Clinical trials: Resuscitations
Educational Problems, Resuscitation
Group Size in Basic Life Support (BLS) Courses
Basic Life Support (BLS) is important for outcome in cardiac arrest.Therefore, it is crucial to improve the quality of education in resuscitation training.
- Trial name
- NCT03773861
- Testing
- errors made in one BLS session
- Where
- Switzerland
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Septic Shock
Guiding Fluid Resuscitation in Septic Shock: Ultrasound vs. Noninvasive Cardiac Output Monitoring
This randomized controlled study investigates the value of critical care ultrasound and non-invasive cardiac output monitoring in guiding fluid resuscitation for patients with septic shock in the emergency department.
- Trial name
- CUS-NICOM-SS (NCT07162857)
- Testing
- non-invasive cardiac output monitoring, Ultrasonic technology
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Mai Xiaowei
Intraoperative Cardiac Arrest
Cardiopulmonary Resuscitation in Operating Room
In the last ten years patient safety during routine surgical interventions has increased; however as there is an increase in the number of specialized surgical interventions and high risk patients like elderly and emergency…
- Trial name
- CPR (NCT02884271)
- Testing
- cardiopulmonary resuscitation
- Where
- Turkey (Türkiye)
- Volunteers
- 7 people
- Sponsor
- Dokuz Eylul University
Septic Shock, Fluid Resuscitation
Restricted or Liberal Fluid for Haemodynamic Resuscitation in Sepsis
A prospective, individual patient data meta-analysis (IPDMA) of four multicentre, open-label, randomised clinical trials of initial haemodynamic resuscitation in patients with septic shock.
- Trial name
- FRESHLY (NCT05453565)
- Testing
- Vasopressors, Fluids
- Volunteers
- 7,838 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Pediatric Cardiac Arrest (Simulated)
Examining the Effect of a Scripted Debriefing on Resuscitation Performance in Pediatrics
The investigative team's purpose for conducting this research is to improve effective and efficient translation and implementation of evidence based advanced life support practice to providers of care for children.
- Trial name
- EXPRESS (NCT01682629)
- Testing
- Debriefing Script, High Physical Realism Simulation
- Where
- Canada
- Volunteers
- 443 people, healthy volunteers welcome
- Sponsor
- KidSIM Simulation Program
Acute Coronary Syndrome
Effects and Plasma Concentration of Ticagrelor, After Crushed and Non-crushed Intake, After Acute Coronary Syndrome
The first aim of the study is to prove that after starting the therapy with crushed tablets, the platelet inhibition will be as expected after starting therapy with intact tablets. Gurbel et al.
- Trial name
- ticagrelor (NCT02341729)
- Testing
- ticagrelor
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- University Hospital, Ghent
Trauma, Hypovolemic Shock
Evaluation of Resuscitation Markers in Trauma Patients
Severe trauma patients have an elevated risk of multiple organ failure and death. In order to increase survival possibilities the initial treatment must be focused into resuscitation from shock.
- Trial name
- NCT02772653
- Testing
- Blood Lactate, Blood Base Excess, Blood B-type Natriuretic Peptide
- Where
- Spain
- Volunteers
- 66 people
- Sponsor
- Andrea Campos-Serra
Extracorporeal Membrane Oxygenation, Cardiac Arrest
ON-SCENE Initiation of Extracorporeal CardioPulmonary Resuscitation During Refractory Out-of-Hospital Cardiac Arrest
Hypothesis: Implantation of on-scene ECPR by the HEMS teams in patients with sustained out-of-hospital cardiac arrest, results in the rapid return of circulation and, thus, improved survival and less neurological impairment…
- Trial name
- ON-SCENE (NCT04620070)
- Testing
- ECPR
- Where
- 4 sites in Netherlands
- Volunteers
- 221 people
- Sponsor
- Erasmus Medical Center
Code Status Discussions With Medical In-patients
Checklist-guided Shared Decision-making for Code Status Discussions in Medical Inpatients.
This cluster-randomized, multicenter trial is designed to investigate the effect of checklist-guided shared decision-making including decision aids and communication of expected outcome on patients' decision regarding their code…
- Trial name
- NCT03872154
- Testing
- Checklist-guided shared decision-making
- Where
- Switzerland
- Volunteers
- 2,663 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Cardiac Arrest, Sudden, Ventricular Tachycardia
Cardiopulmonary Resuscitation Performance of Professional Rescuers With a New Defibrillation Algorithm
In the Paris (France) Medical Emergency system, in the early phase of Out-of-hospital Cardiac Arrest (OHCA), the treatment of a Ventricular Fibrillation (VF) consists of delivering an External Electric Shock (EES) by a rescuer…
- Conditions
- Cardiac Arrest, Sudden, Ventricular Tachycardia, Ventricular Fibrillation, Sudden Cardiac Death
- Trial name
- DEFI-2022 (NCT04691089)
- Where
- France
- Volunteers
- 285 people
- Sponsor
- French Defence Health Service
End Stage Liver DIsease, Obesity
Use of Direct Peritoneal Resuscitation in High-risk Liver Transplant Recipients
This study is being conducted to assess the safety of Direct Peritoneal Resuscitation (DPR) in high-risk liver transplant patients.
- Conditions
- End Stage Liver DIsease, Obesity, Acute Kidney Injury
- Trial name
- NCT05195125
- Testing
- Direct Peritoneal Resuscitation
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Colorado, Denver
Critical Illness, Fluid Over-load
Effect of Dynamic Arterial Elastance and Assisted Fluid Management Software Guided Resuscitation in Septic Shock: Pilot Study
To investigate the benefit of using the AFM and Eadyn-guided fluid and vasopressor therapy in septic shock resuscitation for mechanically ventilated patients compared with the standard of care.
- Conditions
- Critical Illness, Fluid Over-load, Dynamic Arterial Elastance, Septic Shock
- Trial name
- DAFM shock (NCT06937918)
- Testing
- The AFM and Eadyn - guided resuscitation group, The standard care for septic shock
- Where
- 3 sites in Thailand
- Volunteers
- 60 people
- Sponsor
- Mahidol University
Cardiac Death, Cardiac Arrest
Quality of Cardiopulmonary Resuscitation Pre- and Intra Hospital
The survival after intrahospital cardiac arrest has been reported to 15%. In Norway this varies between 16 and 23%.). Many factors are associated with survival after cardiac arrest, both intra- and prehospital.
- Conditions
- Cardiac Death, Cardiac Arrest, Cardiac Arrhythmia, Cardiac Disease
- Trial name
- NCT04295291
- Volunteers
- 300 people
- Sponsor
- Ostfold University College
Severe Sepsis and Septic Shock
Statistical Analysis Plan for an Individual Patient Data Meta-analysis of Three, International Trials Comparing Protocolised With Usual Resuscitation in Patients Presenting to the Emergency Department With Severe Sepsis and Septic Shock
This is the statistical analysis plan for an individual patient data meta-analysis (IPDMA) of three EGDT clinical trials.
- Trial name
- NCT02030158
- Volunteers
- 4,210 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Heart Arrest, Heart Arrest, Out-Of-Hospital
An Educational Program to Improve Cardiac Arrest Diagnostic Accuracy of Ambulance Telecommunicators
Cardiac arrest is the number one cause of death in Canada. It is often the first symptom of cardiac disease for the victims. Eighty-five percent of victims collapse in their own home.
- Conditions
- Heart Arrest, Heart Arrest, Out-Of-Hospital, Cardiac Arrest, Death, Sudden, Cardiac
- Trial name
- NCT03894059
- Testing
- Educational Intervention
- Where
- Canada
- Volunteers
- 12,224 people
- Sponsor
- Ottawa Hospital Research Institute
Cardiopulmonary Resuscitation, Echocardiography
Correlation Between End-tidal CO2 and Degree of Compression of Heart During CPR Measured by Ultrasound
Individual optimization of cardiopulmonary resuscitation (CPR) in real time may increase the success rate of the procedure. End-tidal CO2 (EtCO2) levels reflect cardiac output induced by CPR.
- Trial name
- NCT03852225
- Testing
- Intra-arrest echocardiography
- Where
- Czechia
- Volunteers
- 20 people
- Sponsor
- Emergency Medical Service of the Central Bohemian Region, Czech Republic
Burn Shock
Evaluation of Sublingual Microcirculation in Burn During Resuscitation
The adequacy of fluid resuscitation will be monitored in burn patients using microcirculation. Microcirculation camera will be placed on the base of the tongue and at different four quadrants.
- Trial name
- NCT05096559
- Testing
- Microcirculation cytocam
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Acute Kidney Failure, Renal Replacement Therapy for Acute Kidney Injury in ICU
Effects of Sedation, TEmperature and Pressure After Cardiac Arrest and REsuscitation on Major Adverse Kidney Events (STEPCARE-MAKE)
The STEPCARE-MAKE study is a predefined sub-study of the large Sedation, TEmperature and Pressure after Cardiac Arrest and REsuscitation (STEPCARE) trial, which evaluates the effects of three interventions in comatose adult…
- Conditions
- Acute Kidney Failure, Renal Replacement Therapy for Acute Kidney Injury in ICU, Sedation in Intensive Care Unit Patients, Sedation in the ICU
- Trial name
- STEPCARE-MAKE (NCT07579390)
- Testing
- Feedback-controlled temperature device, High MAP, Deep sedation
- Where
- 52 sites in Australia, Belgium and 12 more
- Volunteers
- 3,500 people
- Sponsor
- Helsinki University Central Hospital
Out-of-Hospital Cardiac Arrest, Cardiopulmonary Resuscitation
Improving Bystander CPR Quality Through Dispatcher-assisted Basic Life Support Education Program
In an attempt to enhance OHCA survival by increasing bystander CPR rate, this study will assess the effectiveness of the new basic life support with dispatch assistance (DA-BLS) education program through a simulation experiment.
- Trial name
- NCT02527473
- Testing
- Dispatcher-Assisted Basic Life Support CPR Education
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Out-Of-Hospital Cardiac Arrest
International Termination of Resuscitation Practices
Neither the international nor the interregional variation in survival following OHCA is fully understood, but may rely on multiple factors such as: organization of the Emergency Medical Service (EMS) system bystander…
- Trial name
- NCT05029180
- Testing
- Termination of resuscitation
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
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