Clinical trials: Retina; Change
Retinal Vascular
Physiologic Change of Posterior Ocular Segment During Pregnancy
Women's physiology changes markedly during normal pregnancy. The most distinct alterations occur in the hormonal and cardiovascular systems. There is a dramatic increase in both estrogen and progesterone.
- Trial name
- NCT04731415
- Testing
- Optical coherence tomography and optical coherence tomography angiography (Optovue®)
- Where
- Thailand
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Khon Kaen University
Rhegmatogenous Retinal Detachment
Anatomical and Functional Macular Changes in Retinal Detachment
The purpose of this study is to evaluate the correlation between morphologic changes in the outer retina and visual function after successful repair of rhegmatogenous retinal detachment with macula off.
- Trial name
- NCT01343134
- Testing
- Measure the outer retina by spectral domain optical coherence tomography (HRA Spectralis; Heidelberg), and microperimetry (OPKO Instruments)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Thyroid Associated Orbitopathy
OCT Angiography Drived Alterations in Thyroid-associated Orbitopathy
The aim of this observational study is to evaluate retinal microvascular alterations in patients with thyroid-associated orbitopathy (TAO) using optical coherence tomography angiography (OCTA).
- Trial name
- TAO (NCT07341347)
- Where
- Croatia
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Osijek University Hospital
Optical Coherence Tomography, Diabetic Retinopathy
A Longitudinal Study of Choroidal Changes After Cataract Surgery in Eyes With Diabetic Retinopathy
To determine the influence of phacoemulsification on choroidal vasculature in patients with diabetic retinopathy (DR) undergoing cataract surgery
- Conditions
- Optical Coherence Tomography, Diabetic Retinopathy, Choroid
- Trial name
- NCT04499768
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Ruijin Hospital
COVID-19
Retinal Vascular Changes in Patients After Coronavirus Disease 2019 (COVID-19)
The study examines changes in retinal oximetry in patients after COVID-19 disease. It aims to analyze and quantify possible retinal microvascular abnormalities that may result from possible post-inflammatory damage to the…
- Trial name
- NCT05747547
- Testing
- Central visual acuity, Intraocular pressure measurement, Slit lamp examination
- Where
- Czechia
- Volunteers
- 34 people
- Sponsor
- University Hospital Olomouc
Pregnancy Induced Hypertension
Optical Coherence Tomography Angiography Compared to Maternal Doppler in Screening for Hypertension in Pregnancy
Pregnancy related hypertension is one of the most prevalent obstetric complications. The aim of the study is to evaluate the validity and sensitivity of OCT angiography in prediction of pregnancy induced hypertensive disorders in…
- Trial name
- NCT05330949
- Testing
- Optical coherence Tomography Angiography, Uterine artry doppler
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Minia University
Rhegmatogenous Retinal Detachment
Topographic Changes of Retinal Layers After Resolution of Acute Retinal Detachment
Experimental retinal detachment and reattachment models have demonstrated the recovery process of successfully reattached retina.
- Trial name
- NCT01587794
- Volunteers
- 21 people
- Sponsor
- Samsung Medical Center
All Comers
A-EYE: A Mixed Quantitative and Qualitative Study to Develop and Evaluate the Application of Artificial Intelligence (AI) Methods Using Retinal Imaging for the Identification of Adverse Retinal Changes Associated With Cancer Therapies.
This is a data collection study involving the gathering of clinical data and OCT (optical coherence tomography) scans from 350 patients.
- Trial name
- A-EYE (NCT04901468)
- Testing
- No Intervention
- Where
- United Kingdom
- Volunteers
- 350 people
- Sponsor
- University of Manchester
Age-related Macular Degeneration (AMD)
Medico-economic Evaluation of Anti-VEGF Treatments in the Treatment of naïve Age-related Macular Degeneration (AMD): a Model Adapted to the French Context
Age-related macular degeneration (AMD) is the leading cause of blindness after 50 years in industrialized countries, compromising daily activities and reducing quality of life.
- Trial name
- MEDIAL (NCT03577041)
- Where
- France
- Volunteers
- 600 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Retinitis Pigmentosa, Usher Syndrome Type 2
Retinal Imaging in CNTF -Releasing Encapsulated Cell Implant Treated Patients for Early-stage Retinitis Pigmentosa
This clinical trial is a single-site, 30 patient study for participants who have early stage retinitis pigmentosa, or Usher syndrome (type 2 or 3). Funding Source - FDA OOPD and Foundation Fighting Blindness.
- Conditions
- Retinitis Pigmentosa, Usher Syndrome Type 2, Usher Syndrome Type 3
- Trial name
- NCT01530659
- Testing
- NT-501
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Neurotech Pharmaceuticals
Age-related Macular Degeneration
The Effect of Eggs and Egg Products on Macular Pigment
Age-related macula degeneration (AMD, encompassing both dry and wet form), the late stage of Age-related maculopathy (ARM), is the leading cause of blindness in many developed countries in older persons (usually over 60 years of…
- Trial name
- NCT00527553
- Testing
- not enriched egg, lutein, zeaxanthin
- Where
- Netherlands
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Retinal Detachment, Refractive Errors
Refractive Changes Following Vitrectomy
We aimed o compare the refractive changes associated with pars plana vitrectomy with or without intraocular gas tamponade in pseudophakic eyes.
- Conditions
- Retinal Detachment, Refractive Errors, Vitreous Hemorrhage, Epiretinal Membrane
- Trial name
- NCT04712786
- Testing
- pars plana vitrectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 47 people
- Sponsor
- Bursa Retina Eye Hospital
Visual Impairment, Amblyopia
Developing Better Computerised Vision Tests (CVTV)
Clinical vision measurements usually involve printed charts with an eye care professional interpreting patient responses to generate a score. Those scores determine the need for or outcome of treatment.
- Conditions
- Visual Impairment, Amblyopia, Macular Degeneration, Ophthalmic Disease
- Trial name
- CVTV (NCT06224751)
- Testing
- Near logMAR letter acuity, Near LogMAR word acuity, Red Green Stereoacuity
- Where
- United Kingdom
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Cognitive Change
Yoga Training and Retinal Vasculature With Parkinson's Disease
This study will compare the impact of a novel high-speed, cued yoga program to a standard yoga program on retinal microvasculature, cognition and neuromuscular function in persons with Parkinson's disease.
- Trial name
- NCT06194227
- Testing
- High-speed, Cognitive Challenge Yoga, Traditional Yoga
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Miami
Nerve Fiber Bundle Defect, Optic Nerve Diseases
Changes of the Peripapillary Retinal Nerve Fiber Layer After Filtration Surgery in Glaucoma Patients
At present, trabeculectomy is the most common performed and effective surgical method of filtration surgery for patients with medically uncontrolled glaucoma.
- Trial name
- NCT01422525
- Testing
- spectral domain optical coherence tomography
- Where
- Germany
- Volunteers
- 12 people
- Sponsor
- University Eye Hospital, Würzburg
Pre Diabetes, Vascular Stiffness
Dietary Exchanges With Avocado and Mango in Pre-diabetes
The research is designed as a randomized, 2-arm, parallel, controlled, human clinical trial to investigate the effects of avocado and mango consumption for 8 weeks on indices of macro- and micro- vascular function in individuals…
- Conditions
- Pre Diabetes, Vascular Stiffness, Vascular Dilation, Cognitive Change
- Trial name
- AVMa (NCT05353790)
- Testing
- Meals + snacks: control, Meals + snacks: Avocado mango
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Macular Pucker, Macular Cyst
Inner Nuclear Macular Microcyst is a Risk Factor for Macular Cystoid Changes After Phacoemulsification in Eyes With Previous Vitrectomy and Macular Pucker Removal
To evaluate the visual acuity, macular thickness, morphological changes after cataract surgery in eyes with previous vitrectomy for macular pucker. Associated risk factors were also investigated.
- Trial name
- NCT03934190
- Volunteers
- 46 people
- Sponsor
- Changhua Christian Hospital