as a Treatment for COVID-19
In this study, defined cases of COVID-19 confirmed with PCR, with a mild, moderate or severe pneumonia will be treated with chlorpromazine.
- Trial name
- NCT04354805
- Testing
- Chlorpromazine
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University
COVID-19
A Clinical Trial of a Recombinant Adenovirus 5 Vectored COVID-19 Vaccine (Ad5-nCoV) With Two Doses in Healthy Adults
This is a clinical trial to evaluate the safety and immunogenicity of a recombinant adenovirus 5 vectored COVID-19 vaccine (Ad5-nCoV) with two doses and with different adminstration routes in healthy adults aged 18 years and…
- Trial name
- NCT04552366
- Testing
- Ad5-nCoV
- Where
- China
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Institute of Biotechnology, Academy of Military Medical Sciences, PLA of China
Non-small Cell Lung Cancer
Study to Assess the Efficacy and Safety of Adjuvant Osimertinib in NSCLC With Uncommon EGFRm
This is an open-label, multi-centre, single-arm study assessing the efficacy and safety of osimertinib as adjuvant treatment in stage IB-IIIB (8th AJCC) NSCLC with uncommon EGFRm after receiving complete surgical resection with…
- Trial name
- NCT05546866
- Testing
- Osimertinib
- Where
- 10 sites in China
- Volunteers
- 51 people
- Sponsor
- AstraZeneca
Pulmonary Disease, Chronic Obstructive, Chronic Bronchitis
Add-on Effects of Tiotropium Over Formoterol in Exercise Tolerance on Chronic Obstructive Pulmonary Disease Patients
The primary objective is to comparatively evaluate the isolated effects of a long-acting beta2-adrenergic (formoterol fumarate 12µg b.i.d.
- Conditions
- Pulmonary Disease, Chronic Obstructive, Chronic Bronchitis, Pulmonary Emphysema
- Trial name
- NCT00680056
- Testing
- Formoterol plus Tiotropium
- Where
- Brazil
- Volunteers
- 33 people
- Sponsor
- Federal University of São Paulo
Obstructive Apnea
Comparison of a Demand Oxygen Delivery
Conducting a randomized control trial of oxygen in children with Down syndrome to treat moderate to severe obstructive sleep apnea.
- Trial name
- DOSA (NCT06609694)
- Testing
- Portable oxygen concentrator Inogen G5 model
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Pneumonia
Evaluate Safety and Pharmacokinetic To Assess Bronchopulmonary Disposition of Intravenous Delafloxacin in Healthy Adults
The purpose of this study is to evaluate the steady-state intrapulmonary disposition of delafloxacin in healthy adult participants.
- Trial name
- NCT03534622
- Testing
- Delafloxacin
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Melinta Therapeutics, Inc.
Lung Diseases
Longitudinal Analysis of Spirometry in Black Children
To conduct a longitudinal investigation of early childhood lower respiratory illness (LRI) and patterns of lung growth using an existing electronic dataset generated by an 18-year study (1972-1990) of a population of 102 Black…
- Trial name
- NCT00005422
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Immunotherapy, Rhinitis, Allergic
Monitoring Allergen Immunotherapy in Allergic Rhinitis
Allergic rhinitis (hay fever) can be treated successfully with allergen-specific immunotherapy (AIT) for 3-5 years. This relative expensive and prolonged treatment is not suitable for everyone and therefore it is important to…
- Conditions
- Immunotherapy, Rhinitis, Allergic, Treatment Outcome
- Trial name
- NCT05621356
- Testing
- A nasal fluid Basophil Activation Test (BAT)
- Where
- Netherlands
- Volunteers
- 25 people
- Sponsor
- Rijnstate Hospital
Influenza
A Study to Evaluate the Safety and Immunogenicity of GSK Biologicals' Seasonal Influenza Vaccine in Children
This study is designed to test the immunogenicity and safety of an investigational influenza vaccine, in children compared to two other influenza vaccines.
- Trial name
- NCT01198756
- Testing
- Quadrivalent seasonal influenza vaccine GSK2282512A, Fluarix™ VB, Fluarix™ YB
- Where
- 33 sites in United States, Canada and 3 more
- Volunteers
- 3,109 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Cystic Fibrosis
DNA Methylation and Lung Disease in Cystic Fibrosis
Lung disease progression is variable among cystic fibrosis (CF) patients and depends on DNA mutations in the CFTR gene, polymorphic variations in disease-modifier genes and environmental exposure.
- Trial name
- METHYLCF (NCT02884622)
- Testing
- nasal epithelial, Blood sampling
- Where
- France
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Bacterial Infections, Bone Diseases, Infectious
Fosfomycin I.v. for Treatment of Severely Infected Patients
The purpose of this European, multicentric, prospective, non-interventional study is to document and evaluate the efficacy and safety of the treatment of severely infected patients with intravenously administered fosfomycin…
- Conditions
- Bacterial Infections, Bone Diseases, Infectious, Osteomyelitis, Central Nervous System Bacterial Infections
- Trial name
- FORTRESS (NCT02979951)
- Where
- 50 sites in Austria, Germany and 3 more
- Volunteers
- 1,000 people
- Sponsor
- Infectopharm Arzneimittel GmbH
COPD
Physical Activity Enhancement Using Pedometers in COPD
Physical activity is reduced in COPD affecting morbidity and mortality and the usual advice is not good enough to increase the physical activity level.
- Trial name
- NCT01739751
- Testing
- pedometers
- Where
- Chile
- Volunteers
- 90 people
- Sponsor
- University of Chile
Chronic Bronchitis
Feasibility Study of the Pulsed Electric Field Ablation System in Treating Chronic Bronchitis
To preliminarily evaluate the safety and feasibility of the pulsed electric field ablation system independently developed by Zhouling (Shanghai) Medical Appliance Co., Ltd. in the treatment of chronic bronchitis.
- Trial name
- NCT05771129
- Testing
- Pulse electric field ablation system developed by Zhouling (Shanghai) Medical Appliance Co., Ltd.
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Jiayuan Sun
Non-small Cell Lung Cancer
Therapeutic Resistance Prediction of Tyrosine Kinase Inhibitors
The investigators propose a non-invasive prognostic tool for TKIs resistance in patients with stage IV EGFR-mutant non-small cell lung cancer (NSCLC) by computed tomography phenotypic features, which can be conveniently…
- Trial name
- NCT02851329
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Sciences
Carcinoma, Non-Small-Cell Lung
Immune Neoadjuvant Therapy Study of Durvalumab in Early Stage Non-small Cell Lung Cancer
Lung cancer is still the leading cause of cancer related-deaths worldwide, with an overall all-stage 5-year survival of approximately 17%. The primary treatment of early stage (I-IIIA) NSCLC is curative surgery.
- Trial name
- IONESCO (NCT03030131)
- Testing
- Durvalumab
- Where
- 31 sites in France
- Volunteers
- 50 people
- Sponsor
- Intergroupe Francophone de Cancerologie Thoracique
Carcinoma, Non-Small-Cell Lung, Melanoma
Study of Safety and Efficacy of DKY709 Alone or in Combination With PDR001 in Patients With Advanced Solid Tumors.
This is a phase I/Ib, open label study. The escalation portion will characterize the safety and tolerability of DKY709 and DKY709 in combination with PDR001 in subjects with NSCLC or melanoma who have received prior…
- Conditions
- Carcinoma, Non-Small-Cell Lung, Melanoma, Nasopharyngeal Carcinoma, Microsatellite Stable Colorectal Cancer
- Trial name
- NCT03891953
- Testing
- DKY709, PDR001
- Where
- 9 sites in United States, Germany and 4 more
- Volunteers
- 98 people
- Sponsor
- Novartis Pharmaceuticals
Asthma
A Study of Lebrikizumab in Patients With Uncontrolled Asthma Who Are on Inhaled Corticosteroids and A Second Controller Medication (VERSE)
This randomized, multicenter, double-blind, placebo-controlled, parallel-group study will assess the efficacy and safety of lebrikizumab in patients with asthma whose disease remains uncontrolled despite daily therapy with an…
- Trial name
- NCT01545453
- Testing
- lebrikizumab
- Where
- 63 sites in United States, Australia
- Volunteers
- 205 people
- Sponsor
- Genentech, Inc.
Influenza
A Re-licensing Study to Assess the Efficacy of Inflexal V Formulated With WHO Recommended 2009/2010 Influenza Virus Strains for the Northern Hemisphere
This study is to assess whether the Northern Hemisphere 2009/2010 season influenza vaccine Inflexal V fulfills the EMEA requirements for re-registration of influenza vaccines.
- Trial name
- NCT01306253
- Testing
- Inflexal V
- Where
- Switzerland
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Crucell Holland BV
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