Clinical trials: Resuscitations
Sepsis, Severe Bacterial Infections
Evaluation of the Dialytic Clearance of the Combination of Peracillin and Tazobactam
Severe bacterial infections, often responsible for sepsis and septic shock, are a major challenge in critical care: approximately 50% of patients are affected, with a mortality rate of up to 40%.
- Trial name
- EPIC (NCT07167524)
- Testing
- Dosage concentration of piperacillin and tazobactam
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Rouen
Cardiac Arrest
Assessing CPR Quality During In-Hospital Cardiac Arrest
Using an investigational monitor/defibrillator that passively records CPR quality parameters, including chest compression rate and depth and ventilation rate and volume, we are prospectively recording CPR quality during…
- Trial name
- NCT00228293
- Testing
- investigational monitor/defibrillator with CPR feedback
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Chicago
Septic Shock
Protocolized Reduction of Non-resuscitation Fluids Versus Usual Care in Septic Shock Patients
The objective of this trial is to assess the beneficial and harmful effects of a restrictive strategy for administration of non-resuscitation fluids in adult patients with septic shock.
- Trial name
- REDUSE (NCT06140147)
- Testing
- Protocolised reduction of non-resuscitation fluids, Usual care
- Where
- 22 sites in Finland, Sweden and 1 more
- Volunteers
- 1,850 people
- Sponsor
- Region Skane
Out-Of-Hospital Cardiac Arrest, In-hospital Cardiac Arrest
RIAC - Registro Italiano Arresti Cardiaci (Italian Registry of Cardiac Arrest)
RIAC - An Observational, Prospective, Multi-centre, Study of Epidemiology, Treatment, and Outcome of Cardiac Arrest in Italy.
- Trial name
- RIAC (NCT03220269)
- Testing
- Out-of-hospital cardiac arrest (OHCA), In-hospital cardiac arrest (IHCA)
- Where
- Italy
- Volunteers
- 8,000 people
- Sponsor
- Italian Resuscitation Council
Renal Failure
Renal Replacement Therapy in Neonates
The circumstances for setting up dialysis in the neonatal period are multiple: congenital anomaly of the kidney and urinary tract (CAKUT), secondary acute renal failure whose etiologies are multiple (sepsis, hypovolemia…
- Trial name
- Neo-Renal (NCT05456659)
- Where
- France
- Volunteers
- 72 people
- Sponsor
- University Hospital, Strasbourg, France
Decision Making, Resuscitation
Evaluation of a Decision Aid About Life-sustaining Therapies
Introduction: Clinical practice guidelines recommend shared decision making (SDM) to facilitate goals-of-care discussions. This study will train clinicians about how to use a context-adapted decision aid (DA) and SDM to conduct…
- Conditions
- Decision Making, Resuscitation, Intensive Care Unit, Goals-of-care
- Trial name
- NCT04034979
- Testing
- decision aid
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- Laval University
Cardiac Arrest With Successful Resuscitation
A Novel Patient Decision Aid for Surrogate Decision Makers of Comatose Survivors of Cardiac Arrest
This study will test the feasibility and acceptability of deploying a decision aid for surrogate decision makers of comatose survivors of cardiac arrest early during hospitalization.
- Trial name
- NCT03908346
- Testing
- Decision Aid for Surrogate Decision Makers of Comatose Survivors of Cardiac Arrest
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Colorado, Denver
Cardiac Arrest
Aminophylline in Bradyasystolic Cardiac Arrest
The purpose of this study is to evaluate the effect of aminophylline in patients with out-of-hospital bradyasystolic cardiac arrest.
- Trial name
- NCT00312273
- Testing
- Aminophylline (250mg IV +/- a second dose of 250mg IV)
- Where
- Canada
- Volunteers
- 966 people
- Sponsor
- Vancouver General Hospital
Cardiac Arrest
Multifaceted Intervention for Increasing Performance of CPR by Laypersons in Out-of-hospital Cardiac Arrest
Cardiac arrest (CA) early recognition is essential in order to rapidly activate emergency services and for bystanders to begin cardiopulmonary resuscitation (CPR).
- Trial name
- DISPATCH (NCT03633370)
- Testing
- Multifaceted intervention including 3 components
- Where
- 15 sites in France
- Volunteers
- 2,481 people
- Sponsor
- University Hospital, Grenoble
Cardiac Arrest
Sustained Inflation and Chest Compression vs 3:1 C:V Ratio in Asphyxiated Newborns
Newborn infants who require cardiopulmonary resuscitation at birth receive chest compression using a 3-Compression to 1-Ventilation (3:1 C:V) ratio.
- Trial name
- SUR1VE-2 (NCT06577818)
- Testing
- CC+SI (Chest compression during sustained inflation), 3:1 C:V (3:1 Compression:Ventilation ratio)
- Where
- Canada
- Volunteers
- 554 people
- Sponsor
- University of Alberta
Cardiac Arrest
Effects of Epinephrine and Intravenous (I.V.) Needle on Cardiopulmonary Resuscitation (CPR) Outcome
Intravenous epinephrine has been part of the guidelines for cardiopulmonary resuscitation since the start. It improves outcome in animal studies, but has never been investigated in a controlled study in humans.
- Trial name
- NCT00121524
- Testing
- Epinephrine, Intravenous needle, Atropine
- Where
- Norway
- Volunteers
- 904 people
- Sponsor
- Petter Andreas Steen
Severe Sepsis, Septic Shock
Efficacy of Volume Substitution and Insulin Therapy in Severe Sepsis (VISEP Trial)
The purpose of this trial is to determine the influence of colloid versus crystalloid volume resuscitation and of intensive vs conventional insulin therapy on morbidity and mortality of patients with severe sepsis and septic…
- Trial name
- NCT00135473
- Testing
- 10% Hemohes® (10% Hydroxyethyl starch), Sterofundin® (Ringer lactate solution), Actrapid® (Insulin)
- Where
- 16 sites in Germany
- Volunteers
- 600 people
- Sponsor
- SepNet - Critical Care Trials Group
Cardiac Surgery
Double Blind Randomized Trial of Saline vs Pentaspan for Resuscitation After Cardiac Surgery
This is a randomized double blind trial of the use of the use of colloids vs crystalloid solutions for resuscitation of patients after cardiac surgery.
- Trial name
- NCT00337805
- Testing
- Pentaspan
- Where
- Canada
- Volunteers
- 240 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Cardiac Arrest, Out-Of-Hospital
The REVIVE-PEEP Trial: Positive End-expiratory Pressure Versus Sham Valve/Zero End-expiratory Pressure in Cardiopulmonary Resuscitation During Manual Ventilation to Improve Neurological Outcomes at Discharge in Adult Patients Suffering an Out-of-hospital Cardiac Arrest
The goal of this clinical trial is to learn if applying positive end-expiratory pressure (PEEP) during cardiopulmonary resuscitation (CPR) improves neurological outcome in adults with out-of-hospital cardiac arrest who receive an…
- Trial name
- REVIVE-PEEP (NCT07905482)
- Testing
- Fixed PEEP Valve
- Where
- 3 sites in Netherlands
- Volunteers
- 3,200 people
- Sponsor
- Jeroen van Eijk
Heart Arrest
Dispatcher-Assisted Resuscitation Trial (DART)
The purpose of this study is to determine whether dispatcher-assisted CPR instructions with compressions and ventilations versus dispatcher-assisted CPR instructions with compressions only improves survival from out-of-hospital…
- Trial name
- NCT00219687
- Testing
- dispatcher-assisted CPR with compressions & ventilations, dispatcher-assisted CPR instructions with compressions only
- Where
- 3 sites in United States, United Kingdom
- Volunteers
- 5,494 people
- Sponsor
- Public Health - Seattle and King County
End-of-life Care, Palliative Care
Prehospital Care of End-of-Life Patients by the Strasbourg Mobile Emergency and Resuscitation Service: A Qualitative Study of Healthcare Professionals' Experiences and Use of a Comfort Care Booklet
Prehospital end-of-life care presents complex clinical, ethical, relational, and organizational challenges for healthcare professionals working in the Strasbourg Mobile Emergency and Resuscitation Service (SMUR).
- Conditions
- End-of-life Care, Palliative Care, Prehospital Emergency Care, Healthcare Professionals' Experiences and Perceptions
- Trial name
- PALLI-SMUR1 (NCT07895940)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Strasbourg, France
Basic Life Support
Early or Late Booster for Basic Life Support?
Attrition of skills after basic life support (BLS) training is common. Psychology studies have established that for basic memory recall tasks, spaced learning strategies improve retention.
- Trial name
- NCT02998723
- Testing
- Early Booster Teaching, Late Booster Teaching
- Where
- Canada
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Cardiac Surgery
Impact of Intravascular Fluid Resuscitation and Whole Blood Viscosity for Cardiac Surgery
After obtaining approval from the Institutional Review Board of our institution, written informed consent is obtained from patients undergoing cardiac surgery are enrolled in this prospective study and randomly allocated into one…
- Trial name
- NCT02757118
- Testing
- Intravenous Crystalloid, Intravenous HES
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Konkuk University Medical Center
Ventricular Fibrillation
Influence of Mild Therapeutic Hypothermia on Leukocyte Count
Mild therapeutic hypothermia is indicated in patients surviving out-of-hospital cardiac arrest due to ventricular fibrillation. Potential immunologic responses are unknown.
- Trial name
- INCA (NCT00520520)
- Where
- Germany
- Sponsor
- Charite University, Berlin, Germany
Neurologic Manifestations, Premature Birth
The Neu-Prem Trial: Neuromonitoring of Preterm Newborn Brain During Birth Resuscitation
The purpose of this study is to characterize the normal brain function of premature infants (23 to 31+6 weeks GA) during birth transition and through the first 72 hours of life.
- Conditions
- Neurologic Manifestations, Premature Birth, Hypoxia-Ischemia, Brain
- Trial name
- Neu-Prem (NCT02605733)
- Testing
- EEG, NIRS
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Sharp HealthCare
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