Clinical trials: Response
Non-small Cell Lung Cancer (NSCLC), Carcinoma, Non-Small Cell Lung
Neoadjuvant Inhaled Azacytidine With Platinum-Based Chemotherapy and Durvalumab (MEDI4736) - a Combined Epigenetic-Immunotherapy (AZA-AEGEAN) Regimen for Operable Early-Stage Non-Small Cell Lung Cancer (NSCLC)
Background: Lung cancer is the leading cause of cancer-related death worldwide. Non-small cell lung cancer (NSCLC) is the most common type of lung cancer.
- Conditions
- Non-small Cell Lung Cancer (NSCLC), Carcinoma, Non-Small Cell Lung, Non-Small Cell Lung Carcinoma, Non Small Cell Lung Cancer
- Trial name
- NCT06694454
- Testing
- azacytidine, carboplatin, paclitaxel
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Cancer Institute (NCI)
Vaccine Response Impaired, Respiratory Syncytial Virus Infections
RSV Vaccine in Transplant Recipients
Adjuvant, non-live RSV vaccine will be administered to adult lung and allogeneic hematopoietic stem cell transplant recipients. The safety and immunogenicity of this intervention will be studied.
- Conditions
- Vaccine Response Impaired, Respiratory Syncytial Virus Infections, Immune Suppression
- Trial name
- RSVax (NCT06593210)
- Testing
- Adjuvant, non-live RSV vaccine
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University Health Network, Toronto
Sepsis, Systemic Inflammatory Response Syndrome (SIRS)
Effect of Lactiplantibacillus Plantarum DAD-13 on Inflammatory Markers in ICU Sepsis Patients
This study investigated whether giving the probiotic Lactiplantibacillus plantarum DAD-13 to sepsis patients in the intensive care unit (ICU) could help reduce inflammation and improve bowel function.
- Conditions
- Sepsis, Systemic Inflammatory Response Syndrome (SIRS), Critical Illness
- Trial name
- LactoSepsis (NCT07072871)
- Testing
- Lactiplantibacillus plantarum DAD-13
- Where
- Indonesia
- Volunteers
- 32 people
- Sponsor
- PT Royal Medikalink Pharmalab
Locally Advanced Rectal Carcinoma
Neoadjuvant FOLFOXIRI and Chemoradiotherapy Versus Neoadjuvant CAPOX/FOLFOX and Chemoradiotherapy Followed by Surgery or a Watch-and-Wait Approach in High Risk Locally Advanced Rectal Cancer
The aim of this clinical trial is to compare triplet induction therapy (FOLFOXIRI) with doublet induction therapy (CAPOX/FOLFOX), followed by chemoradiotherapy and either surgery or a watch-and-wait approach, in patients with…
- Trial name
- MEND-IT II (NCT07472868)
- Testing
- FOLFOXIRI, CAPOX, FOLFOX (5-fluorouracil, Leucovorin, Oxaliplatin)
- Where
- 20 sites in Netherlands
- Volunteers
- 394 people
- Sponsor
- J. W. A. Burger
Sedentary Behavior, Acute Exercise
Acute Endocrine Responses to Aerobic and Anaerobic Exercise in Sedentary Women: A Comparative Analysis of Thyroid Hormones and Cortisol
This study aims to compare acute thyroid hormone and cortisol responses to aerobic and anaerobic exercise in sedentary women. Thirty sedentary women aged 18-25 years will voluntarily participate in the study.
- Conditions
- Sedentary Behavior, Acute Exercise, Endocrine Response
- Trial name
- AERAE (NCT07823335)
- Testing
- 20-Meter Shuttle Run Test, Wingate Anaerobic Test
- Where
- Turkey (Türkiye)
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Assoc. Prof. Dr. Özgür EKEN
Inflammatory Response, Inflammation
Sleep and Inflammatory Resolution Pathway
Goal of this project is to investigate whether increases in inflammation that result from common patterns of restricting sleep on week nights and catching up on sleep over the weekend are caused by disruption in the newly…
- Conditions
- Inflammatory Response, Inflammation, Sleep, Sleep Restriction
- Trial name
- NCT03377543
- Testing
- Aspirin
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Poor Sleep Quality, Gut Microbiome
The Impact of Overnight Active Temperature Regulation on the Gut Microbiome, Inflammation, and Circadian Rhythm.
This study examines whether two continuous weeks of overnight active temperature regulation (via the Eight Sleep Pod) use affects gut microbiome composition, inflammation, and the body's daily temperature and blood pressure…
- Conditions
- Poor Sleep Quality, Gut Microbiome, Gut Health, Inflammation
- Trial name
- NCT07848594
- Testing
- Overnight Active Temperature Regulation: Eight Sleep Pod System
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Eight Sleep Inc.
Improves Daytime Energy Levels, Reduces Afternoon Energy Crashes and Midday Fatigue
A Clinical Trial to Evaluate the Effects of Adrenal Adapt on Sleep Quality, Daytime Energy, Stress Resilience, and Cognitive Performance.
This is a single-group, open-label, uncontrolled clinical trial designed to evaluate the effects of Adrenal Adapt, a commercially available dietary supplement, on sleep quality, daytime energy, stress resilience, and cognitive…
- Conditions
- Improves Daytime Energy Levels, Reduces Afternoon Energy Crashes and Midday Fatigue, Improves Overall Sleep Quality and Restorative Sleep, Helps People Fall Asleep Faster and Wake Less During the Night
- Trial name
- NCT07893561
- Testing
- Adrenal Adapt
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Bioligent
Hormonal Response, Mineral Metabolism
Effects of Chronic Exercise on Hormonal and Mineral Biomarkers in Male University Students
The purpose of this study is to investigate the effects of a high-intensity interval training (HIIT) program on hormonal and mineral biomarkers and aerobic fitness in male university students.
- Conditions
- Hormonal Response, Mineral Metabolism, Exercise Training
- Trial name
- NCT07893613
- Testing
- High-intensity interval training program
- Where
- Tunisia
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- High Institute of Sports and Physical Education of Kef
Diabetes (DM), Diabetes Mellitus
Changes in Person-reported Outcomes and Behavior Using the Accu-Chek SmartGuide CGM and Predict App
The goal of this controlled pre-post-trial is to test the Accu-Chek SmartGuide continuous glucose monitoring (CGM) system and whether its predictive features provide additional benefits for adults with type 1 diabetes or insulin…
- Conditions
- Diabetes (DM), Diabetes Mellitus, Diabetes Mellitus Type 2, Diabetes Mellitus Type 1
- Trial name
- NCT07814508
- Testing
- SmartGuide CGM with Predictive Features
- Where
- Germany
- Volunteers
- 89 people
- Sponsor
- FIDAM RDC
Surgical Stress Response, Inflammation
CoreSys Monitoring for Intraoperative Stress Management in Abdominal Hysterectomy
This randomized controlled trial evaluates whether intraoperative guidance using the CoreSys monitor reduces the surgical stress response in patients undergoing elective open abdominal hysterectomy.
- Conditions
- Surgical Stress Response, Inflammation, Anesthesia, Perioperative Care
- Trial name
- CORESTRESS (NCT07571473)
- Testing
- propofol, CoreSys Monitor, Remifentanil (Target-Controlled Infusion)
- Where
- Argentina
- Volunteers
- 30 people
- Sponsor
- Hospital Provincial de Rosario
Sepsis, Septic Shock
Implementation of Timely Management of Sepsis and Septic Shock Protocol in the Emergency Department and Intensive Care Unit: A Quality Improvement Project at AFHJ
Study Title: Implementation of a Sepsis Management Protocol at Armed Forces Hospital Jazan (AFHJ). Purpose: The purpose of this quality improvement project is to determine if implementing a standardized, evidence-based "sepsis…
- Conditions
- Sepsis, Septic Shock, Systemic Inflammatory Response Syndrome (SIRS), Critical Illness
- Trial name
- NCT07460024
- Testing
- Adapted Surviving Sepsis Campaign (SSC) Protocol, Standard Clinical Care
- Where
- Saudi Arabia
- Volunteers
- 120 people
- Sponsor
- Al-Azhar University
High-Grade Osteosarcoma
Treatment Patterns and Survival Outcomes in High-Grade Osteosarcoma: A Multicenter Retrospective Study
This is a multicenter, medical-record-based, retrospective observational study of approximately 400 patients with high-grade osteosarcoma treated at four sites in the Republic of Korea.
- Trial name
- NCT07878364
- Where
- 4 sites in South Korea
- Volunteers
- 400 people
- Sponsor
- MedPacto, Inc.
Respiratory Tract Infections (RTI), Mucosal Immunity
Fermented Milk Drink With Lacticaseibacillus Paracasei Strain Shirota Helps Triathletes With Cold-Like Symptoms Before and After a Race
This study aims to evaluate whether a fermented milk drink containing the probiotic strain Lacticaseibacillus paracasei strain Shirota (LCS), commonly found in Yakult®, can help reduce upper respiratory symptoms in triathletes…
- Conditions
- Respiratory Tract Infections (RTI), Mucosal Immunity, Systemic Inflammation, Depressive Disorder
- Trial name
- NCT06970964
- Where
- Brazil
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Sepsis, Inflammatory Response
Correlation of Memory CD8+ T Cells With Sepsis Severity and Mortality: a Single-center, Unblinded, Prospective, Non-interventional, Observational Study
Sepsis is defined as a life-threatening organ dysfunction that is caused by a dysregulated host response to infection. Severe sepsis is the most common cause of death among critically ill patients in non-coronary intensive care…
- Trial name
- NCT05875740
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Inflammatory Response, Perioperative Hypothermia
Effects of Intraoperative Warming Methods on Hematologic Inflammatory Indices in Laparoscopic Cholecystectomy
Perioperative hypothermia is a frequent and preventable complication that may cause adverse outcomes such as increased blood loss, impaired coagulation, and delayed recovery.
- Conditions
- Inflammatory Response, Perioperative Hypothermia, Laparoscopic Cholecystectomy, Surgical Stress Response
- Trial name
- WARM-CHOL (NCT07232251)
- Testing
- Standard Active Warming Blanket, Intravenous Warmer Group, External Warmer Group
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people
- Sponsor
- Ataturk University
Mucosal Immune Response to Influenza Vaccination
How Healthy Adults Respond to the Nasal Flu Vaccine
This study is looking at how the immune system in the nose responds after receiving the FluMist nasal flu vaccine in healthy adults. FluMist is an FDA-approved influenza vaccine that is given as a nasal spray.
- Trial name
- MOSAIC (NCT07726862)
- Testing
- FluMist (Live Attenuated Influenza Vaccine)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Immune Responses, Post Operative Recovery
Comparative Study Between the Effects of Deep Versus Moderate Neuromuscular Blockade on Postoperative Recovery and Immune Function in Patients Undergoing Total Hip Replacement Surgery.
. The investigators hypothesized that DNMB ( Deep NeuroMuscular Block) would yield superior postoperative recovery quality and attenuate the surgery-induced immune suppression compared to MNMB ( Moderate NeuroMuscular Block)in…
- Trial name
- NCT07870954
- Testing
- ToF ( Train of Four) Scan
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Inpatient Experience Survey Administration, Inpatient Experience Survey Response
FIQS Dissemination and Implementation
This study is testing Family Input for Quality and Safety (FIQS), a mobile-based survey tool that allows hospitalized children's families and adolescent patients to report safety concerns in real-time by responding to a text…
- Conditions
- Inpatient Experience Survey Administration, Inpatient Experience Survey Response, Inpatient Pediatric Care, Inpatient Pediatric Engagement and Shared Decision-Making
- Trial name
- FIQS DI (NCT07871136)
- Testing
- Text-Only Enrollment Strategy, Text Plus In-Person Enrollment Strategy, Anonymous Safety Reporting with Impact Website
- Where
- 8 sites in United States
- Volunteers
- 21,800 people
- Sponsor
- University of California, San Francisco
Blood Glucose, Satiety Response
Dairy and Vegan Cheese: Effect on Satiety and Blood Glucose
The project will consist of two studies. One study will explore the satiating properties of dairy cheese and its dairy-free substitute when consumed ad libidum, and another study will investigate their effects on postprandial…
- Trial name
- NCT06568497
- Testing
- Food
- Where
- Canada
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Mount Saint Vincent University