Clinical trials: Response Rates
Syphilis
Serological Response to Retreatment of Serofast Early Syphilis Cases With Benzathine Penicillin
A continuing challenge to determining the response to treatment of early syphilis (primary, secondary, early latent syphilis) is exemplified by the substantial proportion of patients who fail to achieve serological cure and…
- Trial name
- NCT02884115
- Testing
- benzathine penicillin
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Peking Union Medical College Hospital
Catheter-Related Infections, Bacteremia
Comparison of Infection Rates Among Patients Using Two Catheter Access Devices
Intravenous catheters are placed in nearly every hospitalized patient. These catheters, since they are breaks in skin integrity, are potential sources of infection that occur in the bloodstream.
- Trial name
- NCT00965198
- Where
- 2 sites in United States
- Volunteers
- 10,000 people
- Sponsor
- Emory University
Colorectal Neoplasms
Brazilian Total Neoadjuvant Therapy Trial
Standard therapy for localized rectal cancer includes chemotherapy and radiation therapy, followed by a "recovery" period of 7-12 weeks, surgery and adjuvant chemotherapy for 3-6 months.
- Trial name
- BRAZIL-TNT (NCT05081687)
- Testing
- Folfirinox
- Where
- Brazil
- Volunteers
- 150 people
- Sponsor
- Hospital Israelita Albert Einstein
Sarcopenia, Critical Illness
ICU Sarcopenia Rates by Abdominal CT: Sepsis vs. Trauma
Using abdominal computed tomography (CT) imaging, the investigators will estimate total body muscle mass at two time points in Intensive Care Unit (ICU) by assessing cross-sectional muscle areas at the L3 vertebral body level.
- Conditions
- Sarcopenia, Critical Illness, Sepsis, Trauma
- Trial name
- NCT03982628
- Testing
- Abdominal CT imaging
- Where
- Canada
- Volunteers
- 146 people
- Sponsor
- University of Calgary
Thermoablation, Chronic Liver Disease
Comparison of Response and Recurrence Rates Following Percutaneous Microwave Coagulation Therapy Versus Percutaneous Radiofrequency Ablation
To date, the majority of studies that have evaluated the efficacy of microwave ablation (MWA) in the treatment of hepatocellular carcinoma (HCC) lesions in cirrhotic patients and compared its efficacy with that of percutaneous…
- Conditions
- Thermoablation, Chronic Liver Disease, Hepatocellular Carcinoma
- Trial name
- Thermoablation (NCT02859753)
- Testing
- Percutaneous Radiofrequency Ablation, Percutaneous Microwave Ablation
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Esophageal Adenocarcinoma, Esophageal Squamous Cell Carcinoma
A Phase II Trial to Evaluate the Effect of Itraconazole on Pathologic Complete Response Rates in Resectable Esophageal Cancer
Esophageal cancer, which has a low 5-year overall survival rate (<20%) is increasing in incidence. Previous studies have shown that Hedgehog, AKT, and angiogenic signaling pathways are activated in a significant number of…
- Conditions
- Esophageal Adenocarcinoma, Esophageal Squamous Cell Carcinoma, Gastroesophageal Junction Carcinoma
- Trial name
- NCT05563766
- Testing
- Itraconazole
- Where
- 7 sites in United States
- Volunteers
- 78 people
- Sponsor
- VA Office of Research and Development
Renal Dialysis
Effect of Levamisole Supplementation on Tetanus Vaccination Response Rates in Hemodialysis Patients
Levamisole as an immunomodulator drug has been demonstrated to improve the immune response to Hepatitis B virus (HBV) vaccination in hemodialysis patients.
- Trial name
- NCT00705692
- Testing
- Levamisole
- Where
- Iran
- Volunteers
- 40 people
- Sponsor
- Shiraz University of Medical Sciences
Safety and Tolerability, Compare SHINGRIX Vaccine Response Rates
Response to the SHINGRIX Varicella Zoster Virus (VZV) Vaccine in Chronic Lymphocytic Leukemia (CLL) and CLL Treated With Bruton's Tyrosine Kinase Inhibitor (BTK-I)
Background: People who have cancer tend to get sick more often. This is in part because of the cancer treatments they get. Because of this, they may get shingles.
- Conditions
- Safety and Tolerability, Compare SHINGRIX Vaccine Response Rates, Chronic Lymphocytic Leukemia (CLL), Small Lymphocytic Lymphoma (SLL)
- Trial name
- NCT03702231
- Testing
- Zoster Vaccine Recombinant, Adjuvanted
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Chronic Hepatitis C
A Study to Investigate HCV Response Rates in Real World Patients: HEARTLAND Study
This is a Phase IV, open label, single center study of OBV/PTV/r + DSV +/- RBV for 12 or 24 weeks for the treatment of chronic HCV-1 infection in a real world urban clinical setting.
- Trial name
- HEARTLAND (NCT03710252)
- Testing
- paritaprevir/ritonavir/ombitasvir + dasabuvir +/- ribavirin
- Volunteers
- 100 people
- Sponsor
- American Research Corporation
The Whole-body Protein Synthesis Response to Protein With Amino Acid or Amino Acids
The Effects of LEUVATE on Glycemia, Insulinemia, Aminoacidemia, and Protein Synthesis in GLP-1 RA-treated Adults
GLP-1 receptor agonists have recently emerged as highly effective pharmacological agents for promoting weight loss and improving metabolic health.
- Trial name
- Leuvate001 (NCT07595575)
- Testing
- GLP-1
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Nutraceutical Innovations LLC
Gout
Study of KRYSTEXXA® (Pegloticase) Plus Methotrexate in Participants With Uncontrolled Gout
The purpose of this study is to assess the potential for pegloticase with methotrexate (MTX) to increase the response rate seen with pegloticase alone, and to characterize the safety, tolerability and pharmacokinetics (PK) of the…
- Trial name
- MIRROR RCT (NCT03994731)
- Testing
- Pegloticase, methotrexate, folic acid
- Where
- 60 sites in United States
- Volunteers
- 152 people
- Sponsor
- Amgen
Wound Infection
A Comparison of Surgical Preparations and Wound Infection Rates for Elective Cesarean Sections
The purpose of this study is to find out if chlorhexidine gluconate solution is better at reducing the rate of wound infection after cesarean section compared to povidone-iodine.
- Trial name
- NCT00528008
- Testing
- povidone-iodine solution, chlorhexidine gluconate
- Where
- Canada
- Volunteers
- 268 people, healthy volunteers welcome
- Sponsor
- Memorial University of Newfoundland
Peri-operative Fluid Management
Response to Varying the Rate of Administration of a Fluid Challenge
Administration of intravenous fluids is a key step in the management of the post-operative patient. Fluid management has been identified as one area that can affect rates of post-operative complications and outcomes.
- Trial name
- NCT03300323
- Testing
- IV fluid challenge administration
- Volunteers
- 40 people
- Sponsor
- St George's Healthcare NHS Trust
Hepatitis C
Does Induction PEG-Intron in Combination With Rebetol Enhance the Sustained Response Rates in Patients With CHC
The purpose of this study is to see which of two doses of PEG (polyethylene glycol) interferon alfa-2b in combination with Ribavirin for 48 weeks is more effective at elimination of hepatitis C.
- Trial name
- NCT00207363
- Testing
- Ribavirin, Peg interferon alfa 2b, induction therapy
- Where
- United States
- Volunteers
- 610 people
- Sponsor
- Brooke Army Medical Center
Depression in Adolescence
Increasing Treatment Response Rates in Depressed Adolescents Via Feedback-Informed IPDT
The overarching research project aims to evaluate of an internet-delivered affect-focused psychodynamic treatment (IPDT) for adolescents aged 15-19 with depression.
- Trial name
- ERiCA3 (NCT06193772)
- Testing
- Internet-delivered psychodynamic therapy (IPDT)
- Where
- Sweden
- Volunteers
- 35 people
- Sponsor
- Björn Philips
Cancer, Immunotherapy
A Prospective Real World Evidence Study (PROWES) for Concordance Rate of Blood-based 3D Genome Conformation Mapping (Episwitch CiRT®) to Identify Likelihood of Response and Actual Response Rates to PD-(L)-1 Checkpoint Inhibitors Across Multiple Oncological Indications.
The purpose of this research is to test whether a blood-based 3D genome conformation mapping test called the Episwitch CiRT® can help to identify likelihood of response to PD-(L)-1 checkpoint inhibitors (a class of cancer drugs)…
- Conditions
- Cancer, Immunotherapy, PD-1, PD-L1
- Trial name
- PROWES (NCT06635954)
- Where
- 3 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- Oxford Biodynamics Inc.
Malaria, Severe Malaria
Evaluation of Oral Activated Charcoal on Antimalarial Drug's Ability to Kill Parasites in Malian Children With Malaria
Background: Malaria is caused by small parasites carried by some mosquitoes. People can get malaria if an infected mosquito bites them. Malaria destroys red blood cells.
- Trial name
- NCT01955382
- Testing
- Actidose Aqua, Artesunate, Amodiaquine
- Where
- Mali
- Volunteers
- 70 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Breast Cancer Triple Negative
Neoadjuvant Goserelin for Triple Negative Breast Cancer
This is a phase II randomized trial that will evaluate the effect of adding LHRH analogue, goserelin, to the standard neoadjuvant chemotherapy to patients with triple negative breast cancer.
- Trial name
- NeoGONT (NCT03444025)
- Testing
- Goserelin
- Volunteers
- 180 people
- Sponsor
- Kasr El Aini Hospital
Multiple Myeloma
Engaging T-cells to Eliminate MRD in Newly Diagnosed Myeloma Optimizing Response With Talquetmab and Teclistamab (ROTATE)
Multiple myeloma is characterized by a pattern of recurrent relapse and remains an incurable malignancy. Participants with minimal residual disease (MRD) after front line therapy with induction and transplant have worse prognosis…
- Trial name
- ROTATE (NCT06993675)
- Testing
- Talquetamab, Teclistamab
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Noffar Bar
Diabetes
Assessment of Response Rates and Yields for Two Tools for Early Detection of Non-diabetic Hyperglycaemia and Diabetes
The purpose of this study is to establish the most effective method of increasing attendance to screening of type 2 Diabetes within a primary care setting within the backdrop of the NHS Health Check programme.
- Trial name
- ATTEND (NCT00950313)
- Testing
- Self Assessment, Electronic risk score
- Where
- United Kingdom
- Volunteers
- 432 people, healthy volunteers welcome
- Sponsor
- University of Leicester