Clinical trials: Resuscitation
Patient Care Team
The Learning Outcome of Resuscitation Teamwork Training in Postgraduate Year Doctors and Nurses
It is challenging for healthcare team to manage emergency patient effectively. Most of these critical patients have medical conditions and need complex medical managements.
- Trial name
- NCT05302414
- Testing
- Board game-based learning, Simulation-based learning, Lecture-based learning
- Where
- Taiwan
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University Hospital
Shock, Septic
Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis: A Pilot Feasibility Study
The objective of this pilot study is to assess overall feasibility prior to embarking on a larger randomized pragmatic trial comparing the clinical effectiveness of fluid resuscitation with NS versus LR for pediatric patients…
- Trial name
- PRoMPT BOLUS (NCT03340805)
- Testing
- Lactated Ringer, Normal saline
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Children's Hospital of Philadelphia
Cardiac Arrest, Cardiopulmonary Resuscitation
Circulation Improving Resuscitation Care (CIRC)
During resuscitation of out of hospital cardiac arrest patients the use of a mechanical chest compression device Autopulse will improve survival compared to manual compressions.
- Trial name
- CIRC (NCT00597207)
- Testing
- AutoPulse, Manual
- Where
- 5 sites in United States, Austria and 1 more
- Volunteers
- 4,231 people
- Sponsor
- Zoll Medical Corporation
Heart Arrest, Cardiac Arrest
Pre-arrival Instructions Effect on Bystander Cardiopulmonary Resuscitation (CPR).
The investigators hypothesized that pre-arrival instructions would increase the likelihood of bystanders performing Cardiopulmonary Resuscitation (CPR).
- Conditions
- Heart Arrest, Cardiac Arrest, Cardiopulmonary Arrest, Out of Hospital Cardiac Arrest
- Trial name
- NCT02007499
- Testing
- Pre-Arrival Instructions
- Where
- United States
- Volunteers
- 274 people
- Sponsor
- Medical College of Wisconsin
Sepsis
Mechanistic Inflammatory Sub-study Embedded Within the Albumin vs Balanced Crystalloid Trial
MIS-ABC Sepsis is a sub-study looking to understand how the immune response in patients with infection changes during the early stages of the illness, as well as after intravenous fluid treatment.
- Trial name
- MIS-ABC Sepsis (NCT04963569)
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- University of Edinburgh
Sepsis
Feasibility of 5% Albumin Compared With Balanced Crystalloid, as Intravenous Fluid Resuscitation in Adult Patients With Sepsis, Presenting as an Emergency to Hospital
The aim of this research study is to compare two different fluids (Human Albumin Solution (HAS) and Balanced Crystalloid that are given via a drip to patients with severe infection (sepsis).
- Trial name
- ABC Sepsis (NCT04540094)
- Testing
- Human albumin, Balanced crystalloid solution
- Where
- 15 sites in United Kingdom
- Volunteers
- 300 people
- Sponsor
- University of Edinburgh
Edema, Hypoproteinemia
Furosemide and Albumin for Diuresis of Edema: A Pilot Randomized Controlled Trial
Critically ill patients usually require intravenous fluids to correct low blood pressure and improve blood flow to vital organs.
- Trial name
- FADE (NCT02055872)
- Testing
- Intravenous albumin, Normal saline
- Where
- Canada
- Volunteers
- 46 people
- Sponsor
- Hamilton Health Sciences Corporation
Preterm Birth, Extreme Prematurity
Sustained Aeration of Infant Lungs Trial
This study is a 2-arm randomized, controlled, multi-center clinical trial to determine which of two strategies at birth are best to optimally aerate the lung of preterm infants.
- Trial name
- SAIL (NCT02139800)
- Testing
- Sustained Inflation, Standard of Care
- Where
- 21 sites in United States, Australia and 7 more
- Volunteers
- 460 people
- Sponsor
- University of Pennsylvania
Traumatic Shock
AVERT Shock: Arginine Vasopressin During the Early Resuscitation of Traumatic Shock
Trauma patients, who are transfused with multiple blood products to treat shock due to blood loss, frequently develop inappropriately low vasopressin levels.
- Trial name
- AVERTShock (NCT01611935)
- Testing
- Vasopressin
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- University of Pennsylvania
Alzheimer Disease, Dementia
Aligning Patient Preferences: a Role Offering Alzheimer's Patients, Caregivers, and Healthcare Providers Education and Support
Nursing home (NH) patients with Alzheimer's disease and related dementias often receive unwanted, burdensome treatments such as hospitalization.
- Trial name
- APPROACHES (NCT03323502)
- Testing
- APPROACHES ACP Specialist Program, Standard of care
- Where
- 2 sites in United States
- Volunteers
- 47,396 people
- Sponsor
- Indiana University
Alzheimer Disease, Dementia
Pragmatic Trial of Video Education in Nursing Homes
This is a pragmatic cluster-randomized control trial (RCT) of an Advance Care Planning (ACP) Video Program for nursing home (NH) patients ≥ 65 years old who are cared for in 360 NH facilities (intervention arm n=119; control arm…
- Conditions
- Alzheimer Disease, Dementia, Heart Failure, Pulmonary Disease, Chronic Obstructive
- Trial name
- PROVEN (NCT02612688)
- Testing
- ACP Video Program
- Where
- 2 sites in United States
- Volunteers
- 197,692 people
- Sponsor
- Brown University
Spinal Cord Injury (Quadraplegia)
Reanimation in Tetraplegia
The purpose of this clinical study is to allow the investigation of the Neural Bridging System for participants with tetraplegia to assess if the investigational device can reanimate a paralyzed limb under voluntary control by…
- Trial name
- NCT01997125
- Testing
- Neural Bridge System
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Marcia Bockbrader
Out-of-hospital Cardiac Arrest
CPR Quality Between Flexible Stretcher and Standard Stretcher in OHCA
This study aims to compare the quality of emergency medical services cardiopulmonary resuscitation between flexible stretcher and standard stretcher during ambulance transport to hospital among out-of-hospital cardiac arrest…
- Trial name
- ASIA-CPR (NCT02527694)
- Testing
- Flexible EMS stretcher cart, mechanical CPR
- Where
- South Korea
- Volunteers
- 49 people
- Sponsor
- Seoul National University Hospital
Birth Asphyxia
Echocardiography Sub-Study of the Umbilical Cord Milking in Non-Vigorous Infants Trial (MINVI)
Non-vigorous infants enrolled in the MINVI trial will be approached for consent for ongoing data collection. As part of the data collection, an optional echocardiogram will be performed if the parent consents.
- Trial name
- NCT03798093
- Testing
- Umbilical Cord Milking, Early Cord Clamping
- Where
- United States
- Volunteers
- 227 people
- Sponsor
- Sharp HealthCare
Respiratory Depression Neonatal
Bedside Improvement of Resuscitation Through mHealth Feedback (BIRTH Study)
Purpose: To evaluate the effectiveness of newborn resuscitation feedback supported by a mobile health application called LIVEBORN; secondarily, to evaluate the relative effectiveness of real-time guidance vs debriefing.
- Trial name
- NCT05963516
- Testing
- LIVEBORN: A Mobile Health Application (app) for Newborn Resuscitation, NeoBeat: Heart Rate Meter for Newborn Resuscitation
- Where
- 4 sites in Democratic Republic of the Congo
- Volunteers
- 14,679 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Out of Hospital Cardiac Arrest
Effects of a New Dispatcher-Assisted Basic Life Support Training Program
Despite aggressive cardiopulmonary resuscitation (CPR) training, the outcome of cardiac arrest is not good. The problem is method of education.
- Trial name
- HEROS (NCT02142387)
- Testing
- BLS CPR program with dispatcher assisted CPR simulation
- Where
- South Korea
- Volunteers
- 18,822 people
- Sponsor
- Seoul National University Hospital
Septic Shock
The Conservative vs. Liberal Approach to Fluid Therapy of Septic Shock in Intensive Care Trial
The purpose of this trial is to assess patient important benefits and harms of IV fluid restriction vs. standard care fluid therapy in patients with septic shock.
- Trial name
- CLASSIC (NCT03668236)
- Testing
- Isotonic crystalloids
- Where
- 31 sites in Belgium, Czechia and 6 more
- Volunteers
- 1,554 people
- Sponsor
- Anders Perner, MD, PhD
Cardiac Arrest, Extracorporeal Membrane Oxygenation Complication
Advanced Reperfusion Strategies for Refractory Cardiac Arrest
This is a Phase II, single center (Under the Center for Resuscitation Medicine at the University of Minnesota Medical School), partially blinded, prospective, intention to treat, safety and efficacy clinical trial, randomizing…
- Conditions
- Cardiac Arrest, Extracorporeal Membrane Oxygenation Complication, Ventricular Fibrillation, Pulseless Ventricular Tachycardia
- Trial name
- ARREST (NCT03880565)
- Testing
- Early Extracorporeal Membrane Oxygenation (ECMO) Facilitated Resuscitation, Standard Advanced Cardiac Life Support (ACLS) Resuscitation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Minnesota
Premature Infant, Extremely Low Birth Weight
Time to Accurate Heart Rate on Neonatal Outcomes
The goal of this trial is to compare the time to first heart rate displayed for iRes Warmer with ResusView and using iRes Warmer without ResusView when used in the resuscitation (e.g.
- Conditions
- Premature Infant, Extremely Low Birth Weight, Extreme Prematurity
- Trial name
- GE-EKG (NCT04587934)
- Testing
- iRes Warmer with ResusView, iRes Warmer without ResusView
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Sharp HealthCare
Critical Illness
Code Status Video in the Intensive Care Unit: Video Assisted Patient Education
This is a single-center, randomized control trial of a code status video as an educational tool in the intensive care unit. Subjects are stratified by patient or surrogate and are randomized to either watch an educational video…
- Trial name
- NCT01610076
- Testing
- Code Status Video
- Where
- United States
- Volunteers
- 208 people
- Sponsor
- Mayo Clinic