Clinical trials: Resynchronization Therapy
Atrial Fibrillation (AF), Heart Failure
LBBAP vs. CS Pacing for CRT in Permanent Atrial Fibrillation and Heart Failure (SYNC-AF)
This is a prospective, multicenter, randomized controlled trial comparing Left Bundle Branch Area Pacing (LBBAP)-based cardiac resynchronization therapy (CRT) with conventional coronary sinus (CS) lead-based CRT in patients with…
- Conditions
- Atrial Fibrillation (AF), Heart Failure, Cardiomyopathies
- Trial name
- SYNC-AF (NCT07560891)
- Testing
- Left Bundle Branch Area Pacing (LBBAP) for CRT, Coronary Sinus (CS) Lead-Based Biventricular CRT
- Volunteers
- 44 people
- Sponsor
- Yonsei University
Heart Failure
BBAP With CS Mapping Guidance
Study Title Efficacy and Safety of Coronary Sinus-Based Left Atrial Mapping for Guiding Atrial Lead Implantation Targeting Bachmann Bundle Capture in Cardiac Resynchronization Therapy Research Objectives This study intends to use…
- Trial name
- NCT07531368
- Testing
- CS mapping guidance, ECG guidance
- Volunteers
- 40 people
- Sponsor
- Shanghai Zhongshan Hospital
Cardiac Resynchronization Therapy, Heart Failure
POsition of Leads in Advanced heaRt Failure: the POLAR Study
The primary objective is to determine if lead positioning in the lateral wall of the left ventricle in patients meeting criteria for cardiac resynchronization therapy plays a role in determining myocardial function and affects…
- Trial name
- POLAR (NCT01515761)
- Testing
- Postero-lateral, Antero-Lateral
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Sergio Thal, M.D.
Sleep Apnea, Arrhythmias
Automate Detection of Sleep Apnea by ApneascanTM
The purpose of the study is to compare, three months after implantable cardioverter-defibrillator (ICD) or cardiac resynchronization therapy-defibrillator (CRT-D), the apnea-hypopnea index (AHI) obtained from conventional in-lab…
- Trial name
- AIRLESS (NCT02045173)
- Testing
- Apneascan TM, Polysomnography/polygraphy
- Where
- 5 sites in France
- Volunteers
- 41 people
- Sponsor
- University Hospital, Grenoble
Atrial Fibrillation, Persistent
Optimal Pacing Rate for Cardiac Resynchronization Therapy
This is a prospective, randomized crossover study. The objective of the study is to determine if a pacing rate of 80 beats per minute (bpm) improves exercise tolerance during the 6-minute walk test.
- Trial name
- OPT-RATE AF (NCT06445439)
- Testing
- Pacing rate of 80 bpm, Pacing rate of 60 bpm
- Where
- 5 sites in United States
- Volunteers
- 60 people
- Sponsor
- Medstar Health Research Institute
Non-ischemic Cardiomyopathy, Heart Failure
LBBP as Initial Therapy in Patients With Non-ischemic Heart Failure and LBBB
The present study will recruit 50 symptomatic non-ischemic cardiomyopathy (NICM) patients with left ventricular ejection fraction (LVEF) below 35% and complete left bundle branch block (CLBBB), who have not received complete…
- Conditions
- Non-ischemic Cardiomyopathy, Heart Failure, Left Bundle-Branch Block
- Trial name
- LIT-HF (NCT05572957)
- Testing
- Guideline-Directed Medical Therapy(GDMT), left bundle branch pacing combined with Guideline-Directed Medical Therapy(LBBP+GDMT)
- Where
- 6 sites in China
- Volunteers
- 50 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Heart Failure, Cardiac Resynchronization Therapy
Comparative Study to Examine Whether Echocardiography Performed During Cardiac Resynchronization Therapy Device Implantation Can Improve the Response Rate
Empirical implantation of the left ventricular lead is the prevailing practice in cardiac resynchronization therapy device implantation.
- Conditions
- Heart Failure, Cardiac Resynchronization Therapy, Echocardiography
- Trial name
- E-OPT (NCT01014000)
- Testing
- Empirical group, Echocardiography-guided approach
- Where
- China
- Sponsor
- Princess Margaret Hospital, Hong Kong
Atrial Fibrillation
Initial Experience With Spatial Resynchronization Therapy in Patients With Atrial Fibrillation
Demonstrate initial safety and performance of Spatial Resynchronization Therapy (SRT) in patients with persistent atrial fibrillation.
- Trial name
- SR-TheAF (NCT05461612)
- Testing
- Spatial Resynchronization Therapy delivered by the MAX-SRS, external recording and stimulation device
- Where
- Georgia
- Volunteers
- 30 people
- Sponsor
- Maxwell Biomedical
Heart Failure, Cardiac Resynchronization Therapy
Tissue Doppler Imaging (TDI) Versus Electrocardiography (ECG) Interventricular Pacing Delay Optimization in Cardiac Resynchronization Therapy (CRT)
The aim of this study was to compare the response to cardiac resynchronization therapy when the interventricular pacing interval was optimized by Tissue Doppler Imaging (TDI) to response when it was optimized following QRS width…
- Trial name
- NCT01179997
- Testing
- Interventricular pacing delay optimization by using Tissue Doppler-derived displacement curves, Electrocardiographic optimization of the interventricular pacing delay according to QRS width
- Where
- Spain
- Volunteers
- 156 people
- Sponsor
- Hospital Clinic of Barcelona
Mitral Regurgitation
Mitral Insufficiency Reduction With Biventricular Pacing
The purpose of this study is to show that CRT(Cardiac Resynchronization Therapy) pacing in patients with severe functional MR (Mitral Regurgitation) who are not currently indicated for CRT will demonstrate chronic benefit of MR…
- Trial name
- MiRBi (NCT01242397)
- Testing
- CRT pacing
- Volunteers
- 50 people
- Sponsor
- Trinity Medical Center, Illinois
Heart Failure
The Application of Negative Atrioventricular Hysteresis in Cardiac Resynchronization Therapy
The purpose of this study is to evaluate the application of Negative Atrioventricular Hysteresis (NAVH) to improve electrical synchrony in Cardiac Resynchronization Therapy (CRT) patients.
- Trial name
- NCT02903940
- Testing
- CRT+NAVH
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Abbott Medical Devices
Heart Failure (HF)
Systematic Withdrawal of Neurohumoral Blocker Therapy in Optimally Responding CRT Patients
The primary objective of this study is to demonstrate that in patients with recuperated/normalized left ventricular function, defined as an ejection fraction (EF) ≥ 50%, after implantation of cardiac resynchronization therapy…
- Trial name
- STOP-CRT (NCT02200822)
- Testing
- beta blockers, RAAS blockers
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- Hasselt University
Cardiac Resynchronization Therapy, Heart Failure
Septal Mapping And Resynchronisation Therapy- (SMART) Study
Normal heart function involves rhythmic contraction of all four chambers of the heart and this rhythm is maintained by the electrical wiring (conduction system) of the heart.
- Trial name
- NCT04595305
- Testing
- Cardiac resynchronization therapy by CRT-P or CRT-D implantation
- Where
- Australia
- Volunteers
- 3 people
- Sponsor
- Abbott Medical Devices
Congestive Heart Failure
Non-Invasive Cardiac Output Measurement for CRT Optimization
This proposal aims to evaluate the added clinical and echocardiographic benefit of using the non-invasive impedance-based cardiac output measurement system (NICaS) for optimizing atrio-ventricular and inter-ventricular delays in…
- Trial name
- NICaS-CRT (NCT02126241)
- Testing
- NICaS guided CRT optimization
- Where
- Israel
- Volunteers
- 42 people
- Sponsor
- Sheba Medical Center
Heart Failure, Congestive, Cardiac Pacing, Artificial
Effect of Targeting Left Ventricular Lead Position on the Rate of Response to Cardiac Resynchronization Therapy.
Identifying \& optimizing strategies to reduce the burden of heart failure is vital. Despite advances in pharmacotherapy, patients with heart failure are at high risk for death \& hospitalization.
- Conditions
- Heart Failure, Congestive, Cardiac Pacing, Artificial, Defibrillators
- Trial name
- INCREMENTAL (NCT00399594)
- Testing
- A, B
- Where
- 3 sites in Canada
- Volunteers
- 96 people
- Sponsor
- University of Calgary
Cardiac Resynchronization Therapy, Chronic Heart Failure
Exercise Training Following Cardiac Resynchronization Therapy in Patients With Chronic Heart Failure
Cardiac resynchronization therapy(CRT) is recommended to reduce mortality and morbidity in chronic heart failure(CHF) patients New York Heart Association(NYHA) class III-IV who are symptomatic despite optimal medical therapy…
- Trial name
- NCT02413151
- Testing
- Exercise training program, Cardiac resynchronization therapy (CRT)
- Where
- Portugal
- Volunteers
- 62 people
- Sponsor
- University of Lisbon
Heart Failure, Diabetes Mellitus, Type 2
BIO-2-HEART: Identification of Biomarkers in T2DM and Heart Failure
The primary aim of the current study is a better understanding of the role of Type 2 Diabetes Mellitus (T2DM) in heart failure and, in particular, changes in cardiac metabolism, which may contribute to heart failure.
- Trial name
- BIO-2-HEART (NCT03323216)
- Testing
- 6-minute walk test, Study specific questionnaire, Blood collection
- Where
- Germany
- Volunteers
- 400 people
- Sponsor
- RWTH Aachen University
Non-left Bundle Branch Block, Ischemic or Non-ischemic Cardiomyopathy
CRT Implant Strategy Using the Longest Electrical Delay for Non-left Bundle Branch Block Patients
The purpose of this study is to analyze the effect of left ventricular lead pacing location in the non-left bundle branch block (non-LBBB) heart failure patient population.
- Trial name
- ENHANCE CRT (NCT01983293)
- Testing
- QLV based implant strategy, Standard of care implant strategy
- Where
- 32 sites in United States
- Volunteers
- 248 people
- Sponsor
- Abbott Medical Devices
Heart Failure
OptiVol® Care Pathway
Medtronic, Inc. is sponsoring the OptiVol® Care Pathway Study, a prospective, randomized, multi-center, post-market clinical trial in the United States.
- Trial name
- NCT00847288
- Testing
- Monthly Review Arm, Quarterly Review Arm
- Where
- 108 sites in United States
- Volunteers
- 1,682 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Heart Failure, Systolic
SyncAV Study: Investigation of the Efficacy of the SyncAV Fusion Pacing Algorithm on Exercise
In patients with weak pumping function of the heart, uncoordinated contraction of the chambers can be corrected using a cardiac resynchronization therapy ("CRT") pacemaker.
- Trial name
- NCT03768804
- Testing
- SyncAV algorithm on, SyncAV algorithm off
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- University of Oxford