Clinical trials: Response Rates
Leukemia
Decitabine for Older or Unfit Patients With Acute Myeloid Leukemia (AML)
The goal of this clinical research study is to compare how well 2 different dosing schedules of decitabine may help control AML.
- Trial name
- NCT01786343
- Testing
- Decitabine
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- M.D. Anderson Cancer Center
Acute Appendicitis
Comparison of Diagnostic Methods in Patients Operated for Suspected Appendicitis
Acute appendicitis is one of the most common surgical emergencies, but diagnostic uncertainty may still lead to unnecessary appendectomy in some patients.
- Trial name
- APP-AIR (NCT07496723)
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Sanliurfa Education and Research Hospital
Lung Cancer
Lung Cancer Screening Eligibility Assessment
The primary purpose of this study evaluate if different messaging impacts response rates to a brief survey (i.e., the simplified eligibility tool) that is designed to estimate pack-year eligibility for lung cancer screening…
- Trial name
- NCT06133816
- Testing
- Framed Introductory Message A, Framed Introductory Message B, Framed Introductory Message C
- Where
- United States
- Volunteers
- 6,125 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Sepsis, Hyperglycemia
Gluconeogenesis Rates and Its Precursors in Pediatric Sepsis
Critically ill children have abnormal utilization of nutrients such as glucose, lipids and protein. Often sick children have increased glucose concentrations in blood.
- Conditions
- Sepsis, Hyperglycemia, Critical Illness
- Trial name
- NCT01890928
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Attention-Deficit/Hyperactivity Disorder (ADHD)
Treating Young Children With Attention Deficit Hyperactivity Disorder
This project will evaluate the effectiveness of Methylphenidate versus Guanfacine in treating Attention-Deficit/Hyperactivity Disorder (ADHD) in children aged 3 through 5 years (inclusive), as measured by clinician rating of…
- Trial name
- TYCA (NCT07300956)
- Testing
- Guanfacine (GUA), Methylphenidate (MPH)
- Where
- 5 sites in United States
- Volunteers
- 370 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Bacteremia
Effectiveness of Routine Sterile Gloving in Blood Culture
The purpose of this study is to determine whether routine sterile gloving can lower contamination rates in blood culture.
- Trial name
- NCT00973063
- Testing
- Routine sterile gloving
- Where
- South Korea
- Volunteers
- 1,854 people
- Sponsor
- Seoul National University Hospital
Coal Workers' Pneumoconiosis (Complicated)
Examination of Pirfenidone (Esbriet®) Therapy in Coal Workers' Pneumoconiosis With Pulmonary Fibrosis
Examination of pirfenidone (Esbriet®) therapy in coal workers' pneumoconiosis (black lung) with pulmonary fibrosis (scarring of the lung).
- Trial name
- NCT04461587
- Testing
- Pirfenidone
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Pulmonary Research of Abingdon, LLC
Muscle Protein Synthetic Response to Protein
The Effectiveness of a Diet With Beef as Key Protein Component Versus a Plant-Based Diet to Support Integrated Muscle Protein Synthesis Rates in Healthy Older Individuals
Muscles are composed out of proteins. These proteins in turn are composed out of smaller building blocks, called amino acids. By consuming a sufficient amount of dietary protein, a sufficient amount of amino acids become…
- Trial name
- OmniVeg_Diet (NCT07049224)
- Testing
- Meat diet, Plant diet
- Where
- Netherlands
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Vasovagal Syncope
Assessment of Stroke Volume and Cardiac Output in Response to Varying Heart Rates
The investigators will seek to determine the effects of different heart rates on both stroke volume and cardiac output using non-invasive hemodynamic assessments.
- Trial name
- Pacing_SV (NCT03446326)
- Testing
- Pacing
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- University of Calgary
Idiopathic Thrombocytopenic Purpura
Interventional Study in Adults With Immune Thrombocytopenia Purpura (ITP) Receiving Romiplostim
The purpose of this study is to describe the number of months with a platelet response over a 12 month treatment period and to describe ITP remission rates in adults with ITP receiving romiplostim.
- Trial name
- NCT01143038
- Testing
- Romiplostim
- Where
- 48 sites in United States, Australia and 7 more
- Volunteers
- 75 people
- Sponsor
- Amgen
Fever
Clinical Immunization Safety Assessment (CISA) Project: Pilot Study to Assess the Effect of Prophylactic Antipyretics on Immune Responses and Fever After IIV
The study team aims to conduct a double-blind, placebo-controlled, pilot study to assess the effect of prophylactic antipyretics on the immune responses and rates of fever after inactivated influenza vaccine (IIV) in children 12…
- Trial name
- NCT01946594
- Testing
- Acetaminophen
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Duke University
Breast Cancer
Physical Exercise During Preoperative Chemotherapy for Breast Cancer
Neoadjuvant chemotherapy (NACT) is increasingly used in breast cancer. The best proof of NACT efficacy is pathological complete response (pCR), i.e. the absence of invasive tumour on post-NACT surgical histopathology.
- Trial name
- Neo-ACT (NCT05184582)
- Testing
- Physical training
- Where
- 13 sites in Australia, Finland and 2 more
- Volunteers
- 712 people
- Sponsor
- Karolinska Institutet
Chronic Myelogenous Leukemia
Nilotinib + Pegylated Interferon Alpha 2a for Untreated Chronic Phase Chronic Myelogenous Leukemia
The aim of this study is to demonstrate the safety and the efficacy of a combination of 2 treatments shown to have some efficacy in Chronic Phase Chronic Myelogenous Leukemia (CP CML) separately, but that have never been combined…
- Trial name
- NILOPEG (NCT01294618)
- Testing
- Nilotinib,Novartis,300 mg twice a day +Pegylated interferon 2a,Roche, 45 microg weekly starting Month 2-Month 12 or beyond according to investigator choice.
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Hospices Civils de Lyon
Malaria
Plasmodium Falciparum Clearance Rates in Response to Artesunate in Eastern Cambodia
Plasmodium falciparum parasite clearance rates (PCRs) after oral artesunate treatment of patients with uncomplicated malaria were recently found to be significantly slower in Pailin (Western Cambodia) compared to Wang Pha…
- Trial name
- NCT01240603
- Where
- Cambodia
- Volunteers
- 415 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Obstructive Airway Disease
In Patients With Obstructive Airway Disease, Investigate the Effects of Different Breathing Strategies and Pedaling Rates on the Physiological Response to Bicycle Exercise
The definition of obstructive airway disease is a ratio of the forced expiratory volume in one second (FEV1) to the forced vital capacity (FVC) of less than 0.7, which includes conditions such as chronic obstructive pulmonary…
- Trial name
- NCT06332820
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital