Clinical trials: Response Inhibition
Bipolar Disorder, Bipolar and Related Disorders
Targeted Alternating Current and Cognitive Training Intervention for Cognitive Control in Bipolar Disorders
This study is testing whether a type of gentle brain stimulation, combined with computer-based brain training exercises, can help improve thinking skills in Veterans with bipolar disorder.
- Conditions
- Bipolar Disorder, Bipolar and Related Disorders, Veterans, Suicide
- Trial name
- TACTIC-BD (NCT07845409)
- Testing
- Soterix 1x1 tES mini-CT
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Idiopathic Parkinson's Disease
Dopamine Effect on Inhibitory Control
The effect of Levodopa medication on inhibitory control in Parkinson's patients is extremely debated despite the fact that this has potential clinical and therapeutic implications.
- Trial name
- DEI (NCT03665493)
- Testing
- PD patients H&Y=1.5-2 Medications ON, PD patients H&Y=1.5-2 Medications OFF, Healthy age-matched controls
- Where
- Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Giovanni Mirabella
Balance Changes
Effect of the Suboccipital Inhibition Technique on Balance Changes
Postural balance is an essential capacity for functional autonomy and the performance of activities of daily living, relying on the continuous integration of visual, vestibular, and somatosensory information.
- Trial name
- NCT07670819
- Testing
- Intervention Technique
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Escola Superior de Tecnologia da Saúde do Porto
Alzheimer Disease
A Study of Healthy Subjects to Assess the Effect of LY450139 on Amyloid Beta Peptide Production Rate and or Dose Response.
To test that LY450139, a gamma-secretase inhibitor, will reduce the rate of newly synthesize Amyloid Beta by determining the amount of newly synthesized 13C6 leucine-labeled Amyloid Beta in lumbar cerebrospinal fluid from…
- Trial name
- NCT00765115
- Testing
- LY450139
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Behavioral Inhibition, Anxiety
A Multi-Method Early Intervention Program for Inhibited and Anxious Preschoolers
This project aims to develop and evaluate a novel early intervention program that targets the specific risk factors implicated in the development and persistence of shyness, social reticence, and withdrawal in children.
- Trial name
- NCT03486860
- Testing
- Parent Psychoeducation, Turtle Program
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Maryland, College Park
Ovulation Inhibition
A Study to Evaluate the Effect of a Contraceptive Vaginal Ring Delivering Ulipristal Acetate Combined With a Single or Repeated Levonorgestrel on Inhibition of Ovulation, Endometrial Changes and Bleeding Patterns in Normal Cycling Women
The purpose of this study is to determine the effect of a contraceptive vaginal ring on inhibition of ovulation, endometrial changes and bleeding patterns in normal cycling women.
- Trial name
- NCT02451826
- Testing
- Ulipristal acetate
- Where
- Dominican Republic
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Population Council
Healthy
Effects of Sodium Intake on (PK/PD) Relationship of a Single Dose of a Renin Angiotensin System-Blocker
The impact of sodium intake on plasma drug concentrations has previously been reported in the literature for verapamil and quinidine but, to the investigators' knowledge, never with renin-angiotensin system blockers such as AT1R…
- Trial name
- NCT00310778
- Testing
- high sodium diet, low sodium diet, ramipril 10 mg
- Where
- France
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Class I Dental Caries
Clinical Evaluation of Bioactive Restorative Materials
The objectives of this study are to evaluate and compare the biofilm inhibition and re-mineralizing potential at tooth restoration interface and their 2-year clinical performance in class I cavities.The patients will be selected…
- Trial name
- NCT07003360
- Testing
- application of beautiful blukfill II shofu composite, application of Ivoclar vivadent bulkfill composite, application of Predicta bulk fill composite
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Instability; Back
Neuromuscular Electrical Stimulation and Motor Control
Phase I, this study aims to:- 1. Establish intra- and inter-rater reliability and minimal detectable change of ultrasound imaging measurement 2.
- Trial name
- NCT03786627
- Testing
- Combined NMES and motor control
- Where
- Thailand
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Bulimia Nervosa
Changes in Inhibition and Valuation After Eating
An impaired ability to exert control has been implicated in bulimia nervosa (BN), but this impairment may not represent a stable trait or be the most effective focus for treatment.
- Trial name
- NCT05995496
- Testing
- Fasting state, Fed state, Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Macular Dystrophy, Corneal
Phase 1 Pilot Study of 4-MP to Treat Stargardt Macular Dystrophy
The purpose of this study is to investigate whether taking 4-methylpyrazole (4-MP, fomepizole, Antizol™) inhibits dark adaptation of the eye.
- Trial name
- NCT00346853
- Testing
- 4-Methylpyrazole, saline
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Utah
Healthy
Effect of Steady State Meloxicam on Low Dose Aspirin Induced Inhibition of Platelet Aggregation and Thromboxane Synthesis in Healthy Males and Females
The objective of this study was to investigate the influence of meloxicam on low dose aspirin induced inhibition of platelet aggregation and thromboxane B2, when meloxicam is given before aspirin.
- Trial name
- NCT02187562
- Testing
- Meloxicam, Aspirin
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Healthy Volunteers
In Vivo Inhibition Profile of CYP2C9 by Pineapple Juice
The goal of this study is to evaluate the actual potential for in vivo pineapple juice inhibition with CYP2C9 substrates in human volunteers with use of diclofenac as a marker of CYP2C9 activity.
- Trial name
- NCT01649492
- Testing
- pineapple juice (Carrefour n°1) 500 ml/day 5 days
- Where
- Belgium
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Inhibition (Psychology), Schizophrenia
Prepulse Inhibition (PPI) of Startle Reflex in Schizophrenia Patients Related to Type of Treatment and Illness Duration
PPI is an objective measure to assess pre-attentive processes that have already been tested before in the case of schizophrenia.
- Conditions
- Inhibition (Psychology), Schizophrenia, Medication Adherence
- Trial name
- NCT02484521
- Testing
- PPI monitoring device protocol, Questionnaires
- Where
- Israel
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- HaEmek Medical Center, Israel
Diabetes Mellitus, Type 2, Hydroxymethylglutaryl-CoA Reductase Inhibitors
The Effect of HMG-CoA Reductase Inhibition on Postprandial GLP-1 Secretion
The primary objective of the present study is to evaluate the effect of HMG-CoA reductase inhibition during 14 days on the postprandial plasma GLP-1 response in healthy individuals.
- Trial name
- NCT03018444
- Testing
- Atorvastatin
- Where
- Denmark
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Physical Functioning, Cognitive Functioning
Group Recreation to Enhance Function Aging
Investigators will develop and deliver a community-based recreation program, delivering group artmaking and group SMARTfit dual-task exergaming to community-dwelling older adults.
- Trial name
- NCT07050589
- Testing
- Exercise and art
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Aging
Rapalog Pharmacology (RAP PAC) Study
The objective of RAP PAC is to identify safe and effective weekly dose(s) for the mTOR inhibitors sirolimus and everolimus that intervene on the underlying fundamental biology of aging.
- Trial name
- NCT05949658
- Testing
- Sirolimus, Everolimus
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Obstructive Sleep Apnea, Hypertension
Effect of Selective and Nonselective Cyclooxygenase Enzyme Inhibition on Arterial Blood Pressure and Cerebral Blood Flow With Exposure to Intermittent Hypoxia in Humans
The study has been designed to assess the effect of cyclooxygenase inhibition on blood pressure, cerebral blood flow, ventilation and renal hemodynamics following chronic intermittent hypoxia exposure.
- Conditions
- Obstructive Sleep Apnea, Hypertension, Cardiovascular Diseases, Stroke
- Trial name
- NCT01280006
- Testing
- Intermittent hypoxia, Indomethacin, Celecoxib
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Relaxation; Joint, Limitation, Mobility
Comparing the Reciprocal Inhibition Method and Post-isometric Inhibition Method of Muscle Energy Technique on the Spinal Reflex Excitability in Healthy Subjects
This a cross-over study to compare the effect of two different muscle energy techniques (MET) including post-isometric inhibition and reciprocal inhibition on the spinal reflex excitability.
- Conditions
- Relaxation; Joint, Limitation, Mobility, Relaxation; Lumbosacral
- Trial name
- NCT03980106
- Testing
- Reciprocal Inhibition Muscle Energy Technique, Post-Isometric Inhibition Muscle Energy Technique
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of North Georgia
Healthy Aging
The Role of GABA-mediated Inhibition in Multisensory Temporal Processing & Postural Control in Older Adults
In recent years evidence has accumulated on the association between age-related decline in multisensory temporal processing and postural control.
- Trial name
- NCT03328455
- Testing
- Inhibitory control training, Knowledge-based training
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Nevada, Reno