Clinical trials: Restless Leg Syndrome
Obstructive Sleep Apnea Syndrome, Restless Leg Syndrome
Prevalence of OSAS in Chinese Elderly and Its CPAP Compliance
Objective: Obstructive sleep apnoea syndrome (OSAS) is a common form of sleep-disordered breathing (SDB) causing sleep fragmentation, daytime sleepiness, cognitive function impairment, and poor health status in addition to…
- Trial name
- NCT02085720
- Testing
- CPAP therapy
- Where
- Hong Kong
- Volunteers
- 819 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Restless Legs Syndrome
Glutamate, Hyperarousal and Restless Legs Syndrome
Restless Legs Syndrome (RLS) research has focused on the sensory features and failed to address an important aspect of RLS; i.e. a 'hyperarousal' or profound chronic sleep loss without significant excessive daytime sleepiness.
- Trial name
- NCT01675323
- Where
- 2 sites in United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Restless Legs Syndrome
Functional Connectivity of the Interoceptive Network in RLS
Restless Legs Syndrome (RLS) is a sensorimotor disorder primarily characterized by an irresistible urge to move the legs while at rest.
- Trial name
- IntoRLS (NCT07001891)
- Testing
- Clinical assessment, auto-questionnaires (PSQI, ISI, ESS and HADS), Ecological Momentary Assessment (EMA)
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Shift-Work Sleep Disorder, Insomnia
Fire Fighter Fatigue Management Program: Operation Fight Fatigue
Firefighters frequently work extended duration shifts and long work weeks which have adverse effects on alertness, health, safety and performance.
- Conditions
- Shift-Work Sleep Disorder, Insomnia, Restless Leg Syndrome, Obstructive Sleep Apnea
- Trial name
- NCT01672502
- Testing
- Sleep health education provided via a web-based program, Sleep disorder detection and treatment, Optimization of Sleep in Fire Station
- Where
- United States
- Volunteers
- 620 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Restless Legs Syndrome (RLS)
Efficacy of Tyrosine in Restless Legs Syndrome
Tyrosine is a non essential amino acid that is the precursor of the neurotransmitter, dopamine. Tyrosine is converted into Levodihydrophenylalanine (L-Dopa) and L-Dopa is subsequently and avidly converted into dopamine.
- Trial name
- NCT01494766
- Testing
- L-Tyrosine
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Seton Healthcare Family
Restless Legs Syndrome
A Study to Evaluate the Effect of Gabapentin on Cardiac Repolarization in Healthy Volunteers
This will be a randomized, double-blind, placebo- controlled cross-over study to investigate the effect of GEn on cardiac repolarisation parameters compared with placebo and a positive control, moxifloxacin.
- Trial name
- NCT01516372
- Testing
- GEn 1200mg, Gen 6000 mg, Moxifloxacin
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- XenoPort, Inc.
Akathisia
Akathisia (Restless Legs Syndrome) in People With Schizophrenia and Mental Retardation
Akathisia is a movement disorder that is often a side effect of certain psychiatric drugs. People with akathisia are unable to sit or keep still, complain of restlessness, fidget, rock from foot to foot, and pace.
- Trial name
- NCT00065286
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Diabetic Retinopathy, Macular Degeneration
Advancing Understanding of Transportation Options
This Stage II randomized, controlled, longitudinal trial seeks to assess the acceptability, feasibility, and effects of a driving decision aid use among geriatric patients and providers.
- Conditions
- Diabetic Retinopathy, Macular Degeneration, Glaucoma, Retinitis Pigmentosa
- Trial name
- AUTO (NCT04141891)
- Testing
- Driving Decision Aid, Older Drivers Website
- Where
- 3 sites in United States
- Volunteers
- 529 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Restless Legs Syndrome
Bupropion and Restless Legs Syndrome
The purpose of this study is to determine if bupropion will improve the symptoms of restless legs syndrome (RLS).
- Trial name
- NCT00621517
- Testing
- Bupropion
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- East Tennessee State University
Restless Leg Syndrome (RLS), Spinal Cord Stimulation (SCS)
The Effect of Spinal Cord Stimulators on Restless Leg Syndrome
This study aims to evaluate neurophysiological responses and symptom changes in individuals with Restless Legs Syndrome (RLS) and/or chronic pain.
- Trial name
- NCT07179406
- Testing
- H-Reflex, Somatosensory evoked potential (SSEP), Vibratory Electrophysiological Response Potential (ERP)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Restless Legs Syndrome
Effect of Ropinirole on Spinal Cord Reflexes and Restless Legs Syndrome
This study will examine the effects of the drug Ropinirole on spinal cord reflexes and on symptoms of restless legs syndrome (RLS).
- Trial name
- NCT00051961
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Restless Legs Syndrome (RLS)
Study on the Mechanism of Gut Microbiota Mediating Restless Legs Syndrome Through Iron Metabolism
The goal of this observational study is to collect fecal and serum samples from patients with restless legs syndrome (RLS) and healthy controls for differential microbiota analysis to identify key bacterial species involved in…
- Trial name
- NCT07307482
- Testing
- Not applicable- observational study
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Wenxia Jiang
Restless Legs Syndrome
Autonomic Function and Cardiovascular Risk in Restless Legs Syndrome
The purpose of this study is to explore whether patients with restless legs syndrome (RLS) differ from healthy subjects in daytime and night time autonomic function and cardiovascular risk markers and whether 4 week treatment…
- Trial name
- AUTOREST (NCT02025608)
- Testing
- Pramipexole
- Where
- 2 sites in Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mauro Manconi
Iron Deficiency Anemia of Pregnancy, Iron-deficiency
Non-invasive Detection of Iron Deficiency in Obstetrics
Validation of non-invasive measurement of zinc protoporphyrin for detection of iron deficiency in pregnancy. In addition, the impact of iron deficiency on the incidence of postpartum depression, restless legs syndrome, obstetric…
- Conditions
- Iron Deficiency Anemia of Pregnancy, Iron-deficiency, Restless Leg Syndrome in Pregnancy, Restless Leg Syndrome Due to Iron Deficiency Anaemia
- Trial name
- PICCOLINO (NCT07083492)
- Testing
- non-invasive measurement of zink protoporphyrin
- Where
- Germany
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Wuerzburg University Hospital
RLS
Hemodialysis Patients With Restless Legs Syndrome Used Vibration
Restless Legs Syndrome (RLS) is a chronic disorder characterized by abnormal sensations, usually accompanied by pain and restlessness in the legs and/or any part of the body.
- Trial name
- NCT05249907
- Testing
- Massage
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Baskent University
Restless Legs Syndrome
The Effect of Progressive Muscle Relaxation Exercise Training Given to Pregnant Women With Restless Leg Syndrome
Restless Leg Syndrome (RLS) is a sensory-motor problem characterized by an uncomfortable and unpleasant feeling that causes a strong and overwhelming desire to move the legs, usually during periods of inactivity during sleep.It…
- Trial name
- NCT04853771
- Testing
- progressive muscle relaxation exercise training
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Gazi University