Clinical trials: Respiratory Tract Infections (RTI)
Tonsillitis
Perioperative Tonsillectomy Protocol Development
Pediatric patients who are undergoing a tonsillectomy at the Children's hospital will be randomly assigned to one of three drug groups: 1) acetaminophen (Tylenol) administered pre-operatively and a low dose of anti-inflammatory…
- Trial name
- NCT03323047
- Testing
- Acetaminophen, Low-dose Dexamethasone, High-Dose Dexamethasone
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- London Health Sciences Centre
Diphtheria, Pertussis
Pertussis Vaccine in Healthy Pregnant Women
The purpose of this study is to look at the safety and immunogenicity of a combination vaccine that includes tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap).
- Conditions
- Diphtheria, Pertussis, Tetanus
- Trial name
- NCT00707148
- Testing
- Tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine adsorbed
- Where
- 4 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Lung Cancer, Lung Tuberculosis
68Ga-AlfatideII for the Differential Diagnosis of of Lung Cancer and Lung Tuberculosis by PET/CT
Comparison of 68Ga-AlfatideII and 18F-FDG in differential diagnosis effectiveness towards the solitary pulmonary nodules of lung cancer or tuberculosis.
- Trial name
- NCT02481726
- Testing
- 68Ga-labeled peptides of dimer RGD (Alfatide II) and 18F-FDG
- Volunteers
- 31 people
- Sponsor
- Xijing Hospital
Chronic Tonsillitis, Tonsillar Hypertrophy, Tonsillitis
Comparing Two Agents Used to Stop Bleeding During Tonsil Removal Surgery: Adrenaline Versus Hydrogen Peroxide
The goal of this quasi-experimental study is to compare the effectiveness of topical adrenaline and 3% hydrogen peroxide for controlling bleeding (hemostasis) during tonsil removal surgery in patients aged 5 to 18 years.
- Conditions
- Chronic Tonsillitis, Tonsillar Hypertrophy, Tonsillitis, Tonsillectomy
- Trial name
- NCT07675278
- Testing
- Adrenaline, Hydrogen Peroxide
- Where
- Pakistan
- Volunteers
- 64 people
- Sponsor
- Rawalpindi Medical College
COVID-19 Respiratory Infection
Evaluation of Peripheral Muscle With Ultrassonografic of Critical Patients With Covid-19
Currently, the tools available for assessing peripheral muscle dysfunction in the intensive care setting require patient collaboration.
- Trial name
- NCT05055440
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Pernambuco
Coronavirus Infection, Severe Acute Respiratory Syndrome
COVID-19 Seroprevalence Study in French Guiana
Serological surveys measuring anti-severe acute respiratory syndrome coronavirus 2 (anti-SARS-CoV-2) antibodies in the population to assess the extent of the infection and the COVID-19 immunity of the population in French Guiana.
- Conditions
- Coronavirus Infection, Severe Acute Respiratory Syndrome, SARS-CoV Infection, Covid19
- Trial name
- EPI-COVID-POP (NCT04490850)
- Testing
- Blood sample
- Where
- 5 sites in French Guiana
- Volunteers
- 3,541 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Menstrual Irregularity, Stress Related Disorder
Women's Menstruation During the Covid-19 Pandemic
The COVID-19 crisis has rapidly become the most significant public health crisis of our times. It has particularly impacted healthcare workers (HCW) due to the over-whelming of healthcare resources, as well as a critical absence…
- Conditions
- Menstrual Irregularity, Stress Related Disorder, COVID-19 Pneumonia, Fear
- Trial name
- NCT05197491
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Fayoum University
COVID-19
Exercise in Adults with Post-Acute Sequelae of SARS-CoV-2 (COVID-19) Infection Study
To examine the efficacy of an 8-week exercise training program on functional, cognitive, and emotional health outcomes compared to a no treatment control condition in adults with PASC.
- Trial name
- PASC (NCT05218174)
- Testing
- Exercise Prescription
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Baylor Research Institute
Influenza
Seasonal Influenza DNA Vaccine & Seasonal Influenza Trivalent Inactivated Vaccine (TIV) in Children & Adolescents
This is a Phase I, dose escalation study in healthy adolescents and children (6-17 years) to evaluate the safety, tolerability, and immunogenicity of a prime-boost regimen of the 2012/2013 seasonal influenza DNA vaccine (HA DNA)…
- Trial name
- NCT01609998
- Testing
- Seasonal Influenza DNA vaccine, TIV
- Where
- 5 sites in United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Coronavirus Infection, COVID
Assessment of Exam Findings in Coronavirus Disease 2019 (COVID-19) With Point-of-Care Ultrasonography (POCUS)
Specific Aims: 1. The investigators will prospectively evaluate and analyze changes in the appearance of the lungs and heart through serial acquisition of focused point-of-care ultrasound images in a cohort of patients with or…
- Conditions
- Coronavirus Infection, COVID, Covid-19, SARS-CoV-2
- Trial name
- NCT04339998
- Testing
- Point-of-Care Ultrasonography (POCUS)
- Where
- 2 sites in United States
- Volunteers
- 129 people
- Sponsor
- University of Minnesota
COVID-19, SARS-CoV-2 Infection
PERC Health Canada COVID-19
Although there are several licensed vaccines for SAR-CoV-2 (COVID-19) in Canada, none of them are approved for use in children under the age of 12, leaving five million children under 12 years unvaccinated.
- Trial name
- NCT05040763
- Testing
- Buccal Swabc- Copan flocked swab, Standard of Care COVID-19 swab
- Where
- 13 sites in Canada
- Volunteers
- 7,263 people
- Sponsor
- University of Calgary
Athletes, Respiratory Infection
Vitamin D Level Among Athletes in Uzbekistan
The purpose of the study is to determine vitamin D (VD) levels and upper respiratory tract infections (URTI) morbidity among elite athletes engaged in water sports in Uzbekistan.
- Conditions
- Athletes, Respiratory Infection, Cytokines, Vitamin D
- Trial name
- NCT03623763
- Testing
- Serologic tests of blood samples
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Research Institute of Epidemiology, Microbiology and Infectious Diseases, Uzbekistan
Influenza
Safety and Immunogenicity of the Butantan Institute Influenza Vaccine Compared to Sanofi Pasteur Influenza Vaccine
The overall aim of this study is to evaluate the safety and immunogenicity of Butantan Institute Trivalent Seasonal Influenza Vaccine in comparison with the Sanofi Trivalent Seasonal Influenza Vaccine.
- Trial name
- NCT03777163
- Testing
- Butantan Institute Trivalent Seasonal Influenza Vaccine, Sanofi Trivalent Seasonal Influenza Vaccine
- Where
- 4 sites in Brazil
- Volunteers
- 632 people, healthy volunteers welcome
- Sponsor
- Butantan Institute
Stroke, Rehabilitation
Stroke Rehabilitation Outcome During COVID-19 Lockdown
COVID-19 has a big impact on individuals and society as a whole. Especially persons with (multiple) comorbidities such as stroke are affected.
- Conditions
- Stroke, Rehabilitation, COVID-19, Cohort Studies
- Trial name
- SROCL (NCT04373109)
- Testing
- Observation
- Where
- Switzerland
- Volunteers
- 36 people
- Sponsor
- Jeremia Held
Oral Hygiene, Pneumonia, Bacterial
Effectiveness of Oral Management Strategies on Improving Oral Frailty and Oral Bacteria
The aim of this study is to examine the effectiveness of nurse-driven oral management for improvements of oral frailty, and oral bacteria pneumonia patients with oral frailty using a randomized controlled trial (RCT) design.
- Trial name
- NCT05407532
- Testing
- Group with oral management, Group with oral care
- Where
- Taiwan
- Volunteers
- 55 people
- Sponsor
- National Cheng-Kung University Hospital
Post-Measles Pneumonia, Measles
Prophylactic Antibiotics in Measles
Objective It is the objective to test whether the use of prophylactic antibiotics in measles infection will reduce the incidence of post-measles pneumonia and/or admissions to hospital with 50%.
- Trial name
- NCT00168532
- Testing
- Sulfamethoxazole-Trimethoprim
- Where
- Guinea-Bissau
- Volunteers
- 218 people
- Sponsor
- Bandim Health Project
Influenza
Acute Respiratory Infection Consortium
Recently, the emergence and rapid global dissemination of novel swine-origin influenza A virus (H1N1) with unique epidemiologic characteristics has heightened awareness and concern of this viral pathogen, and its potential for…
- Trial name
- ARIC (NCT01021098)
- Where
- 5 sites in United States
- Volunteers
- 2,018 people, healthy volunteers welcome
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Covid19
A Study to Evaluate the Efficacy and Safety of Proxalutamide (GT0918) in Hospitalized COVID-19 Subjects
This study is an adaptive Phase III randomized double-blind placebo-controlled trial to evaluate the efficacy and safety of Proxalutamide (GT0918) in hospitalized adults diagnosed with COVID-19.
- Trial name
- NCT05009732
- Testing
- GT0918, Standard of care
- Where
- 30 sites in United States, China and 3 more
- Volunteers
- 139 people
- Sponsor
- Suzhou Kintor Pharmaceutical Inc,
COVID-19
Vitamin D for COVID-19 Trial
The Vitamin D for COVID-19 Trial (VIVID) is a randomized, placebo-controlled clinical trial in 2024 men and women from across the U.S. and Mongolia to investigate whether taking a daily dietary supplement of vitamin D vs.
- Trial name
- VIVID (NCT04536298)
- Testing
- vitamin D
- Where
- United States
- Volunteers
- 2,024 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Covid19
Hyperbaric Versus Normobaric Oxygen Therapy for COVID-19 Patients
At least 1 in 6 COVID-19 patients admitted to hospital to receive extra oxygen will die of complications. In patients with COVID-19, invasive treatment such as mechanical ventilation (e.g.
- Trial name
- NCT04500626
- Testing
- Oxygen
- Where
- 2 sites in Canada
- Volunteers
- 234 people
- Sponsor
- Ottawa Hospital Research Institute
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